SG11202005007VA - Fatty acid derivatives for treating non-alcoholic steatohepatitis - Google Patents

Fatty acid derivatives for treating non-alcoholic steatohepatitis

Info

Publication number
SG11202005007VA
SG11202005007VA SG11202005007VA SG11202005007VA SG11202005007VA SG 11202005007V A SG11202005007V A SG 11202005007VA SG 11202005007V A SG11202005007V A SG 11202005007VA SG 11202005007V A SG11202005007V A SG 11202005007VA SG 11202005007V A SG11202005007V A SG 11202005007VA
Authority
SG
Singapore
Prior art keywords
fatty acid
acid derivatives
alcoholic steatohepatitis
treating non
treating
Prior art date
Application number
SG11202005007VA
Other languages
English (en)
Inventor
Hilde Hermansen Steineger
David Alan Fraser
Tore Skjaeret
Original Assignee
Basf As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf As filed Critical Basf As
Publication of SG11202005007VA publication Critical patent/SG11202005007VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11202005007VA 2017-12-06 2018-12-05 Fatty acid derivatives for treating non-alcoholic steatohepatitis SG11202005007VA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NO20171944 2017-12-06
NO20171945 2017-12-06
US201862743013P 2018-10-09 2018-10-09
PCT/IB2018/001459 WO2019111048A1 (fr) 2017-12-06 2018-12-05 Dérivés d'acide gras pour le traitement de la stéatohépatite non alcoolique

Publications (1)

Publication Number Publication Date
SG11202005007VA true SG11202005007VA (en) 2020-06-29

Family

ID=65012040

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005007VA SG11202005007VA (en) 2017-12-06 2018-12-05 Fatty acid derivatives for treating non-alcoholic steatohepatitis

Country Status (13)

Country Link
US (2) US11925614B2 (fr)
EP (1) EP3720431A1 (fr)
JP (2) JP7346408B2 (fr)
KR (1) KR20200096791A (fr)
CN (1) CN111712240A (fr)
AU (1) AU2018381124B2 (fr)
BR (1) BR112020011431A2 (fr)
CA (1) CA3084728A1 (fr)
CL (1) CL2020001504A1 (fr)
IL (2) IL275002B2 (fr)
MX (1) MX2020005621A (fr)
SG (1) SG11202005007VA (fr)
WO (1) WO2019111048A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016173923A1 (fr) 2015-04-28 2016-11-03 Pronova Biopharma Norge As Utilisation d'acides gras structurellement améliorés contenant du soufre pour prévenir et/ou traiter la stéatose hépatique non alcoolique
CA3073956A1 (fr) 2017-09-03 2019-03-07 Angion Biomedica Corp. Heterocycles vinyliques utilises en tant qu'inhibiteurs de la kinase bispiralee associee a rho (rock)
BR112020011431A2 (pt) 2017-12-06 2020-11-24 Basf As derivados de ácido graxo para o tratamento de esteato-hepatite não alcoólica
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
MA55890A (fr) 2019-05-08 2022-03-16 Aligos Therapeutics Inc Modulateurs de thr-beta et leurs procédés d'utilisation
CN114470217B (zh) * 2020-11-24 2023-06-20 深圳微芯生物科技股份有限公司 预防和治疗代谢异常或炎症引起的组织损伤的药物组合物
EP4267124A1 (fr) 2020-12-22 2023-11-01 Northsea Therapeutics B.V. Polythérapies comprenant des acides gras structuralement améliorés contenant de l'oxygène pour le traitement de la stéatohépatite non alcoolique
CN113855812B (zh) * 2021-12-01 2022-03-11 上海翰森生物医药科技有限公司 聚乙二醇洛塞那肽或其药物组合物的新医药用途
KR20240099045A (ko) 2022-12-20 2024-06-28 주식회사 티에치팜 나트륨 포도당 운반체-2 저해제 및 안지오텐신 ⅱ 수용체 차단제를 함유하는 비알코올성 지방간 질환 예방 또는 치료용 약학적 조성물

