SI2849746T1 - A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano- 3,4, b) indol) -4-amine and meloxicam - Google Patents
A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano- 3,4, b) indol) -4-amine and meloxicam Download PDFInfo
- Publication number
- SI2849746T1 SI2849746T1 SI201330919T SI201330919T SI2849746T1 SI 2849746 T1 SI2849746 T1 SI 2849746T1 SI 201330919 T SI201330919 T SI 201330919T SI 201330919 T SI201330919 T SI 201330919T SI 2849746 T1 SI2849746 T1 SI 2849746T1
- Authority
- SI
- Slovenia
- Prior art keywords
- active ingredient
- pharmacologically active
- pain
- pharmaceutical composition
- composition according
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 15
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 title claims abstract 5
- 229960001929 meloxicam Drugs 0.000 title claims abstract 5
- 239000002831 pharmacologic agent Substances 0.000 claims abstract 15
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 208000002193 Pain Diseases 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 2
- CSMVOZKEWSOFER-UHFFFAOYSA-N 6-fluoro-n,n-dimethyl-1'-phenylspiro[4,9-dihydro-3h-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine Chemical compound C1CC2(C3=C(C4=CC(F)=CC=C4N3)CCO2)CCC1(N(C)C)C1=CC=CC=C1 CSMVOZKEWSOFER-UHFFFAOYSA-N 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 230000003040 nociceptive effect Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001107 psychogenic effect Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 229960001850 droxicam Drugs 0.000 abstract 1
- OEHFRZLKGRKFAS-UHFFFAOYSA-N droxicam Chemical compound C12=CC=CC=C2S(=O)(=O)N(C)C(C2=O)=C1OC(=O)N2C1=CC=CC=N1 OEHFRZLKGRKFAS-UHFFFAOYSA-N 0.000 abstract 1
- 229960002202 lornoxicam Drugs 0.000 abstract 1
- OXROWJKCGCOJDO-JLHYYAGUSA-N lornoxicam Chemical compound O=C1C=2SC(Cl)=CC=2S(=O)(=O)N(C)\C1=C(\O)NC1=CC=CC=N1 OXROWJKCGCOJDO-JLHYYAGUSA-N 0.000 abstract 1
- 229960002702 piroxicam Drugs 0.000 abstract 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 abstract 1
- 229960002871 tenoxicam Drugs 0.000 abstract 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003896 | 2012-05-18 | ||
| PCT/EP2013/001469 WO2013170970A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an oxicam |
| EP13724168.3A EP2849746B1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and meloxicam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2849746T1 true SI2849746T1 (en) | 2018-02-28 |
Family
ID=48470899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201330919T SI2849746T1 (en) | 2012-05-18 | 2013-05-16 | A pharmaceutical composition comprising (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro (cyclohexane-1,1'-pyrano- 3,4, b) indol) -4-amine and meloxicam |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9308196B2 (enExample) |
| EP (1) | EP2849746B1 (enExample) |
| JP (1) | JP6116677B2 (enExample) |
| CN (2) | CN108451956A (enExample) |
| AU (1) | AU2013262076B2 (enExample) |
| BR (1) | BR112014028569A2 (enExample) |
| CA (1) | CA2873863A1 (enExample) |
| CY (1) | CY1119824T1 (enExample) |
| DK (1) | DK2849746T3 (enExample) |
| EA (1) | EA026719B1 (enExample) |
| ES (1) | ES2659948T3 (enExample) |
| HR (1) | HRP20171843T1 (enExample) |
| HU (1) | HUE035122T2 (enExample) |
| IL (1) | IL235652B (enExample) |
| LT (1) | LT2849746T (enExample) |
| MX (1) | MX354685B (enExample) |
| NO (1) | NO2849746T3 (enExample) |
| PL (1) | PL2849746T3 (enExample) |
| PT (1) | PT2849746T (enExample) |
| RS (1) | RS56830B1 (enExample) |
| SI (1) | SI2849746T1 (enExample) |
| WO (1) | WO2013170970A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427493A (zh) | 2015-01-23 | 2017-12-01 | 格吕伦塔尔有限公司 | 用于治疗肝功能受损和/或肾功能受损的受试者的疼痛的Cebranopadol |
| MX2018010367A (es) | 2016-02-29 | 2018-12-10 | Guenenthal Gmbh | Titulacion de cebranopadol. |
| GB202405898D0 (en) * | 2024-04-26 | 2024-06-12 | Univ Surrey | Mycobacterial infections |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068838B1 (en) | 1981-06-26 | 1986-09-17 | The Upjohn Company | Analgesic process and composition |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| ES2098264T3 (es) | 1989-05-22 | 1997-05-01 | Biochemical Veterinary Res | Sales metalicas divalentes de indometacina. |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| EA004032B1 (ru) * | 1998-09-10 | 2003-12-25 | Нюкомед Данмарк А/С | Фармацевтические композиции лекарственных веществ с быстрым высвобождением |
