IN164232B - - Google Patents

Info

Publication number
IN164232B
IN164232B IN300/BOM/85A IN300BO1985A IN164232B IN 164232 B IN164232 B IN 164232B IN 300BO1985 A IN300BO1985 A IN 300BO1985A IN 164232 B IN164232 B IN 164232B
Authority
IN
India
Prior art keywords
alkyl
aryl
cycloalkyl
represents hydrogen
integer
Prior art date
Application number
IN300/BOM/85A
Other languages
English (en)
Inventor
Samba Laxminarayan Kattige
Ramchandra Ganapati Naik
Aftab Dawoodbhai Lakdawala
Alihussein Nomanbha Dohadwalla
Souza Neol John De
Richard Helmut Rupp
Original Assignee
Hoechst India
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst India filed Critical Hoechst India
Publication of IN164232B publication Critical patent/IN164232B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IN300/BOM/85A 1986-04-11 1985-10-31 IN164232B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863612337 DE3612337A1 (de) 1986-04-11 1986-04-11 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
IN164232B true IN164232B (sl) 1989-02-04

Family

ID=6298535

Family Applications (1)

Application Number Title Priority Date Filing Date
IN300/BOM/85A IN164232B (sl) 1986-04-11 1985-10-31

Country Status (16)

Country Link
US (1) US4900727A (sl)
EP (1) EP0241003B1 (sl)
JP (1) JPH0686446B2 (sl)
KR (1) KR950009861B1 (sl)
AT (2) ATE95519T1 (sl)
AU (1) AU602891B2 (sl)
CA (1) CA1332238C (sl)
DE (2) DE3612337A1 (sl)
DK (1) DK169760B1 (sl)
ES (1) ES2060582T3 (sl)
HK (1) HK1006021A1 (sl)
IE (1) IE62244B1 (sl)
IL (1) IL82149A (sl)
IN (1) IN164232B (sl)
PT (1) PT84654B (sl)
ZA (1) ZA872555B (sl)

