DE60235535D1 - Aminderivat mit kaliumkanalregulierender funktion, dessen herstelung und verwendung - Google Patents
Aminderivat mit kaliumkanalregulierender funktion, dessen herstelung und verwendungInfo
- Publication number
- DE60235535D1 DE60235535D1 DE60235535T DE60235535T DE60235535D1 DE 60235535 D1 DE60235535 D1 DE 60235535D1 DE 60235535 T DE60235535 T DE 60235535T DE 60235535 T DE60235535 T DE 60235535T DE 60235535 D1 DE60235535 D1 DE 60235535D1
- Authority
- DE
- Germany
- Prior art keywords
- derivativity
- amine
- production
- regulating function
- channel regulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/08—Monoamines containing alkyl groups having a different number of carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01101656 CN1250519C (zh) | 2001-01-19 | 2001-01-19 | 具有调节钾通道功能的胺衍生物及其制备方法和应用 |
CN 01101655 CN1250518C (zh) | 2001-01-19 | 2001-01-19 | 具有抗神经缺血缺氧损伤作用的胺衍生物及其在医药学中的应用 |
PCT/CN2002/000029 WO2003080556A1 (fr) | 2001-01-19 | 2002-01-21 | Derive d'amine a fonction regulatrice des canaux potassiques, sa preparation et son utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60235535D1 true DE60235535D1 (de) | 2010-04-15 |
Family
ID=28455393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60235535T Expired - Lifetime DE60235535D1 (de) | 2001-01-19 | 2002-01-21 | Aminderivat mit kaliumkanalregulierender funktion, dessen herstelung und verwendung |
Country Status (7)
Country | Link |
---|---|
US (1) | US7560473B2 (de) |
EP (1) | EP1386908B1 (de) |
JP (1) | JP4279685B2 (de) |
KR (2) | KR20090028654A (de) |
AU (1) | AU2002226266A1 (de) |
DE (1) | DE60235535D1 (de) |
WO (1) | WO2003080556A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
EP2404605B1 (de) | 2004-08-25 | 2015-04-22 | Essentialis, Inc. | Pharmazeutische Formulierungen von Kalium-ATP-Kanalöffnern und deren Verwendungen |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
EP1843734A4 (de) | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | Zusammensetzungen und verfahren zur intensivierung kognitiver funktionen |
WO2006088875A2 (en) * | 2005-02-14 | 2006-08-24 | Albert Einstein College Of Medicine Of Yeshiva University | Intranasal administration of modulators of hypothalamic atp-sensitive potassium channels |
JP5543110B2 (ja) * | 2006-01-05 | 2014-07-09 | エッセンシャリス,インク. | カリウムatpチャネルオープナの塩およびその使用 |
AU2012203517B2 (en) * | 2006-01-05 | 2014-04-24 | Essentialis, Inc. | Salts of potassium ATP channel openers and uses thereof |
US20070231273A1 (en) * | 2006-03-31 | 2007-10-04 | Jie Wu | Method for Decreasing Blood Glucose Levels |
CN101795691A (zh) * | 2007-07-02 | 2010-08-04 | 伊森舍丽斯有限公司 | 钾atp通道开放剂的盐及其用途 |
CN102014897B (zh) | 2008-04-21 | 2015-08-05 | 西格纳姆生物科学公司 | 化合物、组合物和其制备方法 |
PL2315740T3 (pl) | 2008-07-08 | 2018-05-30 | Catabasis Pharmaceuticals, Inc. | Salicylany acetylowane kwasem tłuszczowym i ich zastosowania |
US9085527B2 (en) | 2008-07-08 | 2015-07-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid acylated salicylates and their uses |
US20100082490A1 (en) * | 2008-09-30 | 2010-04-01 | Apple Inc. | Systems and methods for secure wireless transactions |
USRE46608E1 (en) | 2009-09-01 | 2017-11-14 | Catabasis Pharmaceuticals, Inc. | Fatty acid niacin conjugates and their uses |
CN102724877B (zh) | 2009-09-01 | 2015-05-13 | 凯特贝希制药公司 | 脂肪酸烟酸缀合物及其用途 |
WO2011044138A1 (en) * | 2009-10-05 | 2011-04-14 | Catabasis Pharmaceuticals, Inc. | Lipoic acid acylated salicylate derivatives and their uses |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB873780A (en) | 1959-03-28 | 1961-07-26 | Bayer Ag | New secondary amines |
US3067101A (en) | 1959-11-25 | 1962-12-04 | Lilly Co Eli | Method for controlling hypertension |
US3168567A (en) | 1960-02-29 | 1965-02-02 | Lilly Co Eli | Hindered alkyl and alkylene secondary amines |
DE1197091B (de) | 1960-08-25 | 1965-07-22 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von N-(tertiaer Alkyl)-aminen |
US3152180A (en) * | 1960-08-25 | 1964-10-06 | Studiengesellschaft Kohle Mbh | Process for the production of nu-tert-alkyl amides and, if desired, nu-tert. alkyl amines |
US3673249A (en) | 1970-06-09 | 1972-06-27 | American Cyanamid Co | Process for preparing tertiary amyl urea |
JPS4836129A (de) | 1971-09-16 | 1973-05-28 | ||
DE2338087A1 (de) * | 1973-04-30 | 1975-01-16 | Albert Ag Chem Werke | Neue aldonsaeureamide als arzneimittel |
US4157257A (en) | 1976-10-01 | 1979-06-05 | Utsunomiya University | Benzenesulfonamide derivatives |
EG18833A (en) | 1988-12-09 | 1994-11-30 | Kumiai Chemical Industry Co | Cyclic amide compounds and herbicides |
WO1995022327A1 (en) | 1994-02-22 | 1995-08-24 | Knoll Ag | Use of 1-(arylalkylaminoalkyl) imidazoles for treating neurological damage |
AU1649900A (en) | 1998-12-18 | 2000-07-12 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
-
2002
- 2002-01-21 JP JP2003578314A patent/JP4279685B2/ja not_active Expired - Lifetime
- 2002-01-21 EP EP02716048A patent/EP1386908B1/de not_active Expired - Lifetime
- 2002-01-21 DE DE60235535T patent/DE60235535D1/de not_active Expired - Lifetime
- 2002-01-21 KR KR1020097003591A patent/KR20090028654A/ko active Search and Examination
- 2002-01-21 KR KR1020037009608A patent/KR100939243B1/ko active IP Right Grant
- 2002-01-21 AU AU2002226266A patent/AU2002226266A1/en not_active Abandoned
- 2002-01-21 WO PCT/CN2002/000029 patent/WO2003080556A1/zh active Application Filing
- 2002-01-21 US US10/466,712 patent/US7560473B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1386908A1 (de) | 2004-02-04 |
KR20030090625A (ko) | 2003-11-28 |
US20040266822A1 (en) | 2004-12-30 |
JP2005519974A (ja) | 2005-07-07 |
KR100939243B1 (ko) | 2010-01-29 |
US7560473B2 (en) | 2009-07-14 |
EP1386908B1 (de) | 2010-03-03 |
KR20090028654A (ko) | 2009-03-18 |
WO2003080556A1 (fr) | 2003-10-02 |
JP4279685B2 (ja) | 2009-06-17 |
EP1386908A4 (de) | 2006-07-12 |
AU2002226266A1 (en) | 2003-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |