SI2600846T1 - Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin - Google Patents

Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin

Info

Publication number
SI2600846T1
SI2600846T1 SI201130711T SI201130711T SI2600846T1 SI 2600846 T1 SI2600846 T1 SI 2600846T1 SI 201130711 T SI201130711 T SI 201130711T SI 201130711 T SI201130711 T SI 201130711T SI 2600846 T1 SI2600846 T1 SI 2600846T1
Authority
SI
Slovenia
Prior art keywords
cylohexane
pyrano
indol
spiro
dihydro
Prior art date
Application number
SI201130711T
Other languages
English (en)
Inventor
Marc Schiller
Nadja Gruning
Ashish Hemani
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43382487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2600846(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of SI2600846T1 publication Critical patent/SI2600846T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201130711T 2010-08-04 2011-08-04 Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin SI2600846T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37064810P 2010-08-04 2010-08-04
EP10008117 2010-08-04
EP11745928.9A EP2600846B1 (en) 2010-08-04 2011-08-04 Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine
PCT/EP2011/003900 WO2012016695A2 (en) 2010-08-04 2011-08-04 Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
SI2600846T1 true SI2600846T1 (sl) 2016-02-29

Family

ID=43382487

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201130711T SI2600846T1 (sl) 2010-08-04 2011-08-04 Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin

Country Status (27)

Country Link
EP (1) EP2600846B1 (sl)
JP (1) JP6010534B2 (sl)
KR (1) KR101882663B1 (sl)
CN (1) CN103079548A (sl)
AR (1) AR082561A1 (sl)
AU (1) AU2011287952B2 (sl)
BR (1) BR112013002696A2 (sl)
CA (1) CA2804077C (sl)
CL (1) CL2012003583A1 (sl)
CO (1) CO6640317A2 (sl)
DK (1) DK2600846T3 (sl)
EC (1) ECSP13012424A (sl)
ES (1) ES2563735T3 (sl)
HK (1) HK1183612A1 (sl)
HR (1) HRP20151337T1 (sl)
HU (1) HUE028436T2 (sl)
IL (1) IL223888A (sl)
MX (1) MX2013000015A (sl)
NZ (1) NZ605841A (sl)
PE (1) PE20131106A1 (sl)
PL (1) PL2600846T3 (sl)
PT (1) PT2600846E (sl)
RS (1) RS54659B1 (sl)
RU (1) RU2589831C2 (sl)
SI (1) SI2600846T1 (sl)
TW (1) TWI526445B (sl)
WO (1) WO2012016695A2 (sl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013002734A2 (pt) 2010-08-04 2016-06-07 Gruenenthal Gmbh uso de agente farmacologicamente ativo e forma de dosagem farmacêutica
WO2013087591A1 (en) * 2011-12-12 2013-06-20 Grünenthal GmbH Solid forms of (1r,4r)-6'-fluoro-(n,n-dimethyl)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and sulfuric acid
EP2797923B1 (en) * 2011-12-12 2016-09-07 Grünenthal GmbH Solid forms of (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine hydrochloride
US9855286B2 (en) * 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
US9345689B2 (en) * 2012-05-18 2016-05-24 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant
US9320725B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid
US20130310435A1 (en) * 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9308196B2 (en) * 2012-05-18 2016-04-12 Gruenenthal Gmbh Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
US8912226B2 (en) * 2012-05-18 2014-12-16 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r) -6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a NSAR
US10034958B2 (en) 2013-06-19 2018-07-31 The Brigham And Women's Hospital, Inc. Nanocomposite hydrogels
DK3247352T3 (da) * 2015-01-23 2020-09-07 Gruenenthal Gmbh Cebranopadol til behandling af smerter hos individer med forringet lever- og/eller forringet nyrefunktion
US11083780B2 (en) 2015-07-20 2021-08-10 The Brigham And Women's Hospital, Inc. Shear-thinning compositions as an intravascular embolic agent
BR112018017167A2 (pt) 2016-02-29 2019-01-02 Gruenenthal Gmbh titulação de cebranopadol
CA3178470A1 (en) * 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