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909554A (en) 1956-07-23 1959-10-20 Monsanto Chemicals Process for the manufacture of (alkylmercapto) alkyl sulfates
JPS4839001B1 (fr) 1970-11-09 1973-11-21
US4040781A (en) 1974-06-06 1977-08-09 Lever Brothers Company Novel 2-(alkylsulfinyl)ethyl sulfates and compositions employing same
US4032564A (en) 1974-09-09 1977-06-28 Zoecon Corporation Esters of cyclopropylalkanols
GB1523276A (en) 1974-09-20 1978-08-31 Lafon Labor Sulphur-containing amino compounds
US4009211A (en) 1975-07-29 1977-02-22 Gulf Research & Development Company Beta,beta-dialkylethylmercaptoethoxylate as new compounds
US4209410A (en) 1976-04-28 1980-06-24 Phillips Petroleum Company Lubricants
DE2861974D1 (en) 1977-11-11 1982-09-16 Ciba Geigy Ag Pyridine dicarboxylic acid derivatives, their mixtures with metallic stabilisers and their use in stabilising chlorine-containing thermoplasts
JPS5570841A (en) 1978-11-24 1980-05-28 Konishiroku Photo Ind Co Ltd Forming method of dye image
US4368190A (en) 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
EP0050327B1 (fr) 1980-10-21 1984-06-20 Roche Diagnostics GmbH Phospholipides contenant du soufre, leur procédé de préparation et médicaments contenant ces composés
US4411808A (en) 1982-08-04 1983-10-25 Exxon Research & Engineering Co. Multifunctional additive for power transmission shift fluids
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4775223A (en) 1984-09-20 1988-10-04 Canon Kabushiki Kaisha Lactic acid derivative, liquid crystal composition containing same and liquid crystal device
CA2010000A1 (fr) 1989-04-07 1990-10-07 Paul B. Merkel Materiau d'enregistrement photographique contenant un coupleur de formation de colorant bleu-vert
JPH0451149A (ja) 1990-06-19 1992-02-19 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
FR2663928B1 (fr) 1990-06-27 1994-04-08 Norsolor Nouveaux composes acryliques soufres, un procede pour leur preparation et leur application a la synthese de nouveaux polymeres.
EP0487809A1 (fr) 1990-11-28 1992-06-03 Monsanto Europe S.A./N.V. Compositions de caoutchouc ayant une usinabilité améliorée et ayant des meilleures propriétés dans leurs vulcanisats
CH683149A5 (fr) 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
JPH0543529A (ja) 1991-08-10 1993-02-23 Taisho Pharmaceut Co Ltd アルカンアミドアンモニウム化合物
JP2755279B2 (ja) 1992-03-19 1998-05-20 三井化学株式会社 熱可塑性樹脂組成物およびその成形体
JP2793458B2 (ja) 1992-03-19 1998-09-03 三井化学株式会社 コネクター用ポリアミド系樹脂組成物およびコネクター
DE69431596T4 (de) 1993-06-10 2003-10-30 University Of North Carolina At Chapel Hill, Chapel Hill (phospho)lipide zum bekämpfen einer hepatitis b-infektion
JP3110918B2 (ja) 1993-06-18 2000-11-20 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
US5523430A (en) 1994-04-14 1996-06-04 Bristol-Myers Squibb Company Protein farnesyl transferase inhibitors
GB2290789B (en) 1994-07-01 1998-09-16 Ciba Geigy Ag Titanium and zirconium complexes of carboxylic acids as corrosion inhibitors
KR100463709B1 (ko) 1994-10-13 2005-08-04 위민스 앤드 칠드런스 호스피털 애드레이드 변형된불포화지방산
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
FR2741619B1 (fr) 1995-11-28 1998-02-13 Pf Medicament Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique
JP2000508645A (ja) 1996-04-12 2000-07-11 ペプテック リミテッド ポリ不飽和脂肪酸を使用する免疫病の治療方法
US6060515A (en) 1997-01-24 2000-05-09 The Regents Of The University Of California Treatment of skin conditions by use of PPARα activators
JP2001509165A (ja) 1997-01-24 2001-07-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア バリヤ機能の回復、表皮の分化の促進及び増殖の抑制のためのＦＸＲ、ＰＰＡＲα及びＬＸＲαの活性剤の使用
AU4806497A (en) 1997-10-01 1999-04-23 Procter & Gamble Company, The Glyoxylic compound comprising one or more active ingredient
JPH11180929A (ja) 1997-12-19 1999-07-06 Asahi Glass Co Ltd エステル誘導体
AU7240398A (en) 1998-05-08 1999-11-29 Rolf Berge Use of non-beta-oxidizable fatty acid analogues for treatment of syndrome-x conditions
FR2786187B1 (fr) 1998-11-19 2001-11-09 Univ Paris Curie Composes du type 2-acylamino-2-deoxy-glucono-1,5-lactone, procede d'obtention, compositions les comportant et utilisations
FR2792312B1 (fr) 1999-04-15 2001-06-08 Oreal Composes (poly)thia-alcynoiques et leurs derives, compositions les comprenant et leur utilisation
