SG11201803145RA - Methods and compositions for inducing hematopoietic cell differentiation - Google Patents

Methods and compositions for inducing hematopoietic cell differentiation

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Publication number
SG11201803145RA
SG11201803145RA SG11201803145RA SG11201803145RA SG11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA SG 11201803145R A SG11201803145R A SG 11201803145RA
Authority
SG
Singapore
Prior art keywords
compositions
methods
cell differentiation
hematopoietic cell
inducing hematopoietic
Prior art date
Application number
SG11201803145RA
Other languages
English (en)
Inventor
Bahram Valamehr
Raedun Clarke
Ryan Bjordahl
Original Assignee
Fate Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2016/014918 external-priority patent/WO2016123100A1/en
Application filed by Fate Therapeutics Inc filed Critical Fate Therapeutics Inc
Publication of SG11201803145RA publication Critical patent/SG11201803145RA/en

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Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10626372B1 (en) 2015-01-26 2020-04-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
PT3292150T (pt) 2015-05-04 2020-06-01 Cytomx Therapeutics Inc Anticorpos anti-cd166 ativáveis e os seus métodos de utilização
EP3324982A4 (en) 2015-07-21 2019-01-09 The Children's Medical Center Corporation HEMATOPOIETIC STEM CELLS EXPRESSING PD-L1 AND USES
WO2017078807A1 (en) 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
EP4249074A3 (en) 2015-11-04 2024-01-10 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
WO2017123806A1 (en) 2016-01-12 2017-07-20 Cedars-Sinai Medical Center A method of non destructive monitoring of biological processes in microfluidic tissue culture systems
US11413309B2 (en) 2016-01-20 2022-08-16 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
CA3013357A1 (en) 2016-02-01 2017-08-10 Cedars-Sinai Medical Center Systems and methods for growth of intestinal cells in microfluidic devices
CN109790517B (zh) * 2016-04-15 2023-05-02 纪念斯隆-凯特林癌症中心 转基因t细胞和嵌合抗原受体t细胞组合物和相关方法
JP7215994B2 (ja) 2016-09-06 2023-01-31 ザ チルドレンズ メディカル センター コーポレーション 人工多能性幹細胞由来の免疫細胞
JP7098615B2 (ja) 2016-12-05 2022-07-11 フェイト セラピューティクス,インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
WO2018140647A1 (en) 2017-01-25 2018-08-02 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
CN110691844B (zh) * 2017-02-07 2023-09-08 新加坡科技研究局 从多能干细胞产生模拟的先天免疫细胞的方法和试剂盒
US11920156B2 (en) 2017-02-09 2024-03-05 Indapta Therapeutics, Inc. Engineered natural killer (NK) cells and compositions and methods thereof
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
TWI848906B (zh) * 2017-03-15 2024-07-21 美商歐卡生物系統公司 用於造血幹細胞移植的組合物及方法
US11414648B2 (en) 2017-03-24 2022-08-16 Cedars-Sinai Medical Center Methods and compositions for production of fallopian tube epithelium
WO2018199186A1 (ja) * 2017-04-26 2018-11-01 国立大学法人京都大学 造血前駆細胞マーカー
US11220544B2 (en) 2017-07-14 2022-01-11 Cytomx Therapeutics, Inc. Anti-CD166 antibodies and uses thereof
CA3071683A1 (en) * 2017-08-08 2019-02-14 Sangamo Therapeutics, Inc. Chimeric antigen receptor mediated cell targeting
