SG11201900170VA - Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof - Google Patents
Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereofInfo
- Publication number
- SG11201900170VA SG11201900170VA SG11201900170VA SG11201900170VA SG11201900170VA SG 11201900170V A SG11201900170V A SG 11201900170VA SG 11201900170V A SG11201900170V A SG 11201900170VA SG 11201900170V A SG11201900170V A SG 11201900170VA SG 11201900170V A SG11201900170V A SG 11201900170VA
- Authority
- SG
- Singapore
- Prior art keywords
- microfiltration
- international
- manufacture
- volume fraction
- high volume
- Prior art date
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/265—Separation of sediment aided by centrifugal force or centripetal force by using a vortex inducer or vortex guide, e.g. coil
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/10—Centrifuges combined with other apparatus, e.g. electrostatic separators; Sets or systems of several centrifuges
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/088—Channel loops
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
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- B01L2400/04—Moving fluids with specific forces or mechanical means
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- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03B—SEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS
- B03B5/00—Washing granular, powdered or lumpy materials; Wet separating
- B03B5/28—Washing granular, powdered or lumpy materials; Wet separating by sink-float separation
- B03B5/30—Washing granular, powdered or lumpy materials; Wet separating by sink-float separation using heavy liquids or suspensions
- B03B5/32—Washing granular, powdered or lumpy materials; Wet separating by sink-float separation using heavy liquids or suspensions using centrifugal force
Abstract
WO 18/0 17 0 22 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 January 2018 (25.01.2018) W I PO I PCT Iiiimmommionotioloommolomonomoinovoimill (10) International Publication Number WO 2018/017022 Al (51) International Patent Classification: BOIL 3/00 (2006.01) BOlD 43/00 (2006.01) (21) International Application Number: PCT/SG2017/050373 (22) International Filing Date: 21 July 2017 (21.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201606028T 21 July 2016 (21.07.2016) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: GOH, Shireen; c/o Bioprocessing Technolo- gy Institute, 20 Biopolis Way, Centros #06-01, Singapore 138668 (SG). TAN, Shan Mei; c/o Bioprocessing Technol- ogy Institute, 20 Biopolis Way, Centros #06-01, Singapore 138668 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: APPARATUS FOR OUTER WALL FOCUSING FOR HIGH VOLUME FRACTION PARTICLE MICROFILTRATION AND METHOD FOR MANUFACTURE THEREOF 300 FIG. 3 (57) : An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such mi- crofiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each includ- ing a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. In an embodiment, multiple inertial microfluidic devices are connected in sequence for combined inner wall and outer wall focusing. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles. [Continued on next page] WO 2018/017022 Al IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIH IIII00 IIIIIIIIIIIII01101OHOIIIIIIIIIMOIIIIII SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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SG10201606028T | 2016-07-21 | ||
PCT/SG2017/050373 WO2018017022A1 (en) | 2016-07-21 | 2017-07-21 | Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof |
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SG11201900170VA true SG11201900170VA (en) | 2019-02-27 |
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SG10202108510UA SG10202108510UA (en) | 2016-07-21 | 2017-07-21 | Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof |
SG11201900170VA SG11201900170VA (en) | 2016-07-21 | 2017-07-21 | Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof |
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US (2) | US20190275521A1 (en) |
EP (1) | EP3487626A4 (en) |
JP (2) | JP7082453B2 (en) |
CN (2) | CN113663749B (en) |
SG (2) | SG10202108510UA (en) |
WO (1) | WO2018017022A1 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7124475B2 (en) * | 2018-01-17 | 2022-08-24 | 株式会社Ihi | Cell culture system and cell culture method |
JP7087704B2 (en) * | 2018-06-13 | 2022-06-21 | 株式会社Ihi | Cell culture system and cell culture method |
