HUE043546T2 - Polianionok alkalmazása hisztonok citotoxikus aktivitásának gátlására szepszis kezelésében - Google Patents

Polianionok alkalmazása hisztonok citotoxikus aktivitásának gátlására szepszis kezelésében

Info

Publication number
HUE043546T2
HUE043546T2 HUE11845528A HUE11845528A HUE043546T2 HU E043546 T2 HUE043546 T2 HU E043546T2 HU E11845528 A HUE11845528 A HU E11845528A HU E11845528 A HUE11845528 A HU E11845528A HU E043546 T2 HUE043546 T2 HU E043546T2
Authority
HU
Hungary
Prior art keywords
polyanions
histones
sepsis
inhibit
treatment
Prior art date
Application number
HUE11845528A
Other languages
English (en)
Hungarian (hu)
Inventor
Ross Stephens
Christopher Parish
Craig Freeman
Timothy Senden
Original Assignee
Univ Australian National
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Australian National filed Critical Univ Australian National
Publication of HUE043546T2 publication Critical patent/HUE043546T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HUE11845528A 2010-12-01 2011-11-29 Polianionok alkalmazása hisztonok citotoxikus aktivitásának gátlására szepszis kezelésében HUE043546T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41882610P 2010-12-01 2010-12-01

Publications (1)

Publication Number Publication Date
HUE043546T2 true HUE043546T2 (hu) 2019-08-28

Family

ID=46171086

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE11845528A HUE043546T2 (hu) 2010-12-01 2011-11-29 Polianionok alkalmazása hisztonok citotoxikus aktivitásának gátlására szepszis kezelésében

Country Status (15)

Country Link
US (1) US9226939B2 (enExample)
EP (1) EP2646037B1 (enExample)
JP (2) JP2014501730A (enExample)
KR (1) KR101956335B1 (enExample)
CN (1) CN103402526B (enExample)
AU (1) AU2011335881B2 (enExample)
BR (1) BR112013013544B1 (enExample)
CA (1) CA2819642C (enExample)
DK (1) DK2646037T3 (enExample)
ES (1) ES2710857T3 (enExample)
HU (1) HUE043546T2 (enExample)
IL (1) IL226667A (enExample)
NZ (1) NZ611316A (enExample)
SG (1) SG190438A1 (enExample)
WO (1) WO2012071611A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3105593B2 (ja) 1991-10-18 2000-11-06 東海パルプ株式会社 パルパー制御装置
CN110446511B (zh) 2017-03-10 2024-04-02 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
EP3691653B1 (en) 2017-11-03 2025-03-12 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
CN117427084A (zh) 2017-12-15 2024-01-23 澳大利亚国立大学 用于治疗和预防细胞外组蛋白介导的病理的化合物
EP3810152A4 (en) * 2018-06-20 2022-04-27 The University of North Carolina at Chapel Hill CELL PROTECTION METHODS AND COMPOSITIONS
WO2020033824A1 (en) * 2018-08-09 2020-02-13 University Of Vermont And State Agricultural College Inhibitors of acute severe inflammatory conditions
CN113473992A (zh) * 2019-02-25 2021-10-01 澳大利亚国立大学 用于治疗和预防中性粒细胞胞外陷阱相关并发症的化合物
WO2022116981A1 (zh) * 2020-12-01 2022-06-09 远大医药（中国）有限公司 一种聚阴离子纤维二糖苷类化合物的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847338A (en) 1985-03-28 1989-07-11 University Of Iowa Research Foundation Low molecular weight heparin fragments as inhibitors of complement activation
DK505488D0 (da) * 1987-12-21 1988-09-09 Bar Shalom Daniel Middel og anvendelse af samme
US5583121A (en) 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US5792241A (en) 1994-09-21 1998-08-11 Allrad No. 28 Pty Ltd. Precipitator
AUPN261895A0 (en) * 1995-04-28 1995-05-18 Australian National University, The Preparation and use of sulfated oligosaccharides
WO1999004826A1 (en) 1997-07-24 1999-02-04 The Australian National University Method for detection of fibrin clots
ITMI20021294A1 (it) 2002-06-12 2003-12-12 Inalco Spa Polisaccaridi batterici o-solfatati e loro uso
US20050282775A1 (en) * 2004-06-16 2005-12-22 Paringenix, Inc. Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome
US7468358B2 (en) * 2004-06-16 2008-12-23 Paringenix, Inc. Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome
US20060229276A1 (en) 2004-07-28 2006-10-12 Magnus Hook Use of glycosoaminoglycans for the prevention and treatment of sepsis
PT1877105E (pt) 2005-04-29 2013-11-11 Univ Australian Método para formar uma composição radioativa injetável de partículas radioativas encapsuladas em carbono
EP1747785A1 (en) 2005-07-28 2007-01-31 Istituto Clinico Humanitas Cyclodextrins for blood detoxification
WO2007062403A2 (en) 2005-11-28 2007-05-31 Vernon D Rowe Compositions useful for reducing nephrotoxicity and methods of use thereof
WO2007095688A1 (en) * 2006-02-23 2007-08-30 The Australian National University Methods for increasing the number of circulating cells
GB2450087A (en) * 2007-06-11 2008-12-17 Diosamine Dev Corp Use of sulphated saccharides in the treatment of inflammatory and/or auto-immune diseases
US8716218B2 (en) * 2007-11-06 2014-05-06 Oklahoma Medical Research Foundation Extracellular histones as biomarkers for prognosis and molecular targets for therapy
EP2282782B1 (en) 2008-04-24 2018-01-24 The Australian National University Methods for radiolabelling macromolecules
JP2011256111A (ja) * 2008-10-03 2011-12-22 Hayashibara Biochem Lab Inc 敗血症の予防及び治療剤

