SI1000063T1 - 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO(4,5-b)INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY - Google Patents

4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO(4,5-b)INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY

Info

Publication number
SI1000063T1
SI1000063T1 SI9830309T SI9830309T SI1000063T1 SI 1000063 T1 SI1000063 T1 SI 1000063T1 SI 9830309 T SI9830309 T SI 9830309T SI 9830309 T SI9830309 T SI 9830309T SI 1000063 T1 SI1000063 T1 SI 1000063T1
Authority
SI
Slovenia
Prior art keywords
pyridazino
indole
dihydro
oxo
therapy
Prior art date
Application number
SI9830309T
Other languages
English (en)
Slovenian (sl)
Inventor
Yannick Evanno
Laurent Dubois
Mireille Sevrin
Frank Marguet
Jacques Froissant
Regine Bartsch
Catherine Gille
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of SI1000063T1 publication Critical patent/SI1000063T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI9830309T 1997-07-30 1998-07-28 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO(4,5-b)INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SI1000063T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
EP98941468A EP1000063B1 (fr) 1997-07-30 1998-07-28 DERIVES DE 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
PCT/FR1998/001667 WO1999006406A1 (fr) 1997-07-30 1998-07-28 DERIVES DE 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b] INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
SI1000063T1 true SI1000063T1 (en) 2003-04-30

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830309T SI1000063T1 (en) 1997-07-30 1998-07-28 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO(4,5-b)INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY

Country Status (32)

Country Link
US (1) US6262045B1 (cs)
EP (1) EP1000063B1 (cs)
JP (1) JP4322421B2 (cs)
KR (1) KR100497782B1 (cs)
CN (1) CN1134440C (cs)
AR (1) AR013264A1 (cs)
AT (1) ATE226584T1 (cs)
AU (1) AU736600B2 (cs)
BG (1) BG64283B1 (cs)
BR (1) BR9811582B1 (cs)
CA (1) CA2298522C (cs)
CO (1) CO5210883A1 (cs)
CZ (1) CZ290011B6 (cs)
DE (1) DE69808921T2 (cs)
DK (1) DK1000063T3 (cs)
EE (1) EE04317B1 (cs)
ES (1) ES2186212T3 (cs)
FR (1) FR2766823B1 (cs)
HU (1) HU229430B1 (cs)
IL (1) IL133633A (cs)
NO (1) NO313963B1 (cs)
NZ (1) NZ502361A (cs)
PL (1) PL194245B1 (cs)
PT (1) PT1000063E (cs)
RU (1) RU2197490C2 (cs)
SI (1) SI1000063T1 (cs)
SK (1) SK283075B6 (cs)
TR (1) TR200000278T2 (cs)
TW (1) TW506971B (cs)
UA (1) UA57088C2 (cs)
WO (1) WO1999006406A1 (cs)
ZA (1) ZA986786B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
GB0000564D0 (en) * 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
EP1824820A2 (en) * 2004-12-07 2007-08-29 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran,pyrrolidine and tetrahydrothiophene derivatives
EP1895982A2 (en) * 2005-05-05 2008-03-12 Sanofi-Aventis U.S. LLC Stable nanoparticle formulations
AU2006285111B8 (en) * 2005-08-29 2012-05-17 Sanofi-Aventis U.S. Llc Amorphous solid dispersions of 7-chloro-N,N, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4H-pyridazino [4, 5-b] indole-1-acetamide
SI1924585T1 (sl) * 2005-08-29 2012-09-28 Sanofi Aventis Us Llc Nova kristalinična oblika piridazino (4,5-b) indolnega derivata
CA2623026A1 (en) * 2005-09-23 2007-04-05 Schering Corporation Fused tetracyclic mglur1 antagonists as therapeutic agents
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
JP2012500268A (ja) * 2008-08-18 2012-01-05 サノフィ−アベンティス・ユー・エス・エルエルシー ７−クロロ−Ｎ，Ｎ，５−トリメチル−４−オキソ−３−フェニル−３，５−ジヒドロ−４Ｈ−ピリダジノ［４，５−ｂ］インドール−１−アセトアミドの多形体を製造するための方法
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
FI94531C (fi) * 1990-03-13 1995-09-25 Ime Intermed Enterpris Sa Menetelmä farmaseuttisesti aktiivisen 1,3,4,6,7,8-heksahydro-2H-pyrimido-(1,2-a)-pyrimidiinijohdannaisen valmistamiseksi
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
ZA986786B (en) 1999-02-02
AU736600B2 (en) 2001-08-02
PL194245B1 (pl) 2007-05-31
US6262045B1 (en) 2001-07-17
DE69808921T2 (de) 2003-07-03
CZ2000320A3 (cs) 2000-05-17
TR200000278T2 (tr) 2000-08-21
HU229430B1 (en) 2013-12-30
NO20000462D0 (no) 2000-01-28
TW506971B (en) 2002-10-21
FR2766823B1 (fr) 1999-10-08
NO313963B1 (no) 2003-01-06
BG64283B1 (bg) 2004-08-31
ES2186212T3 (es) 2003-05-01
CA2298522C (en) 2008-07-15
FR2766823A1 (fr) 1999-02-05
UA57088C2 (uk) 2003-06-16
PL338445A1 (en) 2000-11-06
KR100497782B1 (ko) 2005-06-27
RU2197490C2 (ru) 2003-01-27
IL133633A (en) 2004-02-08
PT1000063E (pt) 2003-03-31
WO1999006406A1 (fr) 1999-02-11
BR9811582A (pt) 2000-09-26
BR9811582B1 (pt) 2010-10-19
EE04317B1 (et) 2004-06-15
EE200000056A (et) 2000-10-16
JP4322421B2 (ja) 2009-09-02
NZ502361A (en) 2001-06-29
ATE226584T1 (de) 2002-11-15
SK1292000A3 (en) 2000-08-14
DK1000063T3 (da) 2003-02-24
CN1134440C (zh) 2004-01-14
HUP0002650A3 (en) 2002-09-30
IL133633A0 (en) 2001-04-30
EP1000063B1 (fr) 2002-10-23
NO20000462L (no) 2000-03-29
SK283075B6 (sk) 2003-02-04
KR20010022356A (ko) 2001-03-15
EP1000063A1 (fr) 2000-05-17
HK1028027A1 (en) 2001-02-02
CZ290011B6 (cs) 2002-05-15
DE69808921D1 (de) 2002-11-28
JP2001512122A (ja) 2001-08-21
CO5210883A1 (es) 2002-10-30
CN1265108A (zh) 2000-08-30
BG104096A (en) 2000-08-31
AR013264A1 (es) 2000-12-13
AU8983298A (en) 1999-02-22
HUP0002650A2 (hu) 2001-01-29
CA2298522A1 (en) 1999-02-11

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