SG11201900901QA - Laser ablation system - Google Patents
Laser ablation systemInfo
- Publication number
- SG11201900901QA SG11201900901QA SG11201900901QA SG11201900901QA SG11201900901QA SG 11201900901Q A SG11201900901Q A SG 11201900901QA SG 11201900901Q A SG11201900901Q A SG 11201900901QA SG 11201900901Q A SG11201900901Q A SG 11201900901QA SG 11201900901Q A SG11201900901Q A SG 11201900901QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- transfer conduit
- ablation
- laser ablation
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
- H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0004—Imaging particle spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/105—Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N2001/045—Laser ablation; Microwave vaporisation
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIP0 I PCT omit IIl °nolo io 1111111 ow (10) International Publication Number WO 2018/026898 Al (51) International Patent Classification: HO1J 49/04 (2006.01) (21) International Application Number: PCT/US2017/045060 (22) International Filing Date: 02 August 2017 (02.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/370,180 02 August 2016 (02.08.2016) US (71) Applicant: FLUIDIGM CANADA INC. [CA/CA]; 1380 Rodick Road, Suite 400, Markham, Ontario L3R 4G5 (CA). (72) Inventor: LOBODA, Alexander V.; 726 Yorkhill Boule- vard, Thornhill, Ontario L4Y 5G7 (CA). (74) Agent: KITCES, Matthew T. et al.; Kilpatrick Townsend & Stockton LLP, Mailstop: IP Docketing - 22, 1100 Peachtree Street, Suite 2800, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = (54) Title: LASER ABLATION SYSTEM FIGURE 7B Abtationfro the sampling h e (57) : The invention relates to methods and devices for analysis of samples using laser ablation imaging mass cytometry and mass spectrometry. The invention provides methods and devices in which individual ablation plumes are distinctively captured and rapidly transferred to the ionization system, followed by analysis by mass spectrometry. A transfer conduit can be used to convey ablation plumes to an ionization system. The transfer conduit can include an asymmetric cone. The transfer conduit can be tapered. A flow sacrificing system can be adapted to divert a part of the sheath flow out a sacrificial outlet while the core of the sheath flow containing ablation plumes enters the ionization system. [Continued on next page] WO 2018/026898 Al 1#110H111111111111111111111111111111111111111111101111111111111101111111111111111111 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662370180P | 2016-08-02 | 2016-08-02 | |
PCT/US2017/045060 WO2018026898A1 (en) | 2016-08-02 | 2017-08-02 | Laser ablation system |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201900901QA true SG11201900901QA (en) | 2019-02-27 |
Family
ID=59656188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201900901QA SG11201900901QA (en) | 2016-08-02 | 2017-08-02 | Laser ablation system |
Country Status (6)
Country | Link |
---|---|
US (1) | US10622199B2 (en) |
EP (1) | EP3494591A1 (en) |
CN (1) | CN109791868A (en) |
CA (1) | CA3032861A1 (en) |
SG (1) | SG11201900901QA (en) |
WO (1) | WO2018026898A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3195346B1 (en) * | 2014-09-18 | 2020-05-06 | Universiteit Gent | Laser ablation probe |
US20210239707A1 (en) * | 2018-04-27 | 2021-08-05 | Fluidigm Canada Inc. | Reagents and methods for elemental mass spectrometry of biological samples |
WO2020046892A1 (en) * | 2018-08-28 | 2020-03-05 | Virgin Instruments Corporation | Molecular imaging of biological samples with sub-cellular spatial resolution and high sensitivity |
US20210373313A1 (en) * | 2018-09-10 | 2021-12-02 | Fluidigm Canada Inc. | Autofocus sample imaging apparatus and method |
GB201815123D0 (en) * | 2018-09-17 | 2018-10-31 | Micromass Ltd | Tissue analysis |
EP3911760A4 (en) * | 2019-01-15 | 2022-10-12 | Fluidigm Canada Inc. | Direct ionization in imaging mass spectrometry |
CA3140663A1 (en) * | 2019-06-18 | 2020-12-24 | Paul Corkum | Improved mass cytometry |
JP7349632B2 (en) * | 2019-06-28 | 2023-09-25 | 株式会社エス・テイ・ジャパン | Cells and analyzers for laser ablation |
WO2021127657A1 (en) * | 2019-12-20 | 2021-06-24 | Fluidigm Canada Inc. | Plasma and sampling geometries for imaging mass cytometry |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4200497A1 (en) * | 1992-01-10 | 1993-07-15 | Bayer Ag | Rapid identification of plastics by mass spectrometry - using laser beam for local heating in inert atmos. and heated capillary for direct transfer |
US5526110A (en) * | 1994-07-08 | 1996-06-11 | Iowa State University Research Foundation, Inc. | In situ calibration of inductively coupled plasma-atomic emission and mass spectroscopy |
US7479630B2 (en) | 2004-03-25 | 2009-01-20 | Bandura Dmitry R | Method and apparatus for flow cytometry linked with elemental analysis |
US6683277B1 (en) * | 2002-12-20 | 2004-01-27 | Osram Opto Semiconductors | Laser ablation nozzle assembly |
WO2008019492A1 (en) | 2006-08-15 | 2008-02-21 | Alexei Antonov | Apparatus and method for elemental analysis of particles by mass spectrometry |
WO2014079802A2 (en) * | 2012-11-20 | 2014-05-30 | Ventana Medical Systems, Inc. | Laser ablation inductively-coupled plasma mass spectral tissue diagnostics |
KR20150114963A (en) * | 2013-02-14 | 2015-10-13 | 일렉트로 싸이언티픽 인더스트리이즈 인코포레이티드 | Laser ablation cell and torch system for a compositional analysis system |
US20140268134A1 (en) * | 2013-03-15 | 2014-09-18 | Electro Scientific Industries, Inc. | Laser sampling methods for reducing thermal effects |
AU2013382989B2 (en) * | 2013-03-22 | 2018-06-07 | Eth Zurich | Laser ablation cell |
CA3191952A1 (en) * | 2013-04-17 | 2014-10-23 | Fluidigm Canada Inc. | Sample analysis for mass cytometry |
US20160260598A1 (en) * | 2015-02-04 | 2016-09-08 | Fluidigm Canada Inc. | Laser enabled imaging mass cytometry |
-
2017
- 2017-08-02 EP EP17754534.0A patent/EP3494591A1/en not_active Withdrawn
- 2017-08-02 CA CA3032861A patent/CA3032861A1/en active Pending
- 2017-08-02 WO PCT/US2017/045060 patent/WO2018026898A1/en unknown
- 2017-08-02 CN CN201780059191.0A patent/CN109791868A/en active Pending
- 2017-08-02 SG SG11201900901QA patent/SG11201900901QA/en unknown
- 2017-08-02 US US16/322,418 patent/US10622199B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10622199B2 (en) | 2020-04-14 |
WO2018026898A1 (en) | 2018-02-08 |
CN109791868A (en) | 2019-05-21 |
CA3032861A1 (en) | 2018-02-08 |
US20190180996A1 (en) | 2019-06-13 |
EP3494591A1 (en) | 2019-06-12 |
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