SI2315740T1 - Maščobnokislinski acetilirani salicilati in njihove uporabe - Google Patents

Maščobnokislinski acetilirani salicilati in njihove uporabe Download PDF

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SI2315740T1
SI2315740T1 SI200931789T SI200931789T SI2315740T1 SI 2315740 T1 SI2315740 T1 SI 2315740T1 SI 200931789 T SI200931789 T SI 200931789T SI 200931789 T SI200931789 T SI 200931789T SI 2315740 T1 SI2315740 T1 SI 2315740T1
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Slovenia
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compound
alkyl
independently
use according
disease
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SI200931789T
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Jill C. Milne
Michael R. Jirousek
Jean E. Bemis
Jesse J. Smith
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Catabasis Pharmaceuticals, Inc.
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Application filed by Catabasis Pharmaceuticals, Inc. filed Critical Catabasis Pharmaceuticals, Inc.
Publication of SI2315740T1 publication Critical patent/SI2315740T1/sl

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    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/609—Amides, e.g. salicylamide
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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Claims (21)

  1. Maščobnokislinski acetilirani salicilati in njihove uporabe Patentni zahtevki
    1. Spojina s formulo I,
    Formula I ali njena farmacevtsko sprejemljiva sol, hidrat, solvat, enantiomer ali stereoizomer, kjer: Ri, R2, R3 in R4 so vsak neodvisno izbrani iz skupine, ki jo sestavljajo H, Cl, F, CN, -NH(C,-C3 alkil), -N(CrC3 alkil)2, -NH(C(0)CrC3 alkil), -N(C(0)CrC3 alkil)2, -C(0)H, -C(0)CrC3 alkil, -C(0)0CrC3 alkil, -C(0)NH2, -C(0)NH(CrC3 alkil), -C(0)N(CrC3 alkil)2, -0-CrC3 alkil, -S(0)CrC3 alkil in -S(0)2CrC3 alkil; Wi in W2 sta vsak neodvisno nič, O ali NH, ali kadar sta Wi in W2 oba NH, potem sta oba Wi in W2 lahko skupaj, da tvorita piperazinski del; -----predstavlja vez po izbiri, ki takrat, ko je prisotna, zahteva, daje Q nič; a in c sta vsak neodvisno H, CH3, -OCH3, -OCH2CH3 ali C(0)0H; b je H, CH3, C(0)0H ali O-Z; d je H ali C(0)0H; vsak n, o, p in q je neodvisno 0 ali 1; vsak Z je H ali
    s pridržkom, da je v spojini vsaj en
    vsak rje neodvisno 2 ali 3 in vsak s je neodvisno 5 ali 6; ali vsak rje neodvisno 7 in vsak s je neodvisno 3; vsak t je neodvisno 0 ali 1; Q je nič, C(0)CH3, Z, ali
    e je H ali katera koli od stranskih verig naravno nahajočih aminokislin; W3 je nič,-O- ali-N(R)-; Rje H ali C1-C3 alkil; in T je H, C(0)CH3 ali Z.
  2. 2. Spojina po zahtevku 1, kjer je Wj ali W2 NH.
  3. 3. Spojina po zahtevku 1 ali 2, kjer jer 2, s je 6, t je 1 in Z je
  4. 4. Spojina po zahtevku 1, kjer je Q Z ali
  5. 5. Spojina po zahtevku 1, kjer je Z maščobna kislina, izbrana iz skupine, ki jo sestavljajo vse-cis-5,8,11,14,17-eikozapentaenojska kislina (EPA), vse-cis-4,7,10,13,16,19-dokozaheksaenojska kislina (DHA) in vse-cis-9,12,15-oktadekatrienojska kislina (ALA).
  6. 6. Spojina po zahtevku 1, kjer je Z rje 2 in s je 6.
  7. 7. Spojina po zahtevku 1, kjer je Z
    rje 3 in s je 5.
