SI1670444T1 - Uporaba derivatov indolocetne kisline, ki zvišajo serumsko raven IGF-1,za pripravo terapevtskega sestavka za zdravljenje različnih bolezni - Google Patents

Uporaba derivatov indolocetne kisline, ki zvišajo serumsko raven IGF-1,za pripravo terapevtskega sestavka za zdravljenje različnih bolezni

Info

Publication number
SI1670444T1
SI1670444T1 SI200332019T SI200332019T SI1670444T1 SI 1670444 T1 SI1670444 T1 SI 1670444T1 SI 200332019 T SI200332019 T SI 200332019T SI 200332019 T SI200332019 T SI 200332019T SI 1670444 T1 SI1670444 T1 SI 1670444T1
Authority
SI
Slovenia
Prior art keywords
preparation
treatment
composition
level
increase
Prior art date
Application number
SI200332019T
Other languages
English (en)
Inventor
Hubert Jean-Marie Francois Gillessen
Original Assignee
Veijlen N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Veijlen N V filed Critical Veijlen N V
Publication of SI1670444T1 publication Critical patent/SI1670444T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/168—Steroids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/184—Hormones
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
SI200332019T 2003-10-03 2003-10-03 Uporaba derivatov indolocetne kisline, ki zvišajo serumsko raven IGF-1,za pripravo terapevtskega sestavka za zdravljenje različnih bolezni SI1670444T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2003/011171 WO2005039546A2 (en) 2003-10-03 2003-10-03 Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases
EP03757934A EP1670444B1 (en) 2003-10-03 2003-10-03 Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases

Publications (1)

Publication Number Publication Date
SI1670444T1 true SI1670444T1 (sl) 2011-09-30

Family

ID=34429223

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200332019T SI1670444T1 (sl) 2003-10-03 2003-10-03 Uporaba derivatov indolocetne kisline, ki zvišajo serumsko raven IGF-1,za pripravo terapevtskega sestavka za zdravljenje različnih bolezni

Country Status (16)

