SG129448A1 - Preparation of 1,3-diphenylprop-2-en-1-one derivatives - Google Patents
Preparation of 1,3-diphenylprop-2-en-1-one derivativesInfo
- Publication number
- SG129448A1 SG129448A1 SG200700644A SG200700644A SG129448A1 SG 129448 A1 SG129448 A1 SG 129448A1 SG 200700644 A SG200700644 A SG 200700644A SG 200700644 A SG200700644 A SG 200700644A SG 129448 A1 SG129448 A1 SG 129448A1
- Authority
- SG
- Singapore
- Prior art keywords
- diphenylprop
- preparation
- derivatives
- group
- substituted
- Prior art date
Links
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical class C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0308354A FR2857361B1 (fr) | 2003-07-08 | 2003-07-08 | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG129448A1 true SG129448A1 (en) | 2007-02-26 |
Family
ID=33522868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200700644A SG129448A1 (en) | 2003-07-08 | 2004-07-08 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7385082B2 (no) |
| EP (1) | EP1644312B1 (no) |
| JP (1) | JP2007516189A (no) |
| KR (1) | KR20060030110A (no) |
| CN (1) | CN1819986B (no) |
| AT (1) | ATE468317T1 (no) |
| AU (1) | AU2004255905B2 (no) |
| BR (1) | BRPI0412370A (no) |
| CA (1) | CA2531443C (no) |
| DE (1) | DE602004027251D1 (no) |
| DK (1) | DK1644312T3 (no) |
| EA (1) | EA010410B1 (no) |
| ES (1) | ES2343803T3 (no) |
| FR (1) | FR2857361B1 (no) |
| IL (1) | IL172825A (no) |
| MX (1) | MXPA06000159A (no) |
| NO (1) | NO332411B1 (no) |
| NZ (1) | NZ544792A (no) |
| PL (1) | PL213226B1 (no) |
| SG (1) | SG129448A1 (no) |
| WO (1) | WO2005005369A1 (no) |
| ZA (1) | ZA200601040B (no) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| FR2841900B1 (fr) * | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| CA2781451C (en) | 2009-11-26 | 2019-04-16 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
| DK2571843T3 (da) | 2010-05-17 | 2018-01-29 | Genfit | Forbedret fremstilling af chalcon-derivater |
| ES2702038T3 (es) * | 2013-01-18 | 2019-02-27 | Genfit | Métodos de tratamiento de fibrosis y cánceres |
| WO2017143038A1 (en) | 2016-02-16 | 2017-08-24 | Concert Pharmaceuticals, Inc. | Deuterated gft-505 |
| CN106674069B (zh) * | 2016-12-06 | 2018-05-11 | 上海博志研新药物技术有限公司 | Gft505及其中间体的制备方法 |
| JP2020505355A (ja) * | 2017-01-22 | 2020-02-20 | クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド | Ｇｆｔ−５０５の結晶形及びその製造方法並びに用途 |
| MX2019009908A (es) | 2017-02-21 | 2019-10-14 | Genfit | Combinacion de un agonista de ppar con un agonista de fxr. |
| BR112020002261A2 (pt) | 2017-08-04 | 2020-07-28 | Advitech Advisory And Technologies Sa | processo para a preparação de elafibranor, composto e uso de pelo menos um composto |
| EP3710425A1 (en) | 2017-11-16 | 2020-09-23 | Teva Pharmaceuticals International GmbH | Solid state forms of elafibranor |
| CN109608318A (zh) * | 2019-01-31 | 2019-04-12 | 上海生农生化制品股份有限公司 | 一种戊唑醇中间体α的工业合成方法 |
| CN110156648A (zh) * | 2019-05-30 | 2019-08-23 | 河北科技大学 | 一种Elafibranor中间体的制备方法 |
| CN110143902B (zh) * | 2019-06-12 | 2021-06-04 | 天津科技大学 | 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用 |
| CN110143890B (zh) * | 2019-06-12 | 2020-12-22 | 天津科技大学 | 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用 |
| WO2021059023A1 (en) | 2019-09-26 | 2021-04-01 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| CN113121394B (zh) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | 一种苯氧乙酸类衍生物的制备方法 |
| TW202207911A (zh) | 2020-05-18 | 2022-03-01 | 法商Ｇｅｎｆｉｔ公司 | 治療原發性硬化性膽管炎之方法 |
| BR112023003317A2 (pt) | 2020-08-26 | 2023-03-21 | Genfit | Composições e métodos para o tratamento da colangite biliar primária |