  8. 8. Spojina po zahtevku 1, kjer je spojina
  9. 9. Spojina po zahtevku 1, kjer je spojina
  10. 10. Farmacevtski sestavek, ki obsega spojino po katerem koli od zahtevkov 1-9 in farmacevtsko sprejemljiv nosilec.
  11. 11. Spojina za uporabo v zdravljenju vnetja, ki je povezano z metabolno motnjo, vnetno črevesno boleznijo, nevrodegenerativno motnjo ali boleznijo usihanja mišic, kjer je spojina spojina s formulo I:
    Formula I ali njena farmacevtsko sprejemljiva sol, hidrat, solvat, enantiomer ali stereoizomer, kjer: Ri, R2, R35 in R4 so vsak neodvisno izbrani iz skupine, ki jo sestavljajo H, Cl, F, CN, -NH(CrC3 alkil), -N(CrC3 alkil)2, -NH(C(0)CrC3 alkil), -N(C(0)CrC3 alkil)2, -C(0)H, -C(0)CrC3 alkil, -C(0)0CrC3 alkil, -C(0)NH2, -C(0)NH(CrC3 alkil), -C(0)N(CrC3 alkil)2, -0-Ci-C3 alkil, -S(0)CrC3 alkil in -S(0)2CrC3 alkil; Wj in W2 sta vsak neodvisno nič, O ali NH, ali kadar sta Wi in W2 oba NH, potem sta oba Wi in W2 lahko skupaj, da tvorita piperazinski del; -----predstavlja vez po izbiri, ki takrat, ko je prisotna, zahteva, daje Q nič; a in c sta vsak neodvisno H, CH3, -OCH3, -OCH2CH3 ali C(0)0H; b je H, CH3, C(0)0H ali O-Z; d je H ali C(0)0H; vsak n, o, p in q je neodvisno 0 ali 1; vsak Z je H ali
    s pridržkom, da je v spojini vsaj en
    vsak rje neodvisno 2 ali 3 in vsak s je neodvisno 5 ali 6; ali vsak rje neodvisno 7 in vsak s je neodvisno 3; vsak t je neodvisno 0 ali 1; Q je nič, C(0)CH3, Z, ali
    e je H ali katera koli od stranskih verig naravno nahajočih aminokislin; W3 je nič, -O- ali -N(R)-; Rje H ali C1-C3 alkil; in TjeH, C(0)CH3 ali Z.
  12. 12. Spojina za uporabo po zahtevku 11, kjer je vnetje povezano z motnjo ali boleznijo, izbrano iz skupine, v kateri so diabetes tipa II, inzulinska resistenca, kardiovaskularna bolezen, aritmija, ateroskleroza, koronama arterijska bolezen, hipertrigliceridemija, dislipidemija, retinopatija, nefropatija, nevropatija, makulami edem, ileitis, ulcerozni kolitis, Barrettov sindrom, Crohnova bolezen, nevrodegeneracija, Alzheimerjeva bolezen, multipla skleroza, Huntingtonova bolezen, infekcijski meningitis, encefalomielitis, Parkinsonova bolezen, amiotrofična lateralna skleroza, encefalitis, mišična distrofija, dermatomozitis, miozitis inkluzijskih telesc, polimiozitis ali kaheksija.
  13. 13. Spojina za uporabo po zahtevku 12, kjer je vnetje povezano z mišično distrofijo.
  14. 14. Spojina za uporabo po zahtevku 12, kjer je vnetje povezano z diabetesom tipa II.
  15. 15. Spojina za uporabo po zahtevku 11, kjer je vnetje povezano z vnetno črevesno boleznijo.
  16. 16. Spojina za uporabo po zahtevku 12, kjer je vnetje povezano z ulceroznim kolitisom.
  17. 17. Spojina za uporabo po zahtevku 12, kjer je vnetje povezano s Crohnovo boleznijo.
