SG11201805592RA - Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor - Google Patents
Methods of producing patient-specific anti-cancer therapeutics and methods of treatment thereforInfo
- Publication number
- SG11201805592RA SG11201805592RA SG11201805592RA SG11201805592RA SG11201805592RA SG 11201805592R A SG11201805592R A SG 11201805592RA SG 11201805592R A SG11201805592R A SG 11201805592RA SG 11201805592R A SG11201805592R A SG 11201805592RA SG 11201805592R A SG11201805592R A SG 11201805592RA
- Authority
- SG
- Singapore
- Prior art keywords
- emeryville
- suite
- california
- street
- horton
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46432—Nervous system antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5052—Cells of the immune system involving B-cells
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
- A61K2239/11—Antigen recognition domain
- A61K2239/13—Antibody-based
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
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- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 11111 0111011101110011110111 10111110H III International Bureau 0.. .... .. ..... ..or:;„, (10) International Publication Number (43) International Publication Date WO 2017/123978 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: [CN/US]; 5858 Horton Street, Suite 320, Emeryville, Cali- C07K16/00 (2006.01) C07K 16/30 (2006.01) fornia 94608 (US). FOX, George L. [US/US]; 5858 Hor- C07K 16/28 (2006.01) G01N 33/569 (2006.01) ton Street, Suite 320, Emeryville, California 94608 (US). RADEL, Peggy A. [US/US]; 5858 Horton Street, Suite (21) International Application Number: 320, Emeryville, California 94608 (US). PCT/US2017/013483 (74) Agents: MCNEILL, Rebecca M. et al.; McNeill Baur (22) International Filing Date: PLLC, 125 Cambridge Park Drive, Suite 301, Cambridge, 13 January 2017 (13.01.2017) Massachusetts 02140 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (30) Priority Data: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 62/279,341 15 January 2016 (15.01.2016) US DO, DZ, EC, EE, EG, ES, FE GB, GD, GE, GH, GM, GT, 62/411,690 23 October 2016 (23.10.2016) US HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 62/412,092 24 October 2016 (24.10.2016) US KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (71) Applicant: BERKELEY LIGHTS, INC. [US/US]; 5858 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, Horton Street, Suite 320, Emeryville, California 94608 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (US). RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (72) Inventors; and ZA, ZM, ZW. (71) Applicants : CHAPMAN, Kevin T. [US/US]; 5858 Hor- - ton Street, Suite 320, Emeryville, California 94608 (US). (84) Designated States (unless otherwise indicated, for every _ kind ARIPO (BW, GH, WHITE, Mark P. [US/US]; 5858 Horton Street, Suite of regional protection available): GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 320, Emeryville, California 94608 (US). WANG, Xiaohua = 5858 Horton Street, Suite 320, Emeryville, Cali- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [CN/US]; fornia 94608 (US). PARK, Minha [US/US]; 5858 Horton TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FE FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = Street, Suite 320, Emeryville, California 94608 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, STADLER, Guido K. [AT/US]; 5858 Horton Street, Emeryville, California 94608 (US). LOWE, JR., Randall SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = D. 5858 Horton Street, Suite 320, Emeryville, GW, KM, ML, MR, NE, SN, TD, TG). [US/US]; = California 94608 (US). GUAN, Xiao [CN/US]; 5858 Hor- Published: = ton Street, Suite 320, Emeryville, California 94608 (US). with international search report (Art. 21(3)) — MCEWEN, Jason M. [US/US]; 5858 Horton Street, Suite 320, Emeryville, California 94608 (US). WANG, Gang, F. = = = = = = = 1-1 GC IN C :N (54) Title: METHODS OF PRODUCING PATIENT-SPECIFIC ANTI-CANCER THERAPEUTICS AND METHODS OF TREAT- en el MENT THEREFOR 1-1 ---- (57) : A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from IN at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a C flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissoci - el ated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) us - , ing the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells ,71 . 9 can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engin - .,. eered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662279341P | 2016-01-15 | 2016-01-15 | |
US201662411690P | 2016-10-23 | 2016-10-23 | |
US201662412092P | 2016-10-24 | 2016-10-24 | |
PCT/US2017/013483 WO2017123978A1 (en) | 2016-01-15 | 2017-01-13 | Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor |
Publications (1)
Publication Number | Publication Date |
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SG11201805592RA true SG11201805592RA (en) | 2018-07-30 |
Family
ID=57960827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201805592RA SG11201805592RA (en) | 2016-01-15 | 2017-01-13 | Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor |
Country Status (10)
Country | Link |
---|---|
US (1) | US10712344B2 (en) |
EP (2) | EP3889176A1 (en) |
JP (3) | JP6902548B2 (en) |
KR (1) | KR102512608B1 (en) |
CN (1) | CN109952313B (en) |
AU (2) | AU2017207450B2 (en) |
CA (1) | CA3011087A1 (en) |
SG (1) | SG11201805592RA (en) |
TW (2) | TWI821913B (en) |
WO (1) | WO2017123978A1 (en) |
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EP2966084B1 (en) | 2008-08-28 | 2018-04-25 | Taiga Biotechnologies, Inc. | Modulators of myc, methods of using the same and methods of identifying agents that modulate myc |
CN114645015A (en) | 2012-07-20 | 2022-06-21 | 泰加生物工艺学公司 | Enhanced reconstitution and autoreconstitution of hematopoietic compartments |
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US10272115B2 (en) | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
TWI808934B (en) | 2015-12-31 | 2023-07-21 | 美商伯克利之光生命科技公司 | Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide |
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US10583156B2 (en) | 2016-12-02 | 2020-03-10 | Taiga Biotechnologies, Inc. | Nanoparticle formulations |
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JP6992079B2 (en) | 2017-04-23 | 2022-01-13 | ヒューレット-パッカード デベロップメント カンパニー エル.ピー. | Particle separation |
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ES2905757T3 (en) * | 2017-08-03 | 2022-04-12 | Taiga Biotechnologies Inc | Methods and compositions for the treatment of melanoma |
US10149898B2 (en) | 2017-08-03 | 2018-12-11 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
CN116250868A (en) | 2017-09-12 | 2023-06-13 | 木兰医药技术股份有限公司 | Fluid control device and method of using the same |
US10871440B2 (en) | 2017-12-23 | 2020-12-22 | Lumacyte, LLC | Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics |
SG11202011180UA (en) * | 2018-05-31 | 2020-12-30 | Berkeley Lights Inc | Automated detection and characterization of micro-objects in microfluidic devices |
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