SI2911699T1 - Modificirano protitelo, protitelo-konjugat in proces za njihovo pripravo - Google Patents

Modificirano protitelo, protitelo-konjugat in proces za njihovo pripravo Download PDF

Info

Publication number
SI2911699T1
SI2911699T1 SI201330948T SI201330948T SI2911699T1 SI 2911699 T1 SI2911699 T1 SI 2911699T1 SI 201330948 T SI201330948 T SI 201330948T SI 201330948 T SI201330948 T SI 201330948T SI 2911699 T1 SI2911699 T1 SI 2911699T1
Authority
SI
Slovenia
Prior art keywords
antibody
group
glcnac
hetero
conjugate
Prior art date
Application number
SI201330948T
Other languages
English (en)
Inventor
Delft Floris Louis Van
Geel Remon Van
Maria Antonia Wijdeven
Original Assignee
Synaffix B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50544942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2911699(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synaffix B.V. filed Critical Synaffix B.V.
Publication of SI2911699T1 publication Critical patent/SI2911699T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (14)

  1. MODIFICIRANO PROTITELO, PROTITELO-KONJUGAT IN PROCES ZA NJIHOVO PRIPRAVO PATENTNI ZAHTEVKI
    1. Proces za pripravo protitelesa-konjugata, ki obsega reagiranje modificiranega protitelesa z linker-konjugatom, kjer omenjeni linker-konjugat obsega (hetero) cikloalkinilno skupino in eno ali več molekul, ki nas zanimajo pri čemer je omenjeno modificirano protitelo je protitelo, ki vsebuje GlcNAc-S(A)x substituent, kjer je GlcNAc N-acetilglukozamin, kjer je S(A)X sladkorni derivat, ki obsega x funkcionalne skupine A, kjer je A azido skupina in x je 1, 2, 3 ali 4, kjer je omenjeni GlcNAc-S(A)x substituent vezan na protitelo preko C1 N-acetilglukozamina omenjenega GlcNAc-S(A)x substituenta in kjer je navedeni GlcNAc po izbiri fukoziliran.
  2. 2. Proces po zahtevku 1, ki obsega stopnje: (i) kontaktiranje protitelesa, ki vsebuje jedro N-acetilglukozamin (GlcNAc) substituent s spojino s formulo S(A)x-P v prisotnosti katalizatorja, kjer je omenjeni jedrni N-acetilglukozaminski substituent po izbiri fukoziliran, kjer navedeni katalizator obsega mutantno katalitsko domeno iz galaktoziltransferaze, pri čemer je S(A)X derivat sladkorja, ki vsebuje x funkcionalne skupine A, kjer je A azido skupina in je x 1, 2, 3 ali 4, kjer je P izbran iz skupine, ki jo sestavljajo uridin difosfat (UDP), gvanozin difosfat (GDP) in citidin difosfat (CDP), da dobimo modificirano protitelo, kjer je modificirano protitelo definirano kot protitelo, ki obsega GlcNAc-S(A)x substituent, vezan na protitelo preko C1 N-acetilglukozamina omenjenega GlcNAc-S(A)xsubstituenta, in kjer je navedeno modificirano protitelo po formuli (4):
    pri čemer S(A)X in x sta, kot je definirano zgoraj; AB predstavlja protitelo; GlcNAc je N-acetilglukozamin; Fucjefukoza; b je 0 ali 1; in y je 1 do 20; in (ii) reagiranje omenjenega modificiranega protitelesa z linker-konjugatom, kjer omenjeni linker-konjugat obsega (hetero)cikloalkinil skupino in eno ali več molekul, ki nas zanimajo.
  3. 3. Proces po zahtevku 1 ali 2, kjer je katalizator katalizator, ki obsega mutantno katalitično domeno iz /3(1,4)-galaktoziltransferaze, prednostno izbrano iz skupine, ki jo sestavljajo GalT Y289L, GalT Υ289Ν, GalT Υ289Ι, GalT Y289F, GalT Υ289Μ, GalT Y289V, GalT Y289G, GalT Υ289Ι in GalT Υ289Α.
  4. 4. Proces po katerem koli od zahtevkov 1-3, kjer ima omenjeni linker-konjugat formulo (11) ali (11b):
    pri čemer L je linker; D je molekula, ki nas zanima; rje 1 - 20; R1 je neodvisno izbran iz skupine, ki jo sestavljajo vodik, halogen, -OR5, -N02, -CN, -S(0)2R5, Ci - C24 alkilne skupine, C6-C24 (hetero) aril skupine, C7-C24 alkil(hetero)aril skupine in C7-C24 (hetero)arilalkil skupine in pri čemer so alkilne skupine, (hetero)aril skupine, alkil (hetero)aril skupine in (hetero)arilalkil skupine po izbiri substituirane, pri čemer sta lahko dva substituenta R1 povezana skupaj, da tvorita aneliran cikloalkil ali aneliran (hetero)aren substituent in kjer je R5 neodvisno izbran iz skupine, katero sestavljajo vodik, halogen, CrC24 alkilne skupine, C6-C24 (hetero)arilne skupine, C7-C24 alkil(hetero) arilne skupine in C7-C24 (hetero)arilalkilne skupine; X je C (R1)2, O, S ali NR2, kjer je R2 R1 ali L(D)r, in kjer so L, D in r, kot je definirano zgoraj; q je 0 ali 1, s pridržkom, da če je q 0, potem je X N-L(D)r; a je 0,1, 2, 3, 4, 5, 6, 7 ali 8; a'je 0,1, 2, 3, 4, 5, 6, 7 ali 8; in a+a’ < 10.
  5. 5. Proces po katerem koli od zahtevkov 1-4, kjer ima omenjeni linker-konjugat formulo (17):
    pri čemer R1, L, D in r, so kot je definirano v zahtevku 4; Y je O, S ali NR2, kjer je R2, kot je definirano v zahtevku 4; R3 je neodvisno izbran iz skupine, ki jo sestavljajo vodik, halogen, C1-C24 alkilne skupine, C6-C24 (hetero)aril skupine, C7-C24 alkil(hetero)aril skupine in C7-C24 (hetero)arilalkil skupine; R4 je izbran iz skupine, ki jo sestavljajo vodik, Y-L(D)r, -(CH2)n-Y-L(D)r, halogen, C1-C24 alkilne skupine, C6-C24 (hetero)aril skupine, C7-C24 alkil(hetero)aril skupine in C7-C24 (hetero)arilalkil skupine, alkil skupine, ki so po izbiri prekinjene z enim od večih heteroatomov, izbranih iz skupine, ki jo sestavljajo O, N in S, kjer so alkilne skupine, (hetero)arilne skupine, alkil(hetero)aril skupine in (hetero)arilalkilne skupine neodvisno po izbiri substituirane; in n je 1, 2, 3, 4, 5, 6, 7, 8, 9 ali 10, ali kjer ima omenjeni linker-konjugat formulo (15) ali formulo (19):
