SG11201807068WA - Devices and methods for rapid pcr - Google Patents

Devices and methods for rapid pcr

Info

Publication number
SG11201807068WA
SG11201807068WA SG11201807068WA SG11201807068WA SG11201807068WA SG 11201807068W A SG11201807068W A SG 11201807068WA SG 11201807068W A SG11201807068W A SG 11201807068WA SG 11201807068W A SG11201807068W A SG 11201807068WA SG 11201807068W A SG11201807068W A SG 11201807068WA
Authority
SG
Singapore
Prior art keywords
utah
lake city
international
south
east
Prior art date
Application number
SG11201807068WA
Inventor
Kirk Max Ririe
David E Jones
Christopher Paul Pasko
Anson Cole Chamberlain
Derek David
Aaron Wernerehl
Jonathan Allen Bruns
Original Assignee
Biofire Defense Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofire Defense Llc filed Critical Biofire Defense Llc
Publication of SG11201807068WA publication Critical patent/SG11201807068WA/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663Stretching or orienting elongated molecules or particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1816Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using induction heating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1861Means for temperature control using radiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization 11111111011110111010101H HO 11111 011101011101 la HE011111011110111111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/147085 Al 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: 224 South Kensington Avenue, Salt Lake City, Utah 84115 C12Q 1/68 (2006.01) BOIL 3/00 (2006.01) (US). BOIL 7/00 (2006.01) C12N 15/10 (2006.01) (74) Agents: STRINGHAM, John C. et al.; 60 East South (21) International Application Number: Temple, Suite 1000, Salt Lake City, Utah 84111 (US). PCT/US2017/018748 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 21 February 2017 (21.02.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/298,311 22 February 2016 (22.02.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/330,701 2 May 2016 (02.05.2016) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/409,829 18 October 2016 (18.10.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: BIOFIRE DEFENSE, LLC [US/US]; 79 ZA, ZM, ZW. West 4500 South, Suite 14, Salt Lake City, Utah 84107 (84) Designated States (unless otherwise indicated, for every (US). kind of regional protection available): ARIPO (BW, GH, (72) Inventors: RIRIE, Kirk Max; 1364 Kristie Lane, Salt GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, _ Lake City, Utah 84107 (US). JONES, David E.; 15 Sierra TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, — Way, Layton, Utah 84041 (US). PASKO, Christopher TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Paul; 1648 South 1000 East, Salt Lake City, Utah 84105 — (US). CHAMBERLAIN, Anson Cole; 46 East 1400 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = North, American Fork, Utah 84003 (US). DAVID, Derek; SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 6130 South 2300 East, Salt Lake City, Utah 84121 (US). WERNEREHL, Aaron; 224 Kensington Avenue, Salt Published: Lake City, Utah 84115 (US). BRUNS, Jonathan Allen; — — with international search report (Art. 21(3)) = = (54) Title: DEVICES AND METHODS FOR RAPID PCR = = — 510 = = = = 515a 515c 515e 515g 515i 515k 515b 515d 515f 515h 515j 5151 590 — <0 0 1 0 0 0 0 OW = — 514 i 543 553 544 548 566 580 • 1,•• • • • — 522 V 546 564 .:.•,... • :0•FiliXA Vve • . • • . . acc• vf ffff 582 iciickk' .... 11 530 565 538 533 552 562 • orii ire ••_____,______..\" 581 Cf) 0 IN 534 iv FIG. 1 1-1 IN 1-1 (57) : Instruments, methods, and kits are disclosed for performing fast thermocycling. 0 N O
SG11201807068WA 2016-02-22 2017-02-21 Devices and methods for rapid pcr SG11201807068WA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662298311P 2016-02-22 2016-02-22
US201662330701P 2016-05-02 2016-05-02
US201662409829P 2016-10-18 2016-10-18
PCT/US2017/018748 WO2017147085A1 (en) 2016-02-22 2017-02-21 Devices and methods for rapid pcr

Publications (1)

Publication Number Publication Date
SG11201807068WA true SG11201807068WA (en) 2018-09-27

Family

ID=59685549

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201807068WA SG11201807068WA (en) 2016-02-22 2017-02-21 Devices and methods for rapid pcr

Country Status (9)

Country Link
US (1) US10875026B2 (en)
EP (1) EP3420107A4 (en)
JP (2) JP2019513411A (en)
KR (1) KR20180112069A (en)
CN (1) CN109072292A (en)
AU (1) AU2017223404B2 (en)
CA (1) CA3015475A1 (en)
SG (1) SG11201807068WA (en)
WO (1) WO2017147085A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6823204B2 (en) 2017-05-24 2021-01-27 バイオファイアー・ディフェンス・エルエルシー Systems and methods for array point-of-use emissions
WO2019045807A1 (en) 2017-08-31 2019-03-07 Biofire Defense, Llc. Assay devices and methods of use thereof
SG11201903333SA (en) 2017-12-29 2019-08-27 Clear Labs Inc Automated priming and library loading services
WO2019236978A1 (en) * 2018-06-07 2019-12-12 Biofire Diagnostics, Llc Rapid thermocycling methods
CN110819702B (en) * 2018-08-13 2023-03-21 上海新微技术研发中心有限公司 Digital PCR system and digital PCR liquid drop forming method
EP3861129A4 (en) * 2018-10-02 2022-07-20 BioFire Diagnostics, LLC Bacterial response
KR102256757B1 (en) * 2019-04-11 2021-05-27 (주)바이오니아 Polymerase Chain Reaction System
KR102252970B1 (en) * 2019-05-24 2021-05-17 한국기계연구원 Fast molecular diagnosis apparatus and method for fast molecular diagnosis using the same
CN110747294B (en) * 2019-11-08 2021-06-04 宁波胤瑞生物医学仪器有限责任公司 Method for regulating and controlling digital nucleic acid amplification instrument
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
CN111346685B (en) * 2020-03-10 2022-01-25 中国科学院苏州生物医学工程技术研究所 Device and method capable of realizing rapid temperature control
US11181451B1 (en) 2020-06-01 2021-11-23 Shaheen Innovations Holding Limited Infectious disease screening system
IL298682A (en) 2020-06-01 2023-01-01 Shaheen Innovations Holding Ltd An infectious disease screening device
EP3919175A1 (en) * 2020-06-01 2021-12-08 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US20230271189A1 (en) * 2020-07-31 2023-08-31 Seegene, Inc. Thermal cycler comprising damping module
GB2622964A (en) * 2020-10-19 2024-04-03 Quantumdx Group Ltd Integrated thermal conditioning and PCR in a molecular POC diagnostic device and system
KR102362075B1 (en) 2021-05-13 2022-02-14 주식회사 위즈바이오솔루션 Nucleic acid amplification apparatus
KR102533022B1 (en) * 2021-05-27 2023-05-16 옴니시스템 주식회사 Apparatus for controlling temperature of pcr device using thermoelectric element
US20240035016A1 (en) 2022-04-29 2024-02-01 Cepheid Nucleic acid extraction and isolation with heat labile silanes and chemically modified solid supports
US20240017255A1 (en) 2022-05-19 2024-01-18 Cepheid Mvp cartridge and methods of use and manufacture

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE208658T1 (en) * 1993-07-28 2001-11-15 Pe Corp Ny APPARATUS AND METHOD FOR NUCLEIC ACID DUPLICATION
ATE522776T1 (en) * 2001-07-16 2011-09-15 Idaho Technology Inc TEMPERATURE CHANGING SYSTEM AND METHOD OF USE
US20030175749A1 (en) * 2001-12-08 2003-09-18 Jong-Yoon Chun Annealing control primer and its uses
US8916348B2 (en) 2004-05-06 2014-12-23 Clondiag Gmbh Method and device for the detection of molecular interactions
JP4999103B2 (en) * 2004-10-27 2012-08-15 セフィード Multistage nucleic acid amplification reaction in closed system
EP1658898A1 (en) * 2004-11-20 2006-05-24 Roche Diagnostics GmbH Nucleic acid preparation
CA2607661C (en) * 2005-05-09 2017-08-08 Idaho Technology, Inc. A device and method for two-stage nucleic acid amplification
WO2007091230A1 (en) 2006-02-07 2007-08-16 Stokes Bio Limited A microfluidic analysis system
US20080003564A1 (en) 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
DE102006027675B4 (en) * 2006-06-14 2011-05-12 Siemens Ag Method for determining the concentration of nucleic acids
ES2809168T3 (en) * 2006-11-15 2021-03-03 Biofire Diagnostics Llc High-density autonomous biological analysis
CN101802163A (en) * 2007-05-23 2010-08-11 信诚医疗有限公司 Container for liquid reaction mixture, reaction-promoting device using the same and method therefor
CA2691451C (en) * 2007-06-21 2015-03-24 Sara H. Fan Instrument and receptacles for performing processes
US9200329B2 (en) 2008-05-19 2015-12-01 Biofire Diagnostics, Llc Rapid epidemiologic typing of bacteria
CN103540518B (en) * 2010-07-23 2015-07-08 贝克曼考尔特公司 Test box
CN102994369B (en) * 2012-12-14 2014-12-31 张影频 Chip structure for PCR (polymerase chain reaction) rapid reaction
EP3066222B1 (en) 2013-11-05 2020-01-08 BioFire Diagnostics, LLC Induction pcr
CN106061611A (en) * 2013-11-18 2016-10-26 生命技术公司 Systems and methods for loading liquid samples
JP2015154722A (en) * 2014-02-20 2015-08-27 セイコーエプソン株式会社 Nucleic acid amplification reaction vessel and nucleic acid amplification reaction device

Also Published As

Publication number Publication date
JP2019513411A (en) 2019-05-30
CA3015475A1 (en) 2017-08-31
US20190046989A1 (en) 2019-02-14
EP3420107A1 (en) 2019-01-02
CN109072292A (en) 2018-12-21
KR20180112069A (en) 2018-10-11
JP2021153602A (en) 2021-10-07
JP7341190B2 (en) 2023-09-08
US20210078009A1 (en) 2021-03-18
US10875026B2 (en) 2020-12-29
AU2017223404A1 (en) 2019-06-13
EP3420107A4 (en) 2019-07-31
AU2017223404B2 (en) 2022-09-22
WO2017147085A1 (en) 2017-08-31

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