SI3279313T1 - Shigella sevi s prekomerno tvorbo mehurčkov (blebbing) - Google Patents

Shigella sevi s prekomerno tvorbo mehurčkov (blebbing)

Info

Publication number
SI3279313T1
SI3279313T1 SI201032053T SI201032053T SI3279313T1 SI 3279313 T1 SI3279313 T1 SI 3279313T1 SI 201032053 T SI201032053 T SI 201032053T SI 201032053 T SI201032053 T SI 201032053T SI 3279313 T1 SI3279313 T1 SI 3279313T1
Authority
SI
Slovenia
Prior art keywords
shigella strains
hyperblebbing
hyperblebbing shigella
strains
shigella
Prior art date
Application number
SI201032053T
Other languages
English (en)
Inventor
Christiane Gerke
Scorza Francesco Berlanda
Allan Saul
Luana Maggiore
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of SI3279313T1 publication Critical patent/SI3279313T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0283Shigella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25Shigella (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SI201032053T 2009-09-28 2010-09-28 Shigella sevi s prekomerno tvorbo mehurčkov (blebbing) SI3279313T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0917002.8A GB0917002D0 (en) 2009-09-28 2009-09-28 Improved shigella blebs
EP17168855.9A EP3279313B1 (en) 2009-09-28 2010-09-28 Hyperblebbing shigella strains

Publications (1)

Publication Number Publication Date
SI3279313T1 true SI3279313T1 (sl) 2021-02-26

Family

ID=41350492

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201031507T SI2483389T1 (sl) 2009-09-28 2010-09-28 Sevi Shigelle za hipersproščanje mehurčkov
SI201032053T SI3279313T1 (sl) 2009-09-28 2010-09-28 Shigella sevi s prekomerno tvorbo mehurčkov (blebbing)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201031507T SI2483389T1 (sl) 2009-09-28 2010-09-28 Sevi Shigelle za hipersproščanje mehurčkov

Country Status (21)

