PT2849746T - Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e meloxicam - Google Patents

Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e meloxicam

Info

Publication number
PT2849746T
PT2849746T PT137241683T PT13724168T PT2849746T PT 2849746 T PT2849746 T PT 2849746T PT 137241683 T PT137241683 T PT 137241683T PT 13724168 T PT13724168 T PT 13724168T PT 2849746 T PT2849746 T PT 2849746T
Authority
PT
Portugal
Prior art keywords
pyrano
meloxicam
indol
spiro
dihydro
Prior art date
Application number
PT137241683T
Other languages
English (en)
Portuguese (pt)
Inventor
Frosch Stefanie
Schiene Klaus
Linz Klaus
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of PT2849746T publication Critical patent/PT2849746T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT137241683T 2012-05-18 2013-05-16 Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e meloxicam PT2849746T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12003896 2012-05-18

Publications (1)

Publication Number Publication Date
PT2849746T true PT2849746T (pt) 2018-02-22

Family

ID=48470899

Family Applications (1)

Application Number Title Priority Date Filing Date
PT137241683T PT2849746T (pt) 2012-05-18 2013-05-16 Composição farmacêutica compreendendo (1r,4r)-6'-fluoro-n,n-dimetil-4-fenil-4',9'-di-hidro-3'h-espiro[ciclo-hexano-1,1'-pirano[3,4,b]indol]-4-amina e meloxicam

Country Status (22)

Country Link
US (1) US9308196B2 (enExample)
EP (1) EP2849746B1 (enExample)
JP (1) JP6116677B2 (enExample)
CN (2) CN104302288A (enExample)
AU (1) AU2013262076B2 (enExample)
BR (1) BR112014028569A2 (enExample)
CA (1) CA2873863A1 (enExample)
CY (1) CY1119824T1 (enExample)
DK (1) DK2849746T3 (enExample)
EA (1) EA026719B1 (enExample)
ES (1) ES2659948T3 (enExample)
HR (1) HRP20171843T1 (enExample)
HU (1) HUE035122T2 (enExample)
IL (1) IL235652B (enExample)
LT (1) LT2849746T (enExample)
MX (1) MX354685B (enExample)
NO (1) NO2849746T3 (enExample)
PL (1) PL2849746T3 (enExample)
PT (1) PT2849746T (enExample)
RS (1) RS56830B1 (enExample)
SI (1) SI2849746T1 (enExample)
WO (1) WO2013170970A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2974578C (en) 2015-01-23 2020-11-17 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
WO2017148595A1 (en) 2016-02-29 2017-09-08 Grünenthal GmbH Titration of cebranopadol
GB202405898D0 (en) * 2024-04-26 2024-06-12 Univ Surrey Mycobacterial infections

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US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
KR0156231B1 (ko) 1989-05-22 1998-11-16 존 레이 비핀 인도메타신의 2가 전이 금속염을 함유하는 조성물
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AR040778A1 (es) * 2002-08-06 2005-04-20 Glaxo Group Ltd Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina).
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10257824B4 (de) 2002-12-10 2004-11-11 Kochem, Hans-Günter, Dr. Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen
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KR20080012976A (ko) 2005-06-17 2008-02-12 화이자 인코포레이티드 Ｏｒｌ1-수용기 길항제로서의 알파-(아릴- 또는헤테로아릴-메틸)-베타-피페리디노 프로판아마이드 화합물
RU2465263C2 (ru) * 2006-04-28 2012-10-27 Грюненталь Гмбх Фармацевтическая комбинация, включающая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и нестероидный противовоспалительный препарат
CN101147735A (zh) 2006-09-19 2008-03-26 沈阳华泰药物研究有限公司 注射用药物组合物及其药盒
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
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CN100560061C (zh) 2008-06-20 2009-11-18 海南锦瑞制药股份有限公司 一种氯诺昔康冻干粉针剂及其制备方法
BRPI0918919A2 (pt) * 2008-09-05 2015-12-01 Gruenenthal Gmbh composição farmaceutica compreendendo 6-dimetilaminometil-1-(3-metoxifenil)-ciclo-hexano-1,3-diol e um nsaid
RU2674150C1 (ru) * 2008-09-05 2018-12-05 Грюненталь Гмбх Фармацевтическая комбинация
DK2600851T3 (en) * 2010-08-04 2018-06-25 Gruenenthal Gmbh PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN
EP2600838B1 (en) * 2010-08-04 2015-09-16 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
SI2600846T1 (sl) * 2010-08-04 2016-02-29 Gruenenthal Gmbh Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin

Also Published As

Publication number Publication date
AU2013262076B2 (en) 2017-10-26
MX354685B (es) 2018-03-15
EP2849746A1 (en) 2015-03-25
PL2849746T3 (pl) 2018-04-30
CA2873863A1 (en) 2013-11-21
EA201401265A1 (ru) 2015-05-29
ES2659948T3 (es) 2018-03-20
JP2015516450A (ja) 2015-06-11
IL235652B (en) 2018-08-30
US20130310371A1 (en) 2013-11-21
CY1119824T1 (el) 2018-06-27
US9308196B2 (en) 2016-04-12
NO2849746T3 (enExample) 2018-04-14
BR112014028569A2 (pt) 2017-06-27
CN108451956A (zh) 2018-08-28
RS56830B1 (sr) 2018-04-30
IL235652A0 (en) 2015-01-29
SI2849746T1 (en) 2018-02-28
EA026719B1 (ru) 2017-05-31
HUE035122T2 (en) 2018-05-02
DK2849746T3 (en) 2017-12-04
HK1204939A1 (en) 2015-12-11
EP2849746B1 (en) 2017-11-15
LT2849746T (lt) 2018-02-12
CN104302288A (zh) 2015-01-21
AU2013262076A1 (en) 2015-01-22
WO2013170970A1 (en) 2013-11-21
MX2014012862A (es) 2015-01-19
JP6116677B2 (ja) 2017-04-19
HRP20171843T1 (hr) 2018-01-12

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