KR102167548B1 (ko) * 2017-09-21 2020-10-19 한국생명공학연구원 자연살해세포의 제조방법 및 그의 용도
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
US20200308540A1 (en) * 2017-09-29 2020-10-01 Regents Of The University Of Minnesota Methods of making, expanding, and using a human progenitor t cell
IL275177B2 (en) 2017-12-22 2024-05-01 Fate Therapeutics Inc Enhanced effector training cells and their use
EP3740566A4 (en) * 2018-01-18 2021-10-27 Agency for Science, Technology and Research METHOD OF DIFFERENTIATING HUMAN PLURIPOTENT STEM CELL LINES IN A SUSPENSION CULTURE
WO2019195800A1 (en) 2018-04-06 2019-10-10 Cedars-Sinai Medical Center Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
WO2019212691A1 (en) * 2018-04-30 2019-11-07 Cedars-Sinai Medical Center Diagnostic and drug screening for molecular signatures of early onset sporadic parkinson's disease
US20210238550A1 (en) * 2018-07-31 2021-08-05 Thyas Co. Ltd. METHOD FOR PRODUCING REGENERATED T CELL POPULATION VIA iPS CELLS
AU2019349651B2 (en) 2018-09-27 2023-12-07 Celgene Corporation SIRP alpha binding proteins and methods of use thereof
US11591390B2 (en) 2018-09-27 2023-02-28 Celgene Corporation SIRP-α binding proteins and methods of use thereof
CN109266618B (zh) * 2018-10-18 2021-04-23 赛元生物科技(杭州)有限公司 能够靶向肿瘤细胞的巨噬细胞及其制备方法
CA3127593A1 (en) * 2019-01-22 2020-07-30 Washington University Compositions and methods for generating hematopoietic stem cells (hscs)
MX2021009742A (es) 2019-02-15 2021-12-10 Editas Medicine Inc Celulas asesinas naturales (nk) modificadas para inmunoterapia.
WO2020220040A1 (en) * 2019-04-26 2020-10-29 The Regents Of The University Of Colorado, A Body Corporate Generation of functional and patient-specific thymic tissue in vivo from induced pluripotent stem cells
WO2020227677A1 (en) * 2019-05-09 2020-11-12 Figene, Llc Fibroblast generated patient-specific vaccines
CN110106144B (zh) * 2019-05-17 2021-10-08 苏州大学 一种诱导造血干细胞向前t系细胞分化的方法和试剂盒
JP2022545344A (ja) * 2019-08-05 2022-10-27 ノボキュア ゲーエムベーハー Il11活性を阻害することによって、腫瘍治療電場(ttフィールド)に対するがん細胞の感受性を高める
GB201911957D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd Methods of producing haemogenic progenitor cells from pluripotent stem cells
AU2020333918A1 (en) * 2019-08-20 2022-03-24 Adaptimmune Limited Culture medium for haematopoietic induction
GB201911953D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd T cell production fram RAG inacivated iPSCs
CA3151781A1 (en) * 2019-10-07 2021-04-15 Bahram Valamehr Enhanced chimeric antigen receptor for immune effector cell engineering and use thereof
JP2022552314A (ja) * 2019-10-17 2022-12-15 フェイト セラピューティクス,インコーポレイテッド 免疫のための増強されたキメラ抗原受容体エフェクター細胞操作およびその使用
US20220378845A1 (en) * 2019-11-13 2022-12-01 Industry-Academic Cooperation Foundation, Yonsei University Method of isolation of pure culture of vascular endothelial cells, medium for maintaining characteristics of vascular endothelial cells, and culture method including same
WO2021097346A1 (en) * 2019-11-14 2021-05-20 Amgen Inc. Hematopoietic precursor cell production
US20210292713A1 (en) * 2020-02-28 2021-09-23 Millennium Pharmaceuticals, Inc. Method for producing natural killer cells from pluripotent stem cells