Country Link
US (2) US9408405B2 (sl)
EP (1) EP1670444B1 (sl)
JP (1) JP4641942B2 (sl)
CN (1) CN1938018B (sl)
AT (1) ATE506948T1 (sl)
AU (1) AU2003273967A1 (sl)
CA (1) CA2541090C (sl)
CY (1) CY1116665T1 (sl)
DE (1) DE60336934D1 (sl)
DK (1) DK1670444T3 (sl)
ES (2) ES2365847T3 (sl)
HK (1) HK1103963A1 (sl)
PT (2) PT1670444E (sl)
RU (1) RU2345552C2 (sl)
SI (1) SI1670444T1 (sl)
WO (1) WO2005039546A2 (sl)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2541126A1 (en) 2003-10-03 2005-04-21 Veijlen N.V. Animal feed composition
US9408405B2 (en) 2003-10-03 2016-08-09 Veijlen N.V. Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals
WO2005049006A1 (ja) * 2003-11-21 2005-06-02 Ajinomoto Co., Inc. 糖尿病治療剤
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
WO2008121767A2 (en) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Stitched polypeptides
US9063122B2 (en) * 2008-10-17 2015-06-23 Alfredo Gallegos Biomodulators for treatment or prevention of disease
DK2440206T3 (en) 2009-06-11 2018-11-05 Dsm Ip Assets Bv Trigonellin as a muscle stimulant
US9790186B2 (en) 2009-07-21 2017-10-17 Trustees Of Dartmouth College Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection
RU2582678C2 (ru) 2010-08-13 2016-04-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
JP6450191B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2014080640A1 (ja) * 2012-11-26 2014-05-30 国立大学法人東北大学 エリスロポエチン発現増強剤
RU2524634C1 (ru) * 2013-06-25 2014-07-27 Государственное научное учреждение Северо-Кавказский зональный научно-исследовательский ветеринарный институт (ГНУ СКЗНИВИ) Российской академии сельскохозяйственных наук Способ стимуляции роста птицы
MX371329B (es) * 2013-12-19 2020-01-27 Puretein Bioscience Llc Factor de creciemiento similar a la insulina (igf) activo y su uso en infecciones por el virus del síndrome reproductivo y respiratorio porcino (prrsv).
KR102265412B1 (ko) * 2014-08-13 2021-06-14 주식회사 엘지생활건강 그라민 또는 이의 약학적으로 허용가능한 염을 포함하는 피부 미백, 탄력, 주름개선, 보습 또는 항염증용 화장료 또는 약학 조성물
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
EP3233109A4 (en) * 2014-12-16 2018-07-18 Puretein Bioscience, LLC Methods for increasing serum igf-1 in an animal
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
WO2017035288A1 (en) * 2015-08-27 2017-03-02 Trustees Of Dartmouth College Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection
US11701348B1 (en) 2016-07-23 2023-07-18 Turtle Bear Holdings, Llc Psilocybin compositions
US20210069170A1 (en) 2016-07-23 2021-03-11 Paul Edward Stamets Tryptamine compositions for enhancing neurite outgrowth
US20180021326A1 (en) 2016-07-23 2018-01-25 Paul Edward Stamets Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
JP7475702B2 (ja) * 2018-12-13 2024-04-30 エイム・イムノテック・インコーポレイテッド 筋痛性脳脊髄炎患者における運動耐容能を改善する方法
WO2020212948A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Methods of treating neurocognitive disorders, chronic pain and reducing inflammation
CN111407884B (zh) * 2019-06-24 2021-12-07 浙江大学 促生长激素释放激素激动剂ghrh-a在制备抗衰老药物中的用途
WO2021051130A1 (en) * 2019-09-09 2021-03-18 The University Of Chicago Combination therapy for the treatment of migraines
JP2022550463A (ja) 2019-10-01 2022-12-01 エンピリアン ニューロサイエンス， インコーポレイテッド トリプタミン発現を調整する真菌の遺伝子操作
CA3158059A1 (en) 2019-11-19 2021-05-27 Paul Edward Stamets Tryptamine compositions for enhancing neurite outgrowth
US20230219889A1 (en) 2020-05-19 2023-07-13 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
WO2022047580A1 (en) * 2020-09-01 2022-03-10 Magicmed Industries Inc. Hydroxylated psilocybin derivatives and methods of using
CN112138028A (zh) * 2020-10-10 2020-12-29 南京中医药大学 蟾蜍色胺类物质在制备抗抑郁药物中的应用
CN114870018A (zh) * 2022-05-12 2022-08-09 江南大学 炎症小体nlrp3抑制剂通过抑制神经系统炎症在制备治疗阿尔茨海默症药物中的应用
CN115813918B (zh) * 2022-09-30 2024-04-02 中国药科大学 吲哚乙酸在制备抑郁症治疗药物中的应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA957281A (en) * 1970-02-03 1974-11-05 Nathan N. Share Pharmaceutical compositions containing indole-3-acetic acid derivatives as a skeletal muscle stimulant
US4025650A (en) * 1975-11-24 1977-05-24 Control Drug, Inc. Method and composition for preventing nutritional deficiency
GB1475861A (en) 1976-03-19 1977-06-10 Warner Lambert Co Pharmaceutical composition
GB1535778A (en) 1976-12-06 1978-12-13 Mac Sweeney D Compounds useful in treatment of unipolar depression
JPS60199801A (ja) 1984-03-24 1985-10-09 Masaki Kamata 動物に対する植物成長ホルモンの投与方法
US4687763A (en) 1985-02-25 1987-08-18 Massachusetts Institute Of Technology Composition and method for increasing levels or release of brain serotonin
US4650789A (en) * 1985-10-15 1987-03-17 Commonwealth Medical Corporation Of America Method and composition for increasing production of serotonin