    kjer so L, D in r, kot je definirano v zahtevku 4.
  6. 6. Protitelo-konjugat po formuli (20) ali (20b):
    pri čemer L, D, X, R1, a, a', r in q so, kot je definirano v zahtevku 5; b je 0 ali 1; p je 0 ali 1; Q je -N(H)C(0)CH2- ali -CH2-; x je 1, 2, 3 ali 4; y je 1-20; in kjer je AB protitelo, S je sladkor ali derivat sladkorja, GlcNAc je N-acetilglukozamin in Fuc je fukoza.
  7. 7. Protitelo-konjugat po zahtevku 8, kjer je protitelo-konjugat s formulo (21):
    kjer so AB, L, D, S, Q, x, y, b, p, R1 in GlcNAc, kot je definirano v zahtevku 6, in kjer so R3, R4, Y, n in r, kot je definirano v zahtevku 4 ali kjer je protitelo konjugat s formulo (15b) ali s formulo (22):
    kjer so AB, L, D, S, x, y, b, p, Q in GlcNAc, kot so definirani v zahtevku 6:
  8. 8. Protitelo-konjugat po katerem koli od zahtevkov 6 - 7, kjer je omenjena molekula (D) izbrana iz skupine, ki jo sestavljajo snov, ki je biološko in/ali farmacevtsko aktivna, reporter molekula, azid in (hetero)cikloalkinil skupina.
  9. 9. Protitelo-konjugat, ki ga lahko dobimo s postopkom po katerem koli od zahtevkov 1-5.
  10. 10. Protitelo-konjugat po katerem koli od zahtevkov 6 - 9 za uporabo kot zdravilo.
  11. 11. Protitelo-konjugat po katerem koli od zahtevkov 6 - 9 za uporabo pri zdravljenju raka, prednostno raka dojke, bolj prednostno HER2 pozitiven rak dojke.
  12. 12. Proces za pripravo protitelo-zdravilo konjugata, ki obsega korake: (i) kontaktiranje protitelesa, ki vsebuje jedrni N-acetilglukozamin (GlcNAc) substituent s spojino s formulo S(A)x-P v prisotnosti katalizatorja, kjer je omenjeni jedrni N-acetilglukozaminski substituent po izbiri fukoziliran, kjer navedeni katalizator obsega mutantno katalitsko domeno iz galaktoziltransferaze, pri čemer je S(A)X derivat sladkorja, ki obsega x funkcionalne skupine A, kjer je A neodvisno izbran iz skupine ki sestoji iz azido skupine, keto skupine in alkinilne skupine in je x 1, 2, 3 ali 4, kjer je P izbran iz skupine, ki jo sestavljajo uridin difosfat (UDP), gvanozin difosfat (GDP) in citidin difosfat (CDP), da dobimo modificirano protitelo, kjer je modificirano protitelo definirano kot protitelo, ki obsega GlcNAc-S(A)x substituent, vezan na protitelo preko C1 N-acetilglukozamina omenjenega substituenta GlcNAc-S(A)x, in kjer je navedeno modificirano protitelo po formuli (4):
    pri čemer sta S(A)X in x, kot je definirano zgoraj; AB predstavlja protitelo; GlcNAc je N-acetilglukozamin; Fuc je fukoza; b je 0 ali 1; in y je 1 do 20; in (ii) reagiranje omenjenega modificiranega protitelesa s linker- konjugatom, kjer: (a) kadar je navedeno modificirano protitelo azid modificirano protitelo, omenjeni linker- konjugat obsega(hetero)cikloalkinil skupino ali alkinilno skupino in eno ali več molekul, ki nas zanimajo; ali (b) kadar je navedeno modificirano protitelo keto modificirano protitelo, omenjeni linker-konjugat obsega primarno aminsko skupino, aminooksi skupino ali hidrazinilno skupino in eno ali več molekul, ki nas zanimajo; ali (c) kadar je navedeno modificirano protitelo alkin-modificirano protitelo, omenjeni linker-konjugat obsega azido skupino in eno ali več molekul, ki nas zanimajo, kjer je molekula, ki nas zanima (D) konjugirana s protitelesom prek linkerja (L); kjer je omenjena molekula, ki nas zanima snov, ki je biološko in/ali farmacevtsko aktivna.
  13. 13. Protitelo-zdravilo konjugat, ki ga lahko dobimo s postopkom po zahtevku 12.
  14. 14. Proces za pripravo modificiranega protitelesa, pri čemer postopek obsega: (a) deglikozilacijo glikana protitelesa, ki ima jedrni N-acetilglukozamin, v prisotnosti endoglikozidaze, da dobimo protitelo, ki obsega jedrni N-acetilglukozamin substituent, pri čemer je omenjeni jedrni N-acetilglukozamin substituent po izbiri fukoziliran, pri čemer je omenjeni jedrni N-acetilglukozamin substituent vezan preko N-glikozidne vezi z atomom amidnega dušika v stranski verigi asparaginske aminokisline protitelesa in kjer je omenjena endoglikozidaza Endo S, Endo S49, Endo F ali njihova kombinacija; sledi (b) kontaktiranje omenjenega protitelesa s spojino s formulo S(A)X-P v prisotnosti katalizatorja, pri čemer omenjeni katalizator obsega mutantno katalitično domeno iz galaktoziltransferaze, pri čemer je S(A)X derivat sladkorja ki obsega x funkcionalne skupine A, kjer je A neodvisno izbran iz skupine, ki jo sestavljajo azido skupina, keto skupina in alkinilna skupina in je x 1, 2, 3 ali 4, kjer je P izbran iz skupine, ki jo sestavljajo ofuridin difosfat (UDP), gvanozin difosfat (GDP) in citidin difosfat (CDP), kjer je modificirano protitelo definirano kot protitelo, ki obsega GlcNAc-S(A)x substituent, vezan na protitelo preko C1 N-acetilglukozamina omenjenega GlcNAc-S(A)x substituenta.
SI201330948T 2012-10-23 2013-10-23 Modificirano protitelo, protitelo-konjugat in proces za njihovo pripravo SI2911699T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261717187P 2012-10-23 2012-10-23
EP12189604 2012-10-23
EP13188607 2013-10-14
EP13786322.1A EP2911699B1 (en) 2012-10-23 2013-10-23 Modified antibody, antibody-conjugate and process for the preparation thereof
PCT/NL2013/050744 WO2014065661A1 (en) 2012-10-23 2013-10-23 Modified antibody, antibody-conjugate and process for the preparation thereof