CN115135754A (zh) * 2020-02-28 2022-09-30 普渡研究基金会 在限定条件下从人多能干细胞生成主动脉-性腺-中肾样造血细胞
CA3173124A1 (en) * 2020-04-06 2021-10-14 Kyle M. LOH Generating populations of human blood and blood vessel progenitors from pluripotent stem cells
CA3176416A1 (en) * 2020-04-21 2021-10-28 Modassir CHOUDHRY Cellular vaccine platform and methods of use
CN111808812B (zh) * 2020-08-31 2020-12-15 首都医科大学附属北京友谊医院 一种用于多能干细胞向造血干细胞分化的材料和方法
JP2023543248A (ja) * 2020-09-24 2023-10-13 ▲広▼州▲輯▼因医▲療▼科技有限公司 ヒト造血幹細胞移植効率を向上させるための化合物の使用
CN112119977B (zh) * 2020-10-15 2021-10-19 中国人民解放军军事科学院军事医学研究院 Cd317诱导的抑郁和记忆损伤的小鼠模型的构建方法及其应用
EP4232567A1 (en) 2020-10-26 2023-08-30 Shoreline Biosciences, Inc. Methods of inducing antibody-dependent cellular cytotoxicity (adcc) using modified natural killer (nk) cells
CN114525257A (zh) * 2020-10-30 2022-05-24 未来智人再生医学研究院(广州)有限公司 一种表达Tim-3阻断物的多能干细胞或其衍生物及应用
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
KR102681869B1 (ko) * 2020-12-18 2024-07-05 차의과학대학교 산학협력단 줄기 세포를 모니터링하기 위한 조성물, 키트, 및 이를 이용한 줄기 세포를 모니터링하는 방법
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
KR20220113290A (ko) * 2021-02-05 2022-08-12 의료법인 성광의료재단 다능성 줄기세포 유래 조혈 내피세포로부터 림프구계세포의 분화 방법
KR20220113586A (ko) * 2021-02-05 2022-08-16 의료법인 성광의료재단 다능성 줄기세포 유래 조혈 내피세포를 이용한 유전자 편집된 세포의 제조방법
GB202102297D0 (en) * 2021-02-18 2021-04-07 Adaptimmune Ltd Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
CN112831461B (zh) * 2021-02-26 2023-08-08 澳门大学 一种诱导干细胞分化成中胚层谱系或滋养细胞谱系的方法及药物
WO2022226337A1 (en) * 2021-04-22 2022-10-27 Artec Biotech, Inc. Method for producing hematopoietic cells from stem cells using vascular organoids
EP4351599A1 (en) * 2021-05-14 2024-04-17 Appia Bio, Inc. Production of engineered t cells from stem cells
JP2024523332A (ja) * 2021-06-15 2024-06-28 武田薬品工業株式会社 多能性幹細胞からナチュラルキラー細胞を産生するための方法
WO2023019213A1 (en) * 2021-08-13 2023-02-16 Simcere Innovation, Inc. Three-dimensional culturing of pluripotent stem cells to produce hematopoietic stem cells
KR20240051185A (ko) * 2021-08-19 2024-04-19 세다르스-신나이 메디칼 센터 노화-관련 및 신경변성 질환의 예방 및 치료에서 ipsc-유래 면역 세포
KR20230038628A (ko) * 2021-09-10 2023-03-21 의료법인 성광의료재단 전분화능 줄기세포 유래 조혈모세포 제조방법 및 상기 제조된 조혈모세포를 이용한 인간화 마우스 모델 제작방법
CN113801846B (zh) * 2021-09-22 2024-06-04 南京艾尔普再生医学科技有限公司 一种从人诱导多能干细胞分化为自然杀伤细胞的方法
WO2023138680A1 (zh) * 2022-01-20 2023-07-27 科济生物医药(上海)有限公司 诱导细胞分化的方法
CN114350608B (zh) * 2022-01-27 2024-05-28 昭泰英基生物医药(香港)有限公司 一种诱导t细胞重编程为类nk细胞的组合物及其应用
CN114702591B (zh) * 2022-05-17 2022-09-23 诺赛联合(北京)生物医学科技有限公司 成体细胞衍生的类器官制备技术
CN114774365B (zh) * 2022-06-16 2022-08-23 呈诺再生医学科技(北京)有限公司 一种诱导iPSC分化获得CD34+细胞和NK细胞的方法及其应用
KR20230173249A (ko) 2022-06-16 2023-12-27 대한민국(질병관리청 국립보건연구원장) Dusp6가 결핍된 줄기세포 및 이의 용도
WO2023246820A1 (zh) * 2022-06-20 2023-12-28 上海优替济生生物医药有限公司 体外诱导干细胞样记忆细胞的化合物及其应用
WO2023247722A1 (en) * 2022-06-22 2023-12-28 Fondazione Telethon Ets Method for isolating hemogenic endothelial cells
CN114958771B (zh) * 2022-06-27 2023-12-05 广东康盾创新产业集团股份公司 一种ipsc-car-nk细胞的制备方法
WO2024020587A2 (en) 2022-07-22 2024-01-25 Tome Biosciences, Inc. Pleiopluripotent stem cell programmable gene insertion
WO2024036105A2 (en) * 2022-08-11 2024-02-15 H. Lee Moffitt Cancer Center And Research Institute Inc. Method for generating cells of the t cell lineage with engineering broadly reactive human notch ligand