| WO2022189856A1 (en) | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| WO2022238450A1 (en) | 2021-05-11 | 2022-11-17 | Genfit | Ppar-agonists for use in the treatment of liver failure |
| EP4337185A1 (en) | 2021-05-11 | 2024-03-20 | Genfit | Elafibranor derivatives agonists of ppar for use in the treatment of sepsis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2359621C2 (de) * | 1973-11-30 | 1982-11-18 | Hoechst Ag, 6000 Frankfurt | Antiviral wirksame Alkalimetall- oder Ammoniumsalze der Polyacrylsäure |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| JPH023670A (ja) * | 1988-06-22 | 1990-01-09 | Nippon Oil & Fats Co Ltd | アルキルチオカルコン誘導体 |
| JPH05255655A (ja) * | 1992-03-12 | 1993-10-05 | Kanebo Ltd | 紫外線吸収剤 |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| EP0947511A1 (en) * | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
| JPH11302243A (ja) * | 1998-04-24 | 1999-11-02 | Mitsubishi Chemical Corp | ジエチレントリアミン５酢酸誘導体 |
-
2003
- 2003-07-08 FR FR0308354A patent/FR2857361B1/fr not_active Expired - Fee Related
-
2004
- 2004-07-08 WO PCT/FR2004/001797 patent/WO2005005369A1/fr active Application Filing
- 2004-07-08 CN CN2004800195644A patent/CN1819986B/zh active Active
- 2004-07-08 SG SG200700644A patent/SG129448A1/en unknown
- 2004-07-08 DK DK04767629.1T patent/DK1644312T3/da active
- 2004-07-08 AU AU2004255905A patent/AU2004255905B2/en not_active Ceased
- 2004-07-08 PL PL379543A patent/PL213226B1/pl unknown
- 2004-07-08 DE DE602004027251T patent/DE602004027251D1/de active Active
- 2004-07-08 EA EA200600197A patent/EA010410B1/ru not_active IP Right Cessation
- 2004-07-08 MX MXPA06000159A patent/MXPA06000159A/es active IP Right Grant
- 2004-07-08 AT AT04767629T patent/ATE468317T1/de active
- 2004-07-08 US US10/563,057 patent/US7385082B2/en active Active
- 2004-07-08 BR BRPI0412370-0A patent/BRPI0412370A/pt not_active Application Discontinuation
- 2004-07-08 KR KR1020067000562A patent/KR20060030110A/ko not_active Application Discontinuation
- 2004-07-08 ES ES04767629T patent/ES2343803T3/es active Active
- 2004-07-08 EP EP04767629A patent/EP1644312B1/fr active Active
- 2004-07-08 JP JP2006518300A patent/JP2007516189A/ja active Pending
- 2004-07-08 NZ NZ544792A patent/NZ544792A/en not_active IP Right Cessation
- 2004-07-08 CA CA2531443A patent/CA2531443C/fr not_active Expired - Fee Related
-
2005
- 2005-12-26 IL IL172825A patent/IL172825A/en unknown
-
2006
- 2006-01-06 NO NO20060087A patent/NO332411B1/no not_active IP Right Cessation
- 2006-02-06 ZA ZA200601040A patent/ZA200601040B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7385082B2 (en) | 2008-06-10 |
| DE602004027251D1 (de) | 2010-07-01 |
| US20060142611A1 (en) | 2006-06-29 |
| EP1644312A1 (fr) | 2006-04-12 |
| NZ544792A (en) | 2009-02-28 |
| CN1819986B (zh) | 2011-02-02 |
| CA2531443A1 (fr) | 2005-01-20 |
| JP2007516189A (ja) | 2007-06-21 |
| IL172825A (en) | 2010-11-30 |
| PL213226B1 (pl) | 2013-01-31 |
| DK1644312T3 (da) | 2010-08-23 |
| FR2857361B1 (fr) | 2005-09-09 |
| NO20060087L (no) | 2006-02-07 |
| ATE468317T1 (de) | 2010-06-15 |
| BRPI0412370A (pt) | 2006-09-05 |
| KR20060030110A (ko) | 2006-04-07 |
| AU2004255905A1 (en) | 2005-01-20 |
| EP1644312B1 (fr) | 2010-05-19 |
| PL379543A1 (pl) | 2006-10-02 |
| NO332411B1 (no) | 2012-09-17 |
| FR2857361A1 (fr) | 2005-01-14 |
| ZA200601040B (en) | 2007-05-30 |
| IL172825A0 (en) | 2006-06-11 |
| CN1819986A (zh) | 2006-08-16 |
| AU2004255905B2 (en) | 2010-11-18 |
| WO2005005369A1 (fr) | 2005-01-20 |
| MXPA06000159A (es) | 2006-03-21 |
| ES2343803T3 (es) | 2010-08-10 |
| CA2531443C (fr) | 2012-05-01 |
| EA200600197A1 (ru) | 2006-06-30 |
| EA010410B1 (ru) | 2008-08-29 |
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