SG11201807487WA - Generation of midbrain-specific organoids from human pluripotent stem cells - Google Patents
Generation of midbrain-specific organoids from human pluripotent stem cellsInfo
- Publication number
- SG11201807487WA SG11201807487WA SG11201807487WA SG11201807487WA SG11201807487WA SG 11201807487W A SG11201807487W A SG 11201807487WA SG 11201807487W A SG11201807487W A SG 11201807487WA SG 11201807487W A SG11201807487W A SG 11201807487WA SG 11201807487W A SG11201807487W A SG 11201807487WA
- Authority
- SG
- Singapore
- Prior art keywords
- midbrain
- singapore
- international
- deriving
- tissues
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG10201601965P | 2016-03-14 | ||
PCT/SG2017/050126 WO2017160234A1 (fr) | 2016-03-14 | 2017-03-14 | Génération d'organoïdes spécifiques du mésencéphale à partir de cellules souches pluripotentes humaines |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201807487WA true SG11201807487WA (en) | 2018-09-27 |
Family
ID=59851957
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201807487WA SG11201807487WA (en) | 2016-03-14 | 2017-03-14 | Generation of midbrain-specific organoids from human pluripotent stem cells |
SG10201913687VA SG10201913687VA (en) | 2016-03-14 | 2017-03-14 | Generation of midbrain-specific organoids from human pluripotent stem cells |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913687VA SG10201913687VA (en) | 2016-03-14 | 2017-03-14 | Generation of midbrain-specific organoids from human pluripotent stem cells |
Country Status (5)
Country | Link |
---|---|
US (1) | US20190169576A1 (fr) |
EP (1) | EP3430132A4 (fr) |
CN (1) | CN109996870A (fr) |
SG (2) | SG11201807487WA (fr) |
WO (1) | WO2017160234A1 (fr) |
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WO2016061464A1 (fr) | 2014-10-17 | 2016-04-21 | Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center | Modèle in vivo d'intestin grêle humain faisant intervenir des cellules souches pluripotentes et ses procédés de fabrication et d'utilisation |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
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AU2019340838A1 (en) * | 2018-09-11 | 2021-03-25 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Automated generation and analysis of organoids |
CN112996906A (zh) * | 2018-11-15 | 2021-06-18 | Jsr株式会社 | 脑类器官的制造方法 |
CA3129656A1 (fr) * | 2019-02-11 | 2020-08-20 | Miltenyi Biotec B.V. & Co. KG | Generation de structures de tissu artificiel derivees de cellules souches pluripotentes humaines sans matrices tridimensionnelles |
JP7366332B2 (ja) * | 2019-06-05 | 2023-10-23 | 公立大学法人奈良県立医科大学 | 脳幹オルガノイドの作製方法 |
CN114026222A (zh) * | 2019-07-05 | 2022-02-08 | 学校法人庆应义塾 | 脑类器官的制造方法 |
KR102228400B1 (ko) * | 2019-09-24 | 2021-03-16 | 고려대학교 산학협력단 | 뇌 오가노이드 제조 방법 |
US20220389378A1 (en) * | 2019-11-22 | 2022-12-08 | Novo Nordisk A/S | Spin-aggregated neural microspheres and the application thereof |
JP2023512453A (ja) * | 2020-01-13 | 2023-03-27 | アスペン ニューロサイエンス インコーポレイテッド | 神経細胞を分化させる方法ならびに関連する組成物および使用方法 |
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WO2021216622A1 (fr) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Édition génique de gba1 dans des cellules souches et procédé d'utilisation de cellules différenciées à partir de celles-ci |
WO2021232234A1 (fr) * | 2020-05-19 | 2021-11-25 | 武汉睿健医药科技有限公司 | Procédé d'induction sans sérum pour cellule neuronale sensorielle |
