SG11202106603UA - Biologically active cluster of molecules - Google Patents

Biologically active cluster of molecules

Info

Publication number
SG11202106603UA
SG11202106603UA SG11202106603UA SG11202106603UA SG11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA
Authority
SG
Singapore
Prior art keywords
molecules
biologically active
active cluster
cluster
biologically
Prior art date
Application number
SG11202106603UA
Other languages
English (en)
Inventor
Ruben Postel
Hendrik Fuchs
Original Assignee
Sapreme Tech Bv
Univ Berlin Charite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapreme Tech Bv, Univ Berlin Charite filed Critical Sapreme Tech Bv
Publication of SG11202106603UA publication Critical patent/SG11202106603UA/en

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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3475424A1 (en) 2016-06-22 2019-05-01 ProQR Therapeutics II B.V. Single-stranded rna-editing oligonucleotides
EP3618867A4 (en) 2017-05-02 2021-01-20 Cornell University METHODS AND REAGENTS FOR AGAINST TUMOR WITH HIGHER EFFICIENCY AND LOWER TOXICITY
CA3124151A1 (en) * 2018-12-21 2020-06-25 Sapreme Technologies B.V. Saponin conjugates
EP4003427A1 (en) * 2019-07-25 2022-06-01 Sapreme Technologies B.V. Saponin derivatives with improved therapeutic window
CN113527498B (zh) * 2020-04-16 2022-03-04 上海洛启生物医药技术有限公司 抗Trop2纳米抗体及其应用
KR20230043110A (ko) * 2020-06-24 2023-03-30 사프렘 테크놀로지스 비.브이. Vhh를 포함하는 adc 또는 aoc, 및 사포닌 또는 리간드-사포닌 접합체를 포함하는 조합물
US20230365617A1 (en) * 2020-06-24 2023-11-16 Sapreme Technologies B.V. Saponin derivatives for use in medicine
WO2021261998A1 (en) * 2020-06-24 2021-12-30 Sapreme Technologies B.V. Therapeutic combination of galnac-oligonucleotide conjugate and saponin, and uses thereof
EP4171642A1 (en) * 2020-06-24 2023-05-03 Sapreme Technologies B.V. Combination of an antibody-drug conjugate and an antibody-saponin conjugate
EP4171645A2 (en) * 2020-06-24 2023-05-03 Sapreme Technologies B.V. Hydrazone-based saponin derivatives
WO2021261992A1 (en) * 2020-06-24 2021-12-30 Sapreme Technologies B.V. Conjugate of galnac and saponin, therapeutic composition comprising said conjugate and a galnac-oligonucleotide conjugate
WO2022055352A1 (en) * 2020-09-10 2022-03-17 Sapreme Technologies B.V. Semicarbazone-based saponin conjugate
WO2022055351A1 (en) * 2020-09-10 2022-03-17 Sapreme Technologies B.V. Conjugate of saponin, oligonucleotide and galnac
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
EP4222167A1 (en) 2020-09-30 2023-08-09 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
WO2022164316A1 (en) 2021-01-26 2022-08-04 Sapreme Technologies B.V. Semicarbazone-based saponin conjugate
EP4355369A1 (en) * 2021-06-18 2024-04-24 Sapreme Technologies B.V. Conjugate of saponin, oligonucleotide and galnac
WO2023038517A1 (en) 2021-09-09 2023-03-16 Sapreme Technologies B.V. Semicarbazone-based saponin conjugate
WO2023121446A1 (en) 2021-12-22 2023-06-29 Sapreme Technologies B.V. Targeted saponin-nucleic acid conjugates for treatment of muscle wasting disorders
WO2023121445A1 (en) 2021-12-22 2023-06-29 Sapreme Technologies B.V. Compositions comprising therapeutic nucleic acid and saponin for the treatment of muscle-wasting disorders
WO2023121447A1 (en) * 2021-12-22 2023-06-29 Sapreme Technologies B.V. Conjugate of a single domain antibody, a saponin and an effector molecule, pharmaceutical composition comprising the same, therapeutic use of said pharmaceutical composition
WO2023121444A1 (en) 2021-12-22 2023-06-29 Sapreme Technologies B.V. Compositions comprising therapeutic nucleic acid and targeted saponin for the treatment of muscle-wasting disorders
KR20240001074A (ko) * 2022-06-24 2024-01-03 주식회사 피노바이오 하나의 항체에 2종의 약물-링커 접합체가 연결된 항체-약물접합체
WO2024013361A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Oligonucleotides for adar-mediated rna editing and use thereof
WO2024013360A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Chemically modified oligonucleotides for adar-mediated rna editing
EP4331609A1 (en) * 2022-09-01 2024-03-06 Sapreme Technologies B.V. Methods and compositions for enhanced polyplex delivery
WO2024046622A1 (en) * 2022-09-01 2024-03-07 Sapreme Technologies B.V. Compositions of polyplexes and saponins
EP4331610A1 (en) * 2022-09-01 2024-03-06 Sapreme Technologies B.V. Polyplex-saponin covalent conjugate