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US5278174A (en) * 1990-06-04 1994-01-11 Scios Nova, Inc. Sigma binding site agents
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US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
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US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
SK280617B6 (sk) * 1992-01-16 2000-05-16 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, spôsob ich prípravy, f
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US20060241173A1 (en) * 1996-02-16 2006-10-26 Sterix Ltd. Compound
US6087366A (en) * 1996-03-07 2000-07-11 The Trustees Of Columbia University In The City Of New York Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death
US5849733A (en) * 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs
DE19802449A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
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US6399633B1 (en) * 1999-02-01 2002-06-04 Aventis Pharmaceuticals Inc. Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation
DE19959546A1 (de) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
MXPA02007005A (es) * 2000-01-18 2004-09-06 Aventis Pharma Inc Pseudopolimorfo de (-) -cis-2 -(2-clorofenil) -5, 7-dihidorxi -8[4r-(3s-hidroxi -1-meitl) piperidinil] -4h-1-benzopiran -4-ona.
WO2001053294A1 (en) * 2000-01-18 2001-07-26 Aventis Pharmaceuticals Inc. Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one
US6821990B2 (en) * 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
US6576647B2 (en) 2000-01-18 2003-06-10 Aventis Pharmaceuticals Inc. Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6924376B2 (en) 2002-04-17 2005-08-02 Cytokinetics, Inc. Compounds, compositions and methods
US7915301B2 (en) * 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
US7884127B2 (en) * 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
US6949538B2 (en) * 2002-07-17 2005-09-27 Cytokinetics, Inc. Compounds, compositions, and methods
JP2005539062A (ja) * 2002-09-13 2005-12-22 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
WO2005042697A2 (en) * 2003-10-06 2005-05-12 Cytokinetics, Inc. Compounds, compositions and methods
BRPI0417498A (pt) * 2003-12-09 2007-05-29 Us Gov Health & Human Serv método para suprimir uma resposta imune em um indivìduo; método de inibição da proliferação de um célula; método de tratamento de um distúrbio proliferativo em um indivìduo; método para selecionar um agente imunossupressor ou anti-proliferativo; composição farmacêutica e estente vascular
US20050171182A1 (en) * 2003-12-11 2005-08-04 Roger Briesewitz Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
US20090036435A1 (en) 2005-01-21 2009-02-05 Astex Therapeutics Limited Pharmaceutical Compounds
DK2046738T3 (da) 2006-06-21 2014-08-04 Piramal Entpr Ltd Enantiomerisk rene flavonderivativer til behandlingen af proliferative lidelser, samt processer til deres tilberedelse
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
TWI461194B (zh) 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
CA2790993A1 (en) 2010-02-26 2011-09-01 Piramal Enterprises Limited Pyrrolidine substituted flavones for the treatment of inflammatory disorders
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
WO2014167580A1 (en) 2013-04-10 2014-10-16 Council Of Scientific & Industrial Research Novel chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders
CA2908084C (en) 2013-04-17 2022-05-03 Council Of Scientific And Industrial Research Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
TWI680760B (zh) 2013-07-12 2020-01-01 印度商皮拉馬爾企業有限公司 治療黑色素瘤的藥物組合
JP6951973B2 (ja) 2014-11-12 2021-10-20 シージェン インコーポレイテッド グリカン相互作用化合物及び使用方法
RU2717829C2 (ru) 2015-04-20 2020-03-26 Толеро Фармасьютикалз, Инк. Прогнозирование ответа на альвоцидиб с помощью анализа профиля митохондрий
ES2739749T3 (es) * 2015-05-18 2020-02-03 Tolero Pharmaceuticals Inc Profármacos de alvocidib que tienen biodisponibilidad aumentada
WO2017024073A1 (en) 2015-08-03 2017-02-09 Tolero Pharmaceuticals, Inc. Combination therapies for treatment of cancer
WO2017083582A1 (en) 2015-11-12 2017-05-18 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
WO2018094143A1 (en) 2016-11-17 2018-05-24 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
MX2019007332A (es) 2016-12-19 2019-11-18 Tolero Pharmaceuticals Inc Péptidos indicadores y métodos para caracterizar sensibilidad.
AU2018226824A1 (en) 2017-03-03 2019-09-19 Seagen Inc. Glycan-interacting compounds and methods of use
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WO2020213714A1 (ja) * 2019-04-18 2020-10-22 大日本住友製薬株式会社 シス－（－）－フロシノピペリドールの製造方法

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GB1223690A (en) * 1967-10-17 1971-03-03 Fisons Pharmaceuticals Ltd Substituted chromon-2-carboxylic acids
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DE3445852A1 (de) * 1984-12-15 1986-06-19 Bayer Ag, 5090 Leverkusen Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
EP0241003A2 (de) 1987-10-14
KR950009861B1 (en) 1995-08-29
PT84654A (de) 1987-05-01
ATE95519T1 (de) 1993-10-15
IE870941L (en) 1987-10-11
EP0241003B1 (de) 1993-10-06
HK1006021A1 (en) 1999-02-05
AU7139787A (en) 1987-10-15
ATA260587A (de) 1989-07-15
JPH0686446B2 (ja) 1994-11-02
PT84654B (pt) 1989-12-29
AU602891B2 (en) 1990-11-01
IL82149A0 (en) 1987-10-30
ZA872555B (en) 1987-11-25
CA1332238C (en) 1994-10-04
IE62244B1 (en) 1995-01-11
DE3612337A1 (de) 1987-10-15
KR870010045A (ko) 1987-11-30
ES2060582T3 (es) 1994-12-01
US4900727A (en) 1990-02-13
DK185287A (da) 1987-10-12
DK169760B1 (da) 1995-02-20
IL82149A (en) 1994-01-25
DK185287D0 (da) 1987-04-10
DE3787661D1 (de) 1993-11-11
JPS62242680A (ja) 1987-10-23
AT389875B (de) 1990-02-12
EP0241003A3 (en) 1988-10-12

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