SI2480658T1 - Postopek priprave vlp-jev, izpeljanih iz rastlin - Google Patents
Postopek priprave vlp-jev, izpeljanih iz rastlinInfo
- Publication number
- SI2480658T1 SI2480658T1 SI201031558T SI201031558T SI2480658T1 SI 2480658 T1 SI2480658 T1 SI 2480658T1 SI 201031558 T SI201031558 T SI 201031558T SI 201031558 T SI201031558 T SI 201031558T SI 2480658 T1 SI2480658 T1 SI 2480658T1
- Authority
- SI
- Slovenia
- Prior art keywords
- preparing plant
- derived vlps
- vlps
- derived
- plant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/517—Plant cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24478609P | 2009-09-22 | 2009-09-22 | |
PCT/CA2010/001488 WO2011035422A1 (en) | 2009-09-22 | 2010-09-21 | Method of preparing plant-derived vlps |
EP10818190.0A EP2480658B1 (en) | 2009-09-22 | 2010-09-21 | Method of preparing plant-derived vlps |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2480658T1 true SI2480658T1 (sl) | 2017-11-30 |
Family
ID=43795254
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201031558T SI2480658T1 (sl) | 2009-09-22 | 2010-09-21 | Postopek priprave vlp-jev, izpeljanih iz rastlin |
SI201032108T SI3354657T1 (sl) | 2009-09-22 | 2010-09-21 | Postopek za pripravo iz rastlin izpeljanih beljakovin |
SI201031656T SI2480560T1 (sl) | 2009-09-22 | 2010-09-21 | Postopek za pripravo beljakovin, izpeljanih iz rastlin |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201032108T SI3354657T1 (sl) | 2009-09-22 | 2010-09-21 | Postopek za pripravo iz rastlin izpeljanih beljakovin |
SI201031656T SI2480560T1 (sl) | 2009-09-22 | 2010-09-21 | Postopek za pripravo beljakovin, izpeljanih iz rastlin |
Country Status (27)
Country | Link |
---|---|
US (2) | US11833200B2 (sl) |
EP (3) | EP3354657B1 (sl) |
JP (2) | JP5554414B2 (sl) |
KR (4) | KR101773431B1 (sl) |
CN (4) | CN107129973A (sl) |
AR (2) | AR078432A1 (sl) |
AU (2) | AU2010300033B2 (sl) |
BR (2) | BR112012006414B1 (sl) |
CA (2) | CA2772962C (sl) |
DK (3) | DK2480658T3 (sl) |
ES (3) | ES2911037T3 (sl) |
HR (3) | HRP20220478T1 (sl) |
HU (3) | HUE036776T2 (sl) |
IL (4) | IL218393A0 (sl) |
IN (2) | IN2012DN02637A (sl) |
MX (2) | MX2012003372A (sl) |
MY (2) | MY158475A (sl) |
NO (2) | NO2480658T3 (sl) |
NZ (2) | NZ598481A (sl) |
PL (3) | PL2480560T3 (sl) |
PT (3) | PT2480658T (sl) |
RU (2) | RU2579903C2 (sl) |
SG (2) | SG178918A1 (sl) |
SI (3) | SI2480658T1 (sl) |
TR (1) | TR201803560T4 (sl) |
WO (2) | WO2011035423A1 (sl) |
ZA (2) | ZA201202835B (sl) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
DK2610345T3 (en) | 2007-11-27 | 2015-12-07 | Medicago Inc | RECOMBINANT INFLUENZA VIRUS SIMULAR PARTICULARS (VLPS) MADE IN TRANSGENE PLANTS THAT EXPRESS HEMAGGLUTININ |
MX349924B (es) | 2009-06-24 | 2017-08-21 | Medicago Inc * | Partículas similares al virus de la influenza quiméricas que comprenden hemaglutinina. |
IN2012DN02637A (sl) * | 2009-09-22 | 2015-09-04 | Medicago Inc | |
TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
CN103998601B (zh) | 2011-06-13 | 2018-03-20 | 麦迪卡格公司 | 在植物中产生狂犬病病毒样颗粒 |
CN103957891B (zh) * | 2011-09-23 | 2017-01-11 | 美利坚合众国由健康及人类服务部部长代表 | 基于流感血凝素蛋白的新颖疫苗 |
EP2760882B1 (en) | 2011-09-30 | 2023-05-24 | Medicago Inc. | Increasing virus-like particle yield in plants |
US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
JP6041896B2 (ja) * | 2011-12-21 | 2016-12-14 | アプス, エルエルシー | 加水分解酵素に対して耐性があるカプシドを有するvlpを用いるプロセス |
JP6406655B2 (ja) * | 2012-02-22 | 2018-10-17 | 三菱商事フードテック株式会社 | 植物性食品素材の軟化方法、軟化製剤、軟化した植物性食品素材およびそれを用いた食品 |
IN2014DN07152A (sl) * | 2012-03-22 | 2015-04-24 | Fraunhofer Usa Inc | |
US10202423B2 (en) | 2012-09-05 | 2019-02-12 | Medicago Inc. of Quebec, Canada | Picornavirus-like particle production in plants |
US9617297B2 (en) * | 2012-10-11 | 2017-04-11 | The Regents Of The University Of California | Apoplast wash fluid recovery for improved recombinant endoglucanase extraction in tabacco leaves |
EP2978848B1 (en) * | 2013-03-28 | 2020-05-06 | Medicago Inc. | Influenza virus-like particle production in plants |
JP6358257B2 (ja) * | 2013-09-06 | 2018-07-18 | 三菱ケミカル株式会社 | 植物を用いたタンパク質の製造方法 |
BR112016007868A2 (pt) | 2013-10-11 | 2017-12-05 | Us Health | vacinas contra o vírus de epstein-barr |
CA2936350C (en) | 2014-01-10 | 2023-01-31 | Medicago Inc. | Cpmv enhancer elements |
RU2731295C2 (ru) | 2014-07-11 | 2020-09-01 | Медикаго Инк. | Модификация продуцирования белков в растениях |
CN107427571A (zh) | 2014-12-31 | 2017-12-01 | 美利坚合众国,由健康及人类服务部部长代表 | 基于纳米颗粒的新型多价疫苗 |
JP2019129705A (ja) * | 2016-03-31 | 2019-08-08 | 日本たばこ産業株式会社 | 植物に物質を導入する方法 |
IL265121B2 (en) | 2016-09-02 | 2023-11-01 | Us Health | Stable group 2 trimers from the stem region of influenza hemagglutinin and their uses |
JP2021503962A (ja) * | 2017-11-30 | 2021-02-15 | メディカゴ インコーポレイテッド | 改変ノロウイルスvp1タンパク質及び改変ノロウイルスvp1タンパク質を含むvlp |
EP3821014A4 (en) | 2018-07-13 | 2022-04-20 | Medicago Inc. | MODIFIED NOROVIRUS VP1 PROTEINS AND VLPS WITH MODIFIED NOROVIRUS VP1 PROTEINS |
CN109112093B (zh) * | 2018-09-05 | 2021-11-09 | 上海交通大学 | 一种青蒿原生质体高效分离及瞬时转化的方法 |
CN110483616B (zh) * | 2019-07-31 | 2021-06-04 | 中国农业科学院农产品加工研究所 | 从感染病原菌的植物组织中分离病原菌分泌的质外体效应蛋白的方法 |
CN111060696B (zh) * | 2019-12-27 | 2023-09-08 | 湖南农业大学 | 一种降低植物小分子信号肽假阳性率的方法 |
CN111718394A (zh) * | 2020-06-28 | 2020-09-29 | 广西壮族自治区农业科学院 | 一种基于bpp法的甘蔗组织变性蛋白提取方法 |
CN111826394A (zh) * | 2020-08-07 | 2020-10-27 | 浙江华缔药业集团医药开发有限公司 | 植物瞬时表达载体的构建及应用 |
CN117479831A (zh) | 2021-06-09 | 2024-01-30 | 南特知识产权控股有限责任公司 | 用于在植物中生产感兴趣的蛋白质的方法和系统 |
CN114934007B (zh) * | 2022-07-01 | 2023-11-24 | 广东省农业科学院作物研究所 | 一种甘薯原生质体的制备方法 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
EP0203177A4 (en) | 1984-11-29 | 1987-04-28 | Scripps Clinic Res | POLYPEPTIDES AND ANTIBODIES AGAINST DEGGLYCOSILIZED VIRAL GLYCOPROTEINS. |
JPS61265086A (ja) * | 1985-05-21 | 1986-11-22 | Mitsui Toatsu Chem Inc | プロトプラストの培養法 |
US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
US6403865B1 (en) | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
ATE142883T1 (de) | 1991-03-28 | 1996-10-15 | Rooperol Na Nv | Zusammensetzungen von phytosterolen mit phytosterolinen als immunmodulatoren |
UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
US6326470B1 (en) * | 1997-04-15 | 2001-12-04 | The Penn State Research Foundation | Enhancement of accessibility of cellulose by expansins |
US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
GB9414118D0 (en) | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
AU6504796A (en) | 1995-07-20 | 1997-02-18 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
