IL179217A0 - Novel enantiomerically pure beta-agonists, method for the production and the use thereof in the form of a drug - Google Patents

Novel enantiomerically pure beta-agonists, method for the production and the use thereof in the form of a drug

Info

Publication number
IL179217A0
IL179217A0 IL179217A IL17921706A IL179217A0 IL 179217 A0 IL179217 A0 IL 179217A0 IL 179217 A IL179217 A IL 179217A IL 17921706 A IL17921706 A IL 17921706A IL 179217 A0 IL179217 A0 IL 179217A0
Authority
IL
Israel
Prior art keywords
agonists
drug
production
enantiomerically pure
pure beta
Prior art date
Application number
IL179217A
Other versions
IL179217A (en
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966720&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL179217(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IL179217A0 publication Critical patent/IL179217A0/en
Publication of IL179217A publication Critical patent/IL179217A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL179217A 2004-05-14 2006-11-13 Enantiomerically pure 4h-benzol[1,4] oxazin-3-one derivatives that are beta-agonists, intermediate thereof, method for its production and the use thereof in the preparation of a medicament for treating respiratory disorders IL179217A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004024454A DE102004024454A1 (en) 2004-05-14 2004-05-14 Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
PCT/EP2005/005079 WO2005111005A1 (en) 2004-05-14 2005-05-11 Novel enantiomerically pure beta-agonists, method for the production and the use thereof in the form of a drug

Publications (2)

Publication Number Publication Date
IL179217A0 true IL179217A0 (en) 2007-03-08
IL179217A IL179217A (en) 2012-08-30

Family

ID=34966720

Family Applications (1)

Application Number Title Priority Date Filing Date
IL179217A IL179217A (en) 2004-05-14 2006-11-13 Enantiomerically pure 4h-benzol[1,4] oxazin-3-one derivatives that are beta-agonists, intermediate thereof, method for its production and the use thereof in the preparation of a medicament for treating respiratory disorders

Country Status (20)

Country Link
EP (1) EP1789405B1 (en)
JP (1) JP2007537196A (en)
KR (1) KR101270447B1 (en)
CN (4) CN101133039A (en)
AU (1) AU2005243469B2 (en)
BR (1) BRPI0511102B1 (en)
CA (1) CA2562859C (en)
CY (1) CY1114702T1 (en)
DE (1) DE102004024454A1 (en)
DK (1) DK1789405T3 (en)
ES (1) ES2431118T3 (en)
IL (1) IL179217A (en)
MX (1) MXPA06013218A (en)
NZ (1) NZ551416A (en)
PL (1) PL1789405T3 (en)
PT (1) PT1789405E (en)
RU (1) RU2378262C2 (en)
SI (1) SI1789405T1 (en)
WO (1) WO2005111005A1 (en)
ZA (1) ZA200607152B (en)

