SG11202001077UA - Novel acylated insulin analogues and uses thereof - Google Patents

Novel acylated insulin analogues and uses thereof

Info

Publication number
SG11202001077UA
SG11202001077UA SG11202001077UA SG11202001077UA SG11202001077UA SG 11202001077U A SG11202001077U A SG 11202001077UA SG 11202001077U A SG11202001077U A SG 11202001077UA SG 11202001077U A SG11202001077U A SG 11202001077UA SG 11202001077U A SG11202001077U A SG 11202001077UA
Authority
SG
Singapore
Prior art keywords
insulin analogues
acylated insulin
novel acylated
novel
analogues
Prior art date
Application number
SG11202001077UA
Other languages
English (en)
Inventor
Grith Olsen
Bo Hansen
Lauge Schäffer (Deceased)
Ingrid Pettersson
Rita Slaaby
Jakob Brandt
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of SG11202001077UA publication Critical patent/SG11202001077UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
SG11202001077UA 2017-08-17 2018-08-16 Novel acylated insulin analogues and uses thereof SG11202001077UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17186612 2017-08-17
EP17204872 2017-12-01
PCT/EP2018/072191 WO2019034726A1 (en) 2017-08-17 2018-08-16 NOVEL ACYLATED INSULIN ANALOGUES AND USES THEREOF

Publications (1)

Publication Number Publication Date
SG11202001077UA true SG11202001077UA (en) 2020-03-30

Family

ID=63165388

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202001077UA SG11202001077UA (en) 2017-08-17 2018-08-16 Novel acylated insulin analogues and uses thereof

Country Status (19)

Country Link
US (2) US10919949B2 (de)
EP (1) EP3668892A1 (de)
JP (2) JP2020531451A (de)
KR (1) KR20200038502A (de)
CN (1) CN111032685A (de)
AU (1) AU2018317810A1 (de)
BR (1) BR112020002364A2 (de)
CA (1) CA3071686A1 (de)
CL (1) CL2020000310A1 (de)
CO (1) CO2020002500A2 (de)
IL (1) IL272394A (de)
MA (1) MA49896A (de)
MX (1) MX2020001434A (de)
PE (1) PE20211264A1 (de)
PH (1) PH12020550050A1 (de)
RU (1) RU2020108281A (de)
SG (1) SG11202001077UA (de)
TW (1) TW201917134A (de)
WO (1) WO2019034726A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1969004E (pt) 2005-12-28 2011-11-25 Novo Nordisk As Composições que compreendem uma insulina acilada e zinco e método para criar tais composições
KR102691149B1 (ko) 2021-01-20 2024-08-05 바이킹 테라퓨틱스 인코포레이티드 대사 및 간 질환 치료를 위한 조성물 및 방법

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US5616729A (en) 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK155690D0 (da) 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
DK33591D0 (de) 1991-02-27 1991-02-27 Novo Nordisk As
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
EP0946735B1 (de) 1996-12-20 2006-02-08 Novo Nordisk A/S N-terminal verlängerte proteine exprimiert in hefe
ES2180511T3 (es) 1999-01-26 2003-02-16 Lilly Co Eli Formulaciones monodispersas de analogos de insulina acilados hexamericos.
AU5144400A (en) * 1999-05-19 2000-12-05 Xencor, Inc. Novel proteins with insulin-like activity useful in the treatment of diabetes
ATE397017T1 (de) 1999-12-29 2008-06-15 Novo Nordisk As Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern
ATE517119T1 (de) 2003-12-03 2011-08-15 Novo Nordisk As Einzelketteninsulin
WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
ES2438145T3 (es) 2005-02-02 2014-01-16 Novo Nordisk A/S Nuevos derivados de insulina
ATE557037T1 (de) * 2006-02-27 2012-05-15 Novo Nordisk As Insulin derivate
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
CN101784562B (zh) 2007-08-15 2016-07-13 诺沃-诺迪斯克有限公司 具有酰基和亚烷基二醇部分的胰岛素类似物
ES2618073T3 (es) 2008-03-14 2017-06-20 Novo Nordisk A/S Análogos de insulina estabilizados frente a proteasas
EP2910571B1 (de) 2008-03-18 2016-10-05 Novo Nordisk A/S Proteasestabilisierte, acylierte insulinanaloga
EP2376521B1 (de) 2008-12-19 2016-04-13 Indiana University Research and Technology Corporation Auf amid basierende insulin-rpodrugs
CN102256992B (zh) 2008-12-19 2015-04-22 印第安纳大学研究及科技有限公司 胰岛素类似物
EP2376099A4 (de) 2008-12-19 2012-04-25 Univ Indiana Res & Tech Corp Insulinähnliche wachstumsfaktoren auf yl-basis mit hoher aktivität am insulinrezeptor
US20120241356A1 (en) 2009-07-06 2012-09-27 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
WO2011159895A2 (en) 2010-06-16 2011-12-22 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
WO2011159882A2 (en) 2010-06-16 2011-12-22 Indiana University Research And Technology Corporation Novel stabilized insulin agonists
JP5973427B2 (ja) 2010-06-23 2016-08-23 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン類似体
WO2011163460A1 (en) 2010-06-24 2011-12-29 Indiana University Research And Technology Corporation Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor
JP5912112B2 (ja) 2010-06-24 2016-04-27 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ アミド系インスリンプロドラッグ
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
EP2627670A2 (de) 2010-10-15 2013-08-21 Novo Nordisk A/S Neuartige n-terminierte modifizierte insulinderivate
AR087433A1 (es) 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados
EP2793932B1 (de) 2011-12-20 2018-10-03 Indiana University Research and Technology Corporation Insulinanaloga auf ctp-basis zur behandlung von diabetes
JP2015502971A (ja) 2011-12-21 2015-01-29 ノヴォ ノルディスク アー／エス Ｎ末端修飾インスリン誘導体
EP3395358B1 (de) 2012-09-26 2019-11-06 Indiana University Research and Technology Corporation Insulinanalogdimere
EP2925345B1 (de) 2012-12-03 2018-09-05 Merck Sharp & Dohme Corp. Methode zur herstellung von o-glycosyliertem carboxyterminus-peptid (ctp)-basiertem insulin und insulinanaloga
US10421795B2 (en) 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン‐インクレチン複合物
EP3024447A1 (de) 2013-07-24 2016-06-01 Novo Nordisk A/S Pharmazeutische zusammensetzung zur oralen insulinverabreichung mit einem tablettenkern und einer anionischen copolymerbeschichtung
MX366852B (es) 2013-10-04 2019-07-25 Merck Sharp & Dohme Conjugados de insulina sensibles a glucosa.
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
WO2016049174A1 (en) 2014-09-24 2016-03-31 Indiana University Research And Technology Corporation Lipidated amide-based insulin prodrugs
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
US20170355743A1 (en) 2014-11-21 2017-12-14 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
JP6737793B2 (ja) 2015-01-29 2020-08-12 ノヴォ ノルディスク アー／エス 錠剤コアとポリビニルアルコールコーティングとを含む経口インスリン投与のための医薬組成物
EP3268384B1 (de) 2015-03-10 2021-11-03 Merck Sharp & Dohme Corp. Verfahren zur herstellung von rekombinantem insulin unter verwendung von mikrofiltration
WO2016164288A1 (en) 2015-04-08 2016-10-13 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
WO2016172269A2 (en) 2015-04-20 2016-10-27 University Of Utah Research Foundation Insulin analogs having shortened b chain peptides and associated methods
EP3341401A1 (de) * 2015-08-25 2018-07-04 Novo Nordisk A/S Neuartige insulinderivate und medizinische verwendungen davon
US20180244743A1 (en) * 2015-08-25 2018-08-30 Novo Nordisk A/S Novel Insulin Derivatives and the Medical Uses Hereof
JP2018531900A (ja) 2015-08-25 2018-11-01 ノヴォ ノルディスク アー／エス 新規インスリン誘導体及びその医学的使用
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds

Also Published As

Publication number Publication date
IL272394A (en) 2020-03-31
PE20211264A1 (es) 2021-07-15
RU2020108281A3 (de) 2022-03-09
RU2020108281A (ru) 2021-08-26
AU2018317810A1 (en) 2020-03-19
TW201917134A (zh) 2019-05-01
CO2020002500A2 (es) 2020-06-09
JP2022105082A (ja) 2022-07-12
MA49896A (fr) 2020-06-24
BR112020002364A2 (pt) 2020-09-01
PH12020550050A1 (en) 2020-10-19
WO2019034726A1 (en) 2019-02-21
CA3071686A1 (en) 2019-02-21
CN111032685A (zh) 2020-04-17
MX2020001434A (es) 2020-03-20
EP3668892A1 (de) 2020-06-24
US10919949B2 (en) 2021-02-16
CL2020000310A1 (es) 2020-07-10
JP2020531451A (ja) 2020-11-05
US20190194285A1 (en) 2019-06-27
KR20200038502A (ko) 2020-04-13
US20210094999A1 (en) 2021-04-01

Similar Documents

Publication Publication Date Title
IL293377B1 (en) Variants of hsd17b13 and their uses
HUE057965T2 (hu) Új promóter és alkalmazása
ZA201802017B (en) Novel insulin analogs and use thereof
SG11201705765VA (en) Novel promoter and uses thereof
IL256137B (en) Corneal implant and its use
IL268593A (en) Polypeptide variants and uses thereof
ZA201907833B (en) Heteroarylphenylaminoquinolines and analogues
IL270813A (en) Acylated insulin compound
IL266279A (en) Aqueous formulations, stability of pexacin for injection and medical uses thereof
IL253600A0 (en) Insulin analogs and preparations containing them
GB201711749D0 (en) Cyclosporin analogues and uses thereof
IL271073A (en) b4galt1 variants and their uses
PT4073097T (pt) Novos análogos de insulina e suas utilizações
HK1253725A1 (zh) 新型抗微生物肽及其用途
EP3696163C0 (de) Neuartige pseudoceramidverbindung und verwendung davon
IL264473A (en) GPR156 variants and their uses
IL272394A (en) Similar organs based on insulin with acyl and their uses
HK1251724A1 (zh) 一種彈片和終端
IL273671A (en) Cornoline variants and their use
IL275211A (en) Fast and flexible segment chains - division
IL263682A (en) Antibiotic variants and their uses
HK1247220A1 (zh) 環狀甘丙肽類似物及其用途
GB201714409D0 (en) Oligonucleotides and analogues thereof
HK1256605A1 (zh) 苯磺酰基不對稱尿素及其醫學用途
GB201401673D0 (en) Esculentin-2CHa peptide and analogues thereof