SG11201906386XA - Combination therapy involving diaryl macrocyclic compounds - Google Patents
Combination therapy involving diaryl macrocyclic compoundsInfo
- Publication number
- SG11201906386XA SG11201906386XA SG11201906386XA SG11201906386XA SG11201906386XA SG 11201906386X A SG11201906386X A SG 11201906386XA SG 11201906386X A SG11201906386X A SG 11201906386XA SG 11201906386X A SG11201906386X A SG 11201906386XA SG 11201906386X A SG11201906386X A SG 11201906386XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- rule
- ste
- january
- pct
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450455P | 2017-01-25 | 2017-01-25 | |
| US201862619165P | 2018-01-19 | 2018-01-19 | |
| PCT/US2018/015150 WO2018140554A1 (fr) | 2017-01-25 | 2018-01-25 | Polythérapie impliquant des composés macrocycliques de diaryle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201906386XA true SG11201906386XA (en) | 2019-08-27 |
Family
ID=62979021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201906386XA SG11201906386XA (en) | 2017-01-25 | 2018-01-25 | Combination therapy involving diaryl macrocyclic compounds |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11291667B2 (fr) |
| EP (1) | EP3573991A4 (fr) |
| JP (1) | JP7193475B2 (fr) |
| KR (1) | KR102618773B1 (fr) |
| CN (1) | CN110291092A (fr) |
| AU (1) | AU2018212647B2 (fr) |
| BR (1) | BR112019015115A2 (fr) |
| CA (1) | CA3049548A1 (fr) |
| IL (1) | IL267992B2 (fr) |
| MX (1) | MX2019008701A (fr) |
| SG (1) | SG11201906386XA (fr) |
| TW (1) | TWI808958B (fr) |
| WO (1) | WO2018140554A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3572416B1 (fr) | 2014-01-24 | 2022-09-21 | Turning Point Therapeutics, Inc. | Macrocycles de diaryle en tant que modulateurs de protéines kinases |
| RU2732405C2 (ru) | 2015-07-02 | 2020-09-16 | Тёрнинг Поинт Терапьютикс, Инк. | Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ |
| ES2818528T3 (es) | 2015-07-21 | 2021-04-13 | Turning Point Therapeutics Inc | Macrociclo de diarilo quiral y uso del mismo en el tratamiento del cáncer |
| SG11201900163PA (en) | 2016-07-28 | 2019-02-27 | Tp Therapeutics Inc | Macrocycle kinase inhibitors |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| BR112020001695A2 (pt) | 2017-07-28 | 2020-07-21 | Turning Point Therapeutics, Inc. | compostos macrocíclicos e usos dos mesmos |
| KR20200101358A (ko) | 2017-12-19 | 2020-08-27 | 터닝 포인트 테라퓨틱스, 인크. | 질병 치료용 대환식 화합물 |
| BR112021007679A2 (pt) | 2018-10-22 | 2021-07-27 | Esker Therapeutics, Inc | inibidores de tyk2 e seus usos |
| CN111171049B (zh) * | 2018-11-09 | 2021-06-04 | 山东轩竹医药科技有限公司 | 酪氨酸激酶抑制剂及其用途 |
| MX2022006366A (es) * | 2019-11-27 | 2022-06-22 | Turning Point Therapeutics Inc | Terapia de combinacion que implica compuestos de diarilo macrociclico. |
| JP2023505056A (ja) * | 2019-11-27 | 2023-02-08 | ターニング・ポイント・セラピューティクス・インコーポレイテッド | ジアリール大環状化合物を含む併用療法 |
| CN113121568A (zh) * | 2019-12-31 | 2021-07-16 | 成都倍特药业股份有限公司 | 一种大环结构化合物的盐及其制备方法 |
| US20230219978A1 (en) * | 2020-06-04 | 2023-07-13 | Scinnohub Pharmaceutical Co., Ltd | Compound having macrocyclic structure and use thereof |
| WO2022117051A1 (fr) * | 2020-12-03 | 2022-06-09 | 北京鞍石生物科技有限责任公司 | Composé macrocyclique, son procédé de préparation et son utilisation |
| CN116063326A (zh) * | 2021-11-02 | 2023-05-05 | 赛诺哈勃药业（成都）有限公司 | 作为蛋白激酶调节剂的含氨基大环化合物 |
| KR20240128987A (ko) | 2021-12-30 | 2024-08-27 | 바이오메아 퓨전, 인크. | Flt3의 억제제로서의 피라진 화합물 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0690843B1 (fr) | 1993-03-25 | 2000-08-30 | PHARMACIA & UPJOHN COMPANY | Dérivés d'indole substitués par formyl ou cyano à activité dopaminergique |
| PT657458E (pt) | 1993-12-07 | 2002-02-28 | Lilly Co Eli | Inibidores de proteina cinase c |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6251912B1 (en) | 1997-08-01 | 2001-06-26 | American Cyanamid Company | Substituted quinazoline derivatives |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| EP1080092B1 (fr) | 1998-05-26 | 2008-07-23 | Warner-Lambert Company LLC | Pyrimidines bicycliques et 3,4-dihydropyrimidines bicycliques, inhibiteurs de proliferation cellulaire |