| EP1219304B1 (de) | 2000-12-28 | 2004-10-20 | Fresenius Kabi Austria GmbH | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| ATE359827T1 (de) | 2002-06-17 | 2007-05-15 | Chiesi Farma Spa | Prozess für die vorbereitung von piroxicam: beta- cyclodextrin einschlusskomplexe |
| AR040778A1 (es) * | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| AU2006257274A1 (en) | 2005-06-17 | 2006-12-21 | Pfizer Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as ORL1-receptor antagonists |
| CN102675136B (zh) * | 2006-04-28 | 2016-01-20 | 格吕伦塔尔有限公司 | 包含3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和nsaid的药物组合物 |
| CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| WO2010025931A2 (en) * | 2008-09-05 | 2010-03-11 | Grünenthal GmbH | Pharmaceutical combination |
| CA2735139A1 (en) * | 2008-09-05 | 2010-03-11 | Petra Bloms-Funke | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and an nsaid |
| EP3459533A1 (en) * | 2010-08-04 | 2019-03-27 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of nociceptive pain |
| RU2589831C2 (ru) * | 2010-08-04 | 2016-07-10 | Грюненталь Гмбх | ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ- ИЛИ N, N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1, 1'-ПИРАНО[3, 4, b]ИНДОЛ]-4-АМИН |
| AR082559A1 (es) * | 2010-08-04 | 2012-12-19 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica que comprende 6’-fluoro-(n-metil- o n,n-dimetil)-4’-fenil-4’,9’-dihidro-3’h-espiro[ciclohexan-1,1’-pirano[3,4,b]indol]-4-amina |
-
2013
- 2013-05-13 US US13/892,362 patent/US9308196B2/en active Active
- 2013-05-16 PL PL13724168T patent/PL2849746T3/pl unknown
- 2013-05-16 DK DK13724168.3T patent/DK2849746T3/en active
- 2013-05-16 HR HRP20171843TT patent/HRP20171843T1/hr unknown
- 2013-05-16 LT LTEP13724168.3T patent/LT2849746T/lt unknown
- 2013-05-16 JP JP2015511956A patent/JP6116677B2/ja active Active
- 2013-05-16 AU AU2013262076A patent/AU2013262076B2/en not_active Ceased
- 2013-05-16 WO PCT/EP2013/001469 patent/WO2013170970A1/en not_active Ceased
- 2013-05-16 EP EP13724168.3A patent/EP2849746B1/en not_active Not-in-force
- 2013-05-16 NO NO13724168A patent/NO2849746T3/no unknown
- 2013-05-16 HU HUE13724168A patent/HUE035122T2/en unknown
- 2013-05-16 CA CA2873863A patent/CA2873863A1/en not_active Abandoned
- 2013-05-16 CN CN201810667716.5A patent/CN108451956A/zh active Pending
- 2013-05-16 RS RS20180128A patent/RS56830B1/sr unknown
- 2013-05-16 PT PT137241683T patent/PT2849746T/pt unknown
- 2013-05-16 EA EA201401265A patent/EA026719B1/ru not_active IP Right Cessation
- 2013-05-16 ES ES13724168.3T patent/ES2659948T3/es active Active
- 2013-05-16 MX MX2014012862A patent/MX354685B/es active IP Right Grant
- 2013-05-16 SI SI201330919T patent/SI2849746T1/en unknown
- 2013-05-16 CN CN201380025679.3A patent/CN104302288A/zh active Pending
- 2013-05-16 BR BR112014028569A patent/BR112014028569A2/pt not_active IP Right Cessation
-
2014
- 2014-11-12 IL IL235652A patent/IL235652B/en active IP Right Grant
-
2018
- 2018-01-24 CY CY20181100090T patent/CY1119824T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015516450A (ja) | 2015-06-11 |
| JP6116677B2 (ja) | 2017-04-19 |
| LT2849746T (lt) | 2018-02-12 |
| IL235652A0 (en) | 2015-01-29 |
| CY1119824T1 (el) | 2018-06-27 |
| EA026719B1 (ru) | 2017-05-31 |
| AU2013262076B2 (en) | 2017-10-26 |
| US9308196B2 (en) | 2016-04-12 |
| NO2849746T3 (enExample) | 2018-04-14 |
| RS56830B1 (sr) | 2018-04-30 |
| MX2014012862A (es) | 2015-01-19 |
| ES2659948T3 (es) | 2018-03-20 |
| HRP20171843T1 (hr) | 2018-01-12 |
| CN104302288A (zh) | 2015-01-21 |
| HK1204939A1 (en) | 2015-12-11 |
| DK2849746T3 (en) | 2017-12-04 |
| CA2873863A1 (en) | 2013-11-21 |
| PL2849746T3 (pl) | 2018-04-30 |
| HUE035122T2 (en) | 2018-05-02 |
| EP2849746B1 (en) | 2017-11-15 |
| BR112014028569A2 (pt) | 2017-06-27 |
| PT2849746T (pt) | 2018-02-22 |
| EA201401265A1 (ru) | 2015-05-29 |
| CN108451956A (zh) | 2018-08-28 |
| WO2013170970A1 (en) | 2013-11-21 |
| US20130310371A1 (en) | 2013-11-21 |
| AU2013262076A1 (en) | 2015-01-22 |
| IL235652B (en) | 2018-08-30 |
| EP2849746A1 (en) | 2015-03-25 |
| MX354685B (es) | 2018-03-15 |
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