US6723717B1 (en) 1999-06-01 2004-04-20 The University Of Texas Southwestern Medical Center Sulfur-containing thyroxane derivatives and their use as hair growth promotors
AR018472A1 (es) 1999-06-01 2001-11-14 Procter & Gamble Compuesto, composicion y metodo para el tratamiento de la perdida de cabello
AUPQ291499A0 (en) 1999-09-17 1999-10-07 Women's And Children's Hospital Adelaide Novel nitro and sulphur containing compounds
NO328803B1 (no) 2000-03-03 2010-05-18 Thia Medica Nye fettsyreanaloger
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
FR2828487B1 (fr) 2001-08-09 2005-05-27 Genfit S A Nouveaux composes derives d'acides gras, preparation et utilisations
EP1458354A1 (fr) 2001-12-21 2004-09-22 3M Innovative Properties Company Formulations d'aerosol vrai comprenant des complexes de paires d'ions
GB2383355A (en) 2001-12-22 2003-06-25 Schlumberger Holdings An aqueous viscoelastic fluid containing hydrophobically modified polymer and viscoelastic surfactant
GB0202002D0 (en) 2002-01-29 2002-03-13 Leiv Eiriksson Nyotek A S Use
EP1470258B1 (fr) 2002-01-31 2013-08-28 TFL Ledertechnik GmbH Compositions et leur utilisation afin de d'impermeabiliser le cuir ou les fourrures, les textiles et autres matieres fibreuses
AU2003251518B2 (en) 2002-06-13 2009-07-02 New York University Synthetic C-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
FR2845991B1 (fr) 2002-10-16 2005-02-04 Pf Medicament Derives d'alpha-phenyl acetanilides et leur application en therapeutique humaine
US8372430B2 (en) 2002-12-17 2013-02-12 The Procter & Gamble Company Compositions, methods, and kits useful for the alleviation of gastrointestinal effects
EP1600438A4 (fr) 2003-02-28 2007-05-02 Kaneka Corp Procedes pour la production de composes optiquement actifs comportant des substituants en position 2
DE10326303A1 (de) 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
EP1718602A4 (fr) 2004-01-30 2007-12-12 Peplin Biolipids Pty Ltd Molecules porteuses et therapeutiques
JP4563114B2 (ja) 2004-08-30 2010-10-13 出光興産株式会社 潤滑剤用添加剤
US20060252670A1 (en) 2004-10-14 2006-11-09 Intercept Pharmaceuticals Inc. Method of reducing drug-induced adverse side effects in a patient
EP1856213A2 (fr) 2005-03-08 2007-11-21 CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement Particules nanométriques d'oxydes de métaux recouvert avec des n-acylaminomethylene phosphonates spéciaux
EP1888727B1 (fr) 2005-05-04 2015-04-15 Pronova BioPharma Norge AS Nouveaux derives de dha et utilisation de ceux ci en tant que medicaments
CN101213281B (zh) 2005-05-04 2013-03-13 普罗诺瓦生物医药挪威公司 新的dha衍生物及其作为药物的用途
JP4315134B2 (ja) 2005-07-06 2009-08-19 セイコーエプソン株式会社 電子機器
US20070167529A1 (en) 2006-01-17 2007-07-19 Walton Rebecca A Antimicrobial compositions for treating fabrics and surfaces
US8987329B2 (en) 2006-04-12 2015-03-24 Conopco, Inc. Oral composition comprising a polyunsaturated fatty acid and salicylic acid for obtaining an antiinflammatory effect in skin
EP1849449A1 (fr) 2006-04-26 2007-10-31 3M Innovative Properties Company Composition contenant de la charge et precédé de fabrication et d'utilisation correspondants
US7763607B2 (en) 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
JP2009536659A (ja) 2006-05-09 2009-10-15 ヘマクエスト・ファーマシューティカルズ，インコーポレーテッド 血液疾患の治療法
MX2009004337A (es) 2006-11-01 2009-05-22 Pronova Biopharma Norge As Compuestos lipidos omega-3.
KR101438177B1 (ko) 2006-11-01 2014-09-05 프로노바 바이오파마 너지 에이에스 페록시솜 증식자-활성화 수용체의 활성자 또는 조절자인 알파-치환된 오메가-3 지질
WO2008053340A1 (fr) 2006-11-03 2008-05-08 Pronova Biopharma Norge As Produit de combinaison comprenant au moins un lipide substitué en position alpha et au moins un agent hypoglycémique
CN101225064A (zh) 2007-01-19 2008-07-23 上海汇瑞生物科技有限公司 一种制备β-硫杂-α-烷基脂肪酸的新方法
DE102007017179A1 (de) 2007-04-12 2008-10-23 Clariant International Ltd. Verfahren zur Herstellung von Alkylpolyglykolcarbonsäuren und Polyglykoldicarbonsäuren mittels Direktoxidation
US20100267828A1 (en) 2007-10-31 2010-10-21 Anne Kristin Holmeide dha derivatives and their use as medicaments