| ES2245994T3 (es) | 2000-12-08 | 2006-02-01 | Ortho-Mcneil Pharmaceutical, Inc. | Compuestos macro-heterociclicos utilizados como inhibidores de quinasa. |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10063435A1 (de) | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE10307165A1 (de) | 2003-02-20 | 2004-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| TWI377944B (en) | 2007-06-05 | 2012-12-01 | Hanmi Holdings Co Ltd | Novel amide derivative for inhibiting the growth of cancer cells |
| EP2334301B1 (fr) | 2008-09-08 | 2018-02-14 | Merck Serono SA | Pyrimidines macrocycliques en tant qu'inhibiteurs d'aurora kinase |
| ES2464461T3 (es) | 2008-09-22 | 2014-06-02 | Array Biopharma, Inc. | Compuestos de imidazo[1,2B]piridazina sustituidos como inhibidores de la TRK cinasa |
| TWI577680B (zh) | 2008-10-22 | 2017-04-11 | 亞雷生物製藥股份有限公司 | 作為ＴＲＫ激酶抑制劑之經取代吡唑并〔１，５－ａ〕嘧啶化合物 |
| WO2010051549A1 (fr) | 2008-10-31 | 2010-05-06 | Genentech, Inc. | Composés inhibiteurs de jak à la pyrazolopyrimidine et procédés |
| WO2011045330A1 (fr) | 2009-10-13 | 2011-04-21 | Tibotec Pharmaceuticals | Inhibiteurs macrocycliques d'intégrase |
| WO2011071491A1 (fr) | 2009-12-09 | 2011-06-16 | Signal Pharmaceuticals, Llc | Isotopologues du 4-[9-(tétrahydrofuran-3-yl)-8-(2,4,6-trifluorophénylamino)-9h-purin-2-ylamino]cyclohexan-1-ol |
| SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| NZ604708A (en) | 2010-05-20 | 2015-05-29 | Array Biopharma Inc | Macrocyclic compounds as trk kinase inhibitors |
| KR101217526B1 (ko) | 2010-06-11 | 2013-01-02 | 한미사이언스 주식회사 | 아마이드 유도체 또는 이의 약학적으로 허용 가능한 염을 포함하는 약제학적 조성물 |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| EP2508607A1 (fr) | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
| US8828391B2 (en) * | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| WO2013001310A1 (fr) | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Composés macrocycliques et leur utilisation en tant qu'inhibiteurs de cdk8 |
| EP2744331A4 (fr) | 2011-08-19 | 2015-01-21 | Merck Sharp & Dohme | Procédés et intermédiaires pouvant être utilisés pour la préparation de macrolactames |
| US9090630B2 (en) | 2011-09-30 | 2015-07-28 | Oncodesign S.A. | Macrocyclic FLT3 kinase inhibitors |
| WO2013132376A1 (fr) | 2012-03-06 | 2013-09-12 | Pfizer Inc. | Dérivés macrocycliques pour le traitement de maladies prolifératives |
| MX345830B (es) | 2012-03-09 | 2017-02-17 | Lexicon Pharmaceuticals Inc | Compuestos a base de pirazol[1,5-a]pirimidina, composiciones que los comprenden, y metodos para su uso. |
| MX347917B (es) | 2012-03-09 | 2017-05-17 | Lexicon Pharmaceuticals Inc | Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso. |
| GB201205669D0 (en) | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
| CA2904797A1 (fr) * | 2013-03-14 | 2014-09-18 | Pfizer Inc. | Combinaison d'un inhibiteur de l'egfr t790m et d'un inhibiteur de l'egfr dans le traitement d'un cancer du poumon non a petites cellules |
| US20150147326A1 (en) * | 2013-09-30 | 2015-05-28 | Daiichi Sankyo Company, Limited | Protein biomarker and uses thereof |
| EP3572416B1 (fr) | 2014-01-24 | 2022-09-21 | Turning Point Therapeutics, Inc. | Macrocycles de diaryle en tant que modulateurs de protéines kinases |
| RU2732405C2 (ru) * | 2015-07-02 | 2020-09-16 | Тёрнинг Поинт Терапьютикс, Инк. | Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ |
| CN113354653A (zh) | 2015-07-06 | 2021-09-07 | 特普医药公司 | 二芳基大环多晶型物及其制备方法 |
| ES2818528T3 (es) | 2015-07-21 | 2021-04-13 | Turning Point Therapeutics Inc | Macrociclo de diarilo quiral y uso del mismo en el tratamiento del cáncer |
| WO2017066193A1 (fr) * | 2015-10-15 | 2017-04-20 | Princeton Drug Discovery, Llc | Nouveaux inhibiteurs de protéines kinases |
