CA3205464A1 - Traitement de lymphocytes infiltrant les tumeurs - Google Patents
Traitement de lymphocytes infiltrant les tumeursInfo
- Publication number
- CA3205464A1 CA3205464A1 CA3205464A CA3205464A CA3205464A1 CA 3205464 A1 CA3205464 A1 CA 3205464A1 CA 3205464 A CA3205464 A CA 3205464A CA 3205464 A CA3205464 A CA 3205464A CA 3205464 A1 CA3205464 A1 CA 3205464A1
- Authority
- CA
- Canada
- Prior art keywords
- tumor
- tils
- population
- expansion
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
La présente invention concerne des méthodes d'isolement et de cryoconservation de lymphocytes infiltrant les tumeurs (TIL) et de production de populations thérapeutiques de TIL, comprenant des méthodes par l'utilisation d'un kit et d'un dispositif semi-automatique pour la désagrégation, l'enrichissement et la cryoconservation aseptiques d'une tumeur réséquée avant l'expansion de la population TIL. La présente invention concerne également des méthodes d'expansion et/ou de stabilisation de TIL, par exemple des UTIL, des compositions les comprenant et des méthodes de traitement les mettant en jeu.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063127639P | 2020-12-18 | 2020-12-18 | |
US202063127582P | 2020-12-18 | 2020-12-18 | |
US63/127,582 | 2020-12-18 | ||
US63/127,639 | 2020-12-18 | ||
US202163288409P | 2021-12-10 | 2021-12-10 | |
US202163288414P | 2021-12-10 | 2021-12-10 | |
US63/288,409 | 2021-12-10 | ||
US63/288,414 | 2021-12-10 | ||
PCT/IB2021/000883 WO2022130017A2 (fr) | 2020-12-18 | 2021-12-16 | Traitement de lymphocytes infiltrant les tumeurs |
Publications (1)
Publication Number | Publication Date |
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CA3205464A1 true CA3205464A1 (fr) | 2022-06-23 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CA3205464A Pending CA3205464A1 (fr) | 2020-12-18 | 2021-12-16 | Traitement de lymphocytes infiltrant les tumeurs |
Country Status (5)
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EP (1) | EP4263808A2 (fr) |
JP (1) | JP2023554425A (fr) |
AU (1) | AU2021404204A1 (fr) |
CA (1) | CA3205464A1 (fr) |
WO (1) | WO2022130017A2 (fr) |
Families Citing this family (3)
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GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
AU2020408017A1 (en) | 2019-12-20 | 2022-07-14 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
WO2024143453A1 (fr) * | 2022-12-28 | 2024-07-04 | インターステム株式会社 | Composition cellulaire |
Family Cites Families (19)
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US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
CN1322137C (zh) | 1997-12-22 | 2007-06-20 | 牛津生物医学(英国)有限公司 | 基于马传染性贫血病毒(eiav)的逆转录病毒载体 |
US6706289B2 (en) | 2000-10-31 | 2004-03-16 | Pr Pharmaceuticals, Inc. | Methods and compositions for enhanced delivery of bioactive molecules |
IL295201A (en) | 2010-11-12 | 2022-10-01 | Nektar Therapeutics | Conjugations of a part of il-2 and a polymer, preparations containing them and their uses |
RU2671897C2 (ru) | 2013-03-01 | 2018-11-07 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Способы получения из опухоли обогащенных популяций реактивных в отношении опухоли т-клеток |
CN106574244B (zh) | 2014-06-11 | 2022-01-07 | 保利比奥斯博特有限责任公司 | 用细胞因子组合物扩增淋巴细胞用于主动细胞免疫治疗 |
GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
JOP20190224A1 (ar) * | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
GB201801067D0 (en) | 2018-01-23 | 2018-03-07 | Price Nicola Kaye | Biomarkers predictive of tumour infiltrating lymphocyte therapy and uses thereof |
MX2020010264A (es) * | 2018-03-29 | 2020-11-06 | Iovance Biotherapeutics Inc | Procesos para la produccion de linfocitos infiltrantes en tumor y usos de los mismos en inmunoterapia. |
WO2019210131A1 (fr) * | 2018-04-27 | 2019-10-31 | Iovance Biotherapeutics, Inc. | Procédé en circuit fermé pour l'amplification et l'edition de gènes de lymphocytes d'infiltration des tumeurs et leurs utilisations en immunothérapie |
GB201810181D0 (en) | 2018-06-21 | 2018-08-08 | Immetacyte Ltd | Cells expressing chimeric recominant growth factor receptors |
GB201900858D0 (en) | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
JP2022522793A (ja) | 2019-03-01 | 2022-04-20 | アシンプトート リミテッド | 閉じた組織分離および冷凍保存 |
AU2020408017A1 (en) | 2019-12-20 | 2022-07-14 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
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2021
- 2021-12-16 AU AU2021404204A patent/AU2021404204A1/en active Pending
- 2021-12-16 WO PCT/IB2021/000883 patent/WO2022130017A2/fr active Application Filing
- 2021-12-16 CA CA3205464A patent/CA3205464A1/fr active Pending
- 2021-12-16 JP JP2023536944A patent/JP2023554425A/ja active Pending
- 2021-12-16 EP EP21865325.1A patent/EP4263808A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
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WO2022130017A3 (fr) | 2022-07-28 |
JP2023554425A (ja) | 2023-12-27 |
EP4263808A2 (fr) | 2023-10-25 |
WO2022130017A2 (fr) | 2022-06-23 |
AU2021404204A1 (en) | 2023-07-06 |
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