ES2710857T3 - Uso de polianiones para inhibir la actividad citotóxica de las histonas en el tratamiento de la sepsis - Google Patents
Uso de polianiones para inhibir la actividad citotóxica de las histonas en el tratamiento de la sepsis Download PDFInfo
- Publication number
- ES2710857T3 ES2710857T3 ES11845528T ES11845528T ES2710857T3 ES 2710857 T3 ES2710857 T3 ES 2710857T3 ES 11845528 T ES11845528 T ES 11845528T ES 11845528 T ES11845528 T ES 11845528T ES 2710857 T3 ES2710857 T3 ES 2710857T3
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- Prior art keywords
- polyanion
- monosaccharide
- histone
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- sulfate
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- 230000001472 cytotoxic effect Effects 0.000 title claims abstract description 13
- 238000011282 treatment Methods 0.000 title description 33
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- 238000000034 method Methods 0.000 claims abstract description 76
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- 230000015271 coagulation Effects 0.000 claims abstract description 17
- 238000005345 coagulation Methods 0.000 claims abstract description 17
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- 230000036961 partial effect Effects 0.000 claims abstract description 13
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 12
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- 229910052720 vanadium Inorganic materials 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41882610P | 2010-12-01 | 2010-12-01 | |
| PCT/AU2011/001550 WO2012071611A1 (en) | 2010-12-01 | 2011-11-29 | Histone inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2710857T3 true ES2710857T3 (es) | 2019-04-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES11845528T Active ES2710857T3 (es) | 2010-12-01 | 2011-11-29 | Uso de polianiones para inhibir la actividad citotóxica de las histonas en el tratamiento de la sepsis |
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| US (1) | US9226939B2 (enExample) |
| EP (1) | EP2646037B1 (enExample) |
| JP (2) | JP2014501730A (enExample) |
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| CN (1) | CN103402526B (enExample) |
| AU (1) | AU2011335881B2 (enExample) |
| BR (1) | BR112013013544B1 (enExample) |
| CA (1) | CA2819642C (enExample) |
| DK (1) | DK2646037T3 (enExample) |
| ES (1) | ES2710857T3 (enExample) |
| HU (1) | HUE043546T2 (enExample) |
| IL (1) | IL226667A (enExample) |
| NZ (1) | NZ611316A (enExample) |
| SG (1) | SG190438A1 (enExample) |
| WO (1) | WO2012071611A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP3105593B2 (ja) | 1991-10-18 | 2000-11-06 | 東海パルプ株式会社 | パルパー制御装置 |
| CN110446511B (zh) | 2017-03-10 | 2024-04-02 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| US11993627B2 (en) | 2017-07-03 | 2024-05-28 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides |
| EP3691653B1 (en) | 2017-11-03 | 2025-03-12 | The University Of North Carolina At Chapel Hill | Sulfated oligosaccharides having anti-inflammatory activity |
| CN117427084A (zh) | 2017-12-15 | 2024-01-23 | 澳大利亚国立大学 | 用于治疗和预防细胞外组蛋白介导的病理的化合物 |
| EP3810152A4 (en) * | 2018-06-20 | 2022-04-27 | The University of North Carolina at Chapel Hill | CELL PROTECTION METHODS AND COMPOSITIONS |
| WO2020033824A1 (en) * | 2018-08-09 | 2020-02-13 | University Of Vermont And State Agricultural College | Inhibitors of acute severe inflammatory conditions |
| CN113473992A (zh) * | 2019-02-25 | 2021-10-01 | 澳大利亚国立大学 | 用于治疗和预防中性粒细胞胞外陷阱相关并发症的化合物 |
| WO2022116981A1 (zh) * | 2020-12-01 | 2022-06-09 | 远大医药（中国）有限公司 | 一种聚阴离子纤维二糖苷类化合物的应用 |
Family Cites Families (18)