| SG11201900163PA (en) | 2016-07-28 | 2019-02-27 | Tp Therapeutics Inc | Macrocycle kinase inhibitors |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| BR112020001695A2 (pt) | 2017-07-28 | 2020-07-21 | Turning Point Therapeutics, Inc. | compostos macrocíclicos e usos dos mesmos |
| CN109956957B (zh) | 2017-12-22 | 2021-11-09 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一种咪唑并[1,2-b]哒嗪大环类激酶抑制剂 |
| EP3783000B1 (fr) | 2018-04-18 | 2022-07-06 | Hitgen Inc. | Inhibiteur de kinase macrocyclique |
-
2018
- 2018-01-24 TW TW107102558A patent/TWI808958B/zh active
- 2018-01-25 SG SG11201906386XA patent/SG11201906386XA/en unknown
- 2018-01-25 CN CN201880008596.6A patent/CN110291092A/zh active Pending
- 2018-01-25 EP EP18745012.7A patent/EP3573991A4/fr active Pending
- 2018-01-25 WO PCT/US2018/015150 patent/WO2018140554A1/fr unknown
- 2018-01-25 MX MX2019008701A patent/MX2019008701A/es unknown
- 2018-01-25 US US16/480,557 patent/US11291667B2/en active Active
- 2018-01-25 AU AU2018212647A patent/AU2018212647B2/en active Active
- 2018-01-25 CA CA3049548A patent/CA3049548A1/fr active Pending
- 2018-01-25 BR BR112019015115-0A patent/BR112019015115A2/pt active Search and Examination
- 2018-01-25 KR KR1020197021227A patent/KR102618773B1/ko active IP Right Grant
- 2018-01-25 JP JP2019560071A patent/JP7193475B2/ja active Active
-
2019
- 2019-07-11 IL IL267992A patent/IL267992B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR102618773B1 (ko) | 2023-12-27 |
| US11291667B2 (en) | 2022-04-05 |
| CA3049548A1 (fr) | 2018-08-02 |
| RU2019126642A3 (fr) | 2021-03-31 |
| BR112019015115A2 (pt) | 2020-03-10 |
| JP2020514409A (ja) | 2020-05-21 |
| EP3573991A4 (fr) | 2021-01-20 |
| WO2018140554A1 (fr) | 2018-08-02 |
| TWI808958B (zh) | 2023-07-21 |
| US20190381048A1 (en) | 2019-12-19 |
| CN110291092A (zh) | 2019-09-27 |
| AU2018212647B2 (en) | 2022-02-03 |
| IL267992B (en) | 2022-10-01 |
| AU2018212647A1 (en) | 2019-07-11 |
| IL267992B2 (en) | 2023-02-01 |
| JP7193475B2 (ja) | 2022-12-20 |
| MX2019008701A (es) | 2019-09-13 |
| RU2019126642A (ru) | 2021-02-26 |
| EP3573991A1 (fr) | 2019-12-04 |
| TW201831188A (zh) | 2018-09-01 |
| KR20190111939A (ko) | 2019-10-02 |
| IL267992A (en) | 2019-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201906386XA (en) | Combination therapy involving diaryl macrocyclic compounds | |
| SG11201900163PA (en) | Macrocycle kinase inhibitors | |
| SG11201811564QA (en) | Methods of treating ovarian cancer | |
| SG11201907056XA (en) | Compositions and methods for the treatment of hemoglobinopathies | |
| SG11201900480YA (en) | Anti-tim-3 antibodies | |
| SG11201808622SA (en) | Chimeric receptors to flt3 and methods of use thereof | |
| SG11201810600WA (en) | Fxr (nr1h4) modulating compounds | |
| SG11201901390TA (en) | Tetracycline compounds and methods of treatment | |
| SG11201811003PA (en) | Anti-pd-l1 antibodies and uses thereof | |
| SG11201900844UA (en) | Amino pyrimidine ssao inhibitors | |
| SG11201900746RA (en) | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions | |
| SG11201907023UA (en) | Method of reducing neutropenia | |
| SG11201810927QA (en) | Pd-l1-specific antibodies and methods of using the same | |
| SG11201907032RA (en) | Amino pyrimidine compounds useful as ssao inhibitors | |
| SG11201500005SA (en) | Pyrimidine pyrazolyl derivatives | |
| SG11201809751XA (en) | Egfr inhibitor compounds | |
| SG11201900845YA (en) | Uses of il-13 antagonists for treating atopic dermatitis | |
| SG11201901228QA (en) | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide | |
| SG11201900633XA (en) | Piperidine cxcr7 receptor modulators | |
| SG11201810872UA (en) | Composition and method for reducing neutropenia | |
| SG11201909064RA (en) | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer | |
| SG11201805001UA (en) | Method of treating influenza a | |
| SG11201901063SA (en) | Therapeutic agents for neurodegenerative diseases | |
| SG11201810965YA (en) | 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors | |
| SG11201900361RA (en) | Methods of treating prostate cancer |