  18. 18. Spojina za uporabo po zahtevku 12, kjer je vnetje povezano s kaheksijo.
  19. 19. Spojina za uporabo po katerem koli od zahtevkov 11-18, kjer je spojina, kot je definirana v katerem koli od zahtevkov 1-9.
  20. 20. Spojina za uporabo po zahtevku 11, kjer je motnja usihanja mišic Duchennejeva mišična distrofija.
  21. 21. Spojina za uporabo po zahtevku 11, kjer je spojina
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Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1888727B1 (en) 2005-05-04 2015-04-15 Pronova BioPharma Norge AS New dha derivatives and their use as medicaments
CN101535238A (zh) 2006-11-01 2009-09-16 普罗诺瓦生物医药挪威公司 作为过氧化物酶体增生物激活受体(PPAR)的活化剂或调节剂的α-取代的ω-3脂质
ES2733353T3 (es) 2007-11-09 2019-11-28 Basf As Compuestos lípidos para uso en productos cosméticos, como suplemento alimenticio o como un medicamento
US9085527B2 (en) * 2008-07-08 2015-07-21 Catabasis Pharmaceuticals, Inc. Fatty acid acylated salicylates and their uses
CA2729186C (en) 2008-07-08 2018-01-16 Catabasis Pharmaceuticals, Inc. Fatty acid acetylated salicylates and their uses
EP2147910A1 (en) 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Novel lipid compounds
MA33341B1 (fr) 2009-05-08 2012-06-01 Pronova Biopharma Norge As Acides gras polyinsaturés pour le traitement de maladies relatives au domaine des maladies cardiovasculaires, métaboliques et inflammatoires
JP5802209B2 (ja) 2009-09-01 2015-10-28 カタバシス ファーマシューティカルズ，インコーポレイテッド 脂肪酸ナイアシン抱合体およびそれらの使用
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
US20130046013A1 (en) * 2010-01-20 2013-02-21 Ragnar Hovland Salicylate fatty acid derivatives
US20130190327A1 (en) * 2010-02-26 2013-07-25 Catabasis Pharmaceuticals Inc Bis-fatty acid conjugates and their uses
US9216224B2 (en) 2010-03-05 2015-12-22 Catabasis Pharmaceuticals, Inc. Fatty acid COX inhibitor derivatives and their uses
WO2011141341A1 (en) 2010-05-14 2011-11-17 Iberhospitex, S.A. Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
JP2014505017A (ja) 2010-11-05 2014-02-27 プロノヴァ・バイオファーマ・ノルゲ・アーエス 脂質化合物を用いる処置方法
NZ612336A (en) 2010-12-22 2014-05-30 D Western Therapeutics Inst Inc Novel substituted isoquinoline derivative
US20140315786A1 (en) * 2011-03-18 2014-10-23 Catabasis Pharmaceuticals, Inc. Use of intracellular enzymes for the release of covalently linked bioactives
WO2012154564A1 (en) * 2011-05-06 2012-11-15 Catabasis Pharmaceuticals, Inc. Fatty acid phenolic derivatives and their uses
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
WO2013045854A1 (fr) * 2011-09-29 2013-04-04 Ecole Normale Superieure De Lyon Substrat de peptidase fluorogene
WO2013050437A1 (en) 2011-10-06 2013-04-11 Bayer Intellectual Property Gmbh Heterocyclylpyri (mi) dinylpyrazole as fungicidals
SG11201407300VA (en) 2012-05-07 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of neurological disorders
SG11201407303SA (en) 2012-05-07 2014-12-30 Cellix Bio Private Ltd Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders
WO2013167990A1 (en) 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of depression
WO2013167992A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of inflammatory disorders
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
WO2013168023A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of parkinson's disease
WO2013168025A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of blood clotting disorders
WO2013167991A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic disorders
