SG192963A1 - 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of beta-secretase (bace) - Google Patents

Info

Publication number

SG192963A1

SG192963A1 SG2013064746A SG2013064746A SG192963A1 SG 192963 A1 SG192963 A1 SG 192963A1 SG 2013064746 A SG2013064746 A SG 2013064746A SG 2013064746 A SG2013064746 A SG 2013064746A SG 192963 A1 SG192963 A1 SG 192963A1

Authority

SG

Singapore

Prior art keywords

compound

mixture

mmol

vacuo

phenyl

Prior art date

2011-03-01

Links

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• 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract description 20
• 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract description 20
• 239000003112 inhibitor Substances 0.000 title abstract description 8
• IWEFEVCBSHDDLF-UHFFFAOYSA-N 6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine Chemical class NC1=NCCN2N=CC=C12 IWEFEVCBSHDDLF-UHFFFAOYSA-N 0.000 title abstract description 3
• 101150058765 BACE1 gene Proteins 0.000 title 1
• 238000000034 method Methods 0.000 claims abstract description 178
• 150000001875 compounds Chemical class 0.000 claims abstract description 147
• -1 BACEl Proteins 0.000 claims abstract description 43
• 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 41
• 206010012289 Dementia Diseases 0.000 claims abstract description 39
• 238000011282 treatment Methods 0.000 claims abstract description 25
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 19
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
• 208000010877 cognitive disease Diseases 0.000 claims abstract description 12
• 208000027061 mild cognitive impairment Diseases 0.000 claims abstract description 12
• 108010090849 Amyloid beta-Peptides Proteins 0.000 claims abstract description 10
• 102000013455 Amyloid beta-Peptides Human genes 0.000 claims abstract description 10
• 206010067889 Dementia with Lewy bodies Diseases 0.000 claims abstract description 10
• 201000010374 Down Syndrome Diseases 0.000 claims abstract description 10
• 201000002832 Lewy body dementia Diseases 0.000 claims abstract description 10
• 208000018737 Parkinson disease Diseases 0.000 claims abstract description 10
• 206010039966 Senile dementia Diseases 0.000 claims abstract description 10
• 206010044688 Trisomy 21 Diseases 0.000 claims abstract description 10
• 208000035475 disorder Diseases 0.000 claims abstract description 9
• 230000002265 prevention Effects 0.000 claims abstract description 5
• 239000001257 hydrogen Substances 0.000 claims description 31
• 229910052739 hydrogen Inorganic materials 0.000 claims description 31
• 150000003839 salts Chemical class 0.000 claims description 28
• 125000005843 halogen group Chemical group 0.000 claims description 21
• 125000000217 alkyl group Chemical group 0.000 claims description 17
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 16
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
• 125000001072 heteroaryl group Chemical group 0.000 claims description 14
• 239000012453 solvate Substances 0.000 claims description 14
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
• 125000001424 substituent group Chemical group 0.000 claims description 12
• 239000003937 drug carrier Substances 0.000 claims description 11
• 150000002431 hydrogen Chemical class 0.000 claims description 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
• 125000004076 pyridyl group Chemical group 0.000 claims description 6
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 6
• 229910052799 carbon Inorganic materials 0.000 claims description 4
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
• 125000005412 pyrazyl group Chemical group 0.000 claims description 4
• 125000004432 carbon atom Chemical group C* 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 125000002541 furyl group Chemical group 0.000 claims description 2
• 125000002883 imidazolyl group Chemical group 0.000 claims description 2
• 125000001715 oxadiazolyl group Chemical group 0.000 claims description 2
• 125000002971 oxazolyl group Chemical group 0.000 claims description 2
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
• 125000005495 pyridazyl group Chemical group 0.000 claims description 2
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 2
• 230000001225 therapeutic effect Effects 0.000 claims description 2
• 125000001113 thiadiazolyl group Chemical group 0.000 claims description 2
• 125000000335 thiazolyl group Chemical group 0.000 claims description 2
• 125000001544 thienyl group Chemical group 0.000 claims description 2
