SI1259507T1 - Psevdopolimorf (-)-cis-2-(2-klorofenil)-5,7-dihidroksi-8(4R-(3S-hidroksi-1-metil) piperidinil)-4H-1-benzopiran-4-on hidroklorida - Google Patents

Psevdopolimorf (-)-cis-2-(2-klorofenil)-5,7-dihidroksi-8(4R-(3S-hidroksi-1-metil) piperidinil)-4H-1-benzopiran-4-on hidroklorida

Info

Publication number
SI1259507T1
SI1259507T1 SI200130201T SI200130201T SI1259507T1 SI 1259507 T1 SI1259507 T1 SI 1259507T1 SI 200130201 T SI200130201 T SI 200130201T SI 200130201 T SI200130201 T SI 200130201T SI 1259507 T1 SI1259507 T1 SI 1259507T1
Authority
SI
Slovenia
Prior art keywords
pseudopolymorph
benzopyran
piperidinyl
chlorophenyl
dihydroxy
Prior art date
Application number
SI200130201T
Other languages
English (en)
Inventor
Gary L. Bafus
Christine M. Harrison-Bowman
Gary L. Silvey
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SI1259507T1 publication Critical patent/SI1259507T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Stereophonic System (AREA)
  • Inorganic Insulating Materials (AREA)
  • Pyrane Compounds (AREA)
SI200130201T 2000-01-18 2001-01-08 Psevdopolimorf (-)-cis-2-(2-klorofenil)-5,7-dihidroksi-8(4R-(3S-hidroksi-1-metil) piperidinil)-4H-1-benzopiran-4-on hidroklorida SI1259507T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48471700A 2000-01-18 2000-01-18
EP01900939A EP1259507B1 (en) 2000-01-18 2001-01-08 Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one hydrochloride
PCT/US2001/000519 WO2001053293A1 (en) 2000-01-18 2001-01-08 Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one

Publications (1)

Publication Number Publication Date
SI1259507T1 true SI1259507T1 (sl) 2005-02-28

Family

ID=23925305

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130201T SI1259507T1 (sl) 2000-01-18 2001-01-08 Psevdopolimorf (-)-cis-2-(2-klorofenil)-5,7-dihidroksi-8(4R-(3S-hidroksi-1-metil) piperidinil)-4H-1-benzopiran-4-on hidroklorida

Country Status (26)

Country Link
EP (1) EP1259507B1 (sl)
JP (1) JP2003520797A (sl)
KR (1) KR100806464B1 (sl)
CN (1) CN1174977C (sl)
AT (1) ATE273303T1 (sl)
AU (1) AU2001226346A1 (sl)
BR (1) BR0107726A (sl)
CA (1) CA2397593C (sl)
CZ (1) CZ301195B6 (sl)
DE (1) DE60104822T2 (sl)
DK (1) DK1259507T3 (sl)
EA (1) EA005247B1 (sl)
ES (1) ES2222332T3 (sl)
HU (1) HUP0204126A3 (sl)
IL (2) IL150638A0 (sl)
MX (1) MXPA02007005A (sl)
NO (1) NO322572B1 (sl)
NZ (1) NZ520280A (sl)
PL (1) PL200696B1 (sl)
PT (1) PT1259507E (sl)
SI (1) SI1259507T1 (sl)
SK (1) SK287404B6 (sl)
TR (1) TR200402036T4 (sl)
TW (1) TWI284129B (sl)
WO (1) WO2001053293A1 (sl)
ZA (1) ZA200205639B (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803684B (zh) 2016-08-23 2022-08-23 卫材 R&D 管理有限公司 用于治疗肝细胞癌的组合疗法
BR112019019261A2 (pt) 2017-03-16 2020-06-16 Eisai R & D Management Co., Ltd. Terapias de combinação para o tratamento de câncer de mama
JPWO2020130125A1 (ja) 2018-12-21 2021-11-04 第一三共株式会社 抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (sl) * 1986-04-11 1989-02-04 Hoechst India
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs

Also Published As

Publication number Publication date
PT1259507E (pt) 2004-12-31
SK287404B6 (sk) 2010-09-07
CN1395576A (zh) 2003-02-05
EP1259507B1 (en) 2004-08-11
EP1259507A1 (en) 2002-11-27
NZ520280A (en) 2004-04-30
ATE273303T1 (de) 2004-08-15
AU2001226346A1 (en) 2001-07-31
TR200402036T4 (tr) 2004-10-21
CZ301195B6 (cs) 2009-12-02
ZA200205639B (en) 2003-10-15
BR0107726A (pt) 2002-10-01
DE60104822T2 (de) 2005-09-01
DE60104822D1 (de) 2004-09-16
IL150638A (en) 2009-06-15
HUP0204126A3 (en) 2006-02-28
WO2001053293A1 (en) 2001-07-26
EA200200775A1 (ru) 2002-12-26
KR20020069361A (ko) 2002-08-30
NO322572B1 (no) 2006-10-30
CA2397593C (en) 2009-11-10
KR100806464B1 (ko) 2008-02-21
CN1174977C (zh) 2004-11-10
PL200696B1 (pl) 2009-01-30
NO20023386D0 (no) 2002-07-12
CZ20022466A3 (cs) 2002-11-13
JP2003520797A (ja) 2003-07-08
SK10362002A3 (sk) 2003-01-09
MXPA02007005A (es) 2004-09-06
DK1259507T3 (da) 2004-11-01
IL150638A0 (en) 2003-02-12
TWI284129B (en) 2007-07-21
CA2397593A1 (en) 2001-07-26
EA005247B1 (ru) 2004-12-30
PL356165A1 (en) 2004-06-14
HUP0204126A2 (hu) 2003-04-28
NO20023386L (no) 2002-09-12
ES2222332T3 (es) 2005-02-01

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