CN108451956A - 药物组合物 - Google Patents
药物组合物 Download PDFInfo
- Publication number
- CN108451956A CN108451956A CN201810667716.5A CN201810667716A CN108451956A CN 108451956 A CN108451956 A CN 108451956A CN 201810667716 A CN201810667716 A CN 201810667716A CN 108451956 A CN108451956 A CN 108451956A
- Authority
- CN
- China
- Prior art keywords
- pharmacologically active
- active ingredient
- pharmaceutical dosage
- dosage form
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- TWQULNDIKKJZPH-UHFFFAOYSA-K trilithium;phosphate Chemical class [Li+].[Li+].[Li+].[O-]P([O-])([O-])=O TWQULNDIKKJZPH-UHFFFAOYSA-K 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003896 | 2012-05-18 | ||
| EP12003896.3 | 2012-05-18 | ||
| CN201380025679.3A CN104302288A (zh) | 2012-05-18 | 2013-05-16 | 包含(1r,4r)-6’-氟-N,N-二甲基-4-苯基-4’,9’-二氢-3’H-螺[环己烷-1,1’-吡喃并-[3,4,b]吲哚]-4-胺和昔康类的药物组合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380025679.3A Division CN104302288A (zh) | 2012-05-18 | 2013-05-16 | 包含(1r,4r)-6’-氟-N,N-二甲基-4-苯基-4’,9’-二氢-3’H-螺[环己烷-1,1’-吡喃并-[3,4,b]吲哚]-4-胺和昔康类的药物组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108451956A true CN108451956A (zh) | 2018-08-28 |
Family
ID=48470899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810667716.5A Pending CN108451956A (zh) | 2012-05-18 | 2013-05-16 | 药物组合物 |
| CN201380025679.3A Pending CN104302288A (zh) | 2012-05-18 | 2013-05-16 | 包含(1r,4r)-6’-氟-N,N-二甲基-4-苯基-4’,9’-二氢-3’H-螺[环己烷-1,1’-吡喃并-[3,4,b]吲哚]-4-胺和昔康类的药物组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380025679.3A Pending CN104302288A (zh) | 2012-05-18 | 2013-05-16 | 包含(1r,4r)-6’-氟-N,N-二甲基-4-苯基-4’,9’-二氢-3’H-螺[环己烷-1,1’-吡喃并-[3,4,b]吲哚]-4-胺和昔康类的药物组合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9308196B2 (enExample) |
| EP (1) | EP2849746B1 (enExample) |
| JP (1) | JP6116677B2 (enExample) |
| CN (2) | CN108451956A (enExample) |
| AU (1) | AU2013262076B2 (enExample) |
| BR (1) | BR112014028569A2 (enExample) |
| CA (1) | CA2873863A1 (enExample) |
| CY (1) | CY1119824T1 (enExample) |
| DK (1) | DK2849746T3 (enExample) |
| EA (1) | EA026719B1 (enExample) |
| ES (1) | ES2659948T3 (enExample) |
| HR (1) | HRP20171843T1 (enExample) |
| HU (1) | HUE035122T2 (enExample) |
| IL (1) | IL235652B (enExample) |
| LT (1) | LT2849746T (enExample) |
| MX (1) | MX354685B (enExample) |
| NO (1) | NO2849746T3 (enExample) |
| PL (1) | PL2849746T3 (enExample) |
| PT (1) | PT2849746T (enExample) |
| RS (1) | RS56830B1 (enExample) |
| SI (1) | SI2849746T1 (enExample) |
| WO (1) | WO2013170970A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201791662A1 (ru) | 2015-01-23 | 2017-12-29 | Грюненталь Гмбх | Цебранопадол для лечения от боли субъектов с нарушенной печеночной и/или нарушенной почечной функцией |
| JP7373904B2 (ja) | 2016-02-29 | 2023-11-06 | パーク・セラピューティクス・インコーポレイテッド | セブラノパドールの滴定 |
| GB202405898D0 (en) * | 2024-04-26 | 2024-06-12 | Univ Surrey | Mycobacterial infections |
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| US20080125475A1 (en) * | 2006-09-29 | 2008-05-29 | Grunenthal Gmbh | Mixed ORL1/mu-agonists for the treatment of pain |
| CN101327193A (zh) * | 2008-06-20 | 2008-12-24 | 海南锦瑞制药有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| US20100297252A1 (en) * | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
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| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| DK0473655T3 (da) | 1989-05-22 | 1997-02-10 | Biochemical Veterinary Res | Divalente metalsalte af indomethacin |
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| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
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| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
