SI1050530T1 - 1-Aza-2-alkyl-6-aryl-cycloalkanes usefull as memory enhancers - Google Patents

1-Aza-2-alkyl-6-aryl-cycloalkanes usefull as memory enhancers

Info

Publication number
SI1050530T1
SI1050530T1 SI200030240T SI200030240T SI1050530T1 SI 1050530 T1 SI1050530 T1 SI 1050530T1 SI 200030240 T SI200030240 T SI 200030240T SI 200030240 T SI200030240 T SI 200030240T SI 1050530 T1 SI1050530 T1 SI 1050530T1
Authority
SI
Slovenia
Prior art keywords
alkyl
aryl
aza
cycloalkanes
phenyl
Prior art date
Application number
SI200030240T
Other languages
English (en)
Slovenian (sl)
Inventor
Sylvain Rault
Olivier Renault
Jean Guillon
Patrick Dallemagne
Pierre Renard
Bruno Pfeiffer
Pierre Lestage
Marie-Cecile Lebrun
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1050530T1 publication Critical patent/SI1050530T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SI200030240T 1999-05-03 2000-05-02 1-Aza-2-alkyl-6-aryl-cycloalkanes usefull as memory enhancers SI1050530T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9905600A FR2793246B1 (fr) 1999-05-03 1999-05-03 Nouveaux derives de 1-aza-2-alkyl-6-aryl-cycloalcanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP00401199A EP1050530B1 (fr) 1999-05-03 2000-05-02 1-Aza-2-Alkyl-6-Aryl-Cycloalcanes utiles pour améliorer la mémoire

Publications (1)

Publication Number Publication Date
SI1050530T1 true SI1050530T1 (en) 2004-02-29

Family

ID=9545153

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030240T SI1050530T1 (en) 1999-05-03 2000-05-02 1-Aza-2-alkyl-6-aryl-cycloalkanes usefull as memory enhancers

Country Status (24)

Country Link
US (2) US6323222B1 (xx)
EP (1) EP1050530B1 (xx)
JP (1) JP3224376B2 (xx)
KR (1) KR100438086B1 (xx)
CN (1) CN1145612C (xx)
AT (1) ATE252558T1 (xx)
AU (1) AU763685B2 (xx)
BR (1) BR0002076A (xx)
CA (1) CA2308783C (xx)
DE (1) DE60006029T2 (xx)
DK (1) DK1050530T3 (xx)
EA (1) EA002620B1 (xx)
ES (1) ES2209777T3 (xx)
FR (1) FR2793246B1 (xx)
HK (1) HK1032235A1 (xx)
HU (1) HUP0001727A2 (xx)
MX (1) MXPA00004157A (xx)
NO (1) NO315850B1 (xx)
NZ (1) NZ504299A (xx)
PL (1) PL339966A1 (xx)
PT (1) PT1050530E (xx)
SE (1) SE1050530T5 (xx)
SI (1) SI1050530T1 (xx)
ZA (1) ZA200002151B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2793246B1 (fr) * 1999-05-03 2001-06-29 Adir Nouveaux derives de 1-aza-2-alkyl-6-aryl-cycloalcanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2846654A1 (fr) * 2002-11-05 2004-05-07 Servier Lab Nouveaux derives de la 2,3-dihydro-4(1h)-pyridinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US8153808B2 (en) * 2008-12-23 2012-04-10 Roche Palo Alto Llc Dihydropyridone amides as P2X7 modulators
CA2745866A1 (en) * 2008-12-23 2010-07-01 F.Hoffmann-La Roche Ag Dihydropyridone ureas as p2x7 modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2013761A1 (en) * 1970-03-21 1971-10-07 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt 4-azacycloalk-2-enone prepn
US4529732A (en) * 1983-03-14 1985-07-16 Pfizer Inc. 2-[2-Hydroxy-4-(substituted)phenyl]piperidines
DE3414830A1 (de) * 1984-04-19 1985-10-31 Hoechst Ag, 6230 Frankfurt Verfahren und zwischenprodukte zur herstellung von (e)- und (z)-4-methoxy-2,2'-bipyridyl-6-aldoximen und ihre verwendung als arzneimittel
FR2793246B1 (fr) * 1999-05-03 2001-06-29 Adir Nouveaux derives de 1-aza-2-alkyl-6-aryl-cycloalcanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ATE252558T1 (de) 2003-11-15
NO20002315D0 (no) 2000-05-02
DE60006029T2 (de) 2004-06-24
CA2308783A1 (fr) 2000-11-03
CN1277194A (zh) 2000-12-20
CA2308783C (fr) 2004-10-19
HUP0001727A2 (hu) 2002-04-29
ZA200002151B (en) 2000-11-07
US6451789B1 (en) 2002-09-17
US6323222B1 (en) 2001-11-27
SE1050530T3 (sv) 2004-02-10
KR100438086B1 (ko) 2004-07-02
AU763685B2 (en) 2003-07-31
NZ504299A (en) 2001-01-26
DE60006029D1 (de) 2003-11-27
NO315850B1 (no) 2003-11-03
MXPA00004157A (es) 2002-03-08
NO20002315L (no) 2000-11-06
JP3224376B2 (ja) 2001-10-29
HU0001727D0 (en) 2000-07-28
SE1050530T5 (sv) 2004-03-02
EA200000373A3 (ru) 2001-02-26
KR20010020806A (ko) 2001-03-15
EP1050530B1 (fr) 2003-10-22
CN1145612C (zh) 2004-04-14
PL339966A1 (en) 2000-11-06
HK1032235A1 (en) 2001-07-13
EA002620B1 (ru) 2002-06-27
BR0002076A (pt) 2001-01-23
ES2209777T3 (es) 2004-07-01
PT1050530E (pt) 2004-02-27
DK1050530T3 (da) 2004-03-01
EA200000373A2 (ru) 2000-12-25
US20020042413A1 (en) 2002-04-11
FR2793246A1 (fr) 2000-11-10
FR2793246B1 (fr) 2001-06-29
AU3132400A (en) 2000-11-09
JP2000351766A (ja) 2000-12-19
EP1050530A1 (fr) 2000-11-08