BE1000990A3 (nl) 1987-10-09 1989-05-30 Picanol Nv Inrichting voor het op elkaar aansluiten van onderling verplaatsbare elementen, en transportinrichting die eerstgenoemde inrichting toepast.
GB8727099D0 (en) * 1987-11-19 1987-12-23 Cellena Cell Eng A G Compositions containing melantonin/homologues
US4945103A (en) 1989-01-17 1990-07-31 Michael Cohen Method of treating pre-menstrual syndrome
IT1237472B (it) 1989-10-04 1993-06-07 Polifarma Spa Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
US5132113A (en) * 1990-10-26 1992-07-21 Maurizio Luca Nutritional composition containing essential amino acids
US5192753A (en) * 1991-04-23 1993-03-09 Mcgeer Patrick L Anti-rheumatoid arthritic drugs in the treatment of dementia
CA2116036A1 (en) * 1991-10-18 1993-04-29 F. Eugene Yates Device for the transdermal administration of melatonin
GB9214419D0 (en) 1992-07-07 1992-08-19 Concannon Peter Biocidal agents
JPH0725838A (ja) * 1993-05-13 1995-01-27 Yotsuba Yuka Kk 疲労の予防または回復のための経口投与剤
JP3541969B2 (ja) 1994-09-29 2004-07-14 東洋紡績株式会社 ベットマット
JP3617102B2 (ja) * 1995-01-27 2005-02-02 味の素株式会社 ヒト筋肉疲労の早期回復効果を有するアミノ酸栄養組成物
JPH08308580A (ja) * 1995-05-17 1996-11-26 Takeda Chem Ind Ltd 組換え型ヒトｇｈｒｈレセプター蛋白質、その製造法および用途
EP0766966A3 (en) 1995-09-08 2001-02-28 Eli Lilly And Company Method of treating insulin resistance
FR2741799B1 (fr) * 1995-12-04 1998-01-02 Oreal Utilisation de melatonine dans une composition pour traiter les signes cutanes des etats de fatigue
WO1997025060A1 (fr) * 1996-01-09 1997-07-17 The Institute Of Physical And Chemical Research Compositions d'acides amines
FR2746313B1 (fr) 1996-03-22 1998-04-17 Adir Utilisation de la melatonine et des ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention et au traitement du diabete et des complications diabetiques
US5958964A (en) 1997-02-18 1999-09-28 South Alabama Medical Science Foundation Use of melatonin to prevent cytotoxic effects of amyloid beta protein
DE19739763A1 (de) 1997-09-10 1999-09-23 Franz Uhl Vitamin B3/Niacin zur Behandlung von Krankheiten
US6017946A (en) * 1997-10-08 2000-01-25 Posner; Robert Serotonin containing formulation for oral administration and method of use
EP1159292A2 (en) * 1998-08-14 2001-12-05 Administrators of The Tulane Educational Fund Compounds having growth hormone releasing activity
US7304029B1 (en) 1998-09-03 2007-12-04 Neuren Pharmaceuticals Ltd. Neuroprotective effect of growth hormone
IL132366A0 (en) 1998-10-15 2001-03-19 Cell Pathways Inc Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds
CN1069050C (zh) 1998-12-01 2001-08-01 周旭生 一种治疗糖尿病的中药复方制剂
ATE285769T1 (de) 1998-12-04 2005-01-15 Neurosearch As Verwendung von isatinderivaten als ionenkanalaktivierende mittel
FR2795323B1 (fr) 1999-06-23 2001-11-16 Adir Utilisation de ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention ou au traitement des pathologies du systeme gastrointestinal
CN1088597C (zh) * 1999-10-26 2002-08-07 合肥永生制药有限公司 尿多酸肽组合物及其用途
US20020155163A1 (en) * 1999-12-27 2002-10-24 Samuel D. Benjamin Integrated multi-vitamin and mineral combination
AU2001238718A1 (en) 2000-03-02 2001-09-12 The Institutes For Pharmaceutical Discovery, Llc Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor
DE10037773C1 (de) * 2000-08-03 2002-08-22 Hennecke Gmbh Verfahren und Vorrichtung zum Herstellen von mit Langfasern verstärkten Kunststoff-Formteilen
DE10109798A1 (de) 2001-03-01 2002-09-12 Aventis Pharma Gmbh Gesundheitsfördernde Zusammensetzung von Verbindungen
US20030166554A1 (en) * 2001-01-16 2003-09-04 Genset, S.A. Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists
JP2002281914A (ja) 2001-03-27 2002-10-02 Nishi Nippon Green Kk 魚類、家畜類の栄養活力促進剤の製造方法
US20020147155A1 (en) * 2001-04-06 2002-10-10 Foster Warren G. Prevention and treatment of endometriosis with aryl hydrocarbon receptor binding ligands
CN1408397A (zh) 2001-09-26 2003-04-09 北京本元青阳生物科技发展有限公司 含褪黑素和益智中药的组合物
JP2003137808A (ja) * 2001-10-26 2003-05-14 Kakunai Juyotai Kenkyusho:Kk 新規経腸栄養剤の製造法
WO2003080068A1 (en) 2002-03-18 2003-10-02 Pharmacia Corporation Combination of an aldosterone receptor antagonist and nicotinic acid or a nicotinic acid derivative
CN1440744A (zh) 2003-02-15 2003-09-10 高景曦 纳米包覆退黑激素复合保健品
US7592361B2 (en) 2003-04-28 2009-09-22 Bayer Pharmaceuticals Corporation Indole acetic acid derivatives and their use as pharmaceutical agents
US9408405B2 (en) 2003-10-03 2016-08-09 Veijlen N.V. Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals
CA2541126A1 (en) 2003-10-03 2005-04-21 Veijlen N.V. Animal feed composition

