SG54121A1 - Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media - Google Patents
Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast mediaInfo
- Publication number
- SG54121A1 SG54121A1 SG1996001218A SG1996001218A SG54121A1 SG 54121 A1 SG54121 A1 SG 54121A1 SG 1996001218 A SG1996001218 A SG 1996001218A SG 1996001218 A SG1996001218 A SG 1996001218A SG 54121 A1 SG54121 A1 SG 54121A1
- Authority
- SG
- Singapore
- Prior art keywords
- contrast media
- ultrasound contrast
- gases
- microbubbles
- agents
- Prior art date
Links
- 239000007789 gas Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000002961 echo contrast media Substances 0.000 title 2
- 229960003853 ultrasound contrast media Drugs 0.000 title 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogen, Water And Hydrids (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Electron Sources, Ion Sources (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76131191A | 1991-09-17 | 1991-09-17 | |
US07/893,657 US5409688A (en) | 1991-09-17 | 1992-06-05 | Gaseous ultrasound contrast media |
Publications (1)
Publication Number | Publication Date |
---|---|
SG54121A1 true SG54121A1 (en) | 1998-11-16 |
Family
ID=27116965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996001218A SG54121A1 (en) | 1991-09-17 | 1992-09-02 | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
Country Status (19)
Country | Link |
---|---|
US (1) | US5558094B1 (de) |
EP (1) | EP0605477B2 (de) |
JP (2) | JP3231768B2 (de) |
KR (1) | KR100191303B1 (de) |
AT (1) | ATE191346T1 (de) |
AU (2) | AU679428C (de) |
CA (1) | CA2119129C (de) |
CZ (1) | CZ286149B6 (de) |
DE (2) | DE69230885T3 (de) |
DK (1) | DK0605477T4 (de) |
ES (1) | ES2145011T5 (de) |
FI (1) | FI119466B (de) |
GR (1) | GR3033908T3 (de) |
HK (1) | HK1012564A1 (de) |
HU (1) | HU218018B (de) |
NO (1) | NO313577B1 (de) |
RU (1) | RU2114637C1 (de) |
SG (1) | SG54121A1 (de) |
WO (1) | WO1993005819A1 (de) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US5149319A (en) * | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US5305757A (en) * | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US5656211A (en) | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
IN172208B (de) | 1990-04-02 | 1993-05-01 | Sint Sa | |
USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
US6989141B2 (en) * | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US5874062A (en) * | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
CZ286149B6 (cs) * | 1991-09-17 | 2000-01-12 | Sonus Pharmaceuticals, Inc. | Plynná prostředí pro zvýšení kontrastnosti obrazu, získaného ultrazvukem a způsob výběru plynů pro toto použití |
US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
NZ262237A (en) * | 1993-01-25 | 1997-06-24 | Sonus Pharma Inc | Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in |
GB9305349D0 (en) * | 1993-03-16 | 1993-05-05 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US5695740A (en) * | 1993-05-12 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide |
US5701899A (en) * | 1993-05-12 | 1997-12-30 | The Board Of Regents Of The University Of Nebraska | Perfluorobutane ultrasound contrast agent and methods for its manufacture and use |
US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
IL110185A (en) * | 1993-07-02 | 1999-05-09 | Molecular Biosystems Inc | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
US5855865A (en) * | 1993-07-02 | 1999-01-05 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
PT711179E (pt) * | 1993-07-30 | 2005-03-31 | Imcor Pharmaceutical Company | Composicoes de microbolhas estabilizadas para ultra-som |
US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
ES2192572T3 (es) * | 1993-12-15 | 2003-10-16 | Bracco Research Sa | Medios de contraste de ultrasonidos, agentes de contraste que contienen los medios, y metodo. |