WO2024059070A1 (en) * 2022-09-13 2024-03-21 R.P. Scherer Technologies, Llc Method of differentiation of pluripotent stem cells to hematopoietic precursor and stem cells
WO2024059584A1 (en) * 2022-09-14 2024-03-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
KR20240069648A (ko) * 2022-11-10 2024-05-20 의료법인 성광의료재단 전분화능 줄기세포에서 자연살해세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법
WO2024127335A1 (en) * 2022-12-15 2024-06-20 Janssen Biotech, Inc. Materials, methods and systems for cellular redifferentiation and expansion
WO2024173696A2 (en) * 2023-02-16 2024-08-22 Syntax Bio, Inc. Systems for cell programming towards hematopoietic lineage and methods thereof
CN116445408B (zh) * 2023-05-22 2024-02-02 呈诺再生医学科技(北京)有限公司 LSD1抑制剂在促进iPSC向HSC分化和HSC干性维持中的应用
CN116574672B (zh) * 2023-07-11 2023-10-20 北京北启生物医药有限公司 一种诱导化学诱导多能干细胞向生血内皮细胞分化的培养基及方法
CN117050941B (zh) * 2023-10-11 2024-01-26 苏州艾凯利元生物科技有限公司 一种制备自然杀伤细胞的方法
CN117050940B (zh) * 2023-10-11 2024-01-26 苏州艾凯利元生物科技有限公司 一种制备自然杀伤细胞的方法
CN117106714B (zh) * 2023-10-11 2024-01-26 苏州艾凯利元生物科技有限公司 一种制备b细胞的方法
CN117448269A (zh) * 2023-10-25 2024-01-26 中国科学院香港创新研究院再生医学与健康创新中心有限公司 一种诱导人多能干细胞快速分化为巨噬细胞的方法及应用
CN117736988B (zh) * 2023-12-25 2024-06-21 深圳泽医细胞治疗集团有限公司 用于诱导Tscm细胞的培养基、培养方法及其应用
CN118325837B (zh) * 2024-06-12 2024-09-03 深圳市中佳生物医疗科技有限公司 中性粒细胞的无血清无基质细胞培养方法

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
AU749465B2 (en) 1997-06-13 2002-06-27 Japanese Foundation For Cancer Research Smad6 and uses thereof
HUP0003731A3 (en) 1997-07-01 2002-11-28 Warner Lambert Co 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
WO2001062895A2 (en) 2000-02-24 2001-08-30 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
HU230251B1 (hu) 2000-07-19 2015-11-30 Warner-Lambert Co. 4-Jód-fenil-amino-benzhidroxámsav-észter-származékok és ezeket tartalmazó gyógyászati készítmények
JP2002060786A (ja) 2000-08-23 2002-02-26 Kao Corp 硬質表面用殺菌防汚剤
US6689744B2 (en) 2000-09-22 2004-02-10 Genentech, Inc. Notch receptor agonists and uses
US7399633B2 (en) 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
EP1421177A4 (en) 2001-08-20 2006-06-07 Scripps Research Inst ZINC FINGER FASTENING DOMAINS FOR CNN
US7700572B2 (en) 2001-11-02 2010-04-20 Giuliani International, Ltd. SMAD7 inhibitors for the treatment of CNS diseases
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
PL401637A1 (pl) 2002-03-13 2013-05-27 Array Biopharma Inc. N3 alkilowane pochodne benzimidazolu jako inhibitory MEK
US7575925B2 (en) 2002-12-10 2009-08-18 Sunnybrook Health Sciences Centre Cell preparations comprising cells of the T cell lineage and methods of making and using them
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
WO2005051302A2 (en) 2003-11-19 2005-06-09 Array Biopharma Inc. Bicyclic inhibitors of mek and methods of use thereof
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
CA2568344C (en) 2004-05-27 2016-01-19 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
US20070036769A9 (en) 2004-06-03 2007-02-15 Linheng Li BMP pathway methods and compositions