• 125000001425 triazolyl group Chemical group 0.000 claims description 2
• 238000011321 prophylaxis Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 abstract description 169
• 102100021257 Beta-secretase 1 Human genes 0.000 abstract description 10
• 101710150192 Beta-secretase 1 Proteins 0.000 abstract description 6
• 102000004190 Enzymes Human genes 0.000 abstract description 6
• 108090000790 Enzymes Proteins 0.000 abstract description 6
• 230000008569 process Effects 0.000 abstract description 6
• 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 abstract description 4
• IXHBTMCLRNMKHZ-LBPRGKRZSA-N levobunolol Chemical compound O=C1CCCC2=C1C=CC=C2OC[C@@H](O)CNC(C)(C)C IXHBTMCLRNMKHZ-LBPRGKRZSA-N 0.000 abstract description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 357
• 239000000543 intermediate Substances 0.000 description 311
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 241
• 239000002904 solvent Substances 0.000 description 103
• 238000002360 preparation method Methods 0.000 description 99
• 239000000243 solution Substances 0.000 description 95
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 94
• 238000006243 chemical reaction Methods 0.000 description 85
• 239000000741 silica gel Substances 0.000 description 85
• 229910002027 silica gel Inorganic materials 0.000 description 85
• 238000003818 flash chromatography Methods 0.000 description 76
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 74
• 239000007787 solid Substances 0.000 description 68
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 60
• 239000012043 crude product Substances 0.000 description 43
• 239000012044 organic layer Substances 0.000 description 41
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 36
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 35
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 31
• IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 30
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 30
• 239000012071 phase Substances 0.000 description 28
• 238000005481 NMR spectroscopy Methods 0.000 description 27
• 239000003921 oil Substances 0.000 description 25
• 239000011734 sodium Substances 0.000 description 24
• 239000011541 reaction mixture Substances 0.000 description 22
• DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 22
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
• 239000012047 saturated solution Substances 0.000 description 21
• 229910052760 oxygen Inorganic materials 0.000 description 20
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 19
• 238000004808 supercritical fluid chromatography Methods 0.000 description 19
• BMTZEAOGFDXDAD-UHFFFAOYSA-M 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium;chloride Chemical compound [Cl-].COC1=NC(OC)=NC([N+]2(C)CCOCC2)=N1 BMTZEAOGFDXDAD-UHFFFAOYSA-M 0.000 description 17
• 108010064539 amyloid beta-protein (1-42) Proteins 0.000 description 17
• 239000002585 base Substances 0.000 description 17
• 238000010438 heat treatment Methods 0.000 description 17
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 16
• 239000012442 inert solvent Substances 0.000 description 16
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 15
• 238000003556 assay Methods 0.000 description 15
• 239000003795 chemical substances by application Substances 0.000 description 14
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 12
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
• 238000002474 experimental method Methods 0.000 description 12
• 229910052757 nitrogen Inorganic materials 0.000 description 12
• 239000000047 product Substances 0.000 description 12
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 11
• 229910000069 nitrogen hydride Inorganic materials 0.000 description 11
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 10
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
• 241001465754 Metazoa Species 0.000 description 10
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• 239000003814 drug Substances 0.000 description 10
• 230000000694 effects Effects 0.000 description 10
• 239000007924 injection Substances 0.000 description 10
• 238000002347 injection Methods 0.000 description 10
• 108090000765 processed proteins & peptides Proteins 0.000 description 10
• 238000006722 reduction reaction Methods 0.000 description 10
• ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 9
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
• 239000002253 acid Substances 0.000 description 9
• 239000000460 chlorine Substances 0.000 description 9