CN109486653B (en) * | 2018-11-27 | 2022-03-22 | 上海昆道生物技术有限公司 | Trace cell capture system based on micro-fluidic and immunomagnetic separation dual strategies |
CN109827806A (en) * | 2019-03-18 | 2019-05-31 | 中国科学院重庆绿色智能技术研究院 | A kind of acquisition device and method of circulating tumor cell |
CN110687188B (en) * | 2019-09-29 | 2021-05-18 | 东北大学 | Micro-fluidic chip mass spectrometry system for single cell analysis and application method thereof |
US20220395831A1 (en) * | 2019-10-21 | 2022-12-15 | Nanyang Technological University | Direct and scalable isolation of circulating extracellular vesicles from whole blood using centrifugal forces |
CN112973811B (en) * | 2019-12-17 | 2022-10-18 | 香港城市大学深圳研究院 | Exosome enrichment microfluidic chip in blood based on laminar flow diffusion |
JP7435766B2 (en) | 2020-06-02 | 2024-02-21 | 日本電信電話株式会社 | Particle sorting device, method, program, data structure of particle sorting data, and learned model generation method |
CN111774108B (en) * | 2020-06-19 | 2021-11-12 | 东南大学 | Wall surface separation type spiral micro-fluidic chip |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7291310B2 (en) * | 2002-12-17 | 2007-11-06 | The Regents Of The University Of Michigan | Microsystem for determining clotting time of blood and low-cost, single-use device for use therein |
LT2550971T (en) * | 2004-09-30 | 2018-10-25 | Bayer Healthcare Llc | Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules |
CN101086504B (en) * | 2006-06-06 | 2011-04-20 | 北京大学 | Microfluid centrifugal chip and its processing method |
WO2008130977A2 (en) * | 2007-04-16 | 2008-10-30 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Systems and methods for particle focusing in microchannels |
US8208138B2 (en) * | 2009-09-24 | 2012-06-26 | University Of Cincinnati | Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems |
MX344460B (en) * | 2009-12-23 | 2016-12-14 | Cytovera Inc * | A system and method for particle filtration. |
CN107604039B (en) * | 2010-03-04 | 2022-04-15 | 新加坡国立大学 | Microfluidic sorter for detecting and separating cells |
JP2013221780A (en) * | 2012-04-13 | 2013-10-28 | Hitachi High-Technologies Corp | Specimen treatment apparatus |
EP2897730A4 (en) * | 2012-09-21 | 2016-04-27 | Massachusetts Inst Technology | Micro-fluidic device and uses thereof |
US10077462B2 (en) * | 2013-03-15 | 2018-09-18 | The Broad Institute, Inc. | Microfluidic microbe detection and isolation |
GB201316347D0 (en) * | 2013-09-13 | 2013-10-30 | Cancer Rec Tech Ltd | Biological fluid filtration assembly |
WO2015057159A1 (en) * | 2013-10-16 | 2015-04-23 | Clearbridge Biomedics Pte Ltd | Microfluidics sorter for cell detection and isolation |
CN103923825B (en) * | 2014-04-17 | 2016-01-13 | 东南大学 | The micro-fluidic chip system of a kind of integrating cell sorting and detection |
US10806845B2 (en) * | 2014-09-17 | 2020-10-20 | Massachusetts Institute Of Technology | System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion |
CN107250341A (en) * | 2014-09-17 | 2017-10-13 | 麻省理工学院 | Method and microfluid system for irrigating the reservation of bioreactor cell |
CN105214747B (en) * | 2015-11-11 | 2017-05-10 | 东南大学 | Clamping-piece-type microfluidic device and manufacturing method |
-
2017
- 2017-07-21 JP JP2019502624A patent/JP7082453B2/en active Active
- 2017-07-21 WO PCT/SG2017/050373 patent/WO2018017022A1/en unknown
- 2017-07-21 CN CN202111036699.3A patent/CN113663749B/en active Active
- 2017-07-21 EP EP17831446.4A patent/EP3487626A4/en active Pending
- 2017-07-21 SG SG10202108510UA patent/SG10202108510UA/en unknown
- 2017-07-21 US US16/319,276 patent/US20190275521A1/en not_active Abandoned
- 2017-07-21 CN CN201780044668.8A patent/CN109475868B/en active Active
- 2017-07-21 SG SG11201900170VA patent/SG11201900170VA/en unknown
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2022
- 2022-05-26 JP JP2022085713A patent/JP7397123B2/en active Active
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2023
- 2023-05-10 US US18/195,918 patent/US20230356223A1/en active Pending
Also Published As
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JP2022119893A (en) | 2022-08-17 |
CN113663749B (en) | 2023-06-20 |
JP2019531051A (en) | 2019-10-31 |
CN113663749A (en) | 2021-11-19 |
US20190275521A1 (en) | 2019-09-12 |
WO2018017022A1 (en) | 2018-01-25 |
SG10202108510UA (en) | 2021-09-29 |
CN109475868A (en) | 2019-03-15 |
JP7082453B2 (en) | 2022-06-08 |
EP3487626A4 (en) | 2020-03-18 |
JP7397123B2 (en) | 2023-12-12 |
CN109475868B (en) | 2021-08-17 |
US20230356223A1 (en) | 2023-11-09 |
EP3487626A1 (en) | 2019-05-29 |
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