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| US4847338A (en) | 1985-03-28 | 1989-07-11 | University Of Iowa Research Foundation | Low molecular weight heparin fragments as inhibitors of complement activation |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| US5583121A (en) | 1994-01-12 | 1996-12-10 | Michigan State University | Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes |
| US5792241A (en) | 1994-09-21 | 1998-08-11 | Allrad No. 28 Pty Ltd. | Precipitator |
| AUPN261895A0 (en) * | 1995-04-28 | 1995-05-18 | Australian National University, The | Preparation and use of sulfated oligosaccharides |
| WO1999004826A1 (en) | 1997-07-24 | 1999-02-04 | The Australian National University | Method for detection of fibrin clots |
| ITMI20021294A1 (it) | 2002-06-12 | 2003-12-12 | Inalco Spa | Polisaccaridi batterici o-solfatati e loro uso |
| US20050282775A1 (en) * | 2004-06-16 | 2005-12-22 | Paringenix, Inc. | Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome |
| US7468358B2 (en) * | 2004-06-16 | 2008-12-23 | Paringenix, Inc. | Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome |
| US20060229276A1 (en) | 2004-07-28 | 2006-10-12 | Magnus Hook | Use of glycosoaminoglycans for the prevention and treatment of sepsis |
| PT1877105E (pt) | 2005-04-29 | 2013-11-11 | Univ Australian | Método para formar uma composição radioativa injetável de partículas radioativas encapsuladas em carbono |
| EP1747785A1 (en) | 2005-07-28 | 2007-01-31 | Istituto Clinico Humanitas | Cyclodextrins for blood detoxification |
| WO2007062403A2 (en) | 2005-11-28 | 2007-05-31 | Vernon D Rowe | Compositions useful for reducing nephrotoxicity and methods of use thereof |
| WO2007095688A1 (en) * | 2006-02-23 | 2007-08-30 | The Australian National University | Methods for increasing the number of circulating cells |
| GB2450087A (en) * | 2007-06-11 | 2008-12-17 | Diosamine Dev Corp | Use of sulphated saccharides in the treatment of inflammatory and/or auto-immune diseases |
| US8716218B2 (en) * | 2007-11-06 | 2014-05-06 | Oklahoma Medical Research Foundation | Extracellular histones as biomarkers for prognosis and molecular targets for therapy |
| EP2282782B1 (en) | 2008-04-24 | 2018-01-24 | The Australian National University | Methods for radiolabelling macromolecules |
| JP2011256111A (ja) * | 2008-10-03 | 2011-12-22 | Hayashibara Biochem Lab Inc | 敗血症の予防及び治療剤 |
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- 2011-11-29 JP JP2013541148A patent/JP2014501730A/ja active Pending
- 2011-11-29 ES ES11845528T patent/ES2710857T3/es active Active
- 2011-11-29 HU HUE11845528A patent/HUE043546T2/hu unknown
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- 2011-11-29 WO PCT/AU2011/001550 patent/WO2012071611A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2012071611A1 (en) | 2012-06-07 |
| US20130338097A1 (en) | 2013-12-19 |
| JP2016193917A (ja) | 2016-11-17 |
| BR112013013544A2 (pt) | 2016-10-11 |
| BR112013013544B1 (pt) | 2020-09-29 |
| US9226939B2 (en) | 2016-01-05 |
| JP6142039B2 (ja) | 2017-06-07 |
| EP2646037B1 (en) | 2019-01-09 |
| AU2011335881B2 (en) | 2016-07-14 |
| AU2011335881A1 (en) | 2013-06-20 |
| DK2646037T3 (en) | 2019-03-04 |
| EP2646037A1 (en) | 2013-10-09 |
| CN103402526B (zh) | 2016-01-20 |
| CN103402526A (zh) | 2013-11-20 |
| SG190438A1 (en) | 2013-07-31 |
| IL226667A (en) | 2017-02-28 |
| HUE043546T2 (hu) | 2019-08-28 |
| EP2646037A4 (en) | 2015-03-18 |
| JP2014501730A (ja) | 2014-01-23 |
| KR101956335B1 (ko) | 2019-03-08 |
| NZ611316A (en) | 2014-12-24 |
| CA2819642A1 (en) | 2012-06-07 |
| CA2819642C (en) | 2019-07-16 |
| KR20130121877A (ko) | 2013-11-06 |
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