Publications (1)

Publication Number Publication Date
SI2911699T1 true SI2911699T1 (sl) 2018-04-30

Family

ID=50544942

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201330948T SI2911699T1 (sl) 2012-10-23 2013-10-23 Modificirano protitelo, protitelo-konjugat in proces za njihovo pripravo
SI201332049T SI3912642T1 (sl) 2012-10-23 2013-10-23 Modificirano protitelo, konjugat protitelesa in postopek za pripravo le-teh

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201332049T SI3912642T1 (sl) 2012-10-23 2013-10-23 Modificirano protitelo, konjugat protitelesa in postopek za pripravo le-teh

Country Status (16)

Country Link
US (3) US10745488B2 (sl)
EP (3) EP2911699B1 (sl)
JP (3) JP6855661B2 (sl)
CN (2) CN110201186A (sl)
CY (1) CY1120041T1 (sl)
DK (2) DK2911699T3 (sl)
ES (2) ES2949376T3 (sl)
FI (1) FI3912642T3 (sl)
HR (2) HRP20230690T1 (sl)
HU (2) HUE038285T2 (sl)
LT (2) LT3912642T (sl)
PL (2) PL3912642T3 (sl)
PT (1) PT2911699T (sl)
RS (2) RS56953B1 (sl)
SI (2) SI2911699T1 (sl)
WO (1) WO2014065661A1 (sl)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2911699B1 (en) * 2012-10-23 2017-11-15 SynAffix B.V. Modified antibody, antibody-conjugate and process for the preparation thereof
EP3964237A1 (en) * 2013-03-15 2022-03-09 Regeneron Pharmaceuticals, Inc. Biologically active molecules, conjugates thereof, and therapeutic uses
EP3613468A1 (en) * 2013-05-02 2020-02-26 Glykos Finland Oy Glycoprotein-toxic payload conjugates
MX2016002149A (es) 2013-08-26 2016-10-28 Regeneron Pharma Composiciones farmaceuticas que contienen diasteromeros macrolidos, metodos para su sintesis y usos terapeuticos.
EP2935611B1 (en) * 2013-10-14 2021-07-07 SynAffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
WO2015057064A1 (en) * 2013-10-14 2015-04-23 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
CN105814213B (zh) 2013-10-14 2021-05-04 西纳福克斯股份有限公司 经修饰的糖蛋白、蛋白质-缀合物及其制备方法
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
EP3097080A1 (en) 2014-01-24 2016-11-30 SynAffix B.V. Process for the cycloaddition of a halogenated 1,3-dipole compound with a (hetero)cycloalkyne
CN106660967A (zh) 2014-01-24 2017-05-10 西纳福克斯股份有限公司 (杂)芳基1，3‑偶极化合物与(杂)环炔的环加成方法
EP3129402A4 (en) 2014-04-08 2017-12-13 University Of Georgia Research Foundation, Inc. Site-specific antibody-drug glycoconjugates and methods
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
EP2974744A1 (en) 2014-07-16 2016-01-20 Stichting Katholieke Universiteit Strain-promoted oxidation controlled cycloaddition with high reaction rate
EP4148138A1 (en) 2014-08-04 2023-03-15 SynAffix B.V. Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof
JP6733993B2 (ja) * 2014-10-03 2020-08-05 シンアフィックス ビー．ブイ． スルファミドリンカー、スルファミドリンカーのコンジュゲート、及び調製の方法
KR20230144660A (ko) * 2014-12-04 2023-10-16 셀진 코포레이션 생체분자 컨쥬게이트
WO2016109802A1 (en) * 2014-12-31 2016-07-07 Development Center For Biotechnology Site-specific conjugation through glycoproteins linkage and method thereof
US11559581B2 (en) * 2015-01-09 2023-01-24 Oxford University Innovation Limited Antibody conjugates and methods of making the antibody conjugates
CN107995912A (zh) 2015-03-27 2018-05-04 里珍纳龙药品有限公司 美登素类衍生物、其偶联物和使用方法
PT3134520T (pt) 2015-04-23 2018-03-26 Synaffix Bv Resumo
US10988508B2 (en) * 2015-04-24 2021-04-27 University Of Delaware Synthetic N-acetyl-muramic acid derivatives and uses thereof
US11129903B2 (en) 2015-07-06 2021-09-28 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules and uses thereof
US11181527B2 (en) * 2015-08-26 2021-11-23 Vib Vzw Means and methods for monitoring inflammation
KR20180058737A (ko) * 2015-10-07 2018-06-01 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 암 선택적 표지화 및 표적화를 위한 트리거-활성화 대사성 당 전구체
CN107029242A (zh) 2015-11-03 2017-08-11 财团法人工业技术研究院 抗体药物复合物及其制造方法
WO2017100642A1 (en) 2015-12-11 2017-06-15 Regeneron Pharmaceuticals, Inc. Methods for reducing or preventing growth of tumors resistant to egfr and/or erbb3 blockade