• 238000005259 measurement Methods 0.000 description 9
• GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 8
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 8
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 8
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 8
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
• 230000015572 biosynthetic process Effects 0.000 description 8
• 210000004027 cell Anatomy 0.000 description 8
• 238000001816 cooling Methods 0.000 description 8
• CSJLBAMHHLJAAS-UHFFFAOYSA-N diethylaminosulfur trifluoride Chemical compound CCN(CC)S(F)(F)F CSJLBAMHHLJAAS-UHFFFAOYSA-N 0.000 description 8
• 108010037444 diisopropylglutathione ester Proteins 0.000 description 8
• 201000010099 disease Diseases 0.000 description 8
• 239000007789 gas Substances 0.000 description 8
• SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 8
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• 210000004556 brain Anatomy 0.000 description 7
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• 229910002092 carbon dioxide Inorganic materials 0.000 description 7
• 229910002091 carbon monoxide Inorganic materials 0.000 description 7
• RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
• 230000005284 excitation Effects 0.000 description 7
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• 238000004007 reversed phase HPLC Methods 0.000 description 7
• 238000004704 ultra performance liquid chromatography Methods 0.000 description 7
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 6
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 6
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
• 235000019270 ammonium chloride Nutrition 0.000 description 6
• 230000001413 cellular effect Effects 0.000 description 6
• 238000004440 column chromatography Methods 0.000 description 6
• 239000006071 cream Substances 0.000 description 6
• 238000001514 detection method Methods 0.000 description 6
• ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 6
• NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 6
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 6
• 239000000523 sample Substances 0.000 description 6
• 239000003826 tablet Substances 0.000 description 6
• YVGVOPNUEFTVQO-UHFFFAOYSA-N 5-methoxypyrazine-2-carboxylic acid Chemical compound COC1=CN=C(C(O)=O)C=N1 YVGVOPNUEFTVQO-UHFFFAOYSA-N 0.000 description 5
• XHAAOZFLLILFLU-UHFFFAOYSA-N 6-(3-aminophenyl)-6-methyl-7h-pyrazolo[1,5-a]pyrazin-4-amine Chemical compound C1N2N=CC=C2C(N)=NC1(C)C1=CC=CC(N)=C1 XHAAOZFLLILFLU-UHFFFAOYSA-N 0.000 description 5
• MNLXDZRHZRSOGL-UHFFFAOYSA-N 6-(5-amino-2-fluorophenyl)-6-(difluoromethyl)-7h-pyrazolo[1,5-a]pyrazin-4-amine Chemical compound C1N2N=CC=C2C(N)=NC1(C(F)F)C1=CC(N)=CC=C1F MNLXDZRHZRSOGL-UHFFFAOYSA-N 0.000 description 5
• 208000006011 Stroke Diseases 0.000 description 5
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• 239000004480 active ingredient Substances 0.000 description 5
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• 239000002775 capsule Substances 0.000 description 5
• 238000000132 electrospray ionisation Methods 0.000 description 5
• 229940088598 enzyme Drugs 0.000 description 5
• 239000000706 filtrate Substances 0.000 description 5
• 238000002866 fluorescence resonance energy transfer Methods 0.000 description 5
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• ZOMBZLIAKVSBNH-UHFFFAOYSA-N 6-(3-aminophenyl)-6-methyl-2-(trifluoromethyl)-7h-pyrazolo[1,5-a]pyrazin-4-amine Chemical compound C1N2N=C(C(F)(F)F)C=C2C(N)=NC1(C)C1=CC=CC(N)=C1 ZOMBZLIAKVSBNH-UHFFFAOYSA-N 0.000 description 4
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
• 241000282412 Homo Species 0.000 description 4
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
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• 238000003776 cleavage reaction Methods 0.000 description 4
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• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 4
• 230000005764 inhibitory process Effects 0.000 description 4
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• CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 description 4
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• JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 4
• 238000003756 stirring Methods 0.000 description 4
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• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
• 229940124597 therapeutic agent Drugs 0.000 description 4
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