SG78336A1 - Pyrazolopyrimidines and pyrazolotriazines - Google Patents

Pyrazolopyrimidines and pyrazolotriazines

Info

Publication number
SG78336A1
SG78336A1 SG1999001080A SG1999001080A SG78336A1 SG 78336 A1 SG78336 A1 SG 78336A1 SG 1999001080 A SG1999001080 A SG 1999001080A SG 1999001080 A SG1999001080 A SG 1999001080A SG 78336 A1 SG78336 A1 SG 78336A1
Authority
SG
Singapore
Prior art keywords
pyrazolotriazines
pyrazolopyrimidines
Prior art date
Application number
SG1999001080A
Other languages
English (en)
Inventor
Michael Bos
Claus Riemer
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG78336A1 publication Critical patent/SG78336A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SG1999001080A 1998-03-11 1999-03-09 Pyrazolopyrimidines and pyrazolotriazines SG78336A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (1)

Publication Number Publication Date
SG78336A1 true SG78336A1 (en) 2001-02-20

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1999001080A SG78336A1 (en) 1998-03-11 1999-03-09 Pyrazolopyrimidines and pyrazolotriazines

Country Status (34)

Country Link
US (1) US6194410B1 (ja)
EP (1) EP0941994B1 (ja)
JP (1) JP3231288B2 (ja)
KR (1) KR100313181B1 (ja)
CN (1) CN1118468C (ja)
AR (1) AR016453A1 (ja)
AT (1) ATE240332T1 (ja)
AU (1) AU752408B2 (ja)
BR (1) BR9901095A (ja)
CA (1) CA2265095C (ja)
CZ (1) CZ291514B6 (ja)
DE (1) DE69907784T2 (ja)
DK (1) DK0941994T3 (ja)
ES (1) ES2198095T3 (ja)
HK (1) HK1023343A1 (ja)
HR (1) HRP990077B1 (ja)
HU (1) HUP9900589A1 (ja)
ID (1) ID23575A (ja)
IL (1) IL128869A (ja)
MA (1) MA26612A1 (ja)
MY (1) MY119536A (ja)
NO (1) NO312297B1 (ja)
NZ (1) NZ334526A (ja)
PE (1) PE20000337A1 (ja)
PL (1) PL331875A1 (ja)
PT (1) PT941994E (ja)
RU (1) RU2218340C2 (ja)
SG (1) SG78336A1 (ja)
SI (1) SI0941994T1 (ja)
TR (1) TR199900531A2 (ja)
TW (1) TW585865B (ja)
UY (1) UY25419A1 (ja)
YU (1) YU12099A (ja)
ZA (1) ZA991946B (ja)

