ATE397017T1 - Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern - Google Patents
Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufernInfo
- Publication number
- ATE397017T1 ATE397017T1 AT00981169T AT00981169T ATE397017T1 AT E397017 T1 ATE397017 T1 AT E397017T1 AT 00981169 T AT00981169 T AT 00981169T AT 00981169 T AT00981169 T AT 00981169T AT E397017 T1 ATE397017 T1 AT E397017T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin precursors
- precursors
- insulin
- analogues
- precursor analogs
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 11
- 239000002243 precursor Substances 0.000 title abstract 8
- 102000004877 Insulin Human genes 0.000 title abstract 5
- 108090001061 Insulin Proteins 0.000 title abstract 5
- 229940125396 insulin Drugs 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 abstract 1
- 108010075254 C-Peptide Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901868 | 1999-12-29 | ||
| DKPA200000440 | 2000-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397017T1 true ATE397017T1 (de) | 2008-06-15 |
Family
ID=26066172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00981169T ATE397017T1 (de) | 1999-12-29 | 2000-12-04 | Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1246845B1 (de) |
| JP (1) | JP4773023B2 (de) |
| KR (1) | KR20030004317A (de) |
| CN (1) | CN100432104C (de) |
| AT (1) | ATE397017T1 (de) |
| AU (1) | AU1850601A (de) |
| BR (1) | BR0016867A (de) |
| CA (1) | CA2392840C (de) |
| DE (1) | DE60039074D1 (de) |
| ES (1) | ES2307544T3 (de) |
| HU (1) | HUP0203475A3 (de) |
| RU (1) | RU2283846C2 (de) |
| WO (1) | WO2001049742A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1377608B1 (de) * | 2001-04-02 | 2009-09-16 | Novo Nordisk A/S | Insulinvorstufen und verfahren zu deren herstellung |
| US7105314B2 (en) | 2001-04-02 | 2006-09-12 | Novo Nordisk A/S | Method for making human insulin precursors |
| ES2344448T3 (es) | 2001-11-19 | 2010-08-27 | Novo Nordisk A/S | Proceso para preparar compuestos de insulina. |
| WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
| JP5697831B2 (ja) | 2003-12-03 | 2015-04-08 | ノヴォ ノルディスク アー／エス | 単鎖インシュリン |
| CN100460508C (zh) * | 2004-11-03 | 2009-02-11 | 马延高 | 人胰岛素基因在甲醇酵母中的分泌表达方法 |
| CN101778862B (zh) | 2007-08-13 | 2014-12-17 | 诺沃-诺迪斯克有限公司 | 快速作用的胰岛素类似物 |
| ES2526924T3 (es) | 2007-08-15 | 2015-01-16 | Novo Nordisk A/S | Insulinas con una fracción acilo que comprende unidades repetitivas de aminoácidos que contienen alquilenglicol |
| EP2708554A1 (de) | 2007-08-15 | 2014-03-19 | Novo Nordisk A/S | Insulinanaloge mit Acyl- und Alkylenglycolteilen |
| EP2262539B1 (de) | 2008-04-01 | 2015-07-15 | Novo Nordisk A/S | Insulin-albumin-konzentrate |
| EP2585484A1 (de) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Zusätzliche disulfidbindungen enthaltende insulinanaloga |
| EP2585483A1 (de) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Humane insulinanaloga mit zusätzlichen disulfid-bindungen |
| CN102985440B (zh) | 2010-06-23 | 2016-10-26 | 诺沃-诺迪斯克有限公司 | 包含额外的二硫键的胰岛素衍生物 |
| JP6058646B2 (ja) | 2011-06-15 | 2017-01-11 | ノヴォ ノルディスク アー／エス | 多置換インスリン |
| AU2012350586B2 (en) * | 2011-12-15 | 2017-02-02 | Jiangsu Hengrui Medicine Co., Ltd. | Human insulin analogue and acylated derivative thereof |