US5773695A (en) * | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
US20010006950A1 (en) | 1998-02-11 | 2001-07-05 | Juha Punnonen | Genetic vaccine vector engineering |
US6489537B1 (en) | 1998-08-07 | 2002-12-03 | The Trustees Of The University Of Pennsylvania | Phytochelatin synthases and uses therefor |
BR9912875A (pt) | 1998-08-11 | 2002-02-13 | Large Scale Biology Corp | Método para a recuperação de proteìnas a partir do fluido intersticial de tecidos vegetais |
US6287570B1 (en) | 1998-11-23 | 2001-09-11 | Patricia L. Foley | Vaccine against swine influenza virus |
JP2002533090A (ja) | 1998-12-23 | 2002-10-08 | ザ、サミュアル、ラバツ、ノゥブル、ファウンデイシャン、インク | 植物形質転換法 |
FR2791358B1 (fr) | 1999-03-22 | 2003-05-16 | Meristem Therapeutics | Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention |
EP1171618A2 (en) | 1999-04-21 | 2002-01-16 | The Samuel Roberts Noble Foundation | Plant transformation process |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
CA2418091A1 (en) * | 2000-08-08 | 2002-02-14 | The Kitasato Institute | Virus-like particles and process for producing the same |
ES2327719T3 (es) | 2001-01-18 | 2009-11-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Complejos de proteina oligomerica recombinante con potencial inmunogenico mejorado. |
US20050037420A1 (en) | 2001-09-14 | 2005-02-17 | Mei-Yun Zhang | Immunoglobulin having particular framework scaffold and methods of making and using |
ES2806412T3 (es) | 2002-02-13 | 2021-02-17 | Wisconsin Alumni Res Found | Señal para el empaquetamiento de vectores del virus de la gripe |
WO2003068933A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
NZ546945A (en) | 2002-03-19 | 2008-04-30 | Plant Res Int Bv | A plant host cell system for the expression of human GnTIII |
WO2004098530A2 (en) | 2003-05-05 | 2004-11-18 | Dow Agrosciences Llc | Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production |
ZA200508930B (en) | 2003-05-05 | 2007-03-28 | Thompson Boyce Inst Plant Research | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
EP2581093B1 (en) | 2003-06-16 | 2015-03-18 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
CN1560227A (zh) * | 2004-02-25 | 2005-01-05 | 福建师范大学 | 雨生红球藻原生质体制备与再生技术 |
WO2006016380A2 (en) | 2004-08-13 | 2006-02-16 | Council Of Scientific And Industrial Research | A chimeric g protein based rabies vaccine |
US9155483B2 (en) | 2004-12-03 | 2015-10-13 | The Invention Science Fund I, Llc | Vision modification with reflected image |
CA2861310A1 (en) * | 2005-03-15 | 2006-09-28 | Bp Corporation North America Inc. | Cellulases, nucleic acids encoding them and methods for making and using them |
DK2374892T3 (en) | 2005-04-29 | 2018-03-12 | Univ Cape Town | Expression of viral proteins in plants |
CN100410378C (zh) | 2005-05-09 | 2008-08-13 | 中国农业科学院生物技术研究所 | 编码禽流感血凝素的基因及其植物表达载体和应用 |
EP1896596B1 (en) * | 2005-06-24 | 2011-09-07 | Bayer BioScience N.V. | Methods for altering the reactivity of plant cell walls |
BRPI0613625A2 (pt) | 2005-07-19 | 2011-01-18 | Dow Global Technologies Inc | vacinas da gripe recombinantes |
US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
CA2625406C (en) | 2005-10-18 | 2016-08-09 | Novavax, Inc. | Functional influenza virus like particles (vlps) |
CA2630220C (en) * | 2005-11-22 | 2020-10-13 | Doris Coit | Norovirus and sapovirus antigens |
US8124103B2 (en) | 2006-02-13 | 2012-02-28 | Fraunhofer Usa, Inc | Influenza antigens, vaccine compositions, and related methods |
BRPI0710689A2 (pt) | 2006-04-21 | 2012-02-22 | Dow Agrosciences Llc | método para preparação de uma vacina de aiv feita de planta e a referida vacina |
WO2007130327A2 (en) | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
US9511134B2 (en) | 2006-05-18 | 2016-12-06 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
WO2007135480A1 (en) | 2006-05-22 | 2007-11-29 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
US20070286873A1 (en) | 2006-05-23 | 2007-12-13 | Williams John V | Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor |
WO2008088813A1 (en) | 2007-01-17 | 2008-07-24 | Lerner Medical Devices, Inc. | Fiber optic phototherapy device |
US7730950B2 (en) | 2007-01-19 | 2010-06-08 | Halliburton Energy Services, Inc. | Methods for treating intervals of a subterranean formation having variable permeability |
CA2795379A1 (en) | 2007-06-15 | 2008-12-18 | Centre National De La Recherche Scientifique | Modifying glycoprotein production in plants |
KR100964462B1 (ko) | 2007-07-10 | 2010-06-16 | 성균관대학교산학협력단 | 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법 |
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
RU2358981C2 (ru) * | 2007-08-07 | 2009-06-20 | Центр "Биоинженерия" Российской Академии Наук | Универсальная вакцина против вируса гриппа птиц |
US20110059130A1 (en) | 2007-08-20 | 2011-03-10 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods |
CN101422128B (zh) * | 2007-10-29 | 2011-06-08 | 中国水产科学研究院黄海水产研究所 | 马尾藻原生质体的分离和再生 |
DK2610345T3 (en) | 2007-11-27 | 2015-12-07 | Medicago Inc | RECOMBINANT INFLUENZA VIRUS SIMULAR PARTICULARS (VLPS) MADE IN TRANSGENE PLANTS THAT EXPRESS HEMAGGLUTININ |
US8933013B2 (en) | 2007-12-05 | 2015-01-13 | Nono Inc. | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
EP2244581A1 (en) | 2007-12-28 | 2010-11-03 | Unilever PLC | Process for recovering aroma from tea |
US8799801B2 (en) | 2008-01-16 | 2014-08-05 | Qualcomm Incorporated | Interactive ticker |
SG187500A1 (en) | 2008-01-21 | 2013-02-28 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
ES2545607T3 (es) | 2008-07-08 | 2015-09-14 | Medicago Inc. | Antígenos de la gripe recombinantes solubles |
CN101626276A (zh) | 2008-07-10 | 2010-01-13 | 华为技术有限公司 | 广告替换方法、装置及系统 |
CA2730668C (en) | 2008-07-18 | 2020-04-28 | Medicago Inc. | New influenza virus immunizing epitope |
AU2009285667B2 (en) | 2008-08-27 | 2015-05-28 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
US20100167376A1 (en) * | 2008-10-06 | 2010-07-01 | Genvault Corporation | Methods for providing cellular lysates from cell wall-containing samples |
WO2010077712A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Bovine respiratory syncytial virus virus-like particle (vlps) |
AU2010208181B2 (en) | 2009-01-30 | 2015-04-30 | Presympto, Inc. | Conformationally dynamic peptides |
PT3431076T (pt) | 2009-06-10 | 2021-10-26 | Arbutus Biopharma Corp | Formulação lipídica melhorada |
MX349924B (es) | 2009-06-24 | 2017-08-21 | Medicago Inc * | Partículas similares al virus de la influenza quiméricas que comprenden hemaglutinina. |
IN2012DN02637A (sl) | 2009-09-22 | 2015-09-04 | Medicago Inc | |
CA2815887C (en) | 2010-11-04 | 2013-12-10 | Medicago Inc. | Plant expression system |
AU2011323090B2 (en) | 2010-11-05 | 2015-02-12 | Novavax Inc. | Rabies glycoprotein virus-like particles (VLPs) |
TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
TWI620816B (zh) * | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
-
2010
- 2010-09-21 IN IN2637DEN2012 patent/IN2012DN02637A/en unknown
- 2010-09-21 RU RU2012115661/10A patent/RU2579903C2/ru active
- 2010-09-21 US US13/497,767 patent/US11833200B2/en active Active
- 2010-09-21 PL PL10818191T patent/PL2480560T3/pl unknown
- 2010-09-21 TR TR2018/03560T patent/TR201803560T4/tr unknown
- 2010-09-21 PL PL18157629T patent/PL3354657T3/pl unknown
- 2010-09-21 CN CN201710164586.9A patent/CN107129973A/zh active Pending
- 2010-09-21 DK DK10818190.0T patent/DK2480658T3/da active
- 2010-09-21 PL PL10818190T patent/PL2480658T3/pl unknown
- 2010-09-21 AU AU2010300033A patent/AU2010300033B2/en active Active
- 2010-09-21 WO PCT/CA2010/001489 patent/WO2011035423A1/en active Application Filing
- 2010-09-21 WO PCT/CA2010/001488 patent/WO2011035422A1/en active Application Filing
- 2010-09-21 CA CA2772962A patent/CA2772962C/en active Active
- 2010-09-21 HU HUE10818190A patent/HUE036776T2/hu unknown
- 2010-09-21 PT PT108181900T patent/PT2480658T/pt unknown
- 2010-09-21 IN IN2591DEN2012 patent/IN2012DN02591A/en unknown
- 2010-09-21 JP JP2012530059A patent/JP5554414B2/ja active Active
- 2010-09-21 KR KR1020127009357A patent/KR101773431B1/ko active IP Right Grant
- 2010-09-21 RU RU2012115996/10A patent/RU2567012C2/ru active
- 2010-09-21 BR BR112012006414-2A patent/BR112012006414B1/pt active IP Right Grant
- 2010-09-21 SI SI201031558T patent/SI2480658T1/sl unknown
- 2010-09-21 NO NO10818190A patent/NO2480658T3/no unknown
- 2010-09-21 MX MX2012003372A patent/MX2012003372A/es active IP Right Grant
- 2010-09-21 ES ES18157629T patent/ES2911037T3/es active Active
- 2010-09-21 EP EP18157629.9A patent/EP3354657B1/en active Active
- 2010-09-21 MX MX2012003373A patent/MX2012003373A/es active IP Right Grant
- 2010-09-21 NZ NZ598481A patent/NZ598481A/en unknown
- 2010-09-21 ES ES10818190.0T patent/ES2642631T3/es active Active
- 2010-09-21 SI SI201032108T patent/SI3354657T1/sl unknown
- 2010-09-21 NO NO10818191A patent/NO2480560T3/no unknown
- 2010-09-21 NZ NZ598508A patent/NZ598508A/en unknown
- 2010-09-21 KR KR1020187005775A patent/KR20180026562A/ko not_active Application Discontinuation
- 2010-09-21 HR HRP20220478TT patent/HRP20220478T1/hr unknown
- 2010-09-21 BR BR112012006415A patent/BR112012006415B1/pt active IP Right Grant
- 2010-09-21 DK DK10818191.8T patent/DK2480560T3/en active
- 2010-09-21 DK DK18157629.9T patent/DK3354657T3/da active
- 2010-09-21 SG SG2012014254A patent/SG178918A1/en unknown
- 2010-09-21 CN CN2010800423364A patent/CN102549008A/zh active Pending
- 2010-09-21 ES ES10818191.8T patent/ES2662778T3/es active Active
- 2010-09-21 CA CA2772964A patent/CA2772964C/en active Active
- 2010-09-21 SI SI201031656T patent/SI2480560T1/sl unknown
