BR112012006415A2 - método para preparar vlps derivadas de plantas - Google Patents
método para preparar vlps derivadas de plantasInfo
- Publication number
- BR112012006415A2 BR112012006415A2 BR112012006415A BR112012006415A BR112012006415A2 BR 112012006415 A2 BR112012006415 A2 BR 112012006415A2 BR 112012006415 A BR112012006415 A BR 112012006415A BR 112012006415 A BR112012006415 A BR 112012006415A BR 112012006415 A2 BR112012006415 A2 BR 112012006415A2
- Authority
- BR
- Brazil
- Prior art keywords
- plant derived
- preparing plant
- derived vlps
- vlps
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/517—Plant cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24478609P | 2009-09-22 | 2009-09-22 | |
PCT/CA2010/001488 WO2011035422A1 (en) | 2009-09-22 | 2010-09-21 | Method of preparing plant-derived vlps |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012006415A2 true BR112012006415A2 (pt) | 2016-11-16 |
BR112012006415B1 BR112012006415B1 (pt) | 2020-04-28 |
Family
ID=43795254
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012006415A BR112012006415B1 (pt) | 2009-09-22 | 2010-09-21 | método para preparar vlps derivadas de plantas |
BR112012006414-2A BR112012006414B1 (pt) | 2009-09-22 | 2010-09-21 | Métodos para preparação de proteínas derivadas de plantas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012006414-2A BR112012006414B1 (pt) | 2009-09-22 | 2010-09-21 | Métodos para preparação de proteínas derivadas de plantas |
Country Status (27)
Country | Link |
---|---|
US (2) | US11826419B2 (pt) |
EP (3) | EP3354657B1 (pt) |
JP (2) | JP5551780B2 (pt) |
KR (4) | KR20180026562A (pt) |
CN (4) | CN107090021A (pt) |
AR (2) | AR078433A1 (pt) |
AU (2) | AU2010300033B2 (pt) |
BR (2) | BR112012006415B1 (pt) |
CA (2) | CA2772964C (pt) |
DK (3) | DK2480560T3 (pt) |
ES (3) | ES2662778T3 (pt) |
HR (3) | HRP20220478T1 (pt) |
HU (3) | HUE058165T2 (pt) |
IL (4) | IL218393A0 (pt) |
IN (2) | IN2012DN02637A (pt) |
MX (2) | MX2012003372A (pt) |
MY (2) | MY158475A (pt) |
NO (2) | NO2480658T3 (pt) |
NZ (2) | NZ598508A (pt) |
PL (3) | PL2480560T3 (pt) |
PT (3) | PT2480658T (pt) |
RU (2) | RU2579903C2 (pt) |
SG (2) | SG178947A1 (pt) |
SI (3) | SI3354657T1 (pt) |
TR (1) | TR201803560T4 (pt) |
WO (2) | WO2011035423A1 (pt) |
ZA (2) | ZA201202836B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
CN101978066A (zh) | 2007-11-27 | 2011-02-16 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
ES2669303T3 (es) | 2009-06-24 | 2018-05-24 | Medicago Inc. | Partículas pseudovíricas quiméricas de influenza que comprenden hemaglutinina |
BR112012006415B1 (pt) * | 2009-09-22 | 2020-04-28 | Medicago Inc | método para preparar vlps derivadas de plantas |
TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
TWI620816B (zh) * | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
MX350421B (es) * | 2011-06-13 | 2017-09-06 | Medicago Inc | Producción de partículas tipo virus de la rabia en plantas. |
EP2758038B1 (en) * | 2011-09-23 | 2018-05-30 | The United States of America, as represented by The Secretary, Department of Health & Human Services | Novel influenza hemagglutinin protein-based vaccines |
MX358883B (es) | 2011-09-30 | 2018-08-31 | Medicago Inc | Aumentar el rendimiento de particulas similares a virus en plantas. |
US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