AU2017211120C1 (en) 2016-01-25 2021-10-07 Regeneron Pharmaceuticals, Inc. Maytansinoid derivatives, conjugates thereof, and methods of use
CN108495653A (zh) 2016-01-27 2018-09-04 免疫医疗有限责任公司 用于制备具有定义的糖基化模式抗体的方法
CN108883191B (zh) * 2016-02-08 2022-10-14 西纳福克斯股份有限公司 用于靶向cd30肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法
WO2017137457A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
WO2017137423A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Improved sulfamide linkers for use in bioconjugates
JP2017200902A (ja) * 2016-02-08 2017-11-09 シンアフィックス ビー．ブイ． Ｈｅｒ２腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法
US10858641B2 (en) 2016-02-08 2020-12-08 Synaffix B.V. Enzymes for trimming of glycoproteins
JP2017197512A (ja) * 2016-02-08 2017-11-02 シンアフィックス ビー．ブイ． Ｃｄ３０腫瘍を標的化するための改善された治療指数を有する新規な抗体−コンジュゲート及び抗体−コンジュゲートの治療指数を改善するための方法
EP3413915A1 (en) * 2016-02-08 2018-12-19 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting her2 tumours and method for improving therapeutic index of antibody-conjugates
US11951175B2 (en) 2016-02-08 2024-04-09 Synaffix B.V. Bioconjugates containing sulfamide linkers for use in treatment
SG10202007520WA (en) 2016-03-02 2020-09-29 Eisai R&D Man Co Ltd Eribulin-based antibody-drug conjugates and methods of use
WO2017190079A1 (en) 2016-04-28 2017-11-02 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
EP3453758A4 (en) 2016-05-02 2019-12-04 Ajinomoto Co., Inc. FC PROTEIN WITH AZID GROUP
WO2017218891A1 (en) * 2016-06-17 2017-12-21 Life Technologies Corporation Site-specific crosslinking of antibodies
JP7128121B2 (ja) * 2016-06-28 2022-08-30 ヴェンタナ メディカル システムズ， インク． Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用
EP4159749A3 (en) * 2016-07-01 2023-06-14 Daiichi Sankyo Company, Limited A method for producing fc-containing molecule with remodeled sugar chain
WO2018002902A1 (en) 2016-07-01 2018-01-04 Glaxosmithkline Intellectual Property (No.2) Limited Antibody-drug conjugates and therapeutic methods using the same
MX2019003325A (es) * 2016-09-23 2019-08-05 Regeneron Pharma Anticuerpos anti-steap2, conjugados anticuerpo-farmaco, y moleculas de fijacion al antigeno biespecificas que se fijan a steap2 y cd3, y usos de estos.
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
WO2018089373A2 (en) 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
TWI744413B (zh) * 2016-11-14 2021-11-01 醣基生醫股份有限公司 抗體藥物複合體
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
KR102294517B1 (ko) 2016-12-29 2021-08-27 재단법인 생물기술개발중심 당단백질-약물 컨주게이트를 제조하는 방법
WO2018141959A1 (en) 2017-02-06 2018-08-09 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
KR20190126314A (ko) * 2017-02-10 2019-11-11 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 암-선택적 표지화 및 표적화를 위한 트리거 활성화 가능한 당 접합체
JP2020519261A (ja) 2017-05-11 2020-07-02 ブイアイビー ブイゼットダブリュＶｉｂ Ｖｚｗ 可変免疫グロブリンドメインのグリコシル化
IL270594B2 (en) 2017-05-18 2024-06-01 Regeneron Pharma Protein conjugates - a drug of cyclodextrin
CN111065622A (zh) 2017-05-18 2020-04-24 里珍纳龙药品有限公司 双八氢菲羧酰胺类化合物及其蛋白质偶联物
WO2019030284A1 (en) 2017-08-09 2019-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH NOVEL TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF
EP3441766B1 (en) * 2017-08-11 2020-03-11 Life Science Inkubator Sachsen GmbH & Co. KG Novel antibody conjugates suitable for use in discrete fluorescence quenching displacement immunoassays
WO2019065964A1 (ja) * 2017-09-29 2019-04-04 第一三共株式会社 抗体－ピロロベンゾジアゼピン誘導体コンジュゲート
CN111601619A (zh) 2017-11-07 2020-08-28 里珍纳龙药品有限公司 用于抗体药物偶联物的亲水性连接体
US11401345B2 (en) 2017-11-27 2022-08-02 Purdue Pharma L.P. Humanized antibodies targeting human tissue factor
WO2019110725A1 (en) 2017-12-06 2019-06-13 Synaffix B.V. Enediyne conjugates
AU2018395417B2 (en) 2017-12-29 2023-07-13 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
AU2019205542A1 (en) 2018-01-08 2020-07-16 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