| CN105308067B (zh) * | 2013-06-07 | 2020-07-24 | 诺和诺德股份有限公司 | 制备成熟胰岛素多肽的方法 |
| CN105087724B (zh) * | 2014-05-04 | 2019-12-03 | 重庆派金生物科技有限公司 | 酵母重组表达门冬胰岛素的制备方法 |
| CN107417787B (zh) * | 2016-05-23 | 2020-11-17 | 江苏恒瑞医药股份有限公司 | 一种人松弛素2类似物的制备方法 |
| CN107446039B (zh) * | 2016-05-31 | 2021-11-12 | 江苏恒瑞医药股份有限公司 | 一种人胰岛素类似物前体及其制备方法 |
| CN106699872B (zh) * | 2016-12-27 | 2019-12-24 | 江南大学 | 一种提高胰岛素前体产量的方法 |
| SG11202001077UA (en) | 2017-08-17 | 2020-03-30 | Novo Nordisk As | Novel acylated insulin analogues and uses thereof |
| CN108148114B (zh) * | 2017-12-08 | 2020-05-15 | 珠海冀百康生物科技有限公司 | 一种提高重组小分子蛋白表达量的串联前导肽及方法 |
| CN108929370B (zh) * | 2018-07-15 | 2021-06-25 | 渤海大学 | 三种具有ace抑制活性的鸡蛋源活性肽 |
| US11541122B2 (en) | 2018-09-19 | 2023-01-03 | Ziylo Limited | Glucose sensitive insulins and uses thereof |
| CN113773392B (zh) * | 2020-06-09 | 2023-04-07 | 宁波鲲鹏生物科技有限公司 | 一种甘精胰岛素的制备方法 |
| WO2022090448A1 (en) | 2020-10-30 | 2022-05-05 | Novo Nordisk A/S | Novel acylating reagents |
| WO2023144240A1 (en) | 2022-01-26 | 2023-08-03 | Novo Nordisk Research Centre Oxford Limited | Glucose sensitive insulin derivatives and uses thereof |
| WO2025099208A1 (en) | 2023-11-10 | 2025-05-15 | Intervet International B.V. | Recombinant insulin precursor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| AU1272295A (en) * | 1993-12-17 | 1995-07-03 | Novo Nordisk A/S | Proinsulin-like compounds |
| KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
-
2000
- 2000-12-04 BR BR0016867-0A patent/BR0016867A/pt not_active Application Discontinuation
- 2000-12-04 WO PCT/DK2000/000665 patent/WO2001049742A1/en not_active Ceased
- 2000-12-04 HU HU0203475A patent/HUP0203475A3/hu unknown
- 2000-12-04 ES ES00981169T patent/ES2307544T3/es not_active Expired - Lifetime
- 2000-12-04 AT AT00981169T patent/ATE397017T1/de not_active IP Right Cessation
- 2000-12-04 JP JP2001550282A patent/JP4773023B2/ja not_active Expired - Fee Related
- 2000-12-04 AU AU18506/01A patent/AU1850601A/en not_active Abandoned
- 2000-12-04 RU RU2002120512/13A patent/RU2283846C2/ru not_active IP Right Cessation
- 2000-12-04 CA CA2392840A patent/CA2392840C/en not_active Expired - Fee Related
- 2000-12-04 CN CNB008179603A patent/CN100432104C/zh not_active Expired - Lifetime
- 2000-12-04 KR KR1020027008588A patent/KR20030004317A/ko not_active Withdrawn
- 2000-12-04 DE DE60039074T patent/DE60039074D1/de not_active Expired - Lifetime
- 2000-12-04 EP EP00981169A patent/EP1246845B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2392840A1 (en) | 2001-07-12 |
| CN1414974A (zh) | 2003-04-30 |
| RU2283846C2 (ru) | 2006-09-20 |
| HUP0203475A2 (hu) | 2003-02-28 |
| WO2001049742A1 (en) | 2001-07-12 |
| PL355871A1 (en) | 2004-05-31 |
| BR0016867A (pt) | 2002-10-08 |
| RU2002120512A (ru) | 2004-01-27 |
| ES2307544T3 (es) | 2008-12-01 |
| EP1246845B1 (de) | 2008-05-28 |
| JP2003518945A (ja) | 2003-06-17 |
| CN100432104C (zh) | 2008-11-12 |
| DE60039074D1 (de) | 2008-07-10 |
| JP4773023B2 (ja) | 2011-09-14 |
| KR20030004317A (ko) | 2003-01-14 |
| CA2392840C (en) | 2012-07-17 |
| HUP0203475A3 (en) | 2005-11-28 |
| EP1246845A1 (de) | 2002-10-09 |
| AU1850601A (en) | 2001-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |