SG11202011879RA - Ion channel modulators - Google Patents

Ion channel modulators

Info

Publication number
SG11202011879RA
SG11202011879RA SG11202011879RA SG11202011879RA SG11202011879RA SG 11202011879R A SG11202011879R A SG 11202011879RA SG 11202011879R A SG11202011879R A SG 11202011879RA SG 11202011879R A SG11202011879R A SG 11202011879RA SG 11202011879R A SG11202011879R A SG 11202011879RA
Authority
SG
Singapore
Prior art keywords
ion channel
channel modulators
modulators
ion
channel
Prior art date
Application number
SG11202011879RA
Other languages
English (en)
Inventor
Andrew Griffin
Brian Marron
Botella Gabriel Martinez
Kiran Reddy
Marion Wittmann
Original Assignee
Praxis Prec Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Prec Medicines Inc filed Critical Praxis Prec Medicines Inc
Publication of SG11202011879RA publication Critical patent/SG11202011879RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11202011879RA 2018-05-30 2019-05-30 Ion channel modulators SG11202011879RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862677903P 2018-05-30 2018-05-30
US201862738508P 2018-09-28 2018-09-28
PCT/US2019/034653 WO2019232209A1 (en) 2018-05-30 2019-05-30 Ion channel modulators

Publications (1)

Publication Number Publication Date
SG11202011879RA true SG11202011879RA (en) 2020-12-30

Family

ID=68696775

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011879RA SG11202011879RA (en) 2018-05-30 2019-05-30 Ion channel modulators

Country Status (13)

Country Link
US (5) US11866439B2 (zh)
EP (1) EP3801535A4 (zh)
JP (3) JP7359847B2 (zh)
KR (1) KR20210024500A (zh)
CN (2) CN112423760A (zh)
AU (1) AU2019278814A1 (zh)
BR (1) BR112020024379A2 (zh)
CA (1) CA3101324A1 (zh)
IL (2) IL309843A (zh)
MX (2) MX2020012838A (zh)
SG (1) SG11202011879RA (zh)
TW (1) TWI831786B (zh)
WO (1) WO2019232209A1 (zh)

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US11767325B2 (en) 2019-11-26 2023-09-26 Praxis Precision Medicines, Inc. Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
JP2023503343A (ja) * 2019-11-26 2023-01-27 プラクシス プレシジョン メディシンズ， インコーポレイテッド イオンチャネルモジュレーター
CN115038442A (zh) 2019-11-27 2022-09-09 普拉西斯精密医药公司 离子通道调节剂的调配物及制备和使用离子通道调节剂的方法
WO2023211859A1 (en) * 2022-04-26 2023-11-02 Praxis Precision Medicines, Inc. Treatment of neurological disorders
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Also Published As

Publication number Publication date
US20240132501A1 (en) 2024-04-25
TWI831786B (zh) 2024-02-11
US11731978B2 (en) 2023-08-22
US11014931B2 (en) 2021-05-25
JP2021525800A (ja) 2021-09-27
WO2019232209A1 (en) 2019-12-05
CN117756800A (zh) 2024-03-26
JP2024071530A (ja) 2024-05-24
TW202012403A (zh) 2020-04-01
MX2024000150A (es) 2024-01-23
IL309843A (en) 2024-02-01
JP7359847B2 (ja) 2023-10-11
US20220024930A1 (en) 2022-01-27
IL279064A (en) 2021-01-31
EP3801535A4 (en) 2022-03-02
US11731976B2 (en) 2023-08-22
JP2023144130A (ja) 2023-10-06
KR20210024500A (ko) 2021-03-05
US11866439B2 (en) 2024-01-09
MX2020012838A (es) 2021-07-16
US20220220118A1 (en) 2022-07-14
US20210163488A1 (en) 2021-06-03
AU2019278814A1 (en) 2020-12-17
BR112020024379A2 (pt) 2021-03-02
CA3101324A1 (en) 2019-12-05
CN112423760A (zh) 2021-02-26
EP3801535A1 (en) 2021-04-14
US20210087197A1 (en) 2021-03-25

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