SI1226137T1 - Fenil- in pridil-tetrahidro-piridini s TNF inhibitorno aktivnostjo - Google Patents

Fenil- in pridil-tetrahidro-piridini s TNF inhibitorno aktivnostjo

Info

Publication number
SI1226137T1
SI1226137T1 SI200030499T SI200030499T SI1226137T1 SI 1226137 T1 SI1226137 T1 SI 1226137T1 SI 200030499 T SI200030499 T SI 200030499T SI 200030499 T SI200030499 T SI 200030499T SI 1226137 T1 SI1226137 T1 SI 1226137T1
Authority
SI
Slovenia
Prior art keywords
pyridines
tetrahydro
pyridyl
phenyl
inhibiting activity
Prior art date
Application number
SI200030499T
Other languages
English (en)
Inventor
Marco Baroni
Bernard Bourrie
Rosanna Cardamone
Pierre Casellas
Umberto Guzzi
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9913206A external-priority patent/FR2800071B1/fr
Priority claimed from FR0008328A external-priority patent/FR2810984B1/fr
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of SI1226137T1 publication Critical patent/SI1226137T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A43—FOOTWEAR
    • A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
    • A43B7/00—Footwear with health or hygienic arrangements
    • A43B7/12—Special watertight footwear
    • A43B7/125—Special watertight footwear provided with a vapour permeable member, e.g. a membrane
    • A—HUMAN NECESSITIES
    • A43—FOOTWEAR
    • A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
    • A43B9/00—Footwear characterised by the assembling of the individual parts
    • A43B9/02—Footwear stitched or nailed through
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/20—Antivirals for DNA viruses
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    • B29D35/00—Producing footwear
    • B29D35/0009—Producing footwear by injection moulding; Apparatus therefor
    • B29D35/0018—Moulds
    • B29D35/0045—Sealing means for the mould cavity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/06—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
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    • B29D35/06—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising
    • B29D35/061—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding
    • B29D35/062—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding using means to bond the moulding material to the preformed uppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
    • B29D35/122—Soles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
    • B29D35/128—Moulds or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
    • B29D35/14—Multilayered parts
    • B29D35/142—Soles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
    • B29C45/14836—Preventing damage of inserts during injection, e.g. collapse of hollow inserts, breakage
    • B29C2045/14844—Layers protecting the insert from injected material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Mechanical Engineering (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
SI200030499T 1999-10-22 2000-10-19 Fenil- in pridil-tetrahidro-piridini s TNF inhibitorno aktivnostjo SI1226137T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9913206A FR2800071B1 (fr) 1999-10-22 1999-10-22 Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR0008328A FR2810984B1 (fr) 2000-06-28 2000-06-28 Pyridyl-tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
EP00969646A EP1226137B8 (fr) 1999-10-22 2000-10-19 Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt
PCT/FR2000/002910 WO2001029026A1 (fr) 1999-10-22 2000-10-19 Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt

Publications (1)

Publication Number Publication Date
SI1226137T1 true SI1226137T1 (sl) 2005-02-28

Family

ID=26212500

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030499T SI1226137T1 (sl) 1999-10-22 2000-10-19 Fenil- in pridil-tetrahidro-piridini s TNF inhibitorno aktivnostjo

Country Status (35)

Country Link
US (1) US6509351B1 (sl)
EP (1) EP1226137B8 (sl)
JP (1) JP4831908B2 (sl)
KR (1) KR100755115B1 (sl)
CN (1) CN1158276C (sl)
AR (1) AR026188A1 (sl)
AT (1) ATE271554T1 (sl)
AU (1) AU778306B2 (sl)
BG (1) BG65564B1 (sl)
BR (1) BR0014871A (sl)
CA (1) CA2386417C (sl)
CZ (1) CZ301566B6 (sl)
DE (1) DE60012355T2 (sl)
DK (1) DK1226137T3 (sl)
EA (1) EA004508B1 (sl)
EE (1) EE05055B1 (sl)
ES (1) ES2223594T3 (sl)
HK (1) HK1046532B (sl)
HR (1) HRP20020347B1 (sl)
HU (1) HUP0204444A3 (sl)
IL (2) IL149250A0 (sl)
IS (1) IS2308B (sl)
ME (1) MEP25108A (sl)
MX (1) MXPA02003979A (sl)
NO (1) NO322596B1 (sl)
NZ (1) NZ518112A (sl)
PL (1) PL198421B1 (sl)
PT (1) PT1226137E (sl)
RS (1) RS50399B (sl)
SI (1) SI1226137T1 (sl)
SK (1) SK287098B6 (sl)
TR (1) TR200201075T2 (sl)
TW (1) TWI224097B (sl)
UA (1) UA72934C2 (sl)
WO (1) WO2001029026A1 (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
FR2832405B1 (fr) * 2001-11-19 2004-12-10 Sanofi Synthelabo Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
JP4866610B2 (ja) 2003-08-18 2012-02-01 富士フイルムファインケミカルズ株式会社 ピリジルテトラヒドロピリジン類およびピリジルピペリジン類
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991061A (en) * 1975-07-16 1976-11-09 G. D. Searle & Co. Azanaphthaleneacetic acid derivatives
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
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IL149250A0 (en) 2002-11-10
SK287098B6 (sk) 2009-12-07
CA2386417C (en) 2010-09-28
NO322596B1 (no) 2006-10-30
BG106613A (en) 2003-02-28
WO2001029026A1 (fr) 2001-04-26
JP2003512370A (ja) 2003-04-02
EP1226137A1 (fr) 2002-07-31
NZ518112A (en) 2003-11-28
SK5282002A3 (en) 2002-08-06
EP1226137B1 (fr) 2004-07-21
JP4831908B2 (ja) 2011-12-07
PT1226137E (pt) 2004-11-30
CZ20021382A3 (cs) 2002-07-17
CZ301566B6 (cs) 2010-04-21
EA004508B1 (ru) 2004-04-29
UA72934C2 (uk) 2005-05-16
YU28902A (sh) 2004-11-25
IS6336A (is) 2002-04-09
HUP0204444A3 (en) 2004-07-28
ES2223594T3 (es) 2005-03-01
RS50399B (sr) 2009-12-31
AU778306B2 (en) 2004-11-25
EE200200210A (et) 2003-06-16
DE60012355T2 (de) 2005-12-22
AU7931300A (en) 2001-04-30
EP1226137B8 (fr) 2004-12-15
TR200201075T2 (tr) 2002-11-21
EA200200352A1 (ru) 2002-10-31
DE60012355D1 (de) 2004-08-26
AR026188A1 (es) 2003-01-29
HK1046532A1 (en) 2003-01-17
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DK1226137T3 (da) 2004-11-22
NO20021872D0 (no) 2002-04-19
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US6509351B1 (en) 2003-01-21
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HRP20020347A2 (en) 2003-08-31
PL198421B1 (pl) 2008-06-30
EE05055B1 (et) 2008-08-15
IL149250A (en) 2007-08-19
BG65564B1 (bg) 2008-12-30
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HK1046532B (zh) 2005-03-18
HRP20020347B1 (en) 2010-10-31
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