EP2217224B1 (fr) 2007-11-09 2019-05-08 Basf As Composés lipidiques à utiliser dans des produits cosmétiques, en tant que suppléments alimentaires ou en tant que médicaments
PE20100156A1 (es) 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
WO2009149496A1 (fr) 2008-06-10 2009-12-17 Central Northern Adelaide Health Service Traitement du diabète, de ses complications et de troubles associés
FR2933006B1 (fr) 2008-06-27 2010-08-20 Inst Francais Du Petrole Solution absorbante contenant un inhibiteur de degradation soufre a groupement carboxyle et methode pour limiter la degradation d'une solution absorbante
SG192488A1 (en) 2008-07-08 2013-08-30 Catabasis Pharmaceuticals Inc Fatty acid acetylated salicylates and their uses
EP2147910A1 (fr) 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Nouveaux composés lipidiques
NZ624963A (en) * 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
MX2011011614A (es) 2009-05-08 2011-11-18 Pronova Biopharma Norge As Acidos grasos poliinsaturados para el tratamiento de trastornos relacionados a las areas de los trastornos cardiovasculares, metabolicos e inflamatorios.
EP2248798A1 (fr) 2009-05-08 2010-11-10 Pronova BioPharma Norge AS Nouveaux composés de lipides
AU2010289683C1 (en) 2009-09-01 2014-10-16 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
EP2526084A1 (fr) 2010-01-20 2012-11-28 Pronova BioPharma Norge AS Dérivés salicylates acide gras
AU2011324909B2 (en) 2010-11-05 2016-09-08 Pronova Biopharma Norge As Methods of treatment using lipid compounds
WO2012115695A1 (fr) 2011-02-25 2012-08-30 Catabasis Pharmaceuticals, Inc. Conjugués de bis-acides gras et leurs utilisations
WO2014045293A1 (fr) 2012-09-24 2014-03-27 Krisani Bioscience (P) Ltd. Amides d'acides gras comportant un groupe cystéamine ou un groupe cystéamine acétylé et leurs utilisations
WO2013016531A2 (fr) 2011-07-26 2013-01-31 Purdue Research Foundation Composés et méthodes de traitement d'une néoplasie ou d'un cancer
US20130172244A1 (en) 2011-12-29 2013-07-04 Thomas Klein Subcutaneous therapeutic use of dpp-4 inhibitor
KR20150028233A (ko) 2012-05-07 2015-03-13 옴테라 파마슈티칼스, 인크. 스타틴 및 오메가-３ 지방산의 조성물
US9486433B2 (en) 2012-10-12 2016-11-08 Mochida Pharmaceuticals Co. Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
GB201301626D0 (en) 2013-01-30 2013-03-13 Dignity Sciences Ltd Composition comprising 15-OHEPA and methods of using the same
US9365482B2 (en) 2013-02-28 2016-06-14 Pronova Biopharma Norge As Methods of preparing fatty acid derivatives
CN105120842B (zh) 2013-02-28 2020-12-01 普罗诺瓦生物医药挪威公司 包含脂质化合物、甘油三酯和表面活性剂的组合物以及使用它们的方法
WO2014142364A2 (fr) * 2013-03-15 2014-09-18 Mochida Pharmaceutical Co., Ltd. Compositions et méthodes de traitement de la stéatohépatite non alcoolique
US10441560B2 (en) * 2013-03-15 2019-10-15 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
US20160213639A1 (en) * 2013-10-07 2016-07-28 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
UA121208C2 (uk) 2014-04-11 2020-04-27 Сімабей Терапьютікс, Інк. Лікування нажхп та насг
CN106659722A (zh) * 2014-04-18 2017-05-10 株式会社Lg生命科学 用于预防或治疗脂肪肝疾病的组合物
RU2705991C2 (ru) 2015-04-01 2019-11-13 Пронова Биофарма Норге Ас Применение тиаоксосоединений для уменьшения содержания аро с3
WO2016173923A1 (fr) 2015-04-28 2016-11-03 Pronova Biopharma Norge As Utilisation d'acides gras structurellement améliorés contenant du soufre pour prévenir et/ou traiter la stéatose hépatique non alcoolique
BR112020011431A2 (pt) 2017-12-06 2020-11-24 Basf As derivados de ácido graxo para o tratamento de esteato-hepatite não alcoólica

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CN111712240A (zh) 2020-09-25
AU2018381124B2 (en) 2024-06-27
EP3720431A1 (fr) 2020-10-14
IL275002A (en) 2020-07-30
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AU2018381124A1 (en) 2020-06-04
CA3084728A1 (fr) 2019-06-13
KR20200096791A (ko) 2020-08-13
IL275002B2 (en) 2024-04-01
IL308604A (en) 2024-01-01
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IL275002B1 (en) 2023-12-01
JP7346408B2 (ja) 2023-09-19
JP2021505591A (ja) 2021-02-18
US20210177794A1 (en) 2021-06-17
CL2020001504A1 (es) 2020-11-13
US20240156769A1 (en) 2024-05-16

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