EP1967516B1 (en) 2005-05-18 2009-11-04 Array Biopharma, Inc. 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases
WO2007088651A1 (ja) 2006-02-01 2007-08-09 The University Of Tokyo TGF-βシグナル阻害剤と抗腫瘍剤の組み合せ使用
CA2647201C (en) 2006-03-24 2016-03-08 Children's Medical Center Corporation Method to modulate hematopoietic stem cell growth
AR061974A1 (es) 2006-07-14 2008-08-10 Novartis Ag Derivados de pirimidina como inhibidores de alk, composiciones farmaceuticas y procesos de obtencion
WO2008094597A2 (en) 2007-01-30 2008-08-07 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
WO2008121420A1 (en) 2007-03-30 2008-10-09 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
WO2009091826A2 (en) 2008-01-14 2009-07-23 The Board Of Regents Of The University Of Texas System Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car)
WO2009097140A1 (en) 2008-01-30 2009-08-06 Memorial Sloan-Kettering Cancer Center Methods for off -the -shelf tumor immunotherapy using allogeneic t-cell precursors
WO2009104825A1 (en) * 2008-02-18 2009-08-27 Kaist Method for inducing the defferentiation of embryonic stem cells into hemangioblast
BRPI0922345B1 (pt) 2008-12-03 2022-03-22 The Scripps Research Institute Composto, métodos in vitro para estabilizar uma célula animal isolada e para manter a sobrevivência da célula, e, composição
WO2010087594A2 (ko) 2009-01-28 2010-08-05 한국생명공학연구원 시디93 또는 이의 가용성 단편의 용도
JP6189581B2 (ja) 2009-02-20 2017-08-30 セルラー ダイナミクス インターナショナル, インコーポレイテッド 幹細胞の分化のための方法および組成物
US8372642B2 (en) 2009-02-27 2013-02-12 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
JP6215533B2 (ja) 2009-04-09 2017-10-18 サンガモ セラピューティクス, インコーポレイテッド 幹細胞への標的組込み
CN113621576A (zh) 2009-10-16 2021-11-09 斯克里普斯研究所 多能细胞的诱导
PL2816112T3 (pl) 2009-12-10 2019-03-29 Regents Of The University Of Minnesota Modyfikacja DNA za pośrednictwem efektorów TAL
WO2011096482A1 (ja) 2010-02-03 2011-08-11 国立大学法人東京大学 多能性幹細胞を用いた免疫機能再建法
US9206394B2 (en) 2010-02-03 2015-12-08 The University Of Tokyo Method for reconstructing immune function using pluripotent stem cells
US8652845B2 (en) 2010-03-18 2014-02-18 Kyoto University Method for producing mesodermal cells by culturing under adherent conditions and without co-culture with cells from a different species in a serum-free medium
EP4438734A2 (en) 2010-06-14 2024-10-02 The Scripps Research Institute Reprogramming of cells to a new fate
AU2011267849B2 (en) 2010-06-15 2015-02-05 FUJIFILM Cellular Dynamics, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
WO2012012667A2 (en) 2010-07-21 2012-01-26 Sangamo Biosciences, Inc. Methods and compositions for modification of a hla locus
CA2807418C (en) 2010-08-05 2017-04-04 Wisconsin Alumni Research Foundation Simplified basic media for human pluripotent cell culture
EP3278808A1 (en) * 2010-08-12 2018-02-07 Fate Therapeutics, Inc. Improved hematopoietic stem and progenitor cell therapy
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
JP6182456B2 (ja) 2010-12-22 2017-08-23 フェイト セラピューティクス,インコーポレイテッド 単細胞選別のための細胞培養プラットホームおよびiPSCの再プログラミングの増強
US8700106B2 (en) 2011-03-09 2014-04-15 Universal Electronics Inc. System and method for provision of infrared signalling in smart phone devices
