SG46782A1 - Bicyclic-fused pyridines - Google Patents

Bicyclic-fused pyridines

Info

Publication number
SG46782A1
SG46782A1 SG1997002082A SG1997002082A SG46782A1 SG 46782 A1 SG46782 A1 SG 46782A1 SG 1997002082 A SG1997002082 A SG 1997002082A SG 1997002082 A SG1997002082 A SG 1997002082A SG 46782 A1 SG46782 A1 SG 46782A1
Authority
SG
Singapore
Prior art keywords
bicyclic
fused pyridines
pyridines
fused
Prior art date
Application number
SG1997002082A
Other languages
English (en)
Inventor
Arndt Brandes
Michael Logers
Gunter Schmidt
Rolf Angerbauer
Carsten Schmeck
Klaus-Dieter Bremm
Hilmar Bischoff
Delf Schmidt
Joachim Schuhmacher
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SG46782A1 publication Critical patent/SG46782A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG1997002082A 1996-07-08 1997-06-18 Bicyclic-fused pyridines SG46782A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19627430A DE19627430A1 (de) 1996-07-08 1996-07-08 Bicyclisch kondensierte Pyridine

Publications (1)

Publication Number Publication Date
SG46782A1 true SG46782A1 (en) 1998-02-20

Family

ID=7799218

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1997002082A SG46782A1 (en) 1996-07-08 1997-06-18 Bicyclic-fused pyridines

Country Status (30)

Country Link
US (1) US6063788A (bg)
EP (1) EP0825185A1 (bg)
JP (1) JPH1067751A (bg)
KR (1) KR980009247A (bg)
CN (1) CN1172803A (bg)
AR (1) AR007716A1 (bg)
AU (1) AU722365B2 (bg)
BG (1) BG61972B1 (bg)
BR (1) BR9703886A (bg)
CA (1) CA2209609A1 (bg)
CO (1) CO4870759A1 (bg)
CZ (1) CZ214797A3 (bg)
DE (1) DE19627430A1 (bg)
EE (1) EE9700151A (bg)
HN (1) HN1997000082A (bg)
HR (1) HRP970331A2 (bg)
HU (1) HUP9701158A1 (bg)
ID (1) ID17659A (bg)
IL (1) IL121235A0 (bg)
MA (1) MA24261A1 (bg)
NO (1) NO308738B1 (bg)
NZ (1) NZ328260A (bg)
PE (1) PE87798A1 (bg)
PL (1) PL320954A1 (bg)
SG (1) SG46782A1 (bg)
SK (1) SK92697A3 (bg)
TN (1) TNSN97116A1 (bg)
TR (1) TR199700583A2 (bg)
YU (1) YU28897A (bg)
ZA (1) ZA976021B (bg)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
MXPA01006470A (es) 1998-12-23 2003-06-06 Searle Llc Combinaciones de inhibidores de transporte de acido biliar ileal y agentes de secuentro de acido biliar para indicaciones cardiovasculares.
ES2200587T3 (es) 1998-12-23 2004-03-01 G.D. Searle Llc Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares.
AU3103800A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications
EP1340509A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
HUP0104793A2 (en) 1998-12-23 2002-06-29 Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
WO2000038723A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6723752B2 (en) 1999-09-23 2004-04-20 Pharmacia Corporation (R)-chiral halogenated substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
EP1286984A2 (en) 2000-03-10 2003-03-05 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
US20040219619A1 (en) * 2000-07-21 2004-11-04 Ester Fernandez-Salas Methods of identifying compounds that alter toxin persistence and/or protease activity
US6958328B2 (en) 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods
US20050239782A1 (en) * 2001-04-18 2005-10-27 Heintzelman Geoffrey R Arylindenopyridines and related therapeutic and prophylactic methods
US6903109B2 (en) 2001-04-18 2005-06-07 Ortho-Muniel Pharmaceutical, Inc. Arylindenopyridines and related therapeutic and prophylactic methods
ES2333645T3 (es) 2001-06-22 2010-02-25 Bend Research, Inc. Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros.
OA12625A (en) 2001-06-22 2006-06-12 Pfizer Prod Inc Pharmaceutical compositions of adsorbates of amorphous drug.
WO2003040127A1 (en) 2001-11-02 2003-05-15 G.D. Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
EP1469832B2 (en) 2002-02-01 2016-10-26 Bend Research, Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
US20040127510A1 (en) 2002-04-16 2004-07-01 Heintzelman Geoffrey R. Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
CL2004001884A1 (es) 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
CA2532931A1 (en) * 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
EP1670446A2 (en) * 2003-09-26 2006-06-21 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
SI1670768T1 (sl) 2003-10-08 2010-01-29 Lilly Co Eli Spojine in metode za zdravljenje dislipidemije
EP1735320B1 (en) 2004-03-26 2009-06-17 Eli Lilly And Company Compounds and methods for treating dyslipidemia
BRPI0519602A2 (pt) * 2004-12-18 2009-02-25 Bayer Healthcare Ag derivados de tetrahidroquinolina substituÍdos com 4-cicloalquila e seu uso como medicamento
WO2006082518A1 (en) 2005-02-03 2006-08-10 Pfizer Products Inc. Pharmaceutical compositions with enhanced performance
CA2625416A1 (en) 2005-10-21 2007-04-26 Novartis Ag Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
PA8801401A1 (es) * 2007-10-25 2009-05-15 Janssen Pharmaceutica Nv Arilindenopirimidinas y su uso como adenosina a2a
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
GB8626344D0 (en) * 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
ZA911046B (en) * 1990-02-26 1992-10-28 Squibb & Sons Inc Quinoline and pyridine anchors for hmg-coa reductase inhibitors
JPH059179A (ja) * 1990-09-27 1993-01-19 Takeda Chem Ind Ltd 複素環化合物、その製造法及びａｃａｔ阻害剤

Also Published As

Publication number Publication date
TR199700583A2 (xx) 1998-01-21
BG101746A (bg) 1998-03-31
NZ328260A (en) 1998-09-24
NO973144D0 (no) 1997-07-07
YU28897A (sh) 2000-03-21
CO4870759A1 (es) 1999-12-27
JPH1067751A (ja) 1998-03-10
CA2209609A1 (en) 1998-01-08
HU9701158D0 (en) 1997-09-29
ID17659A (id) 1998-01-15
EE9700151A (et) 1998-02-16
KR980009247A (ko) 1998-04-30
AU2844897A (en) 1998-01-15
BG61972B1 (bg) 1998-11-30
IL121235A0 (en) 1998-01-04
BR9703886A (pt) 1998-11-03
DE19627430A1 (de) 1998-01-15
HN1997000082A (es) 1997-12-26
HRP970331A2 (en) 1998-08-31
CN1172803A (zh) 1998-02-11
SK92697A3 (en) 1998-02-04
EP0825185A1 (de) 1998-02-25
AR007716A1 (es) 1999-11-10
ZA976021B (en) 1998-02-02
NO308738B1 (no) 2000-10-23
PL320954A1 (en) 1998-01-19
CZ214797A3 (cs) 1998-01-14
MA24261A1 (fr) 1998-04-01
NO973144L (no) 1998-01-09
TNSN97116A1 (fr) 2005-03-15
US6063788A (en) 2000-05-16
HUP9701158A1 (hu) 1999-09-28
PE87798A1 (es) 1999-02-13
AU722365B2 (en) 2000-08-03

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