WO2019212965A1 (en) 2018-04-30 2019-11-07 Regeneron Pharmaceuticals, Inc. Antibodies, and bispecific antigen-binding molecules that bind her2 and/or aplp2, conjugates, and uses thereof
CN112533951A (zh) 2018-05-09 2021-03-19 里珍纳龙药品有限公司 抗msr1抗体及其使用方法
SG11202011232VA (en) 2018-05-17 2020-12-30 Regeneron Pharma Anti-cd63 antibodies, conjugates, and uses thereof
JP2019206491A (ja) * 2018-05-29 2019-12-05 国立研究開発法人理化学研究所 乳がんまたは胃がんの治療のための抗体−薬物複合体
JP7273858B2 (ja) * 2018-06-15 2023-05-15 シャンハイ ミラコーケン インコーポレイティド 癌を治療するための方法と材料
IL280536B1 (en) * 2018-08-02 2024-08-01 Dyne Therapeutics Inc Muscle oriented clasps and their uses
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
SG11202100934PA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
WO2020028864A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
CN113260384A (zh) 2018-11-05 2021-08-13 西纳福克斯股份有限公司 用于靶向表达trop-2的肿瘤的抗体缀合物
BR112021009673A2 (pt) 2018-11-20 2021-12-14 Regeneron Pharma Derivados de bis-octa-hidrofenantreno carboxamida e conjugados de proteínas dos mesmos para uso como agonistas de lxr
BR112021012233A2 (pt) 2018-12-21 2021-09-08 Regeneron Pharmaceuticals, Inc. Análogos de rifamicina e conjugados de anticorpo-fármaco dos mesmos
BR112021011729A2 (pt) 2018-12-21 2021-11-09 Regeneron Pharma Tubulisinas e conjugados de proteína-tubulisina
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
KR20210110645A (ko) 2018-12-27 2021-09-08 글리코미메틱스, 인크. 갈렉틴-3 억제 c-글리코사이드
CN113905767A (zh) 2019-01-08 2022-01-07 里珍纳龙药品有限公司 无痕连接体及其蛋白质偶联物
GB201901608D0 (en) 2019-02-06 2019-03-27 Vib Vzw Vaccine adjuvant conjugates
CA3128519A1 (en) 2019-02-21 2020-08-27 Regeneron Pharmaceuticals, Inc. Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met
WO2020196475A1 (ja) * 2019-03-25 2020-10-01 第一三共株式会社 抗ｈｅｒ２抗体－ピロロベンゾジアゼピン誘導体コンジュゲート
US20220168440A1 (en) * 2019-03-25 2022-06-02 Daiichi Sankyo Company, Limited Antibody-pyrrolobenzodiazepine deprivative conjugate
BR112021017350A2 (pt) * 2019-03-27 2021-11-16 Daiichi Sankyo Co Ltd Combinação de conjugado de anticorpo-derivado de pirrolobenzodiazepina e inibidor de parp
EP3976112A1 (en) 2019-06-03 2022-04-06 Synaffix B.V. Acetal-based cleavable linkers
JP2022547274A (ja) 2019-09-16 2022-11-11 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 免疫ｐｅｔ撮像のための放射標識されたｍｅｔ結合タンパク質
US11814428B2 (en) 2019-09-19 2023-11-14 Regeneron Pharmaceuticals, Inc. Anti-PTCRA antibody-drug conjugates and uses thereof
KR20210095167A (ko) * 2019-09-29 2021-07-30 맙플렉스 인터내셔널 컴퍼니 리미티드 산 방법에 의한 항체-약물 접합체 중간체의 제조 방법 및 이의 적용
GB201918279D0 (en) 2019-12-12 2020-01-29 Vib Vzw Glycosylated single chain immunoglobulin domains
AU2021205312A1 (en) * 2020-01-09 2022-07-14 Mersana Therapeutics, Inc. Site specific antibody-drug conjugates with peptide-containing linkers
JP2023510850A (ja) 2020-01-13 2023-03-15 シンアフィックス ビー．ブイ． 付加環化を介して両側官能化された抗体
WO2021144315A1 (en) 2020-01-13 2021-07-22 Synaffix B.V. Conjugates of antibodies an immune cell engagers
WO2021144313A1 (en) 2020-01-13 2021-07-22 Synaffix B.V. Via cycloaddition bilaterally functionalized antibodies
BR112022014278A2 (pt) 2020-01-24 2022-09-20 Regeneron Pharma Conjugados de composto proteico-antiviral
US11958910B2 (en) 2020-02-28 2024-04-16 Regeneron Pharmaceuticals, Inc. Bispecific antigen binding molecules that bind HER2, and methods of use thereof
IL297027A (en) 2020-04-16 2022-12-01 Regeneron Pharma Diels-Alder compression methods
KR20230015348A (ko) 2020-05-25 2023-01-31 고에키 자이단 호징 고베 이료 산교 도시 스이신 기코 Th2 개재성 질환을 치료 또는 예방하기 위한 PD-1 작용제 함유 의약 조성물
CN111560078A (zh) * 2020-06-19 2020-08-21 联宁（苏州）生物制药有限公司 具有马来酰亚胺接头的双臂中间体及其合成方法
KR20230028325A (ko) 2020-06-24 2023-02-28 리제너론 파마슈티칼스 인코포레이티드 튜불리신 및 단백질-튜불리신 접합체
WO2021260232A1 (en) 2020-06-26 2021-12-30 Synaffix B.V. Methods for the preparation of linker payload constructs
EP4406608A2 (en) 2020-07-13 2024-07-31 Regeneron Pharmaceuticals, Inc. Protein-drug conjugates comprising camptothecin analogs and methods of use thereof
