BR112013004368A2 - compostos tendo a fórmula geral (i) e composição farmacêutica - Google Patents

compostos tendo a fórmula geral (i) e composição farmacêutica

Info

Publication number
BR112013004368A2
BR112013004368A2 BR112013004368A BR112013004368A BR112013004368A2 BR 112013004368 A2 BR112013004368 A2 BR 112013004368A2 BR 112013004368 A BR112013004368 A BR 112013004368A BR 112013004368 A BR112013004368 A BR 112013004368A BR 112013004368 A2 BR112013004368 A2 BR 112013004368A2
Authority
BR
Brazil
Prior art keywords
compounds
general formula
pharmaceutical composition
heterocyclic
nitrogen
Prior art date
Application number
BR112013004368A
Other languages
English (en)
Inventor
Ullrich Axel
Wolf Alexander
Choidas Axel
Klebl Bert
Schultz Fademrecht Carsten
Eickhoff Jan
Koch Uwe
Original Assignee
Lead Discovery Center Gmbh
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Discovery Center Gmbh, Max Planck Gesellschaft filed Critical Lead Discovery Center Gmbh
Publication of BR112013004368A2 publication Critical patent/BR112013004368A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

compostos tendo a fórmula geral (i) e composição farmacêutica. a presente invenção refere-se a 1-nitrogen-heterocíclico-2-carboxamidas e/ou seus sais farmaceuticamente aceitáveis, o uso desses derivados como agentes farmaceuticamente ativos, especialmente para o tratamento e/ou prevenção de desordens induzidas pela subfamília tirosina-quinase de receptor de axl, incluindo câncer e metástases de tumor primários, e composições farmacêuticas contendo pelo menos um dos referidos derivados de 1-nitrogen-heterocíclico-2-carboxamida e/ou seus saia farmaceuticamente aceitáveis.
BR112013004368A 2010-08-28 2011-08-26 compostos tendo a fórmula geral (i) e composição farmacêutica BR112013004368A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10075374A EP2423208A1 (en) 2010-08-28 2010-08-28 Pharmaceutically active compounds as Axl inhibitors
US34495910P 2010-11-29 2010-11-29
PCT/EP2011/004451 WO2012028332A1 (en) 2010-08-28 2011-08-26 Pharmaceutically active compounds as axl inhibitors

Publications (1)

Publication Number Publication Date
BR112013004368A2 true BR112013004368A2 (pt) 2017-06-27

Family

ID=43269622

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013004368A BR112013004368A2 (pt) 2010-08-28 2011-08-26 compostos tendo a fórmula geral (i) e composição farmacêutica

Country Status (17)

Country Link
US (1) US8999982B2 (pt)
EP (2) EP2423208A1 (pt)
JP (1) JP5843861B2 (pt)
KR (1) KR101624296B1 (pt)
CN (1) CN103124729B (pt)
AU (1) AU2011297889B2 (pt)
BR (1) BR112013004368A2 (pt)
CA (1) CA2807620C (pt)
DK (1) DK2609091T3 (pt)
ES (1) ES2530492T3 (pt)
HK (1) HK1185879A1 (pt)
MX (1) MX2013002289A (pt)
MY (1) MY158494A (pt)
RU (1) RU2573834C2 (pt)
SG (1) SG187597A1 (pt)
WO (1) WO2012028332A1 (pt)
ZA (1) ZA201300533B (pt)

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CN110156770B (zh) 2013-11-27 2022-10-04 圣诺康生命科学公司 作为tam族激酶抑制剂的氨基吡啶衍生物
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WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
WO2017059280A1 (en) * 2015-10-02 2017-04-06 The University Of North Carolina At Chapel Hill Novel pan-tam inhibitors and mer/axl dual inhibitors
WO2017146236A1 (ja) 2016-02-26 2017-08-31 小野薬品工業株式会社 Ａｘｌ阻害剤と免疫チェックポイント阻害剤とを組み合わせて投与することを特徴とする癌治療のための医薬
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CN110612295B (zh) * 2017-05-11 2023-07-14 组合化学工业株式会社 吡唑-3-羧酸酰胺衍生物及有害生物防治剂
JP7156287B2 (ja) 2017-08-23 2022-10-19 小野薬品工業株式会社 Ａｘｌ阻害剤を有効成分として含むがん治療剤
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Also Published As

Publication number Publication date
MY158494A (en) 2016-10-14
ES2530492T3 (es) 2015-03-03
MX2013002289A (es) 2013-10-28
ZA201300533B (en) 2014-03-26
HK1185879A1 (zh) 2014-02-28
EP2609091B1 (en) 2014-11-26
JP2013536813A (ja) 2013-09-26
US20140018365A1 (en) 2014-01-16
DK2609091T3 (en) 2015-01-12
WO2012028332A8 (en) 2013-03-07
CA2807620C (en) 2016-05-17
CN103124729A (zh) 2013-05-29
AU2011297889A8 (en) 2013-06-06
KR101624296B1 (ko) 2016-05-25
AU2011297889B2 (en) 2015-12-24
CN103124729B (zh) 2016-01-20
US8999982B2 (en) 2015-04-07
JP5843861B2 (ja) 2016-01-13
EP2423208A1 (en) 2012-02-29
KR20130084291A (ko) 2013-07-24
RU2013113733A (ru) 2014-10-10
RU2573834C2 (ru) 2016-01-27
AU2011297889A1 (en) 2013-02-21
WO2012028332A1 (en) 2012-03-08
SG187597A1 (en) 2013-03-28
CA2807620A1 (en) 2012-03-08
EP2609091A1 (en) 2013-07-03

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