WO2013168014A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of familial amyloid polyneuropathy
WO2013168011A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of chronic pain
WO2013168001A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2013168005A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US9346742B2 (en) 2012-05-10 2016-05-24 Cellix Bio Private Limited Compositions and methods for the treatment of fibromyalgia pain
WO2013168016A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
WO2013168015A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of asthma and allergy
WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
WO2013168000A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of severe pain
WO2013167999A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurologic diseases
WO2013168012A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
US9315478B2 (en) 2012-05-10 2016-04-19 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9499526B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
WO2013175344A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
CN104583182A (zh) 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 用于治疗粘膜炎的组合物和方法
WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
SG11201407322QA (en) 2012-05-23 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of multiple sclerosis
WO2013175357A2 (en) * 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of inflammatory bowel disease
CA2874244A1 (en) 2012-05-25 2013-11-28 Catabasis Pharmaceuticals, Inc. Methods of lowering proprotein convertase subtilisin/kexin type 9 (pcsk9)
US9056139B2 (en) * 2012-06-28 2015-06-16 Kean University Fatty acid-salicylate conjugates with enhanced therapeutic properties
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
JP2015529218A (ja) 2012-09-08 2015-10-05 セリックスビオ プライヴェート リミテッド 炎症と脂質障害の治療のための組成物及び方法
WO2014115098A1 (en) * 2013-01-26 2014-07-31 Mahesh Kandula Compositions and methods for the treatment of neurological diseases and inflammation
AR094941A1 (es) 2013-02-28 2015-09-09 Olaf Hustvedt Svein Una composición que comprende un compuesto lipídico, un triglicérido y un tensioactivo, y métodos para usarla
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
EP3004049B1 (en) 2013-06-04 2018-09-05 Cellixbio Private Limited Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
EP2889286B1 (en) * 2013-12-30 2016-05-18 Pax Forschung GmbH Pharmaceutically active compound for use as anti-inflammatory agent
KR102323049B1 (ko) 2014-03-10 2021-11-05 마리 케이 인코포레이티드 피부 라이트닝 조성물
US20170158599A1 (en) * 2014-07-18 2017-06-08 Joseph D. Ceccoli Compositions and methods comprising salicylates and polysalicylates
EP3240779B1 (en) 2014-09-26 2020-10-28 Cellixbio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
AU2014407862B2 (en) 2014-09-29 2020-03-26 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
JP6564868B2 (ja) 2014-10-27 2019-08-21 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 多発性硬化症の治療のための、フマル酸モノメチルエステルとピペラジン又はエチレンジアミンとの３つの成分の塩
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
MA41031A (fr) 2014-11-26 2017-10-03 Catabasis Pharmaceuticals Inc Conjugués cystéamine-acide gras et leur utilisation comme activateurs de l'autophagie
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
DK3242869T3 (da) 2015-01-06 2022-01-31 Cellix Bio Private Ltd Sammensætninger og fremgangsmåder til behanding af inflammation og smerte