NL2026400B1 (en) 2020-09-02 2022-05-04 Synaffix Bv Methods for the preparation of bioconjugates
KR20230070337A (ko) 2020-09-14 2023-05-22 리제너론 파마슈티칼스 인코포레이티드 Glp1 펩티도미메틱을 포함하는 항체-약물 접합체 및 이의 용도
WO2022058395A1 (en) 2020-09-15 2022-03-24 Synaffix B.V. Antibody-exatecan conjugates
CN116615256A (zh) 2020-10-16 2023-08-18 乔治亚大学研究基金会 糖缀合物
US20230372528A1 (en) 2020-10-16 2023-11-23 University Of Georgia Research Foundation, Inc. Glycoconjugates
AU2021366691B2 (en) 2020-10-22 2024-06-06 Regeneron Pharmaceuticals, Inc. Anti-FGFR2 antibodies and methods of use thereof
NL2026947B1 (en) 2020-11-20 2022-07-01 Synaffix Bv Tyrosine-based antibody conjugates
EP4267195A1 (en) 2020-12-24 2023-11-01 Synaffix B.V. Glycan-conjugated antibodies binding to fc-gamma receptor
EP4288108A1 (en) 2021-02-08 2023-12-13 Synaffix B.V. Multifunctional antibodies
TW202304524A (zh) 2021-04-10 2023-02-01 美商普方生物製藥美國公司 Folr1結合劑、其結合物及使用方法
TW202308699A (zh) 2021-04-23 2023-03-01 美商普方生物製藥美國公司 Ｃｄ７０結合劑、其結合物及其使用方法
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11672872B2 (en) 2021-07-09 2023-06-13 Dyne Therapeutics, Inc. Anti-transferrin receptor antibody and uses thereof
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
EP4376895A2 (en) 2021-07-28 2024-06-05 Regeneron Pharmaceuticals, Inc. Protein-antiviral compound conjugates
CN118119633A (zh) * 2021-10-20 2024-05-31 岩唐生物科技(杭州)有限责任公司 位点特异性糖蛋白偶联物及其制备方法
CA3235096A1 (en) 2021-11-17 2023-05-25 Disc Medicine, Inc. Methods for treating anemia of kidney disease
WO2023129518A1 (en) 2021-12-29 2023-07-06 Regeneron Pharmaceuticals, Inc. Tubulysins and protein-tubulysin conjugates
WO2023137026A1 (en) 2022-01-12 2023-07-20 Regeneron Pharmaceuticals, Inc. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use
AU2023208050A1 (en) 2022-01-14 2024-07-04 Regeneron Pharmaceuticals, Inc. Verrucarin a derivatives and antibody drug conjugates thereof
CN118541380A (zh) * 2022-01-27 2024-08-23 岩唐生物科技(杭州)有限责任公司 具有多种载荷的蛋白偶联物及其制备方法
WO2023161296A1 (en) 2022-02-22 2023-08-31 Adc Therapeutics Sa Conjugation method involving a transglutaminase at the fc region comprising a trimmed n-glycan
WO2023173132A1 (en) 2022-03-11 2023-09-14 Regeneron Pharmaceuticals, Inc. Anti-glp1r antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof
WO2023180484A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing ptk7
AU2023237620A1 (en) 2022-03-23 2024-08-29 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen
WO2023180490A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing nectin-4
AU2023241225A1 (en) 2022-03-23 2024-08-29 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing trop-2
US11931421B2 (en) 2022-04-15 2024-03-19 Dyne Therapeutics, Inc. Muscle targeting complexes and formulations for treating myotonic dystrophy
EP4285934A1 (en) 2022-05-30 2023-12-06 CER Groupe Modified trimannose-oligosacharides, bisected n-glycans comprising said trimannose core and method for obtaining them
WO2024020164A2 (en) 2022-07-21 2024-01-25 Firefly Bio, Inc. Glucocorticoid receptor agonists and conjugates thereof
WO2024038065A1 (en) 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof
EP4344707A1 (en) 2022-09-29 2024-04-03 Emergence Therapeutics AG New anti-nectin-4 antibody drug conjugates
WO2024118785A2 (en) 2022-11-30 2024-06-06 Regeneron Pharmaceuticals, Inc. Tlr7 agonists and antibody-drug-conjugates thereof
WO2024121123A1 (en) 2022-12-06 2024-06-13 Synaffix B.V. Synthesis of endo-bicyclononene
US20240269308A1 (en) 2022-12-21 2024-08-15 Regeneron Pharmaceuticals, Inc. Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof
WO2024134403A1 (en) * 2022-12-22 2024-06-27 Janssen Research & Development, Llc Methods of preparing antibody-polynucleotide conjugates
EP4389152A1 (en) 2022-12-23 2024-06-26 Synaffix B.V. Conjugates of pbd prodrugs
WO2024150074A2 (en) 2023-01-13 2024-07-18 Takeda Pharmaceutical Company Limited Coronavirus antibodies and therapeutic uses thereof
