SG11202010319RA - Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy - Google Patents
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapyInfo
- Publication number
- SG11202010319RA SG11202010319RA SG11202010319RA SG11202010319RA SG11202010319RA SG 11202010319R A SG11202010319R A SG 11202010319RA SG 11202010319R A SG11202010319R A SG 11202010319RA SG 11202010319R A SG11202010319R A SG 11202010319RA SG 11202010319R A SG11202010319R A SG 11202010319RA
- Authority
- SG
- Singapore
- Prior art keywords
- immunotherapy
- expansion
- same
- gene editing
- tumor infiltrating
- Prior art date
Links
- 238000010362 genome editing Methods 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
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- C12N2523/00—Culture process characterised by temperature
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Physiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862663885P | 2018-04-27 | 2018-04-27 | |
US201862680821P | 2018-06-05 | 2018-06-05 | |
PCT/US2019/029286 WO2019210131A1 (fr) | 2018-04-27 | 2019-04-26 | Procédé en circuit fermé pour l'amplification et l'edition de gènes de lymphocytes d'infiltration des tumeurs et leurs utilisations en immunothérapie |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202010319RA true SG11202010319RA (en) | 2020-11-27 |
Family
ID=66429655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202010319RA SG11202010319RA (en) | 2018-04-27 | 2019-04-26 | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
Country Status (14)
Country | Link |
---|---|
US (4) | US20210130779A1 (fr) |
EP (1) | EP3784254A1 (fr) |
JP (1) | JP2021521846A (fr) |
KR (1) | KR20210005138A (fr) |
CN (1) | CN112368003A (fr) |
AU (1) | AU2019257749A1 (fr) |
BR (1) | BR112020021660A2 (fr) |
CA (1) | CA3098303A1 (fr) |
IL (1) | IL278231A (fr) |
MA (1) | MA52533A (fr) |
MX (1) | MX2020011134A (fr) |
SG (1) | SG11202010319RA (fr) |
TW (1) | TWI831776B (fr) |
WO (1) | WO2019210131A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
EP3765094A4 (fr) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | Compositions de régulation génique et procédés pour améliorer l'immunothérapie |
JP2022553389A (ja) * | 2019-10-25 | 2022-12-22 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍浸潤リンパ球の遺伝子編集及び免疫療法におけるその使用 |
JP2023507432A (ja) * | 2019-12-20 | 2023-02-22 | インスティル バイオ (ユーケイ) リミテッド | 腫瘍浸潤リンパ球を単離するためのデバイスおよび方法ならびにそれらの使用 |
EP4107173A1 (fr) * | 2020-02-17 | 2022-12-28 | Board of Regents, The University of Texas System | Procédés d'expansion de lymphocytes infiltrant les tumeurs et leur utilisation |
JP2023523855A (ja) | 2020-05-04 | 2023-06-07 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用 |
WO2021226085A1 (fr) | 2020-05-04 | 2021-11-11 | Iovance Biotherapeutics, Inc. | Sélection de lymphocytes t réactifs à une tumeur améliorés |
CA3205464A1 (fr) * | 2020-12-18 | 2022-06-23 | Instil Bio (Uk) Limited | Traitement de lymphocytes infiltrant les tumeurs |
CN114686430A (zh) * | 2020-12-31 | 2022-07-01 | 上海赛比曼生物科技有限公司 | 一种制备til的方法 |
WO2022198141A1 (fr) * | 2021-03-19 | 2022-09-22 | Iovance Biotherapeutics, Inc. | Procédés pour la multiplication des lymphocytes infiltrant les tumeurs (til) liés à la sélection de cd39/cd69 et inactivation de gènes dans les til |