CA2983377C (en) 2015-04-28 2023-08-29 Pronova Biopharma Norge As Use of structurally enhanced fatty acids containing sulphur for preventing and/or treating non-alcoholic steatohepatitis
WO2016178066A1 (en) * 2015-05-01 2016-11-10 Mohan M Alapati Compositions and methods for the treatment of hyperglycemia and metabolic syndrome
CA3031893A1 (en) * 2016-08-11 2018-02-15 Cellix Bio Private Limited Compositions and methods for the treatment of irritable bowel syndrome
EP3522710B1 (en) * 2016-10-05 2023-09-20 Baylor College of Medicine Structure of gii.4 norovirus protease -design of broad-spectrum protease inhibitors
EP3676243A4 (en) * 2017-09-01 2021-05-26 Curtin University SYNTHETIC DERIVATIVES OF OLEOYL-LYSOPHOSPHATIDYLINOSITOL (OLEOLYL-LPI) AND ASSOCIATED USES
WO2019067981A1 (en) 2017-09-28 2019-04-04 Sarepta Therapeutics, Inc. POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY
WO2019067975A1 (en) 2017-09-28 2019-04-04 Sarepta Therapeutics, Inc. POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY
JP2020536057A (ja) 2017-09-28 2020-12-10 サレプタ セラピューティクス， インコーポレイテッド 筋ジストロフィーを処置するための併用療法
US20210023029A1 (en) * 2017-11-06 2021-01-28 Catabasis Pharmaceuticals, Inc. Edasalonexent dosing regimen for treating muscular dystrophy
EP3711753A4 (en) * 2017-11-17 2021-08-04 Zhejiang Yuejia Pharmaceuticals Co., Ltd LOCAL ANESTHETICS
IL275002B2 (en) 2017-12-06 2024-04-01 Basf As Fatty acid antecedents for the treatment of nonalcoholic fatty liver disease
WO2020191087A1 (en) 2019-03-18 2020-09-24 Ptc Therapeutics, Inc. Therapeutic combinations for use in treating a muscular dystrophy
CN114853627B (zh) * 2022-04-26 2023-06-20 自然资源部第三海洋研究所 一种取代苯甲酸二十二碳六烯酰胺乙基酯衍生物及其制备方法与应用
CN114853628B (zh) * 2022-05-07 2023-10-13 自然资源部第三海洋研究所 一种二十二碳六烯酰酯衍生物及其制备方法和应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036951A (en) * 1973-03-12 1977-07-19 Synergistics, Inc. Ultra-violet filtration with certain aminosalicylic acid esters
ES428254A1 (es) 1974-07-15 1976-08-16 Inst Internacional Terapeutico Procedimiento para la obtencion de 2-acetoxibenzoatos de n-(2-hidroxietil) amidas de acidos grasos.
US4199576A (en) 1976-12-15 1980-04-22 The Procter & Gamble Company Analgesic and anti-inflammatory compositions for topical application
US4276430A (en) 1976-12-15 1981-06-30 The Procter & Gamble Company Analgesic and anti-inflammatory compounds and compositions containing same
CA1113486A (en) 1977-04-01 1981-12-01 Alfred Halpern Ultra-violet filtration with certain aminosalicylic acid esters
US4204517A (en) * 1978-03-30 1980-05-27 Rumsey Joseph N Fireplace furnace
US4264517A (en) * 1978-12-11 1981-04-28 G.D. Searle & Co. Alkylphenyl 5Z,8Z,11Z,14Z,17Z-eicosapentaenoates
US4551279A (en) 1984-01-09 1985-11-05 G. D. Searle & Co. Protease inhibitors
IT1196348B (it) * 1984-11-29 1988-11-16 Italfarmaco Spa Composti ad attivita'antiinfiammatoria
JPS62223159A (ja) 1986-03-25 1987-10-01 Ono Pharmaceut Co Ltd （ｎ−置換フエニル）不飽和脂肪酸アミド誘導体、それらの製造方法及びそれらを有効成分として含有する５−リポキシゲナ−ゼ阻害剤
US4670465A (en) * 1986-05-21 1987-06-02 Syntex (U.S.A.) Inc. Arachidonic acid analogs
US5760261A (en) * 1990-02-28 1998-06-02 Guttag; Alvin Higher fatty acid derivatives of salicylic acid and salts thereof
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US5792786A (en) 1993-08-02 1998-08-11 Commonwealth Scientific And Industrial Research Organisation Non-steroidal anti-inflammatory fatty acid conjugates and their therapeutic use thereof
GB9403857D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