EP4019636A1 (en) * | 2011-12-21 | 2022-06-29 | Apse Llc | Processes using vlps with capsids resistant to hydrolases |
JP6406655B2 (ja) * | 2012-02-22 | 2018-10-17 | 三菱商事フードテック株式会社 | 植物性食品素材の軟化方法、軟化製剤、軟化した植物性食品素材およびそれを用いた食品 |
US9364530B2 (en) * | 2012-03-22 | 2016-06-14 | Fraunhofer Usa, Inc. | Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof |
JP2015528285A (ja) | 2012-09-05 | 2015-09-28 | メディカゴ インコーポレイテッド | 植物におけるピコルナウイルス様粒子の産生 |
US9617297B2 (en) * | 2012-10-11 | 2017-04-11 | The Regents Of The University Of California | Apoplast wash fluid recovery for improved recombinant endoglucanase extraction in tabacco leaves |
CN105247059B (zh) * | 2013-03-28 | 2021-07-06 | 莫迪卡戈公司 | 植物中流感样病毒颗粒的产生 |
JP6358257B2 (ja) | 2013-09-06 | 2018-07-18 | 三菱ケミカル株式会社 | 植物を用いたタンパク質の製造方法 |
WO2015054639A1 (en) | 2013-10-11 | 2015-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Epstein-barr virus vaccines |
US11441150B2 (en) | 2014-01-10 | 2022-09-13 | Medicago Inc. | CPMV enhancer elements |
EP3167057B1 (en) | 2014-07-11 | 2020-03-25 | Medicago Inc. | Modifying protein production in plants |
BR112017014219A2 (pt) | 2014-12-31 | 2018-03-06 | The Usa As Represented By The Secretary Dept Of Health And Human Services | vacinas à base de nanopartículas multivalentes |
JP2019129705A (ja) * | 2016-03-31 | 2019-08-08 | 日本たばこ産業株式会社 | 植物に物質を導入する方法 |
EP3506938A1 (en) | 2016-09-02 | 2019-07-10 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof |
KR20200092363A (ko) * | 2017-11-30 | 2020-08-03 | 메디카고 인코포레이티드 | 변형된 노로바이러스 vp1 단백질 및 변형된 노로바이러스 vp1 단백질을 포함하는 vlp |
US11759512B2 (en) | 2018-07-13 | 2023-09-19 | Medicago Inc. | Modified norovirus VP1 proteins and VLPs comprising modified norovirus VP1 proteins |
CN109112093B (zh) * | 2018-09-05 | 2021-11-09 | 上海交通大学 | 一种青蒿原生质体高效分离及瞬时转化的方法 |
CN110483616B (zh) * | 2019-07-31 | 2021-06-04 | 中国农业科学院农产品加工研究所 | 从感染病原菌的植物组织中分离病原菌分泌的质外体效应蛋白的方法 |
CN111060696B (zh) * | 2019-12-27 | 2023-09-08 | 湖南农业大学 | 一种降低植物小分子信号肽假阳性率的方法 |
CN111718394A (zh) * | 2020-06-28 | 2020-09-29 | 广西壮族自治区农业科学院 | 一种基于bpp法的甘蔗组织变性蛋白提取方法 |
CN111826394A (zh) * | 2020-08-07 | 2020-10-27 | 浙江华缔药业集团医药开发有限公司 | 植物瞬时表达载体的构建及应用 |
WO2022260849A1 (en) | 2021-06-09 | 2022-12-15 | Nant Holdings Ip, Llc | Methods and systems for producing a protein of interest in a plant |
CN114934007B (zh) * | 2022-07-01 | 2023-11-24 | 广东省农业科学院作物研究所 | 一种甘薯原生质体的制备方法 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
JPS62501263A (ja) | 1984-11-29 | 1987-05-21 | スクリツプス クリニツク アンド リサ−チ フアウンデ−シヨン | 脱グリコシル化ウイルス糖タンパク質に関連するポリペプチド類および抗体 |
JPS61265086A (ja) * | 1985-05-21 | 1986-11-22 | Mitsui Toatsu Chem Inc | プロトプラストの培養法 |
US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
US6403865B1 (en) | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
ATE142883T1 (de) | 1991-03-28 | 1996-10-15 | Rooperol Na Nv | Zusammensetzungen von phytosterolen mit phytosterolinen als immunmodulatoren |
UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
US6326470B1 (en) * | 1997-04-15 | 2001-12-04 | The Penn State Research Foundation | Enhancement of accessibility of cellulose by expansins |
US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
GB9414118D0 (en) | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
US6020169A (en) * | 1995-07-20 | 2000-02-01 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
US5773695A (en) * | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