CA3213163A1 (fr) | 2021-03-25 | 2022-09-29 | Iovance Biotherapeutics, Inc. | Procedes et compositions pour dosages de puissance de coculture de lymphocytes t et utilisation avec des produits de therapie cellulaire |
EP4317423A1 (fr) * | 2021-03-30 | 2024-02-07 | Neogentc Corp. | Procédé de production d'une composition de cellules immunitaires |
US20240207318A1 (en) | 2021-04-19 | 2024-06-27 | Yongliang Zhang | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
CN113244389B (zh) * | 2021-07-06 | 2021-09-17 | 诺赛联合(北京)生物医学科技有限公司 | 一种TILs细胞制备方法及在肿瘤治疗的用途 |
WO2023147488A1 (fr) * | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Compositions et procédés de lymphocytes infiltrant les tumeurs associés à la cytokine |
WO2023147486A1 (fr) * | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Lymphocytes infiltrant les tumeurs modifiés pour exprimer des charges utiles |
WO2023143515A1 (fr) * | 2022-01-29 | 2023-08-03 | 苏州沙砾生物科技有限公司 | Lymphocyte infiltrant les tumeurs modifié et son utilisation |
EP4289939A1 (fr) * | 2022-06-10 | 2023-12-13 | Apeiron Biologics AG | Population de cellules immunitaires transfectées et son procédé de production |
WO2024030758A1 (fr) | 2022-08-01 | 2024-02-08 | Iovance Biotherapeutics, Inc. | Récepteurs de costimulation chimériques, récepteurs de chimiokines et leur utilisation dans des immunothérapies cellulaires |
WO2024055018A1 (fr) * | 2022-09-09 | 2024-03-14 | Iovance Biotherapeutics, Inc. | Procédés de génération de produits til à l'aide d'une double inactivation talen de pd-1/tigit |
WO2024055017A1 (fr) * | 2022-09-09 | 2024-03-14 | Iovance Biotherapeutics, Inc. | Procédés de génération de produits til à l'aide d'une double inactivation de talen pd-1/tigit |
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2019
- 2019-04-26 EP EP19722433.0A patent/EP3784254A1/fr active Pending
- 2019-04-26 MX MX2020011134A patent/MX2020011134A/es unknown
- 2019-04-26 US US17/050,552 patent/US20210130779A1/en active Pending
- 2019-04-26 TW TW108114792A patent/TWI831776B/zh active
- 2019-04-26 WO PCT/US2019/029286 patent/WO2019210131A1/fr active Application Filing
- 2019-04-26 SG SG11202010319RA patent/SG11202010319RA/en unknown
- 2019-04-26 CA CA3098303A patent/CA3098303A1/fr active Pending
- 2019-04-26 AU AU2019257749A patent/AU2019257749A1/en active Pending
- 2019-04-26 BR BR112020021660-7A patent/BR112020021660A2/pt unknown
- 2019-04-26 JP JP2020560273A patent/JP2021521846A/ja active Pending
- 2019-04-26 MA MA052533A patent/MA52533A/fr unknown
- 2019-04-26 CN CN201980042525.2A patent/CN112368003A/zh active Pending
- 2019-04-26 KR KR1020207033718A patent/KR20210005138A/ko unknown
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IL278231A (en) | 2020-11-30 |
EP3784254A1 (fr) | 2021-03-03 |
US20220396768A1 (en) | 2022-12-15 |
CA3098303A1 (fr) | 2019-10-31 |
US20220396769A1 (en) | 2022-12-15 |
KR20210005138A (ko) | 2021-01-13 |
AU2019257749A1 (en) | 2020-10-22 |
US20220403334A1 (en) | 2022-12-22 |
TWI831776B (zh) | 2024-02-11 |
MA52533A (fr) | 2021-03-03 |
US20220010278A1 (en) | 2022-01-13 |
WO2019210131A1 (fr) | 2019-10-31 |
US20220403333A1 (en) | 2022-12-22 |
MX2020011134A (es) | 2020-11-11 |
US11384337B2 (en) | 2022-07-12 |
US11866688B2 (en) | 2024-01-09 |
US20210130779A1 (en) | 2021-05-06 |
BR112020021660A2 (pt) | 2021-02-02 |
TW202014195A (zh) | 2020-04-16 |
JP2021521846A (ja) | 2021-08-30 |
CN112368003A (zh) | 2021-02-12 |
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