Country Link
US (2) US20130052227A1 (sl)
EP (2) EP3279313B1 (sl)
JP (3) JP2013505716A (sl)
KR (1) KR101786025B1 (sl)
CN (2) CN107475168A (sl)
AU (1) AU2010299577B2 (sl)
BR (1) BR112012006912A8 (sl)
CA (1) CA2775642C (sl)
CY (2) CY1118970T1 (sl)
DK (2) DK3279313T3 (sl)
ES (2) ES2632747T3 (sl)
GB (1) GB0917002D0 (sl)
HR (2) HRP20170845T1 (sl)
HU (1) HUE053188T2 (sl)
LT (2) LT3279313T (sl)
NZ (1) NZ599598A (sl)
PL (2) PL3279313T3 (sl)
PT (2) PT2483389T (sl)
SI (2) SI2483389T1 (sl)
WO (1) WO2011036564A2 (sl)
ZA (1) ZA201202934B (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
GB201017519D0 (en) 2010-10-15 2010-12-01 Novartis Vaccines Inst For Global Health S R L Vaccines
WO2014076714A2 (en) * 2012-11-19 2014-05-22 Indian Council Of Medical Research Novel immunogenic antigens of shigella
US9636390B2 (en) 2012-11-19 2017-05-02 Indian Council Of Medical Research Immunogenic antigens of shigella
EA033538B1 (ru) 2013-03-15 2019-10-31 Univ Arkansas Композиции и способы усиления иммунного ответа на кишечные патогены
EP2870974A1 (en) 2013-11-08 2015-05-13 Novartis AG Salmonella conjugate vaccines
CN104974946B (zh) * 2014-04-08 2019-01-11 中国科学院天津工业生物技术研究所 耐高渗透压的重组大肠杆菌及其应用
CL2014001126A1 (es) * 2014-04-29 2014-08-29 Univ Chile Composición farmacéutica útil como vacuna contra bacterias escherichia coli productoras de shigatoxinas (stec), que comprende al menos un antígeno o una proteína de membrana externa inmunogénica o proteína inmunogénica asociada y conservada en cepas stec.
CN107921116A (zh) * 2015-06-16 2018-04-17 葛兰素史密丝克莱恩生物有限公司 免疫原性组合物
CN105647893A (zh) * 2016-03-04 2016-06-08 江南大学 一种D-丙氨酰-D-丙氨酸羧肽酶dacD基因及应用
CN105647892A (zh) * 2016-03-04 2016-06-08 江南大学 一种D-丙氨酰-D-丙氨酸羧肽酶dacA基因及应用
TWI758288B (zh) 2016-05-03 2022-03-21 阿肯色州大學董事會 包含免疫刺激性及抗原性多肽的酵母菌疫苗載體以及其使用方法
US20170360881A1 (en) * 2016-06-17 2017-12-21 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3263695A1 (en) * 2016-06-29 2018-01-03 GlaxoSmithKline Biologicals SA Immunogenic compositions
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2019163785A1 (ja) * 2018-02-20 2019-08-29 株式会社山田養蜂場本社 膜小胞組成物の製造方法
US20210301297A1 (en) * 2018-07-24 2021-09-30 Wacker Chemie Ag Novel bacterial lpp mutants and the use thereof for the secretory production of recombinant proteins
CN111363018B (zh) * 2020-03-26 2021-10-01 廊坊梅花生物技术开发有限公司 重组菌株及其在l-色氨酸制备中的应用
WO2022133289A2 (en) * 2020-12-18 2022-06-23 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
GB202112149D0 (en) 2021-08-24 2021-10-06 Glaxosmithkline Biologicals Sa Shigellla vaccine
CN113897324B (zh) * 2021-10-13 2023-07-28 云南师范大学 一种用作抗锰剂的JcVIPP1重组大肠杆菌及其构建方法
GB202118913D0 (en) 2021-12-23 2022-02-09 Glaxosmithkline Biologicals Sa Method for preparing outer membrane vesicles
CN116855471B (zh) * 2023-09-04 2023-11-28 江苏申基生物科技有限公司 一种嘌呤核苷磷酸化酶突变体及其应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
US6090406A (en) 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
US5916588A (en) 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
AU631377B2 (en) 1988-08-25 1992-11-26 Liposome Company, Inc., The Affinity associated vaccine
WO1990014837A1 (en) 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
KR100278157B1 (ko) 1992-06-25 2001-01-15 장 스테판느 보조약을 함유하는 백신 조성물
DK0812593T4 (da) 1993-03-23 2008-05-13 Smithkline Beecham Biolog Vaccinepræparater indeholdende 3-O-deacyleret monophosphoryllipid-A
WO1995011700A1 (en) 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5681736A (en) 1994-10-05 1997-10-28 Antex Biologics, Inc. Methods for producing enhanced antigenic shigella bacteria and vaccines comprising same
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
GB9513261D0 (en) 1995-06-29 1995-09-06 Smithkline Beecham Biolog Vaccines
US6887483B2 (en) * 1995-12-01 2005-05-03 University Of Iowa Research Foundation Non-toxic mutants of pathogenic gram-negative bacteria
WO1998040100A1 (en) 1997-03-10 1998-09-17 Ottawa Civic Loeb Research Institute USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US6080725A (en) 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
GB9712347D0 (en) 1997-06-14 1997-08-13 Smithkline Beecham Biolog Vaccine
WO1999011241A1 (en) 1997-09-05 1999-03-11 Smithkline Beecham Biologicals S.A. Oil in water emulsions containing saponins
GB9725084D0 (en) 1997-11-28 1998-01-28 Medeva Europ Ltd Vaccine compositions
WO1999040936A2 (en) 1998-02-12 1999-08-19 American Cyanamid Company Pneumococcal and meningococcal vaccines formulated with interleukin-12
US6303114B1 (en) 1998-03-05 2001-10-16 The Medical College Of Ohio IL-12 enhancement of immune responses to T-independent antigens
US6562798B1 (en) 1998-06-05 2003-05-13 Dynavax Technologies Corp. Immunostimulatory oligonucleotides with modified bases and methods of use thereof
GB9817052D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
US6759241B1 (en) * 1999-10-04 2004-07-06 University Of Maryland Biotechnology Institute Adjuvant comprising a lipopolysaccharide antagonist
US20010044416A1 (en) 2000-01-20 2001-11-22 Mccluskie Michael J. Immunostimulatory nucleic acids for inducing a Th2 immune response
DE60132471T2 (de) 2000-09-26 2009-01-15 Idera Pharmaceuticals, Inc., Cambridge Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen
GB0103171D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
WO2003035836A2 (en) 2001-10-24 2003-05-01 Hybridon Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
PT2255826E (pt) 2002-08-02 2016-06-08 Glaxosmithkline Biologicals Sa Composições de vacina de neisseria compreendendo uma combinação de antigénios
ATE485056T1 (de) 2003-03-24 2010-11-15 Intercell Ag Verbesserte impfstoffe
JP5393978B2 (ja) 2004-04-05 2014-01-22 ゾエティス・ピー・エルエルシー マイクロ流動化された水中油型乳剤及びワクチン組成物
CN101203529A (zh) 2005-02-18 2008-06-18 诺华疫苗和诊断公司 来自脑膜炎/脓毒症相关性大肠杆菌的蛋白质和核酸
AU2012207041A1 (en) 2005-02-18 2012-08-16 J. Craig Venter Institute, Inc. Proteins and nucleic acids from meningitis/sepsis-associated Escherichia Coli
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
US8703095B2 (en) 2005-07-07 2014-04-22 Sanofi Pasteur S.A. Immuno-adjuvant emulsion

