SI1789405T1 - Novi enantiomerno ÄŤisti beta agonisti, postopek za njihovo pripravo in njihova uporaba kot zdravilo - Google Patents
Novi enantiomerno ÄŤisti beta agonisti, postopek za njihovo pripravo in njihova uporaba kot zdraviloInfo
- Publication number
- SI1789405T1 SI1789405T1 SI200531756T SI200531756T SI1789405T1 SI 1789405 T1 SI1789405 T1 SI 1789405T1 SI 200531756 T SI200531756 T SI 200531756T SI 200531756 T SI200531756 T SI 200531756T SI 1789405 T1 SI1789405 T1 SI 1789405T1
- Authority
- SI
- Slovenia
- Prior art keywords
- agonists
- drug
- production
- enantiomerically pure
- pure beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004024454A DE102004024454A1 (de) | 2004-05-14 | 2004-05-14 | Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
EP05737938.0A EP1789405B1 (de) | 2004-05-14 | 2005-05-11 | Neue enantiomerenreine betaagonisten, verfahren zu deren herstellung und deren verwendung als arzneimittel |
PCT/EP2005/005079 WO2005111005A1 (de) | 2004-05-14 | 2005-05-11 | Neue enantiomerenreine betaagonisten, verfahren zu deren herstellung und deren verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1789405T1 true SI1789405T1 (sl) | 2013-09-30 |
Family
ID=34966720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200531756T SI1789405T1 (sl) | 2004-05-14 | 2005-05-11 | Novi enantiomerno ÄŤisti beta agonisti, postopek za njihovo pripravo in njihova uporaba kot zdravilo |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1789405B1 (sl) |
JP (1) | JP2007537196A (sl) |
KR (1) | KR101270447B1 (sl) |
CN (4) | CN106146425A (sl) |
AU (1) | AU2005243469B2 (sl) |
BR (1) | BRPI0511102B1 (sl) |
CA (1) | CA2562859C (sl) |
CY (1) | CY1114702T1 (sl) |
DE (1) | DE102004024454A1 (sl) |
DK (1) | DK1789405T3 (sl) |
ES (1) | ES2431118T3 (sl) |
IL (1) | IL179217A (sl) |
MX (1) | MXPA06013218A (sl) |
NZ (1) | NZ551416A (sl) |
PL (1) | PL1789405T3 (sl) |
PT (1) | PT1789405E (sl) |
RU (1) | RU2378262C2 (sl) |
SI (1) | SI1789405T1 (sl) |
WO (1) | WO2005111005A1 (sl) |
ZA (1) | ZA200607152B (sl) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004024452A1 (de) * | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation von Betaagonisten |
US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005007654A1 (de) | 2005-02-19 | 2006-08-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
KR20080036632A (ko) | 2005-08-08 | 2008-04-28 | 아젠터 디스커버리 리미티드 | 바이시클로[2.2.1]헵트-7-일아민 유도체 및 이들의 용도 |
PL1917253T3 (pl) * | 2005-08-15 | 2015-06-30 | Boehringer Ingelheim Int | Sposób wytwarzania betamimetyków |
US7423146B2 (en) * | 2005-11-09 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones |
CA2642239A1 (en) * | 2006-02-16 | 2007-08-23 | Boehringer Ingelheim International Gmbh | Drug combinations for the treatment of respiratory tract diseases |
PE20080142A1 (es) | 2006-03-15 | 2008-04-14 | Boehringer Ingelheim Int | Beta-agonistas enantiomericamente puros y sus procedimientos de preparacion |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
CN107235980A (zh) | 2006-05-04 | 2017-10-10 | 勃林格殷格翰国际有限公司 | 多晶型 |
UY30542A1 (es) * | 2006-08-18 | 2008-03-31 | Boehringer Ingelheim Int | Formulacion de aerosol para la inhalacion de agonistas beta |
UY30550A1 (es) | 2006-08-22 | 2008-03-31 | Boehringer Ingelheim Int | Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos |
AU2008208813B2 (en) * | 2007-01-25 | 2013-05-09 | Boehringer Ingelheim International Gmbh | Method for producing betamimetics |
JP2011502967A (ja) * | 2007-11-05 | 2011-01-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | β模倣薬の結晶性水和物及びその薬剤としての使用 |