US20010006950A1 (en) | 1998-02-11 | 2001-07-05 | Juha Punnonen | Genetic vaccine vector engineering |
US6489537B1 (en) | 1998-08-07 | 2002-12-03 | The Trustees Of The University Of Pennsylvania | Phytochelatin synthases and uses therefor |
CA2349852A1 (en) * | 1998-08-11 | 2000-02-24 | Large Scale Biology Corporation | Method for recovering proteins from the interstitial fluid of plant tissues |
US6287570B1 (en) | 1998-11-23 | 2001-09-11 | Patricia L. Foley | Vaccine against swine influenza virus |
CA2352488A1 (en) | 1998-12-23 | 2000-06-29 | The Samuel Roberts Noble Foundation, Inc. | Plant transformation process |
FR2791358B1 (fr) | 1999-03-22 | 2003-05-16 | Meristem Therapeutics | Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention |
AU4365200A (en) | 1999-04-21 | 2000-11-02 | Samuel Roberts Noble Foundation, Inc., The | Plant transformation process |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
US20040009193A1 (en) * | 2000-08-08 | 2004-01-15 | Yuko Morikawa | Virus-like micrograins and process for producing the same |
WO2002074795A2 (en) | 2001-01-18 | 2002-09-26 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential |
DE60238497D1 (de) | 2001-09-14 | 2011-01-13 | Fraunhofer Ges Forschung | Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung |
KR101113432B1 (ko) | 2002-02-13 | 2012-02-29 | 위스콘신 얼럼나이 리서어치 화운데이션 | 인플루엔자 바이러스 벡터의 패키징을 위한 신호 |
AU2003213060A1 (en) | 2002-02-14 | 2003-09-04 | Novavax, Inc. | Optimization of gene sequences of chimeric virus-like particles for expression in insect cells |
KR101070518B1 (ko) | 2002-03-19 | 2011-10-05 | 스티칭 디엔스트 랜드보위쿤디그 온데조에크 | 식물에서의 gntⅲ 발현 |
NZ543348A (en) * | 2003-05-05 | 2008-08-29 | Thompson Boyce Plant Res | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
CN101123871B (zh) | 2003-05-05 | 2011-05-18 | 美国陶氏益农公司 | 来源于转基因植物细胞的稳定免疫预防性和治疗性组合物及其制备方法 |
EP2581093B1 (en) | 2003-06-16 | 2015-03-18 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
CN1560227A (zh) * | 2004-02-25 | 2005-01-05 | 福建师范大学 | 雨生红球藻原生质体制备与再生技术 |
WO2006016380A2 (en) | 2004-08-13 | 2006-02-16 | Council Of Scientific And Industrial Research | A chimeric g protein based rabies vaccine |
US9155483B2 (en) | 2004-12-03 | 2015-10-13 | The Invention Science Fund I, Llc | Vision modification with reflected image |
NZ594810A (en) * | 2005-03-15 | 2012-12-21 | Verenium Corp | Cellulases, nucleic acids encoding them and methods for making and using them |
DK2374892T3 (en) | 2005-04-29 | 2018-03-12 | Univ Cape Town | Expression of viral proteins in plants |
CN100410378C (zh) | 2005-05-09 | 2008-08-13 | 中国农业科学院生物技术研究所 | 编码禽流感血凝素的基因及其植物表达载体和应用 |
MX2008000097A (es) * | 2005-06-24 | 2008-03-19 | Bayer Bioscience Nv | Metodos para alterar la reactividad de las paredes de las celulas vegetales. |
AU2006270065A1 (en) | 2005-07-19 | 2007-01-25 | Dow Global Technologies Inc. | Recombinant flu vaccines |
US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
CA2625406C (en) | 2005-10-18 | 2016-08-09 | Novavax, Inc. | Functional influenza virus like particles (vlps) |
WO2007081447A2 (en) * | 2005-11-22 | 2007-07-19 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
JP2009526526A (ja) | 2006-02-13 | 2009-07-23 | フラウンホーファー ユーエスエー, インコーポレイテッド | インフルエンザ抗原、ワクチン組成物、および関連する方法 |
AR060565A1 (es) | 2006-04-21 | 2008-06-25 | Dow Agrosciences Llc | Vacuna para la gripe aviaria y metodos de uso |
