SG11201811104TA - Screening kit and method - Google Patents
Screening kit and methodInfo
- Publication number
- SG11201811104TA SG11201811104TA SG11201811104TA SG11201811104TA SG11201811104TA SG 11201811104T A SG11201811104T A SG 11201811104TA SG 11201811104T A SG11201811104T A SG 11201811104TA SG 11201811104T A SG11201811104T A SG 11201811104TA SG 11201811104T A SG11201811104T A SG 11201811104TA
- Authority
- SG
- Singapore
- Prior art keywords
- fondazza
- cellply
- bologna
- international
- microfluidic device
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0275—Interchangeable or disposable dispensing tips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
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- G01N15/1433—
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- G—PHYSICS
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
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- G01N15/1484—Electro-optical investigation, e.g. flow cytometers microstructural devices
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- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G—PHYSICS
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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- G06V20/698—Matching; Classification
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- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2200/0668—Trapping microscopic beads
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- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0609—Holders integrated in container to position an object
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
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- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
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- G06T7/0014—Biomedical image inspection using an image reference approach
Abstract
gaudhumidity Gontwiled hilicroscOp iye () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 December 2017 (21.12.2017) WIPO I PCT omit VIII two III OH VIII ioo Illoono iflo oimIE (10) International Publication Number WO 2017/216739 Al (51) International Patent Classification: G01N 35/10 (2006.01) GO1N 15/10 (2006.01) G01N 15/14 (2006.01) (21) International Application Number: PCT/IB2017/053530 (22) International Filing Date: 14 June 2017 (14.06.2017) (25) Filing Language: Italian (26) Publication Language: English (30) Priority Data: 102016000061106 14 June 2016 (14.06.2016) IT 102016000122158 01 December 2016 (01.12.2016) IT (71) Applicant: CELLPLY S.R.L. [IT/IT]; Via Fondazza, 53, 40125 Bologna (IT). (72) Inventors: BOCCHI, Massimo; c/o Cellply S.r.l., Via Fondazza, 53, 40125 Bologna (IT). FAENZA, Andrea; c/o Cellply S.r.l., Via Fondazza, 53, 40125 Bologna (IT). ROC- CHI, Laura; c/o Cellply S.r.l.., Via Fondazza, 53, 40125 Bologna (IT). BISCARINI, Dario; c/o Cellply S.r.l., Via Fondazza, 53, 40125 Bologna (IT). PECORARI, Nicola; c/o Cellply S.r.l., Via Fondazza, 53, 40125 Bologna (IT). (74) Agent: RIGAMONTI, Dorotea et al.; c/o Jacobacci & Partners S.p.A., Via Senato, 8, 1-20121 Milano (IT). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: SCREENING KIT AND METHOD imagif) analysis Fla 28 (57) : The present invention relates to a method for the large-scale high-content analysis of biological samples, implemented in a reversed open microwell system which comprises an array of open microwells, at least one microchannel, at least one input port for reagents and/or for one or more biological samples and at least one output port for them, said input and output ports being in microfluidic communication with one or more of said microchannels, wherein said microchannel has a cross- section area of micrometric dimensions and provides fluid to said microwells, wherein said reversed open microwell system is inserted in an automated management system which comprises the following features: an incubator at controlled temperature, humidity and CO2, fluid dispensing system, phase- contrast and fluorescence image acquisition. The present invention further relates to a kit for introducing fluids in a microfluidic device which comprises a