US5406950A (en) * | 1993-12-23 | 1995-04-18 | Mallinckrodt Medical, Inc. | Inhalable contrast agent |
US5736121A (en) | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
US5965109A (en) * | 1994-08-02 | 1999-10-12 | Molecular Biosystems, Inc. | Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier |
US5730955A (en) * | 1994-08-02 | 1998-03-24 | Molecular Biosystems, Inc. | Process for making gas-filled microspheres containing a liquid hydrophobic barrier |
WO1998053855A1 (en) * | 1997-05-30 | 1998-12-03 | Alliance Pharmaceutical Corp. | Methods and apparatus for monitoring and quantifying the movement of fluid |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
IL116328A (en) † | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
US5560364A (en) * | 1995-05-12 | 1996-10-01 | The Board Of Regents Of The University Of Nebraska | Suspended ultra-sound induced microbubble cavitation imaging |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
US5674469A (en) * | 1995-06-07 | 1997-10-07 | Molecular Biosystems, Inc. | Gas-exchange method of making gas-filled microspheres |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
US5897851A (en) * | 1995-06-07 | 1999-04-27 | Sonus Pharmaceuticals, Inc. | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US5648098A (en) * | 1995-10-17 | 1997-07-15 | The Board Of Regents Of The University Of Nebraska | Thrombolytic agents and methods of treatment for thrombosis |
US5840276A (en) * | 1996-01-11 | 1998-11-24 | Apfel Enterprises, Inc. | Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis |
DE19602930A1 (de) * | 1996-01-18 | 1997-07-24 | Schering Ag | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
CZ281298A3 (cs) * | 1996-03-05 | 1999-01-13 | Acusphere, Inc. | Fluorované plyny v mikrokapslích jako zobrazující činidla pro ultrazvukové vyšetření |
US6245747B1 (en) | 1996-03-12 | 2001-06-12 | The Board Of Regents Of The University Of Nebraska | Targeted site specific antisense oligodeoxynucleotide delivery method |
WO1997040679A1 (en) | 1996-05-01 | 1997-11-06 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US5728315A (en) * | 1996-05-01 | 1998-03-17 | Alliedsignal Inc. | Azeotrope-like compositions of trifluoromethane, carbon dioxide, ethane and hexafluoroethane |
US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
AU3665297A (en) * | 1996-07-19 | 1998-02-10 | Sonus Pharmaceuticals, Inc. | Enhanced ultrasound contrast imaging using inhaled gases |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
ES2189974T3 (es) | 1996-09-11 | 2003-07-16 | Imarx Pharmaceutical Corp | Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador. |
US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6143276A (en) * | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US6444192B1 (en) | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
US6439236B1 (en) | 1999-10-25 | 2002-08-27 | The Board Of Regents Of The University Of Nebraska | Methods for inducing atrial and ventricular rhythms using ultrasound and microbubbles |
US8512680B2 (en) | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
US7358226B2 (en) * | 2003-08-27 | 2008-04-15 | The Regents Of The University Of California | Ultrasonic concentration of drug delivery capsules |
JP2007511590A (ja) | 2003-11-17 | 2007-05-10 | ビーティージー・インターナショナル・リミテッド | 治療用フォーム |
US8048439B2 (en) | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
EP1715897B2 (de) | 2004-01-20 | 2013-10-30 | Sunnybrook and Women's College Health Sciences Centre | Hochfrequenz-ultraschall-darstellung mit kontrastmitteln |
US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
GB0509824D0 (en) | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
WO2009043031A2 (en) | 2007-09-27 | 2009-04-02 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