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US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
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DE102005007654A1 (en) 2005-02-19 2006-08-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg New long-acting betamimetics for the treatment of respiratory diseases
DE102005035891A1 (en) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals
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US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
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CA2703511A1 (en) * 2007-11-05 2009-05-14 Boehringer Ingelheim International Gmbh Crystalline hydrate of betamimetika and use as medicament thereof
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AR071175A1 (en) 2008-04-03 2010-06-02 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITION THAT INCLUDES AN INHIBITOR OF DIPEPTIDIL-PEPTIDASA-4 (DPP4) AND A COMPARING PHARMACO
UY32030A (en) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "TREATMENT FOR DIABETES IN INAPPROPRIATE PATIENTS FOR THERAPY WITH METFORMIN"
KR20190016601A (en) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 Treatment for diabetes in patients inappropriate for metformin therapy
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
RU2011113823A (en) 2008-09-10 2012-10-20 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) COMBINED THERAPY FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
JP2012512848A (en) 2008-12-23 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Salt forms of organic compounds
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AR074990A1 (en) 2009-01-07 2011-03-02 Boehringer Ingelheim Int TREATMENT OF DIABETES IN PATIENTS WITH AN INAPPROPRIATE GLUCEMIC CONTROL THROUGH METFORMIN THERAPY
WO2010150014A1 (en) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited 5r- 5 -deuterated glitazones for respiratory disease treatment
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
JP2013512229A (en) 2009-11-27 2013-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Treatment of diabetic patients whose genotype has been identified with DDP-IV inhibitors such as linagliptin
WO2011098746A1 (en) 2010-02-09 2011-08-18 Pulmagen Therapeutics (Inflammation) Limited Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
GB201002224D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
GB201002243D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
BR112012028136A2 (en) 2010-05-05 2016-08-09 Boehringer Ingelheim Int combination therapy
EP3725325B1 (en) 2010-06-24 2023-05-31 Boehringer Ingelheim International GmbH Diabetes therapy
WO2012022796A2 (en) * 2010-08-20 2012-02-23 Boehringer Ingelheim International Gmbh Novel combinations
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CN103781788B (en) 2011-07-15 2016-08-17 勃林格殷格翰国际有限公司 Quinazoline, its preparation and the purposes in pharmaceutical composition thereof being substituted
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP3685839A1 (en) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
EP2906218B1 (en) 2012-10-09 2016-12-14 Boehringer Ingelheim International GmbH Beta-2-adrenoceptor agonist for the treatment of cough
CN102993116A (en) * 2012-12-04 2013-03-27 常州大学 Preparation method of benzoxazine excitant
DK3030568T3 (en) 2013-08-08 2019-01-07 Galapagos Nv THIENO [2,3-C] PYRANES AS CFTR MODULATORS
EP3110449B1 (en) 2014-02-28 2023-06-28 Boehringer Ingelheim International GmbH Medical use of a dpp-4 inhibitor
MX2018015089A (en) 2016-06-10 2019-05-13 Boehringer Ingelheim Int Combinations of linagliptin and metformin.
JP2019536812A (en) 2016-12-12 2019-12-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nintedanib for use in methods of treating interstitial lung disease by co-administration with olodaterol
WO2018114887A1 (en) 2016-12-20 2018-06-28 Laboratorios Lesvi, S.L. Improved process for the manufacture of r-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride
CN108822054B (en) * 2018-08-06 2021-06-22 上海方予健康医药科技有限公司 Oxydterol hydrochloride crystal form C and preparation method thereof
CN108997248B (en) * 2018-08-06 2023-08-01 上海方予健康医药科技有限公司 Crystal form B of ondarot hydrochloride and preparation method thereof
CN109096218B (en) * 2018-08-06 2020-10-27 上海方予健康医药科技有限公司 Oxydterol hydrochloride crystal form A and preparation method thereof

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Also Published As

Publication number Publication date
PL1789405T3 (en) 2013-12-31
BRPI0511102A (en) 2007-11-27
AU2005243469A1 (en) 2005-11-24
CA2562859A1 (en) 2005-11-24
BRPI0511102B1 (en) 2021-05-25
CN106995414A (en) 2017-08-01
PT1789405E (en) 2013-08-22
SI1789405T1 (en) 2013-09-30
IL179217A (en) 2012-08-30
ES2431118T3 (en) 2013-11-25
ZA200607152B (en) 2008-04-30
KR20070011602A (en) 2007-01-24
WO2005111005A1 (en) 2005-11-24
CY1114702T1 (en) 2016-10-05
AU2005243469B2 (en) 2011-09-29
RU2006144123A (en) 2008-09-10
NZ551416A (en) 2011-04-29
EP1789405B1 (en) 2013-07-17
CN106146425A (en) 2016-11-23
DE102004024454A1 (en) 2005-12-08
JP2007537196A (en) 2007-12-20
RU2378262C2 (en) 2010-01-10
DK1789405T3 (en) 2013-10-14
CN102827097B (en) 2016-11-23
EP1789405A1 (en) 2007-05-30
KR101270447B1 (en) 2013-06-04
CN101133039A (en) 2008-02-27
CN102827097A (en) 2012-12-19
CA2562859C (en) 2012-05-08
MXPA06013218A (en) 2007-02-08

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