Similar Documents

Publication Publication Date Title
EP1674452A4 (en) NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND ITS USE AS MEK INHIBITOR
ATE417038T1 (de) Phenylpyridincarbonyl piperazinderivate
NO20013379L (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
WO2004000762A3 (en) Propionic acid derivatives and their use as hppars activators
ATE171188T1 (de) In 15-stellung substituierte 4-azasteroide
DK0695755T3 (da) Pyrrolocarbazoler
EP1357124A4 (en) HETEROCYCLIC COMPOUNDS AND COMPOSITIONS IMPROVING CEREBRAL FUNCTIONS CONTAINING THESE AS ACTIVE INGREDIENTS
DK0806413T3 (da) 2-substituerede viatmin D3-derivater
SI1050530T1 (en) 1-Aza-2-alkyl-6-aryl-cycloalkanes usefull as memory enhancers
BR0308643A (pt) Composto do derivado do ácido piridobenzoxazina carboxìlico e agente antibacteriano contendo o mesmo
NO20033917D0 (no) Fremgangsmåte for fremstilling av 2-azetidinonderivat
DK1219621T3 (da) Azaindolizinonderivater og cerebral funktionsforbedrende midler indeholdende disse som den aktive bestanddel
CO5160345A1 (es) Nuevos androgenos oralmente activos derivados de 7 alfa- metil-19-nortestosterona
EP1069115A4 (en) METHOD FOR PRODUCING OXAZOLIDIN-2-ONE COMPOUNDS
ATE244248T1 (de) Herstellung von amino cephalosporansäurederivaten
WO2005051888A3 (en) Diphenylamine derivatives
TW200621807A (en) Cellulose derivative composition, cellulose derivative film and trialkoxybenzoic acid deriv ative compound
DK1219599T3 (da) Vitamin-D-derivater som har substituenter i 2-alfa-position
EP1325913A3 (en) Piperidinecarboxylic acid amide derivatives
ATE275542T1 (de) Arthropodische carboxanilide
ATE177106T1 (de) Ymidothiophosphat-derivat und insektizid, nematozid und akarizid enthalted dasselbe als aktiven bestandteil.