KR102012671B1 - 베타-세크레타제(BACE)의 억제제로서 유용한 6,7-디하이드로-피라졸로[1,5-a]피라진-4-일아민 유도체 - Google Patents

베타-세크레타제(BACE)의 억제제로서 유용한 6,7-디하이드로-피라졸로[1,5-a]피라진-4-일아민 유도체 Download PDF

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KR102012671B1
KR102012671B1 KR1020137022392A KR20137022392A KR102012671B1 KR 102012671 B1 KR102012671 B1 KR 102012671B1 KR 1020137022392 A KR1020137022392 A KR 1020137022392A KR 20137022392 A KR20137022392 A KR 20137022392A KR 102012671 B1 KR102012671 B1 KR 102012671B1
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dementia
alkyl
compound
mixture
phenyl
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KR20140010052A (ko
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안드레스 아벨리노 트라반코-수아레즈
헨리쿠스 야코부스 마리아 기즈센
굴 미치엘 룩 마리아 반
라미로 후안 안토니오 베가
프란치스카 델가도-히메네스
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얀센 파마슈티카 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020137022392A 2011-03-01 2012-02-29 베타-세크레타제(BACE)의 억제제로서 유용한 6,7-디하이드로-피라졸로[1,5-a]피라진-4-일아민 유도체 Expired - Fee Related KR102012671B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11156463 2011-03-01
EP11156463.9 2011-03-01
PCT/EP2012/053455 WO2012117027A1 (en) 2011-03-01 2012-02-29 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of beta-secretase (bace)

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KR20140010052A KR20140010052A (ko) 2014-01-23
KR102012671B1 true KR102012671B1 (ko) 2019-08-21

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US (1) US9346811B2 (enExample)
EP (1) EP2681219B1 (enExample)
JP (1) JP5853033B2 (enExample)
KR (1) KR102012671B1 (enExample)
CN (1) CN103415519B (enExample)
AU (1) AU2012222394B2 (enExample)
BR (1) BR112013022039A2 (enExample)
CA (1) CA2824360C (enExample)
CL (1) CL2013002486A1 (enExample)
CO (1) CO6751282A2 (enExample)
CY (1) CY1117663T1 (enExample)
DK (1) DK2681219T3 (enExample)
EA (1) EA022649B1 (enExample)
ES (1) ES2558779T3 (enExample)
HR (1) HRP20160030T1 (enExample)
HU (1) HUE026338T2 (enExample)
IL (1) IL228158A (enExample)
MX (1) MX338333B (enExample)
MY (1) MY161407A (enExample)
PH (1) PH12013501807A1 (enExample)
PL (1) PL2681219T3 (enExample)
PT (1) PT2681219E (enExample)
SG (1) SG192963A1 (enExample)
SI (1) SI2681219T1 (enExample)
UA (1) UA109800C2 (enExample)
WO (1) WO2012117027A1 (enExample)
ZA (1) ZA201306545B (enExample)

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CN102186841A (zh) 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
KR20120104570A (ko) 2009-12-11 2012-09-21 시오노기세야쿠 가부시키가이샤 옥사진 유도체
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TWI782056B (zh) * 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
KR20210114001A (ko) 2019-01-11 2021-09-17 시오노기 앤드 컴파니, 리미티드 Mgat2 저해 활성을 갖는 다이하이드로피라졸로피라지논 유도체
CN114727974A (zh) 2019-07-30 2022-07-08 艾科尼佐治疗股份有限公司 Hdac6抑制剂及其用途
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AU2012222394A1 (en) 2013-07-25
US9346811B2 (en) 2016-05-24
UA109800C2 (xx) 2015-10-12
CL2013002486A1 (es) 2014-02-21
SI2681219T1 (sl) 2016-02-29
MX338333B (es) 2016-04-11
CY1117663T1 (el) 2017-05-17
HUE026338T2 (en) 2016-05-30
CA2824360C (en) 2020-01-14
IL228158A (en) 2016-07-31
CN103415519B (zh) 2016-03-02
HRP20160030T1 (hr) 2016-02-12
MY161407A (en) 2017-04-14
CO6751282A2 (es) 2013-09-16
EA022649B1 (ru) 2016-02-29
BR112013022039A2 (pt) 2016-11-29
CA2824360A1 (en) 2012-09-07
WO2012117027A1 (en) 2012-09-07
EP2681219B1 (en) 2015-10-28
CN103415519A (zh) 2013-11-27
EA201391251A1 (ru) 2014-01-30
ES2558779T3 (es) 2016-02-08
AU2012222394B2 (en) 2016-06-16
EP2681219A1 (en) 2014-01-08
PT2681219E (pt) 2016-02-10
NZ614551A (en) 2014-06-27
DK2681219T3 (en) 2016-01-18
JP5853033B2 (ja) 2016-02-09
ZA201306545B (en) 2015-03-25
SG192963A1 (en) 2013-09-30
PH12013501807A1 (en) 2015-09-30
JP2014506907A (ja) 2014-03-20
HK1188784A1 (zh) 2014-05-16
PL2681219T3 (pl) 2016-03-31
KR20140010052A (ko) 2014-01-23
US20140005200A1 (en) 2014-01-02
IL228158A0 (en) 2013-11-25
MX2013010040A (es) 2013-11-04

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