Also Published As

Publication number Publication date
ZA201202934B (en) 2012-12-27
BR112012006912A8 (pt) 2017-07-11
CY1118970T1 (el) 2018-01-10
AU2010299577A1 (en) 2012-05-24
LT3279313T (lt) 2021-03-25
BR112012006912A2 (pt) 2016-11-22
HUE053188T2 (hu) 2021-06-28
GB0917002D0 (en) 2009-11-11
EP2483389A2 (en) 2012-08-08
WO2011036564A3 (en) 2011-08-04
PL2483389T3 (pl) 2017-09-29
KR20120106729A (ko) 2012-09-26
AU2010299577B2 (en) 2015-09-03
JP2019068864A (ja) 2019-05-09
JP7023248B2 (ja) 2022-02-21
NZ599598A (en) 2013-08-30
JP2013505716A (ja) 2013-02-21
JP2016105736A (ja) 2016-06-16
CN107475168A (zh) 2017-12-15
ES2846901T3 (es) 2021-07-30
LT2483389T (lt) 2017-07-25
PT2483389T (pt) 2017-07-24
EP3279313A2 (en) 2018-02-07
PT3279313T (pt) 2021-01-13
CN102906245A (zh) 2013-01-30
PL3279313T3 (pl) 2021-05-31
US20160289632A1 (en) 2016-10-06
SI2483389T1 (sl) 2017-08-31
EP2483389B1 (en) 2017-05-03
HRP20210243T1 (hr) 2021-04-02
DK2483389T3 (en) 2017-07-10
CN102906245B (zh) 2017-08-18
CY1123774T1 (el) 2022-05-27
DK3279313T3 (da) 2021-01-25
EP3279313A3 (en) 2018-03-21
CA2775642C (en) 2022-09-06
CA2775642A1 (en) 2011-03-31
EP3279313B1 (en) 2020-11-25
KR101786025B1 (ko) 2017-10-18
ES2632747T3 (es) 2017-09-15
WO2011036564A2 (en) 2011-03-31
HRP20170845T1 (hr) 2017-08-11
US20130052227A1 (en) 2013-02-28
US11339367B2 (en) 2022-05-24

Similar Documents

Publication Publication Date Title
ZA201202934B (en) Hyperblebbing shigella strains
DK3023438T3 (en) Anti-gitr-antistoffer
DK2457337T3 (en) Specialtilpasset impuls-burst
EP2462514A4 (en) GREEN BOOKS
EP2515891A4 (en) 3-keto-N-propargyl-1-aminoindan
EP2519921A4 (en) CALL TRACING
DK2464943T3 (en) Systemintegration
ZA201201854B (en) Document
GB0919470D0 (en) Document
GB0900568D0 (en) Poymerisation
GB0900319D0 (en) Hydrocharger
EP2510125A4 (en) HYPER PRIMER
AU4924P (en) Bonscablue Scaevola aemula
AU4926P (en) Bonscalib Scaevola aemula
AU4240P (en) Tuckerbox xTriticosecale
AU4925P (en) Bonscawi Scaevola aemula
GB0908139D0 (en) Mechanical seal-securing
GB0900167D0 (en) B b
GB0900285D0 (en) Hangermate
GB0900201D0 (en) Lasha2A
GB0900212D0 (en) Shelta
AP2009000321S (en) Doropak
GB0900183D0 (en) Lugg-Scan
AU329913S (en) Cupcan
AP00242S1 (en) Woodstove