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| ATE279920T1 (de) | 2000-12-28 | 2004-11-15 | Fresenius Kabi Austria Gmbh | Stabile infusionslösung von diclofenac-salzen, deren herstellung und verwendung |
| AR040778A1 (es) * | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
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| CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
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| DK2600851T3 (en) * | 2010-08-04 | 2018-06-25 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN |
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-
2013
- 2013-05-13 US US13/892,362 patent/US9308196B2/en active Active
- 2013-05-16 ES ES13724168.3T patent/ES2659948T3/es active Active
- 2013-05-16 PL PL13724168T patent/PL2849746T3/pl unknown
- 2013-05-16 MX MX2014012862A patent/MX354685B/es active IP Right Grant
- 2013-05-16 EA EA201401265A patent/EA026719B1/ru not_active IP Right Cessation
- 2013-05-16 DK DK13724168.3T patent/DK2849746T3/en active
- 2013-05-16 CA CA2873863A patent/CA2873863A1/en not_active Abandoned
- 2013-05-16 AU AU2013262076A patent/AU2013262076B2/en not_active Ceased
- 2013-05-16 HU HUE13724168A patent/HUE035122T2/en unknown
- 2013-05-16 BR BR112014028569A patent/BR112014028569A2/pt not_active IP Right Cessation
- 2013-05-16 CN CN201810667716.5A patent/CN108451956A/zh active Pending
- 2013-05-16 WO PCT/EP2013/001469 patent/WO2013170970A1/en not_active Ceased
- 2013-05-16 LT LTEP13724168.3T patent/LT2849746T/lt unknown
- 2013-05-16 HR HRP20171843TT patent/HRP20171843T1/hr unknown
- 2013-05-16 EP EP13724168.3A patent/EP2849746B1/en not_active Not-in-force
- 2013-05-16 RS RS20180128A patent/RS56830B1/sr unknown
- 2013-05-16 CN CN201380025679.3A patent/CN104302288A/zh active Pending
- 2013-05-16 PT PT137241683T patent/PT2849746T/pt unknown
- 2013-05-16 NO NO13724168A patent/NO2849746T3/no unknown
- 2013-05-16 SI SI201330919T patent/SI2849746T1/en unknown
- 2013-05-16 JP JP2015511956A patent/JP6116677B2/ja active Active
-
2014
- 2014-11-12 IL IL235652A patent/IL235652B/en active IP Right Grant
-
2018
- 2018-01-24 CY CY20181100090T patent/CY1119824T1/el unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671419A (zh) * | 2002-06-17 | 2005-09-21 | 奇斯药制品公司 | 吡罗昔康:β－环糊精包合物的制备方法 |
| US20100297252A1 (en) * | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US20080125475A1 (en) * | 2006-09-29 | 2008-05-29 | Grunenthal Gmbh | Mixed ORL1/mu-agonists for the treatment of pain |
| CN101327193A (zh) * | 2008-06-20 | 2008-12-24 | 海南锦瑞制药有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014028569A2 (pt) | 2017-06-27 |
| IL235652A0 (en) | 2015-01-29 |
| MX354685B (es) | 2018-03-15 |
| HUE035122T2 (en) | 2018-05-02 |
| US9308196B2 (en) | 2016-04-12 |
| CA2873863A1 (en) | 2013-11-21 |
| HK1204939A1 (en) | 2015-12-11 |
| RS56830B1 (sr) | 2018-04-30 |
| LT2849746T (lt) | 2018-02-12 |
| PT2849746T (pt) | 2018-02-22 |
| MX2014012862A (es) | 2015-01-19 |
| HRP20171843T1 (hr) | 2018-01-12 |
| CY1119824T1 (el) | 2018-06-27 |
| IL235652B (en) | 2018-08-30 |
| EP2849746A1 (en) | 2015-03-25 |
| JP2015516450A (ja) | 2015-06-11 |
| EA026719B1 (ru) | 2017-05-31 |
| PL2849746T3 (pl) | 2018-04-30 |
| NO2849746T3 (enExample) | 2018-04-14 |
| AU2013262076A1 (en) | 2015-01-22 |
| JP6116677B2 (ja) | 2017-04-19 |
| CN104302288A (zh) | 2015-01-21 |
| DK2849746T3 (en) | 2017-12-04 |
| AU2013262076B2 (en) | 2017-10-26 |
| EA201401265A1 (ru) | 2015-05-29 |
| EP2849746B1 (en) | 2017-11-15 |
| US20130310371A1 (en) | 2013-11-21 |
| ES2659948T3 (es) | 2018-03-20 |
| SI2849746T1 (en) | 2018-02-28 |
| WO2013170970A1 (en) | 2013-11-21 |
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Application publication date: 20180828 |