GB9508023D0 (en) * 1995-04-20 1995-06-07 Scotia Holdings Plc Fatty acid derivatives
ATE272055T1 (de) 1995-05-01 2004-08-15 Scarista Ltd Nicotinsäureester und diese enthaltende pharmazeutischen zusammensetzungen
MY118354A (en) * 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
USRE40546E1 (en) 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery
CN1187813A (zh) * 1995-05-01 1998-07-15 斯科舍集团有限公司 作为生物活性化合物的脂肪酸酯
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
GB9622636D0 (en) 1996-10-30 1997-01-08 Scotia Holdings Plc Presentation of bioactives
US5728732A (en) 1996-11-27 1998-03-17 Elizabeth Arden Company, Division Of Conopco, Inc. Skin treatment with salicylic acid esters and retinoids
CA2360042A1 (en) 1999-01-29 2000-08-03 Amersham Pharmacia Biotech K.K. Temperature-responsive polymer compound and process for producing the same
GB9930026D0 (en) * 1999-12-21 2000-02-09 Univ Sheffield Novel compounds of unsaturated fatty acids
US6387945B2 (en) 2000-04-11 2002-05-14 The Regents Of The University Of California Lipoic acid analogs
DE60235535D1 (de) 2001-01-19 2010-04-15 Inst Pharm & Toxicology Amms Aminderivat mit kaliumkanalregulierender funktion, dessen herstelung und verwendung
US6821529B2 (en) 2001-09-05 2004-11-23 Deanna Jean Nelson Oligo(ethylene glycoll)-terminated 1,2-dithiolanes and their conjugates useful for preparing self-assembled monolayers
JP4321174B2 (ja) 2002-10-24 2009-08-26 ソニー株式会社 可逆性多色記録媒体、及びこれを用いた記録方法
US20040254357A1 (en) * 2002-12-19 2004-12-16 Zaloga Gary P. Fatty acid phenolic conjugates
EP1836160A1 (en) 2004-12-24 2007-09-26 CTG Pharma S.r.l. Compounds for treating metabolic syndrome
US20070155747A1 (en) 2005-12-29 2007-07-05 Kadmus Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2007116027A1 (en) * 2006-04-12 2007-10-18 Unilever Plc Oral composition comprising a polyunsaturated fatty acid and salicylic acid for obtaining an antiinflammatory effect in skin
JP5669729B2 (ja) 2008-05-13 2015-02-12 ジェンメディカ・セラピューティックス・ソシエダッド・リミターダＧｅｎｍｅｄｉｃａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓｌ 代謝性障害を治療するのに有用なサリチレートコンジュゲート
US9085527B2 (en) 2008-07-08 2015-07-21 Catabasis Pharmaceuticals, Inc. Fatty acid acylated salicylates and their uses
CA2729186C (en) 2008-07-08 2018-01-16 Catabasis Pharmaceuticals, Inc. Fatty acid acetylated salicylates and their uses
US8946451B2 (en) 2009-10-05 2015-02-03 Catabasis Pharmaceuticals, Inc. Lipoic acid acylated salicylate derivatives and their uses
US20110082120A1 (en) 2009-10-05 2011-04-07 Milne Jill C Substituted thioacetic acid salicylate derivatives and their uses
US20130046013A1 (en) 2010-01-20 2013-02-21 Ragnar Hovland Salicylate fatty acid derivatives
WO2012003563A1 (pt) 2010-07-07 2012-01-12 Universidade Federal De Minas Gerais - Ufmg Composições farmacêuticas antineoplásicas contendo compostos nitroaromáticos substituídos
US20140315786A1 (en) 2011-03-18 2014-10-23 Catabasis Pharmaceuticals, Inc. Use of intracellular enzymes for the release of covalently linked bioactives
EP2701509A4 (en) 2011-04-29 2015-06-17 Catabasis Pharmaceuticals Inc GUANIDINE DERIVATIVES OF FATTY ACID AND GUANIDINE OF SALICYLATE AND USES THEREOF
US20130059801A1 (en) 2011-08-31 2013-03-07 Catabasis Pharmaceuticals, Inc. Fatty acid amides, compositions and methods of use
WO2013175357A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of inflammatory bowel disease

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US20210169905A1 (en) 2021-06-10
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