Also Published As

Publication number Publication date
DK2600846T3 (en) 2016-01-11
KR101882663B1 (ko) 2018-07-30
CO6640317A2 (es) 2013-03-22
CA2804077C (en) 2018-09-11
TW201219399A (en) 2012-05-16
HUE028436T2 (hu) 2016-12-28
KR20130097172A (ko) 2013-09-02
WO2012016695A2 (en) 2012-02-09
BR112013002696A2 (pt) 2016-05-31
ES2563735T3 (es) 2016-03-16
RS54659B1 (en) 2016-08-31
IL223888A (en) 2017-01-31
HK1183612A1 (en) 2014-01-03
HRP20151337T1 (hr) 2016-01-01
JP6010534B2 (ja) 2016-10-19
AR082561A1 (es) 2012-12-19
TWI526445B (zh) 2016-03-21
EP2600846A2 (en) 2013-06-12
RU2013109138A (ru) 2014-09-10
CL2012003583A1 (es) 2013-02-01
PL2600846T3 (pl) 2016-05-31
EP2600846B1 (en) 2015-11-25
CN103079548A (zh) 2013-05-01
NZ605841A (en) 2014-07-25
JP2013532695A (ja) 2013-08-19
MX2013000015A (es) 2013-02-01
WO2012016695A3 (en) 2012-08-16
PT2600846E (pt) 2016-02-09
CA2804077A1 (en) 2012-02-09
AU2011287952B2 (en) 2014-08-21
AU2011287952A1 (en) 2013-03-21
ECSP13012424A (es) 2013-03-28
PE20131106A1 (es) 2013-10-17
RU2589831C2 (ru) 2016-07-10

Similar Documents

Publication Publication Date Title
SI2600846T1 (sl) Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin
HRP20181856T1 (hr) Farmaceutski oblik doziranja koji sadrži 6'-fluoro-(n-metil-ili n,n-dimetil-)-4-fenil-4'9'-dihidro-3'h-spiro[ciklohesan-1,1'-pirano[3,4,b]indol]-4-amin za liječenje nociceptivne boli
SI2600838T1 (sl) Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin
ZA201006029B (en) Pharmaceutical dosage form
ZA201005015B (en) Solid pharmaceutical dosage form
IL211400A0 (en) Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
IL222919A0 (en) Alcohol - resistant oral pharmaceutical form
ZA200903858B (en) Pharmaceutical dosage form
IL219617A0 (en) Pharmaceutical solid dosage form
SI2852384T1 (sl) Farmacevtski sestavek, ki obsega (1r,4r)-6'-fluoro-N,N-dimetil-4-fenil- 4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano(3,4,b)indol)-4-amin in antikonvulziv
RS56771B1 (sr) Farmaceutska kompozicija koja sadrži (1r,4r)-6’-fluoro-n,n-dimetil-4-fenil-4’,9’-dihidro-3’h-spiro[cikloheksan-1,1’-pirano-[3,4,b]indol]-4-amin i ibuprofen
ZA201300038B (en) Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl-or n,n-dimethyl-)-4-phenyl-4,9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
IL235658A (en) Pharmaceutical Composition Containing (1r, 4r) - 6 '- Fluoro - n, n - Dimethyl - 4 - Phenyl - 4', 9 '- Dihydro - 3'h - Spiro [Cyclohexane - 1, 1' - Pirano [3, 4 , b] indole] - 4 - amine and gabapentinoid
EP2578199A4 (en) UNIDOSE PACKAGING FOR MEDICAMENTS
HUE041960T2 (hu) 6'-fluor-(N-metil- vagy N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H spiro[ciklohexán-1,1'-pirano[3,4,b]indol]-4-amint tartalmazó gyógyszerészeti dózisforma nociceptív fájdalom kezelésére
ZA201201424B (en) Pharmaceutical dosage form
GB201018760D0 (en) An oral dosage form