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WO2000059907A2 (en) * 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
DE19956791A1 (de) 1999-11-25 2001-05-31 Merck Patent Gmbh Neue Sulfonyloxazolamine
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
BR0208357A (pt) * 2001-03-13 2004-06-29 Bristol Myers Squibb Pharma Co Composto, composição farmacêutica, método de antagonização de um receptor de fator de liberação de corticotropina (crf), método de tratamento de disfunção, método de triagem de ligantes, método de detecção de receptores de crf, método de inibição da ligação de crf, artigo industrializado e usos do composto
DE60218037T2 (de) 2001-06-07 2007-08-23 F. Hoffmann-La Roche Ag Neue indolderivate mit affinität zum 5-ht6-rezeptor
ATE331707T1 (de) 2001-06-15 2006-07-15 Hoffmann La Roche 4 piperazinylindolderivate mit affinität zum 5- ht6-rezeptor
JP2005527463A (ja) * 2001-08-07 2005-09-15 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー Ｃｎｓ疾患を治療するための５−ｈｔ６受容体アフィニティーを有する３−アリールスルホニル−７−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン
CN1309385C (zh) * 2001-12-20 2007-04-11 惠氏公司 作为5－羟色胺－6配体的吲哚基烷基胺衍生物
US6642381B2 (en) * 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en) 2002-07-26 2005-04-05 Bristol-Myers Squibb Company Pyridopyrimidine derivatives as 5-HT6 antagonists
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
TW200418830A (en) * 2003-02-14 2004-10-01 Wyeth Corp Heterocyclyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
JP4564485B2 (ja) 2003-02-28 2010-10-20 帝人ファーマ株式会社 ピラゾロ［１，５−ａ］ピリミジン誘導体
GB0305559D0 (en) * 2003-03-11 2003-04-16 Teijin Ltd Compounds
US20080287405A1 (en) * 2004-05-14 2008-11-20 Thannickal Victor J Compositions and Methods Relating to Protein Kinase Inhibitors
US8309559B2 (en) 2008-01-24 2012-11-13 Nikolay Filippovich Savchuk (EN) substituted 2-amino-3-sulfonyl-pyrazolo[1,5-A] pyrimidines/antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
KR20100119776A (ko) * 2008-01-24 2010-11-10 알라 캠, 엘엘씨 2-알킬아미노-3-아릴설포닐-사이클로알카노[ｅ 또는 ｄ]피라졸로[1,5-Ａ]피리미딘/세로토닌 5-ＨＴ6 수용체의 길항제, 이의 제조방법 및 이의 용도
KR20100119777A (ko) * 2008-01-24 2010-11-10 알라 캠, 엘엘씨 치환된 사이클로알카노［ｅ 및 ｄ］ 피라졸로 ［1,5―Ａ］피리미딘／세로토닌 5―ＨＴ6 수용체의 길항제 및 이의 제조방법 및 이의 용도
RU2369600C1 (ru) 2008-01-24 2009-10-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
RU2384581C2 (ru) 2008-05-07 2010-03-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EP3020719B1 (en) 2008-10-06 2017-09-20 Alla Chem, LLC. Substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines, serotonin 5-ht6 receptor antagonists and methods for the production and use thereof and methods for the production and use thereof
CA2743241A1 (en) * 2008-11-27 2010-06-03 Boehringer Ingelheim International Gmbh 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
WO2012065963A2 (en) 2010-11-15 2012-05-24 Katholieke Universiteit Leuven Novel antiviral compounds
RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
MX342177B (es) 2011-09-30 2016-09-20 Ipsen Pharma Sas Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica.
JP6418950B2 (ja) * 2012-03-09 2018-11-07 レクシコン ファーマシューティカルズ インコーポレイテッド ピラゾロ［１，５−ａ］ピリミジン系化合物、それを含む組成物、及びそれらを使用する方法
TW201542550A (zh) * 2013-09-06 2015-11-16 Lexicon Pharmaceuticals Inc 吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法
WO2016042089A1 (en) 2014-09-17 2016-03-24 Oncodesign S.A. Macrocyclic lrrk2 kinase inhibitors
CA2978170C (en) * 2015-03-09 2024-02-27 Aurigene Discovery Technologies Limited Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors
WO2017052394A1 (en) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Imidazopyridine compounds and their use as 5-ht6 receptor ligands
JP6872541B2 (ja) 2015-11-02 2021-05-19 ヤンセン ファーマシューティカ エヌ．ベー． ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン−７−イル化合物
EP3535268B1 (en) 2016-11-02 2022-02-09 Janssen Pharmaceutica NV [1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors
JP7021208B2 (ja) 2016-11-02 2022-02-16 ヤンセン ファーマシューティカ エヌ．ベー． ＰＤＥ２阻害剤としての［１，２，４］トリアゾロ［１，５－ａ］ピリミジン化合物
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BR9810991A (pt) 1997-07-11 2000-08-08 Smithkline Beecham Plc Novos compostos

Also Published As

Publication number Publication date
KR100313181B1 (ko) 2001-11-05
NO991150L (no) 1999-09-13
CZ291514B6 (cs) 2003-03-12
PE20000337A1 (es) 2000-05-13
HRP990077B1 (en) 2003-08-31
TR199900531A3 (tr) 1999-10-21
MY119536A (en) 2005-06-30
PL331875A1 (en) 1999-09-13
MA26612A1 (fr) 2004-12-20
TW585865B (en) 2004-05-01
NO312297B1 (no) 2002-04-22
JP3231288B2 (ja) 2001-11-19
US6194410B1 (en) 2001-02-27
EP0941994B1 (en) 2003-05-14
ID23575A (id) 2000-05-04
AU2038399A (en) 1999-09-23
ES2198095T3 (es) 2004-01-16
UY25419A1 (es) 2001-11-30
IL128869A (en) 2003-09-17
AR016453A1 (es) 2001-07-04
HUP9900589A1 (hu) 2000-03-28
YU12099A (sh) 2000-10-30
HRP990077A2 (en) 2000-02-29
DE69907784D1 (de) 2003-06-18
CA2265095C (en) 2008-07-22
ATE240332T1 (de) 2003-05-15
HK1023343A1 (en) 2000-09-08
JP2000186090A (ja) 2000-07-04
RU2218340C2 (ru) 2003-12-10
EP0941994A1 (en) 1999-09-15
TR199900531A2 (xx) 1999-10-21
NZ334526A (en) 2000-07-28
IL128869A0 (en) 2000-01-31
CN1118468C (zh) 2003-08-20
CA2265095A1 (en) 1999-09-11
CN1236780A (zh) 1999-12-01
ZA991946B (en) 1999-09-13
DK0941994T3 (da) 2003-09-08
BR9901095A (pt) 2000-05-02
PT941994E (pt) 2003-09-30
NO991150D0 (no) 1999-03-10
DE69907784T2 (de) 2004-03-25
SI0941994T1 (en) 2003-10-31
KR19990077741A (ko) 1999-10-25
AU752408B2 (en) 2002-09-19
CZ82599A3 (cs) 1999-09-15
HU9900589D0 (en) 1999-05-28

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