EP2234544B1 (de) * | 2008-01-23 | 2011-09-07 | Michalakis Averkiou | Atmungsgeführte therapiebeurteilung mit ultraschall-kontrastmittel |
US8846063B2 (en) | 2008-12-16 | 2014-09-30 | Kimberly-Clark Worldwide, Inc. | Personal care composition containing a volatile and a terpene alcohol |
US10357450B2 (en) | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
US9713459B2 (en) | 2012-06-11 | 2017-07-25 | The Regents Of The University Of California | Method and system for in vivo hydrogen peroxide detection with ultrasound |
CN104519989B (zh) | 2012-06-26 | 2016-10-26 | 通用电气医疗集团股份有限公司 | 制备包含气体微泡的组合物 |
WO2014144364A1 (en) | 2013-03-15 | 2014-09-18 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
EP3240579B1 (de) | 2014-12-31 | 2022-07-27 | Lantheus Medical Imaging, Inc. | Lipidverkapselte gasmikrosphärenzusammensetzungen und zugehörige verfahren |
TWI832081B (zh) | 2016-05-04 | 2024-02-11 | 美商藍瑟斯醫學影像公司 | 用於形成充氣微球體及成像個體之方法、震盪裝置及電腦可讀軟體 |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
EP4257576A3 (de) * | 2019-02-08 | 2024-01-10 | Daikin Industries, Ltd. | Verfahren zur herstellung einer organischen verbindung |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4265251A (en) * | 1979-06-28 | 1981-05-05 | Rasor Associates, Inc. | Method of determining pressure within liquid containing vessel |
US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
US4681119A (en) * | 1980-11-17 | 1987-07-21 | Schering Aktiengesellschaft | Method of production and use of microbubble precursors |
JPS57150542A (en) * | 1981-03-13 | 1982-09-17 | Katashi Aoki | Injection, stretching, and blow molding machine |
US4361979A (en) * | 1981-04-07 | 1982-12-07 | Brio Toy Ab | Connection element for making assemblies of toy units |
US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
JPS5967229A (ja) * | 1982-10-08 | 1984-04-16 | Green Cross Corp:The | 超音波診断造影剤 |
US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
DE3834705A1 (de) * | 1988-10-07 | 1990-04-12 | Schering Ag | Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
JPS6073621A (ja) * | 1983-09-30 | 1985-04-25 | Fuji Photo Film Co Ltd | 折畳み式カメラ |
US4767610A (en) * | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
DE3529195A1 (de) * | 1985-08-14 | 1987-02-26 | Max Planck Gesellschaft | Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung |
JPH07110815B2 (ja) * | 1985-11-18 | 1995-11-29 | ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム | 画像及びスペクトル向上(およびスペクトルシフト)のためのポリキレ−ト剤 |
US4865836A (en) * | 1986-01-14 | 1989-09-12 | Fluoromed Pharmaceutical, Inc. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US5284645A (en) * | 1987-08-05 | 1994-02-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems |
US4927623A (en) * | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
ES2054658T3 (es) * | 1986-01-24 | 1994-08-16 | Childrens Hosp Medical Center | Metodo para la preparacion de una emulsion fisiologicamente aceptable. |
EP0245019A3 (de) * | 1986-04-30 | 1989-05-10 | Michael A. Davis | Kontrastmedium mit niedriger Dichte zur Diagnose von pathologischen Bedingungen |
JPS6360943A (ja) * | 1986-09-01 | 1988-03-17 | Green Cross Corp:The | 超音波診断造影剤 |
US5219538A (en) * | 1987-03-13 | 1993-06-15 | Micro-Pak, Inc. | Gas and oxygen carrying lipid vesicles |
US4895876A (en) * | 1987-03-20 | 1990-01-23 | Air Products And Chemicals, Inc. | Concentrated stable fluorochemical aqueous emulsions containing triglycerides |
US5354549A (en) * | 1987-07-24 | 1994-10-11 | Nycomed Imaging As | Iodinated esters |
CN1013830B (zh) * | 1987-08-26 | 1991-09-11 | 宋振才 | B超胃肠造影剂的制造工艺 |
IE61591B1 (en) * | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
EP0586875A1 (de) * | 1988-02-05 | 1994-03-16 | Schering Aktiengesellschaft | Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika |
US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