EP4410313A1 (en) 2023-01-31 2024-08-07 Synaffix B.V. Homogeneous antibody-conjugates with high payload loading
WO2024168199A1 (en) 2023-02-09 2024-08-15 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates via inverse electron demand diels-alder reactions
WO2024182714A1 (en) 2023-03-02 2024-09-06 Alloy Therapeutics, Inc. Anti-cd22 antibodies and uses thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20011671A (fi) 2001-08-20 2003-02-21 Carbion Oy Tuumorispesifiset oligosakkaridisekvenssit ja niiden käyttö
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
CA2510550A1 (en) 2003-01-10 2004-07-29 Pradman Qasba Catalytic domains of .beta./1,4)-galactosyltransferase i having altered donor and acceptor specificities, domains that promote in vitro protein folding, and methods for their use
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
ATE473711T1 (de) 2003-10-29 2010-07-15 Bsn Medical Inc Medizinisches verbandsprodukt
US7332355B2 (en) 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
WO2005051429A2 (en) 2003-11-19 2005-06-09 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Targeted conjugates with a modified saccharide linker
US7697764B2 (en) * 2003-11-21 2010-04-13 National University Corporation Kochi University Similar pattern searching apparatus, method of similar pattern searching, program for similar pattern searching, and fractionation apparatus
US8703459B2 (en) * 2003-12-05 2014-04-22 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Catalytic domains of beta(1,4)-galactosyltransferase I having altered metal ion specificity
US7375078B2 (en) * 2004-02-23 2008-05-20 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
US8431558B2 (en) 2004-11-01 2013-04-30 The Regents Of The University Of California Compositions and methods for modification of biomolecules
WO2008029281A2 (en) * 2006-02-10 2008-03-13 Invitrogen Corporation Labeling and detection of post translationally modified proteins
JP2009531289A (ja) * 2006-02-10 2009-09-03 ライフ テクノロジーズ コーポレーション オリゴ糖によるタンパク質の修飾及び標識方法
EP2001358B1 (en) 2006-03-27 2016-07-13 University Of Maryland, Baltimore Glycoprotein synthesis and remodeling by enzymatic transglycosylation
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
WO2008143944A2 (en) 2007-05-14 2008-11-27 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Methods of glycosylation and bioconjugation
WO2009025646A1 (en) 2007-08-22 2009-02-26 Government Of The U.S.A, As Represented By The Secretary, Department Of Health & Human Services Alpha 1-3 n-galactosyltransferase with altered donor specificities
WO2009025645A1 (en) * 2007-08-22 2009-02-26 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
DK2907525T3 (en) 2007-11-21 2018-08-06 Univ Georgia DIBENZOCYCLOOCTEN COMPOUNDS FOR BIOORTHOGONAL TRANSMISSIONS
WO2009102820A2 (en) * 2008-02-11 2009-08-20 Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services Modified sugar substrates and methods of use
US7914904B2 (en) * 2008-03-25 2011-03-29 General Electric Company Component in a combustion system, and process for preventing slag, ash, and char buildup
US8519122B2 (en) 2010-02-12 2013-08-27 The Regents Of The University Of California Compositions and methods for modification of biomolecules
JP5920936B2 (ja) * 2010-04-27 2016-05-18 シンアフィックス ビー．ブイ． 縮合シクロオクチン化合物及び無金属クリック反応におけるそれらの使用
US20150072396A1 (en) 2011-03-04 2015-03-12 Life Technologies Corporation Compounds and Methods for Conjugation of Biomolecules
EP2688867B1 (en) 2011-03-25 2018-09-05 Life Technologies Corporation Heterobifunctional esters for use in labeling target molecules
HUE031017T2 (en) * 2011-04-01 2017-06-28 Wyeth Llc Antibody Drug Conjugates
GB201115841D0 (en) 2011-09-13 2011-10-26 Genovis Ab Protein and method
EP2911699B1 (en) 2012-10-23 2017-11-15 SynAffix B.V. Modified antibody, antibody-conjugate and process for the preparation thereof