Also Published As

Publication number Publication date
ES2326595T3 (es) 2009-10-15
WO2005039546A2 (en) 2005-05-06
CN1938018B (zh) 2010-09-01
DE60336934D1 (de) 2011-06-09
US9408405B2 (en) 2016-08-09
HK1103963A1 (en) 2008-01-04
AU2003273967A1 (en) 2005-05-11
US20080194553A1 (en) 2008-08-14
CY1116665T1 (el) 2017-03-15
RU2345552C2 (ru) 2009-02-10
CA2541090A1 (en) 2005-05-06
US10716778B2 (en) 2020-07-21
CA2541090C (en) 2013-04-16
EP1670444B1 (en) 2011-04-27
AU2003273967A8 (en) 2005-05-11
CN1938018A (zh) 2007-03-28
RU2006114743A (ru) 2007-11-10
JP2007525405A (ja) 2007-09-06
EP1670444A2 (en) 2006-06-21
DK1670444T3 (da) 2011-08-22
WO2005039546A3 (en) 2007-10-04
PT1670444E (pt) 2011-07-29
JP4641942B2 (ja) 2011-03-02
PT1667678E (pt) 2009-08-05
ES2365847T3 (es) 2011-10-11
US20160331725A1 (en) 2016-11-17
ATE506948T1 (de) 2011-05-15

Similar Documents

Publication Publication Date Title
AU2003273967A8 (en) Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases
MXPA05009933A (es) Composiciones que comprenden acidos grasos y aminoacidos.
EP1784388B8 (en) Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
MXPA04004837A (es) Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1.
MXPA04004842A (es) Inhibidores de 11-(-hidroxiesteroide deshidrogenasa de tipo 1.
IL161154A0 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL159960A (en) Indane acetic acid derivatives, pharmaceutical compositions comprising them and uses thereof for the preparation of medicaments
EA200501710A1 (ru) Замещённые карбоновые кислоты
RU2007117492A (ru) Применение органических соединений
RS44304A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
JP2010111646A (ja) 潰瘍性大腸炎治療剤
WO2019098811A2 (ko) Chp(시클로-히스프로)를 포함하는 골 손실 질환의 예방, 개선 또는 치료용 조성물
CN1287855C (zh) B型慢性肝炎治疗剂
KR100483328B1 (ko) 피로 회복 기능을 가지는 조성물 및 그 제조 방법과 이를이용한 피로 회복제
JP4931306B2 (ja) 骨形成を安全に促進させる医薬複合剤
WO2001051489A3 (en) Methods for lowering uric acid levels
CN1488368A (zh) 鼻炎清
CN1566086A (zh) 一种氨基酸螯合钙及其制剂和应用
CN1201769C (zh) 治疗糖尿病、肾病的药物
TW200600094A (en) Pharmaceutical compositions for prevention or treatment of disorders of lipid metabolism
CN1150005C (zh) 用于治疗癣疮的外用药剂
CN1187046C (zh) 治疗肾病的酮酸制剂
CN1180775C (zh) 复方口腔溃疡胶囊
Saini Oral sex and oral cancer: A virus link
JP2022011232A (ja) タンパク質合成阻害抑制剤