tip, and to a microfluidic device which comprises at least one microchannel and an input region which comprises at [Continued on next page] WO 2017/216739 Al MIDEDIMOMOIDEIRMEMODIMMINEIIMIDEVOIS OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) least one vertical channel, said tip and said vertical channel being dimensioned so to produce an interference coupling therebetween. In a further aspect, a system for discharging one or more fluids in a microfluidic device is described. Said discharge region comprises: a discharge container in fluidic connection with said microfluidic device through at least one discharge channel and an output port.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUA2016A004357A ITUA20164357A1 (en) | 2016-06-14 | 2016-06-14 | Ex vivo screening method |
IT102016000122158A IT201600122158A1 (en) | 2016-12-01 | 2016-12-01 | KIT AND METHOD FOR THE ENTRY OF ONE OR MORE FLUIDS IN A MICROFLUIDIC DEVICE |
PCT/IB2017/053530 WO2017216739A1 (en) | 2016-06-14 | 2017-06-14 | Screening kit and method |
Publications (1)
Publication Number | Publication Date |
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SG11201811104TA true SG11201811104TA (en) | 2019-01-30 |
Family
ID=60664415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811104TA SG11201811104TA (en) | 2016-06-14 | 2017-06-14 | Screening kit and method |
Country Status (11)
Country | Link |
---|---|
US (2) | US10569270B2 (en) |
EP (2) | EP3469376B1 (en) |
JP (1) | JP7212523B2 (en) |
KR (1) | KR20190023067A (en) |
CN (1) | CN109564238A (en) |
AU (1) | AU2017283802B2 (en) |
BR (1) | BR112018076095A2 (en) |
CA (1) | CA3027317A1 (en) |
RU (1) | RU2739327C2 (en) |
SG (1) | SG11201811104TA (en) |
WO (1) | WO2017216739A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10571475B2 (en) | 2010-12-03 | 2020-02-25 | Cellply S.R.L. | Rapid screening of monoclonal antibodies |
JP6804438B2 (en) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | An in vivo model of the human small intestine using pluripotent stem cells, and methods for making and using it. |
CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
FR3086951B1 (en) * | 2018-10-05 | 2021-02-26 | Redberry | METHOD AND DEVICE FOR THE DETECTION OF AT LEAST ONE MICROORGANISM ACCORDING TO ITS MARKING KINETICS, AND DETECTION SUPPORT |
GB2595106B (en) * | 2019-01-22 | 2022-10-12 | Emulate Inc | High-content imaging of microfluidic devices |
US20220275345A1 (en) * | 2019-08-13 | 2022-09-01 | Children's Hospital Medical Center | Methods for making organoid compositions |
EP4038365A1 (en) * | 2019-10-04 | 2022-08-10 | Cellply S.R.L. | High-content analysis method |
CN111781197B (en) * | 2020-07-14 | 2022-09-23 | 中国人民解放军陆军军医大学第一附属医院 | Rapid sepsis detection kit and process |
EP4284557A1 (en) * | 2021-02-01 | 2023-12-06 | Bio-Rad Laboratories, Inc. | Microfluidic devices and processes |
CN113604547B (en) * | 2021-08-06 | 2023-05-02 | 吉林大学 | High-resolution space histology detection method for tissue sample |
WO2024003723A1 (en) * | 2022-06-28 | 2024-01-04 | Cellply S.R.L. | Method for the characterization of products for cell therapy |
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- 2017-06-14 WO PCT/IB2017/053530 patent/WO2017216739A1/en unknown
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- 2017-06-14 EP EP17748570.3A patent/EP3469376B1/en active Active
- 2017-06-14 US US15/623,149 patent/US10569270B2/en active Active
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AU2017283802B2 (en) | 2022-04-14 |
CA3027317A1 (en) | 2017-12-21 |
EP3469376C0 (en) | 2023-09-06 |
CN109564238A (en) | 2019-04-02 |
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EP3469376A1 (en) | 2019-04-17 |
EP3258240A3 (en) | 2017-12-27 |
AU2017283802A1 (en) | 2019-01-24 |
WO2017216739A1 (en) | 2017-12-21 |
EP3258240C0 (en) | 2023-06-07 |
US10569270B2 (en) | 2020-02-25 |
JP7212523B2 (en) | 2023-01-25 |
BR112018076095A2 (en) | 2019-03-26 |
US20180043357A1 (en) | 2018-02-15 |
US20190247848A1 (en) | 2019-08-15 |
EP3258240B1 (en) | 2023-06-07 |
EP3469376B1 (en) | 2023-09-06 |
RU2019100237A3 (en) | 2020-07-27 |
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