US4993415A (en) * | 1988-08-19 | 1991-02-19 | Alliance Pharmaceutical Corp. | Magnetic resonance imaging with perfluorocarbon hydrides |
DE3828905A1 (de) * | 1988-08-23 | 1990-03-15 | Schering Ag | Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel |
US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
GB8900376D0 (en) * | 1989-01-09 | 1989-03-08 | Nycomed As | Iodinated esters |
US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
DK0489773T3 (da) * | 1989-08-30 | 1993-11-29 | Kali Chemie Ag | Fremgangsmåde til adskillelse af blandinger af delvist fluorerede eller perflourerede carbonhydridforbindelser |
JPH062134B2 (ja) * | 1989-09-08 | 1994-01-12 | 株式会社東芝 | 超音波診断装置 |
JPH02196730A (ja) * | 1989-12-15 | 1990-08-03 | Green Cross Corp:The | 超音波診断造影剤 |
US5209720A (en) * | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5228446A (en) * | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5230882A (en) * | 1989-12-22 | 1993-07-27 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
GB9003821D0 (en) * | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
IN172208B (de) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
DE59107006D1 (de) * | 1990-04-25 | 1996-01-18 | Hoechst Ag | Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff. |
US5137928A (en) * | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
ES2112859T3 (es) * | 1990-06-01 | 1998-04-16 | Imarx Pharmaceutical Corp | Medios de contraste para la formacion de imagenes ecograficas. |
US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
FR2665705B1 (fr) * | 1990-08-09 | 1993-07-30 | Atta | Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical. |
AU635449B2 (en) * | 1990-10-05 | 1993-03-18 | Bracco International B.V. | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
US5236693A (en) * | 1990-11-14 | 1993-08-17 | Brigham And Women's Hospital | Medical ultrasound contrast agent and method of using same |
DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
US5107842A (en) * | 1991-02-22 | 1992-04-28 | Molecular Biosystems, Inc. | Method of ultrasound imaging of the gastrointestinal tract |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5496535A (en) * | 1991-04-12 | 1996-03-05 | Alliance Pharmaceutical Corp. | Fluorocarbon contrast media for use with MRI and radiographic imaging |
SE470086B (sv) * | 1991-04-23 | 1993-11-08 | Kabi Pharmacia Ab | Organspecifik emulsion |
US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
DK0586524T3 (de) * | 1991-06-03 | 1997-05-20 | Nycomed Imaging As | |
DE69233119T2 (de) * | 1991-06-18 | 2004-05-13 | Imarx Pharmaceutical Corp., Tucson | Neue liposomale arzneimittelfreisetzungssysteme |
CA2112905A1 (en) * | 1991-07-05 | 1993-01-21 | Michael R. Violante | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
CA2112109A1 (en) * | 1991-07-05 | 1993-01-21 | Arne Berg | Improvements in or relating to contrast agents |
FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
DE4127442C2 (de) * | 1991-08-17 | 1996-08-22 | Udo Dr Gros | Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung |
CZ286149B6 (cs) * | 1991-09-17 | 2000-01-12 | Sonus Pharmaceuticals, Inc. | Plynná prostředí pro zvýšení kontrastnosti obrazu, získaného ultrazvukem a způsob výběru plynů pro toto použití |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
AU2789192A (en) * | 1991-10-04 | 1993-05-03 | Mallinckrodt Medical, Inc. | Gaseous ultrasound contrast agents |
US5344640A (en) * | 1991-10-22 | 1994-09-06 | Mallinckrodt Medical, Inc. | Preparation of apatite particles for medical diagnostic imaging |
AU667491B2 (en) * | 1991-11-19 | 1996-03-28 | Imarx Pharmaceutical Corp. | Gel particle contrast media for improved diagnostic imaging |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
US5344393A (en) * | 1992-02-28 | 1994-09-06 | Alliance Pharmaceutical Corp. | Use of synthetic oxygen carriers to facilitate oxygen delivery |
US5406950A (en) * | 1993-12-23 | 1995-04-18 | Mallinckrodt Medical, Inc. | Inhalable contrast agent |
-
1992
- 1992-09-02 CZ CZ1994612A patent/CZ286149B6/cs not_active IP Right Cessation
- 1992-09-02 CA CA002119129A patent/CA2119129C/en not_active Expired - Lifetime
- 1992-09-02 WO PCT/US1992/007250 patent/WO1993005819A1/en active IP Right Grant
- 1992-09-02 EP EP92919150A patent/EP0605477B2/de not_active Expired - Lifetime
- 1992-09-02 DK DK92919150T patent/DK0605477T4/da active
- 1992-09-02 AT AT92919150T patent/ATE191346T1/de active
- 1992-09-02 SG SG1996001218A patent/SG54121A1/en unknown
- 1992-09-02 KR KR1019940700881A patent/KR100191303B1/ko not_active IP Right Cessation
- 1992-09-02 ES ES92919150T patent/ES2145011T5/es not_active Expired - Lifetime
- 1992-09-02 AU AU25503/92A patent/AU679428C/en not_active Expired
- 1992-09-02 RU RU94030382/14A patent/RU2114637C1/ru active
- 1992-09-02 HU HU9400786A patent/HU218018B/hu unknown
- 1992-09-02 DE DE69230885T patent/DE69230885T3/de not_active Expired - Lifetime
- 1992-09-02 DE DE0605477T patent/DE605477T1/de active Pending
- 1992-09-02 JP JP50605493A patent/JP3231768B2/ja not_active Expired - Fee Related
-
1994
- 1994-03-16 NO NO19940956A patent/NO313577B1/no not_active IP Right Cessation
- 1994-03-16 FI FI941242A patent/FI119466B/fi not_active IP Right Cessation
-
1995
- 1995-02-01 US US08382253 patent/US5558094B1/en not_active Expired - Lifetime
-
1997
- 1997-10-03 AU AU39959/97A patent/AU3995997A/en not_active Abandoned
-
1998
- 1998-12-17 HK HK98113910A patent/HK1012564A1/xx not_active IP Right Cessation
-
2000
- 2000-04-12 JP JP2000150619A patent/JP2001026554A/ja active Pending
- 2000-07-05 GR GR20000401593T patent/GR3033908T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5558094B1 (en) | Methods for using persistent gases as ultrasound contrast media | |
CA2273140A1 (en) | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media | |
PT100867A (pt) | Meios de contraste gasoso para ultrsons e metodo para seleccionar gases para utilizacao como meios de contraste para ultrasons | |
RU94030382A (ru) | Биосовместимая контрастная среда и способ получения ультразвукового изображения | |
DK0788348T3 (da) | Beholder med multifasesammensætning til brug i diagnostiske og terapeutiske anvendelser | |
ATE371834T1 (de) | Sauerstoffanreichungsapparat | |
GB9203037D0 (en) | Contrast agents | |
IL123641A0 (en) | Circular dna molecule with conditional origin of replication method for preparing the same and use thereof in gene therapy | |
MX9200902A (es) | Metodo de anestesia. | |
GR3019661T3 (en) | Device for feeding gaseous substances into liquids | |
AU3028895A (en) | Disease management system | |
MY111060A (en) | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media | |
GB9502987D0 (en) | Medical gas mixture | |
EP0868921A3 (de) | Medizinische Gasmischungen | |
AU6849594A (en) | Orientation aid for use when swimming on the back | |
ATE116007T1 (de) | Gasspülstein. | |
JPS6486862A (en) | Instant carbonated beverage | |
FR2547162B1 (fr) | Procede et dispositif pour l'enrichissement de l'atmosphere des serres avec du dioxyde de carbone pur | |
ITSA930012A0 (it) | Sistema, per strumenti musicali e simili, in grado di interagire con l'utente segnalandogli, mediante illuminazioni, la corretta procedura di esecuzione di un brano. | |
JP2001079383A (ja) | 炭による二酸化炭素固定法 | |
ITPN910075A1 (it) | Procedimento di costruzione di telai in fibra di carbonio. | |
ITRM920224A1 (it) | Sistema ottico per la combinazione di due cammini ottici, in particolare i cammini ottici di uno strumento di diagnostica oculare e di un altro strumento. | |
RO117586B1 (ro) | Compoziţie izotopică pentru soluţii fecundante |