SG190438A1 - Histone inhibition - Google Patents

Info

Publication number

SG190438A1

SG190438A1 SG2013041579A SG2013041579A SG190438A1 SG 190438 A1 SG190438 A1 SG 190438A1 SG 2013041579 A SG2013041579 A SG 2013041579A SG 2013041579 A SG2013041579 A SG 2013041579A SG 190438 A1 SG190438 A1 SG 190438A1

Authority

SG

Singapore

Prior art keywords

sulfate

histone

group

polyanion

monosaccharide

Prior art date

2010-12-01

Links

• Espacenet
• Global Dossier
• Discuss

• 108010033040 Histones Proteins 0.000 title claims abstract description 248
• 230000005764 inhibitory process Effects 0.000 title description 5
• 229920000447 polyanionic polymer Polymers 0.000 claims abstract description 119
• 238000000034 method Methods 0.000 claims abstract description 99
• 102000006947 Histones Human genes 0.000 claims abstract description 91
• 206010040047 Sepsis Diseases 0.000 claims abstract description 73
• 238000011282 treatment Methods 0.000 claims abstract description 30
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 22
• 230000001472 cytotoxic effect Effects 0.000 claims abstract description 18
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 88
• -1 cyclic monosaccharide Chemical class 0.000 claims description 86
• 150000002772 monosaccharides Chemical class 0.000 claims description 41
• 229920001542 oligosaccharide Polymers 0.000 claims description 41
• 150000002482 oligosaccharides Chemical class 0.000 claims description 40
• 102100025409 Orofacial cleft 1 candidate gene 1 protein Human genes 0.000 claims description 31
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 27
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• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 25
• 239000008103 glucose Substances 0.000 claims description 22
• 238000009825 accumulation Methods 0.000 claims description 19
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