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583112A (en) * 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
US5591829A (en) * 1987-05-29 1997-01-07 Matsushita; Shuzo Antibodies modified with toxic substance
US5856571A (en) * 1995-06-07 1999-01-05 Cellpro, Incorporated Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto
CA2290646C (en) * 1997-05-20 2008-03-11 Galenica Pharmaceuticals, Inc. Triterpene saponin analogs having adjuvant and immunostimulatory activity
WO2000009075A2 (en) * 1998-08-14 2000-02-24 Galenica Pharmaceuticals, Inc. Chemically modified saponins and the use thereof as adjuvants
WO2003069997A1 (en) * 2002-02-04 2003-08-28 Corixa Corporation Immunostimulant compositions comprising aminoalkyl glucosaminide phosphates and saponins
CA2522213A1 (en) * 2003-04-08 2004-10-28 Dante J. Marciani Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines
ES2395818T3 (es) * 2004-07-13 2013-02-15 Charite - Universitatsmedizin Berlin Composición que comprende un agente farmacológicamente activo acoplado a un componente específico de célula diana, y una saponina
JP2008510829A (ja) * 2004-08-25 2008-04-10 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン デンドリマーに基づく組成物およびそれらの使用法
AU2006317242A1 (en) 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
ES2630205T3 (es) * 2006-11-20 2017-08-18 Duecom Uso de partículas que contengan lípidos que comprenden saponínas quillaja para el tratamiento del cáncer
US20080311040A1 (en) * 2007-03-06 2008-12-18 Flagship Ventures METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA
EP2282752A4 (en) * 2008-03-26 2011-06-15 Ca Nat Research Council SAPONIN EXTRACT FROM SAPONARIA SPP AND USES THEREOF
ES2710463T3 (es) * 2008-04-11 2019-04-25 Cedars Sinai Medical Center Acido poli(beta málico) con tripéptido colgante Leu-Leu-Leu para la administración eficaz del fármaco citoplasmático
WO2011054811A1 (en) * 2009-11-03 2011-05-12 Santaris Pharma A/S Rna antagonists targeting hsp27 combination therapy
CN103079587B (zh) * 2010-05-13 2016-05-11 印第安纳大学研究及科技有限公司 呈现核激素受体活性的胰高血糖素超家族肽
US9125835B2 (en) * 2010-11-12 2015-09-08 Rutgers, The State University Of New Jersey Synergistic combinations to reduce particle dose for targeted treatment of cancer and its metastases
CN102652836A (zh) * 2011-03-03 2012-09-05 华中科技大学同济医学院附属协和医院 靶向释药的抗癌蛋白质或多肽聚合物前药及其制备方法
US20150023989A1 (en) * 2011-12-14 2015-01-22 Seattle Genetics, Inc. New antibody drug conjugates (adcs) and the use thereof
JP6408478B2 (ja) * 2012-11-26 2018-10-17 プレジデント アンド フェローズ オブ ハーバード カレッジ トリオキサカルシン、トリオキサカルシン−抗体複合体、およびその用途
US9907846B2 (en) * 2013-04-01 2018-03-06 Mx Adjuvac Ab Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions
GB201400994D0 (en) * 2014-01-21 2014-03-05 Ucl Business Plc Drug delivery system
TW201617368A (zh) * 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗mfi2抗體及使用方法
CN106892957B (zh) * 2015-12-17 2018-11-16 广州中医药大学 一种齐墩果烷型三萜皂苷类化合物及其制备方法和应用
EP3469000A1 (en) * 2016-06-08 2019-04-17 AbbVie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
CA3124151A1 (en) * 2018-12-21 2020-06-25 Sapreme Technologies B.V. Saponin conjugates
WO2022055352A1 (en) * 2020-09-10 2022-03-17 Sapreme Technologies B.V. Semicarbazone-based saponin conjugate

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