HRP20160030T1 - Derivati 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina koji su korisni kao inhibitori beta-sekretaze (bace) - Google Patents

Derivati 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina koji su korisni kao inhibitori beta-sekretaze (bace) Download PDF

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Publication number
HRP20160030T1
HRP20160030T1 HRP20160030TT HRP20160030T HRP20160030T1 HR P20160030 T1 HRP20160030 T1 HR P20160030T1 HR P20160030T T HRP20160030T T HR P20160030TT HR P20160030 T HRP20160030 T HR P20160030T HR P20160030 T1 HRP20160030 T1 HR P20160030T1
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HR
Croatia
Prior art keywords
group
polyhalo
hydrogen
3alkyloxy
mono
Prior art date
Application number
HRP20160030TT
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English (en)
Croatian (hr)
Inventor
Andrés Avelino TRABANCO-SUÁREZ
Henricus Jacobus Maria Gijsen
Michiel Luc Maria Van Gool
Juan Antonio Vega Ramiro
Francisca DELGADO-JIMÉNEZ
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20160030T1 publication Critical patent/HRP20160030T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HRP20160030TT 2011-03-01 2012-02-29 Derivati 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina koji su korisni kao inhibitori beta-sekretaze (bace) HRP20160030T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11156463 2011-03-01
PCT/EP2012/053455 WO2012117027A1 (en) 2011-03-01 2012-02-29 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of beta-secretase (bace)
EP12707276.7A EP2681219B1 (en) 2011-03-01 2012-02-29 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of beta-secretase (bace)

Publications (1)

Publication Number Publication Date
HRP20160030T1 true HRP20160030T1 (hr) 2016-02-12

Family

ID=45808845

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20160030TT HRP20160030T1 (hr) 2011-03-01 2012-02-29 Derivati 6,7-dihidro-pirazolo[1,5-a]pirazin-4-ilamina koji su korisni kao inhibitori beta-sekretaze (bace)

Country Status (27)

Country Link
US (1) US9346811B2 (enExample)
EP (1) EP2681219B1 (enExample)
JP (1) JP5853033B2 (enExample)
KR (1) KR102012671B1 (enExample)
CN (1) CN103415519B (enExample)
AU (1) AU2012222394B2 (enExample)
BR (1) BR112013022039A2 (enExample)
CA (1) CA2824360C (enExample)
CL (1) CL2013002486A1 (enExample)
CO (1) CO6751282A2 (enExample)
CY (1) CY1117663T1 (enExample)
DK (1) DK2681219T3 (enExample)
EA (1) EA022649B1 (enExample)
ES (1) ES2558779T3 (enExample)
HR (1) HRP20160030T1 (enExample)
HU (1) HUE026338T2 (enExample)
IL (1) IL228158A (enExample)
MX (1) MX338333B (enExample)
MY (1) MY161407A (enExample)
PH (1) PH12013501807A1 (enExample)
PL (1) PL2681219T3 (enExample)
PT (1) PT2681219E (enExample)
SG (1) SG192963A1 (enExample)
SI (1) SI2681219T1 (enExample)
UA (1) UA109800C2 (enExample)
WO (1) WO2012117027A1 (enExample)
ZA (1) ZA201306545B (enExample)

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Also Published As

Publication number Publication date
CO6751282A2 (es) 2013-09-16
WO2012117027A1 (en) 2012-09-07
US9346811B2 (en) 2016-05-24
MX2013010040A (es) 2013-11-04
PL2681219T3 (pl) 2016-03-31
EA201391251A1 (ru) 2014-01-30
BR112013022039A2 (pt) 2016-11-29
SI2681219T1 (sl) 2016-02-29
NZ614551A (en) 2014-06-27
PH12013501807A1 (en) 2015-09-30
CN103415519A (zh) 2013-11-27
UA109800C2 (xx) 2015-10-12
IL228158A0 (en) 2013-11-25
AU2012222394B2 (en) 2016-06-16
KR20140010052A (ko) 2014-01-23
US20140005200A1 (en) 2014-01-02
EP2681219A1 (en) 2014-01-08
CA2824360A1 (en) 2012-09-07
SG192963A1 (en) 2013-09-30
CN103415519B (zh) 2016-03-02
AU2012222394A1 (en) 2013-07-25
MX338333B (es) 2016-04-11
JP2014506907A (ja) 2014-03-20
CY1117663T1 (el) 2017-05-17
HUE026338T2 (en) 2016-05-30
KR102012671B1 (ko) 2019-08-21
DK2681219T3 (en) 2016-01-18
PT2681219E (pt) 2016-02-10
JP5853033B2 (ja) 2016-02-09
CA2824360C (en) 2020-01-14
CL2013002486A1 (es) 2014-02-21
MY161407A (en) 2017-04-14
ES2558779T3 (es) 2016-02-08
IL228158A (en) 2016-07-31
EP2681219B1 (en) 2015-10-28
HK1188784A1 (zh) 2014-05-16
EA022649B1 (ru) 2016-02-29
ZA201306545B (en) 2015-03-25

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