EP2093219A1 (de) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel |
AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
US8236786B2 (en) | 2008-08-07 | 2012-08-07 | Pulmagen Therapeutics (Inflammation) Limited | Respiratory disease treatment |
US8513264B2 (en) | 2008-09-10 | 2013-08-20 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
BRPI0923862A2 (pt) | 2008-12-30 | 2015-07-28 | Pulmagen Therapeutics Inflammation Ltd | Compostos sulfonamida para o tratamento de distúrbios respiratórios |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
WO2010150014A1 (en) | 2009-06-24 | 2010-12-29 | Pulmagen Therapeutics (Inflammation) Limited | 5r- 5 -deuterated glitazones for respiratory disease treatment |
GB0918923D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminothiazole derivatives |
GB0918922D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
GB0918924D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Azaindole derivatives |
ES2760917T3 (es) | 2009-11-27 | 2020-05-18 | Boehringer Ingelheim Int | Tratamiento de pacientes diabéticos genotipificados con inhibidores DPP-IV como la linagliptina |
WO2011098746A1 (en) | 2010-02-09 | 2011-08-18 | Pulmagen Therapeutics (Inflammation) Limited | Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone |
GB201002243D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
GB201002224D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
BR112012028136A2 (pt) | 2010-05-05 | 2016-08-09 | Boehringer Ingelheim Int | terapia de combinaçao |
ES2953123T3 (es) | 2010-06-24 | 2023-11-08 | Boehringer Ingelheim Int | Terapia para la diabetes |
WO2012022796A2 (de) * | 2010-08-20 | 2012-02-23 | Boehringer Ingelheim International Gmbh | Neue kombinationen |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
ES2713566T3 (es) | 2011-07-15 | 2019-05-22 | Boehringer Ingelheim Int | Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
JP2015533131A (ja) * | 2012-10-09 | 2015-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 咳を治療するためのベータ2−アドレナリン受容体作動薬 |
CN102993116A (zh) * | 2012-12-04 | 2013-03-27 | 常州大学 | 一种苯并噁嗪类激动剂的制备方法 |
MX2016001602A (es) * | 2013-08-08 | 2016-12-15 | Galapagos Nv | Tieno [2, 3-c] piranos como moduladores de cftr. |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
JP2019536812A (ja) | 2016-12-12 | 2019-12-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | オロダテロールとの同時投与による間質性肺疾患の処置方法に使用するためのニンテダニブ |
PL3558954T3 (pl) | 2016-12-20 | 2022-01-31 | Inke, S.A. | Ulepszony sposób wytwarzania chlorowodorku r-6-hydroxy-8-[1-hydroksy-2-[2-(4-metoksyfenylo)-1,1-dimetyloetyloaminoetylo]-2h-1,4-benzoksazyno-3(4h)-onu |
CN109096218B (zh) * | 2018-08-06 | 2020-10-27 | 上海方予健康医药科技有限公司 | 盐酸奥达特罗晶型a及其制备方法 |
CN108822054B (zh) * | 2018-08-06 | 2021-06-22 | 上海方予健康医药科技有限公司 | 盐酸奥达特罗晶型c及其制备方法 |
CN108997248B (zh) * | 2018-08-06 | 2023-08-01 | 上海方予健康医药科技有限公司 | 盐酸奥达特罗晶型b及其制备方法 |
Family Cites Families (12)
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US4656168A (en) * | 1980-12-23 | 1987-04-07 | Merck & Co., Inc. | (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation |
DE3134590A1 (de) * | 1981-09-01 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue benzo-heterocyclen |
US4460581A (en) * | 1982-10-12 | 1984-07-17 | Boehringer Ingelheim Kg | (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones |
DE3743265A1 (de) * | 1987-12-19 | 1989-06-29 | Boehringer Ingelheim Kg | Neue ammoniumverbindungen, ihre herstellung und verwendung |
US5502078A (en) * | 1991-05-28 | 1996-03-26 | Zeneca Limited | Chemical compounds |
JPH0912518A (ja) * | 1995-06-26 | 1997-01-14 | Kanegafuchi Chem Ind Co Ltd | 2−[1−(3´,4´−ジメトキシフェニル)−2−プロピルアミノ]−1−(3´−クロロフェニル)−エタノールの製造方法 |