US8778353B2 (en) | 2006-05-01 | 2014-07-15 | Technovax, Inc. | Influenza virus-like particle (VLP) compositions |
US9511134B2 (en) | 2006-05-18 | 2016-12-06 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
CA2651907C (en) | 2006-05-22 | 2016-12-20 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
US20070286873A1 (en) | 2006-05-23 | 2007-12-13 | Williams John V | Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor |
WO2008088813A1 (en) | 2007-01-17 | 2008-07-24 | Lerner Medical Devices, Inc. | Fiber optic phototherapy device |
US7730950B2 (en) | 2007-01-19 | 2010-06-08 | Halliburton Energy Services, Inc. | Methods for treating intervals of a subterranean formation having variable permeability |
DK2155880T3 (en) | 2007-06-15 | 2016-12-05 | Medicago Inc | Modification of glycoproteinproduktion i plants |
KR100964462B1 (ko) | 2007-07-10 | 2010-06-16 | 성균관대학교산학협력단 | 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법 |
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
RU2358981C2 (ru) * | 2007-08-07 | 2009-06-20 | Центр "Биоинженерия" Российской Академии Наук | Универсальная вакцина против вируса гриппа птиц |
US20110059130A1 (en) | 2007-08-20 | 2011-03-10 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods |
CN101422128B (zh) * | 2007-10-29 | 2011-06-08 | 中国水产科学研究院黄海水产研究所 | 马尾藻原生质体的分离和再生 |
CN101978066A (zh) * | 2007-11-27 | 2011-02-16 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
JP2011508034A (ja) | 2007-12-28 | 2011-03-10 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 茶から香気成分を回収する方法 |
US8799801B2 (en) | 2008-01-16 | 2014-08-05 | Qualcomm Incorporated | Interactive ticker |
SG187500A1 (en) | 2008-01-21 | 2013-02-28 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
CN105753948A (zh) | 2008-07-08 | 2016-07-13 | 麦迪卡格公司 | 可溶性重组流感抗原 |
CN101626276A (zh) | 2008-07-10 | 2010-01-13 | 华为技术有限公司 | 广告替换方法、装置及系统 |
MX2011000657A (es) | 2008-07-18 | 2011-03-21 | Medicago Inc | Epitopo de inmunizacion de nuevo virus de la influenza. |
AU2009285667B2 (en) | 2008-08-27 | 2015-05-28 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
WO2010042551A2 (en) * | 2008-10-06 | 2010-04-15 | Genvault Corporation | Methods for providing cellular lysates from cell wall-containing samples |
WO2010077712A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Bovine respiratory syncytial virus virus-like particle (vlps) |
CN102365295A (zh) | 2009-01-30 | 2012-02-29 | 阿德利夫股份有限公司 | 构象动力肽 |
PT2440231T (pt) | 2009-06-10 | 2020-01-08 | Nono Inc | Co-administração de um agente ligado a um peptido de internalização tat com um inibidor de desgranulação de mastócitos |
DK2440183T3 (en) | 2009-06-10 | 2018-10-01 | Arbutus Biopharma Corp | Improved lipid formulation |
ES2669303T3 (es) | 2009-06-24 | 2018-05-24 | Medicago Inc. | Partículas pseudovíricas quiméricas de influenza que comprenden hemaglutinina |
BR112012006415B1 (pt) | 2009-09-22 | 2020-04-28 | Medicago Inc | método para preparar vlps derivadas de plantas |
ES2614527T3 (es) | 2010-11-04 | 2017-05-31 | Medicago Inc. | Sistema de expresión en plantas |
RS56157B1 (sr) | 2010-11-05 | 2017-11-30 | Novavax Inc | Glikoproteinske čestice nalik virusu (vlp) besnila |
TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
TWI620816B (zh) * | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
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