WO2021251820A1 (fr) * | 2020-06-08 | 2021-12-16 | Technische Universiteit Eindhoven | Procédés de production d'un tissu neuronal (tridimensionnel) |
KR102346243B1 (ko) * | 2020-06-29 | 2022-01-04 | 주식회사 오간팩토리 | 중뇌 오가노이드, 이의 고속 및 대량 제조 방법, 이를 이용한 신경독성물질 스크리닝 방법 및 도파민성 신경세포 관련 질환 치료제 스크리닝 방법 |
CN115885037A (zh) * | 2020-06-29 | 2023-03-31 | 广东省奥干诺伊德生物科技有限公司 | 中脑类器官及其高速大规模制造方法、利用它筛选神经毒性物质和筛选多巴胺能神经元相关疾病药物的方法 |
EP3992280A1 (fr) * | 2020-10-30 | 2022-05-04 | Kugelmeiers Ltd. | Procédé de génération de neurosphères |
CN114736864B (zh) * | 2020-12-23 | 2024-01-26 | 武汉睿健医药科技有限公司 | 一种神经干细胞诱导分化培养基及诱导分化方法 |
CN113046309B (zh) * | 2021-03-26 | 2023-05-05 | 成都云测医学生物技术有限公司 | 悬浮培养脑类器官的培养基及其应用 |
CN113249319B (zh) * | 2021-05-19 | 2022-11-11 | 北京大学 | 一种脑脊液类器官的培养基及其培养方法 |
CN113789301B (zh) * | 2021-08-27 | 2022-05-10 | 广州瑞臻再生医学科技有限公司 | 一种制备高纯度的诱导性多能干细胞来源的人脑多巴胺能神经元的方法 |
CN113493768B (zh) * | 2021-09-06 | 2021-12-24 | 中国科学院动物研究所 | 神经类器官及其制备方法 |
KR20230081737A (ko) * | 2021-11-29 | 2023-06-08 | 주식회사 오간팩토리 | 간 오가노이드, 이의 고속 및 대량 제조 방법, 이를 이용한 약물의 효능 및 독성 스크리닝 방법 |
WO2023137200A2 (fr) * | 2022-01-13 | 2023-07-20 | The Board Of Trustees Of The Leland Stanford Junior University | Génération d'organoïdes d'organisateur neuronal et d'assembloïdes de ligne médiane à partir de cellules souches pluripotentes humaines |
CN115404218A (zh) * | 2022-01-13 | 2022-11-29 | 南华大学附属第一医院 | 一种包含胶质细胞的3d人脑类器官培养方法 |
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EP4286513A1 (fr) | 2022-06-03 | 2023-12-06 | IMBA-Institut für Molekulare Biotechnologie GmbH | Fusion de culture de tissus triple |
WO2024017538A1 (fr) * | 2022-07-19 | 2024-01-25 | Medizinische Hochschule Hannover | Procédé de production d'organoïdes à partir de cellules de mammifère |
EP4310177A1 (fr) * | 2022-07-19 | 2024-01-24 | Medizinische Hochschule Hannover | Procédé de production d'organoïdes à partir de cellules de mammifères |
CN115044539A (zh) * | 2022-08-16 | 2022-09-13 | 中义(北京)健康研究院 | 一种鲨鱼肝细胞及其培养方法 |
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DE102014003465A1 (de) * | 2014-03-11 | 2015-09-17 | NeuroProof GmbH | Gewinnung von Gehirnregion-spezifischen neuronalen Kulturen aus dreidimensionalen Gewebekulturen von Stammzellen |
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CN107427537A (zh) * | 2015-03-03 | 2017-12-01 | 哈佛学院院长及董事 | 产生功能性人体组织的方法 |
LU92845B1 (en) * | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
EP3190176A1 (fr) * | 2016-01-11 | 2017-07-12 | IMBA-Institut für Molekulare Biotechnologie GmbH | Procédé de développement de culture tissulaire sur échafaudage et culture de tissus différenciés |
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2017
- 2017-03-14 US US16/085,553 patent/US20190169576A1/en active Pending
- 2017-03-14 SG SG11201807487WA patent/SG11201807487WA/en unknown
- 2017-03-14 CN CN201780029142.2A patent/CN109996870A/zh active Pending
- 2017-03-14 SG SG10201913687VA patent/SG10201913687VA/en unknown
- 2017-03-14 EP EP17767082.5A patent/EP3430132A4/fr active Pending
- 2017-03-14 WO PCT/SG2017/050126 patent/WO2017160234A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20190169576A1 (en) | 2019-06-06 |
WO2017160234A1 (fr) | 2017-09-21 |
EP3430132A4 (fr) | 2019-12-25 |
CN109996870A (zh) | 2019-07-09 |
EP3430132A1 (fr) | 2019-01-23 |
SG10201913687VA (en) | 2020-03-30 |
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