JPH11255743A (ja) * | 1998-03-06 | 1999-09-21 | Dainippon Pharmaceut Co Ltd | 光学活性のインドール誘導体の製造方法及びその製造中間体 |
NZ525733A (en) | 2000-10-12 | 2005-01-28 | Boehringer Ingelheim Pharma | Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament |
BR0116322A (pt) * | 2000-12-21 | 2003-10-14 | Aventis Pharma Gmbh | Derivados de difenilazetidinona, processo para sua preparação, medicamentos contendo esses compostos e seu emprego |
JP2005504015A (ja) | 2001-06-22 | 2005-02-10 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 抗コリン作用薬、その製造方法及び医薬組成物を製造するためのその使用 |
DE10253282A1 (de) * | 2002-11-15 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung |
WO2005110990A1 (de) * | 2004-05-13 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Hydroxy-substituierte benzkondensierte heterozyklen als betaagonisten zur behandlung von atemwegserkrankungen |
-
2004
- 2004-05-14 DE DE102004024454A patent/DE102004024454A1/de not_active Withdrawn
-
2005
- 2005-05-11 PL PL05737938T patent/PL1789405T3/pl unknown
- 2005-05-11 DK DK05737938.0T patent/DK1789405T3/da active
- 2005-05-11 ES ES05737938T patent/ES2431118T3/es active Active
- 2005-05-11 CN CN201610262144.3A patent/CN106146425A/zh active Pending
- 2005-05-11 BR BRPI0511102-1A patent/BRPI0511102B1/pt active IP Right Grant
- 2005-05-11 CN CN201610884642.1A patent/CN106995414A/zh active Pending
- 2005-05-11 WO PCT/EP2005/005079 patent/WO2005111005A1/de active Application Filing
- 2005-05-11 NZ NZ551416A patent/NZ551416A/en unknown
- 2005-05-11 PT PT57379380T patent/PT1789405E/pt unknown
- 2005-05-11 KR KR1020067026273A patent/KR101270447B1/ko active IP Right Grant
- 2005-05-11 CN CN201210347732.9A patent/CN102827097B/zh active Active
- 2005-05-11 AU AU2005243469A patent/AU2005243469B2/en active Active
- 2005-05-11 JP JP2007512081A patent/JP2007537196A/ja active Pending
- 2005-05-11 EP EP05737938.0A patent/EP1789405B1/de active Active
- 2005-05-11 SI SI200531756T patent/SI1789405T1/sl unknown
- 2005-05-11 CA CA2562859A patent/CA2562859C/en active Active
- 2005-05-11 MX MXPA06013218A patent/MXPA06013218A/es not_active Application Discontinuation
- 2005-05-11 CN CNA2005800154333A patent/CN101133039A/zh active Pending
- 2005-05-11 RU RU2006144123/04A patent/RU2378262C2/ru active Protection Beyond IP Right Term
-
2006
- 2006-08-28 ZA ZA200607152A patent/ZA200607152B/xx unknown
- 2006-11-13 IL IL179217A patent/IL179217A/en active IP Right Grant
-
2013
- 2013-09-18 CY CY20131100810T patent/CY1114702T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200607152B (en) | 2008-04-30 |
JP2007537196A (ja) | 2007-12-20 |
BRPI0511102B1 (pt) | 2021-05-25 |
NZ551416A (en) | 2011-04-29 |
AU2005243469B2 (en) | 2011-09-29 |
ES2431118T3 (es) | 2013-11-25 |
EP1789405B1 (de) | 2013-07-17 |
CN106995414A (zh) | 2017-08-01 |
IL179217A (en) | 2012-08-30 |
KR101270447B1 (ko) | 2013-06-04 |
IL179217A0 (en) | 2007-03-08 |
DK1789405T3 (da) | 2013-10-14 |
CN101133039A (zh) | 2008-02-27 |
DE102004024454A1 (de) | 2005-12-08 |
CN102827097B (zh) | 2016-11-23 |
CN106146425A (zh) | 2016-11-23 |
AU2005243469A1 (en) | 2005-11-24 |
CN102827097A (zh) | 2012-12-19 |
CA2562859A1 (en) | 2005-11-24 |
RU2378262C2 (ru) | 2010-01-10 |
PL1789405T3 (pl) | 2013-12-31 |
KR20070011602A (ko) | 2007-01-24 |
MXPA06013218A (es) | 2007-02-08 |
PT1789405E (pt) | 2013-08-22 |
CY1114702T1 (el) | 2016-10-05 |
EP1789405A1 (de) | 2007-05-30 |
WO2005111005A1 (de) | 2005-11-24 |
RU2006144123A (ru) | 2008-09-10 |
BRPI0511102A (pt) | 2007-11-27 |
CA2562859C (en) | 2012-05-08 |
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