- 2010-09-21 JP JP2012530060A patent/JP5551780B2/ja active Active
- 2010-09-21 CN CN201710005957.9A patent/CN107090021A/zh active Pending
- 2010-09-21 CN CN2010800423330A patent/CN102549148A/zh active Pending
- 2010-09-21 SG SG2012014718A patent/SG178947A1/en unknown
- 2010-09-21 KR KR1020127010044A patent/KR20120093223A/ko not_active Application Discontinuation
- 2010-09-21 EP EP10818191.8A patent/EP2480560B1/en active Active
- 2010-09-21 AU AU2010300034A patent/AU2010300034B2/en active Active
- 2010-09-21 HU HUE10818191A patent/HUE038557T2/hu unknown
- 2010-09-21 PT PT108181918T patent/PT2480560T/pt unknown
- 2010-09-21 EP EP10818190.0A patent/EP2480658B1/en active Active
- 2010-09-21 MY MYPI2012001248A patent/MY158475A/en unknown
- 2010-09-21 PT PT181576299T patent/PT3354657T/pt unknown
- 2010-09-21 MY MYPI2012001251A patent/MY164704A/en unknown
- 2010-09-21 HU HUE18157629A patent/HUE058165T2/hu unknown
- 2010-09-21 KR KR1020197012547A patent/KR102115226B1/ko active IP Right Grant
- 2010-09-21 US US13/497,757 patent/US11826419B2/en active Active
- 2010-09-22 AR ARP100103458A patent/AR078432A1/es unknown
- 2010-09-22 AR ARP100103460A patent/AR078433A1/es unknown
-
2012
- 2012-02-29 IL IL218393A patent/IL218393A0/en unknown
- 2012-03-01 IL IL218422A patent/IL218422B/en active IP Right Grant
- 2012-04-18 ZA ZA2012/02835A patent/ZA201202835B/en unknown
- 2012-04-18 ZA ZA2012/02836A patent/ZA201202836B/en unknown
-
2017
- 2017-10-16 HR HRP20171564TT patent/HRP20171564T1/hr unknown
-
2018
- 2018-01-31 IL IL257261A patent/IL257261B/en active IP Right Grant
- 2018-03-27 HR HRP20180509TT patent/HRP20180509T1/hr unknown
-
2019
- 2019-11-14 IL IL270661A patent/IL270661B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL270661B (en) | A method for preparing vlps that are plant histories | |
ZA202006532B (en) | Method for decreasing immunogenicity | |
IL243021B (en) | A method for preparing multicyclic components | |
HK1203192A1 (en) | Method of preparation of enantiomers of spiro-oxindole compounds | |
PL2634191T3 (pl) | Sposób wytwarzania pochodnych tienopirymidynodionu | |
EP2411023A4 (en) | TISSUE REPAIR PROCEDURES | |
EP2407461A4 (en) | PROCESS FOR PREPARING 1-ALKYL-5-BENZOYL-1H-TETRAZOL DERIVATIVES | |
ZA201101645B (en) | Process for prodcution of vaccines | |
EP2344192A4 (en) | METHOD FOR MANUFACTURING A VACCINE | |
IL222360A0 (en) | Method of vaccination | |
EP2482843A4 (en) | PROCESS FOR IMPROVED VACCINE IMMUNOGENICITY | |
EP2484757A4 (en) | VIRUS FOR THE EXPRESSION OF ALPHA GALACTOSE EPITOPES AND METHOD FOR THE PRODUCTION OF A VACCINE | |
EP2501803A4 (en) | PROCESS FOR PLURIPOTENZINTENSIVATION | |
HRP20130486T1 (en) | Method of preparing neramexane | |
EP2404891A4 (en) | PROCESS FOR THE PREPARATION OF ACYLBENZENES | |
EP2385994A4 (en) | AGGLOMERATION PROCESS | |
EP2586774A4 (en) | PROCESS FOR THE PREPARATION OF RANOLAZINE | |
EP2424539A4 (en) | PROCESS FOR TREATING DEPRESSION | |
PL388062A1 (pl) | Sposób otrzymywania preparatu bioaktywnego | |
GB2470361B (en) | Method of casting | |
GB0916017D0 (en) | Method of producing tantalum | |
GB0908723D0 (en) | Method of imaging | |
GB201015340D0 (en) | Method of producing tantalum | |
HU0900129D0 (en) | Method for biphasic production of lyposomes |