Also Published As

Publication number Publication date
US9504758B2 (en) 2016-11-29
CN110201186A (zh) 2019-09-06
US10745488B2 (en) 2020-08-18
US20150258210A1 (en) 2015-09-17
LT2911699T (lt) 2018-03-26
ES2949376T3 (es) 2023-09-28
CY1120041T1 (el) 2018-12-12
US20210163623A1 (en) 2021-06-03
HUE038285T2 (hu) 2018-10-29
EP3912642A1 (en) 2021-11-24
HRP20230690T1 (hr) 2023-10-13
FI3912642T3 (fi) 2023-07-07
LT3912642T (lt) 2023-07-25
EP3912642A8 (en) 2022-01-05
RS56953B1 (sr) 2018-05-31
EP3912642B1 (en) 2023-04-12
PT2911699T (pt) 2018-02-23
HRP20180268T1 (hr) 2018-03-23
CN105142672A (zh) 2015-12-09
JP2020090526A (ja) 2020-06-11
RS64329B1 (sr) 2023-08-31
EP2911699A1 (en) 2015-09-02
EP2911699B1 (en) 2017-11-15
PL3912642T3 (pl) 2023-08-14
JP2023017820A (ja) 2023-02-07
DK2911699T3 (en) 2018-02-12
JP2015534996A (ja) 2015-12-07
US20150320882A1 (en) 2015-11-12
PL2911699T3 (pl) 2018-04-30
JP6855661B2 (ja) 2021-04-07
HUE062385T2 (hu) 2023-10-28
CN105142672B (zh) 2019-04-05
JP7167071B2 (ja) 2022-11-08
SI3912642T1 (sl) 2023-09-29
WO2014065661A1 (en) 2014-05-01
EP3335733A1 (en) 2018-06-20
DK3912642T3 (da) 2023-06-26
ES2659270T3 (es) 2018-03-14

Similar Documents

Publication Publication Date Title
SI2911699T1 (sl) Modificirano protitelo, protitelo-konjugat in proces za njihovo pripravo
JP2015534996A5 (sl)
WO2013038375A3 (en) Methods for making saccharide-protein glycoconjugates
CZ2012537A3 (cs) Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
HRP20210562T1 (hr) Karbohidratni ligandi koji se vežu na igm antitijela koja djeluju protiv glikoproteina povezanog s mijelinom
JP2023017820A5 (sl)
MX339927B (es) Preparacion de conjugados de maitansinoides y anticuerpos mediante un proceso de una etapa.
MY171008A (en) Preparation of maytansinoid antibody conjugates by a one-step process
MX2015011830A (es) Metodos de fabricacion y sintesis de grupos de enlace de aminoacidos conjugados con compuestos usados para la obtencion de imagenes dirigida de los tumores.
EA201070163A1 (ru) Цитотоксические средства, включающие новые производные томаймицина, и их терапевтическое применение
CA2936865A1 (en) Diaminopyrimidine benzenesulfone derivatives and uses thereof
FR3037957B1 (fr) Nouveaux derives d&#39;hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3747891A3 (en) Compositions and methods for conjugating oligonucleotides
JP2017001031A5 (sl)
HRP20160011T1 (hr) Imidazopiridazini kao inhibitori akt kinaze
DE502008001409D1 (de) Bisamid-zinkbasen
SI2890680T1 (sl) N-(3-fluorobenzil)-2-(5-(4-morfolinofenil)piridin-2-il) acetamid kot modulatorji protein tirozin kinaze
WO2014054058A3 (en) Novel compounds, their synthesis and their uses
BR112012030534A2 (pt) moduladores de receptores 5-ht e métodos de uso dos mesmos
MA32513B1 (fr) Nouveaux derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d&#39;epipodophyllotoxine, leur procede de preparation et leur application en therapeutique comme agent anticancereux
SI2782922T1 (sl) Antibakterijski derivati tilosina in postopki za pripravo le-teh
FR3051792B1 (fr) Nouveaux composes, derives de dioxoborolane ou de dioxaborinane fonctionnalises, leur procede de preparation et leurs utilisations
BR112014013719A2 (pt) compostos inibidores da lipogênese
Kitamura et al. Synthesis of pyrrolidinium salts using a triazine-based reagent under mild conditions
CN102627600B (zh) 一种多效价烟碱化合物及其制备方法和应用