Also Published As

Publication number Publication date
WO2012071611A1 (en) 2012-06-07
US20130338097A1 (en) 2013-12-19
JP2016193917A (ja) 2016-11-17
BR112013013544A2 (pt) 2016-10-11
BR112013013544B1 (pt) 2020-09-29
US9226939B2 (en) 2016-01-05
JP6142039B2 (ja) 2017-06-07
ES2710857T3 (es) 2019-04-29
EP2646037B1 (en) 2019-01-09
AU2011335881B2 (en) 2016-07-14
AU2011335881A1 (en) 2013-06-20
DK2646037T3 (en) 2019-03-04
EP2646037A1 (en) 2013-10-09
CN103402526B (zh) 2016-01-20
CN103402526A (zh) 2013-11-20
SG190438A1 (en) 2013-07-31
IL226667A (en) 2017-02-28
EP2646037A4 (en) 2015-03-18
JP2014501730A (ja) 2014-01-23
KR101956335B1 (ko) 2019-03-08
NZ611316A (en) 2014-12-24
CA2819642A1 (en) 2012-06-07
CA2819642C (en) 2019-07-16
KR20130121877A (ko) 2013-11-06

Similar Documents

Publication Publication Date Title
HUE043546T2 (hu) Polianionok alkalmazása hisztonok citotoxikus aktivitásának gátlására szepszis kezelésében
IL254191B (en) Selective reduction of allelic variants
ZA201302979B (en) Dianosis and treatment relating to th2 inhibition
ZA201304638B (en) Composition for use in the prevention and /or treatment of skin condition and skin diseases.
ZA201209484B (en) Skin antiaging treatment
IL221271A0 (en) Selective reduction of allelic variants
IL219613A (en) For oral administration, for use in the treatment of dry mouth
GB201004137D0 (en) Phytocannabinoids in the treatment of cancer
ZA201208413B (en) Skin treatment composition
ZA201208646B (en) Pharmaceutical combination for the treatment of pain
EP2612676A4 (en) USE OF A G-CSF DIMER IN THE TREATMENT OF NEUTROPENIA
EP2521569A4 (en) COMBINATION THERAPY WITH VB-201
SMT201900527T1 (it) Nucleotide dims0-150 per l’uso nel trattamento della colite ulcerosa attiva cronica
EP2744478A4 (en) ACTIVE COSMETIC PRINCIPLES OF MARINE ORIGIN AND THEIR USE
PT2560662T (pt) Sulodexide para a utilização no tratamento de patologias nas quais as metaloproteínases estão envolvidas
LT2460509T (lt) Kompozicija, skirta karpų gydymui
ZA201405712B (en) Use of nitrogen compounds in the pickling of stainless steel
GB201218050D0 (en) Inhibitors of glucose metabolism for use in the treatment of birt-hogg-dube syndrome
PL2699545T3 (pl) Nowe pochodne aminopirolinowe, ich zastosowanie w zapobieganiu i/lub leczeniu zespołu metabolicznego
IL223219A0 (en) Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies
SI2702033T1 (sl) Uporaba soli 3-karboksi-n-etil-n,n-dimteilpropan-1-amina pri zdravljenju bolezni srca in ožilja
GB201019999D0 (en) Improvements in or relating to the retention of bearings
SG11201400742PA (en) Composition to be applied to the skin, and use thereof
PL2456445T3 (pl) Środek do leczenia chorób skóry
IL219444A (en) Procine for use in the treatment of blood cell infections