CN102732483B (zh) * 2011-03-31 2014-12-03 北京大学 造血祖细胞的制备方法及其专用培养基
US20130071414A1 (en) 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
CA2841165A1 (en) 2011-07-11 2013-01-17 Cellular Dynamics International, Inc. Methods for cell reprogramming and genome engineering
KR101405437B1 (ko) * 2011-08-16 2014-06-11 사회복지법인 삼성생명공익재단 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물
US20130058905A1 (en) * 2011-08-23 2013-03-07 Igor Slukvin Angiohematopoietic Progenitor Cells
CN102329769B (zh) * 2011-09-28 2013-07-31 浙江大学 一种获得造血干细胞的方法
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
WO2013075222A1 (en) 2011-11-21 2013-05-30 University Health Network Populations of hematopoietic progenitors and methods of enriching stem cells therefor
JP6220791B2 (ja) 2011-12-02 2017-10-25 フェイト セラピューティクス,インコーポレイテッド 増強された幹細胞組成物
WO2013086029A1 (en) 2011-12-05 2013-06-13 Primorigen Biosciences Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
CA2858069C (en) 2011-12-08 2020-02-11 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
EP2606884A1 (en) 2011-12-21 2013-06-26 Ecole Polytechnique Fédérale de Lausanne (EPFL) Inhibitors of notch signaling pathway and use thereof in treatment of cancers
IN2014DN07853A (zh) * 2012-02-24 2015-04-24 Hutchinson Fred Cancer Res
CA2870571A1 (en) 2012-04-17 2013-10-24 University Of Washington Through Its Center For Commercialization Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof
EP2839013B1 (en) 2012-04-18 2020-08-26 The Board of Trustees of the Leland Stanford Junior University Non-disruptive gene targeting
EP2841563B1 (en) 2012-04-24 2019-06-12 Dan S. Kaufman Method for developing natural killer cells from stem cells
EP2853590B1 (en) 2012-05-22 2018-11-07 The University of Tokyo Method for producing antigen-specific t cells
CN104718284A (zh) 2012-05-25 2015-06-17 塞勒克提斯公司 工程化用于免疫疗法的异体和免疫抑制耐受性t细胞的方法
US20150148292A1 (en) 2012-07-09 2015-05-28 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
EP2903637B1 (en) 2012-10-02 2019-06-12 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
JP6494515B2 (ja) 2012-10-19 2019-04-03 エージェンシー フォー サイエンス, テクノロジー アンド リサーチ 幹細胞を1又は2以上の細胞系列に分化させる方法
US9382531B2 (en) * 2012-10-22 2016-07-05 Wisconsin Alumni Research Foundation Induction of hemogenic endothelium from pluripotent stem cells
WO2014089212A1 (en) 2012-12-05 2014-06-12 Sangamo Biosciences, Inc. Methods and compositions for regulation of metabolic disorders
EP2934555B1 (en) 2012-12-21 2021-09-22 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells
PL2970912T3 (pl) 2013-03-13 2019-08-30 Wisconsin Alumni Research Foundation Sposoby i materiały do hematopoetyczno-śródbłonkowego różnicowania ludzkich pluripotentnych komórek macierzystych w zdefiniowanych warunkach
MX2015013104A (es) 2013-03-15 2016-06-16 Sloan Kettering Inst Cancer Composiciones y métodos para la inmunoterapia.
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
DK2981607T3 (da) 2013-04-03 2020-11-16 Memorial Sloan Kettering Cancer Center Effektiv generering af tumormålrettede t-celler afledt af pluripotente stamceller
CN105518146B (zh) * 2013-04-04 2022-07-15 哈佛学院校长同事会 利用CRISPR/Cas系统的基因组编辑的治疗性用途
US9381210B2 (en) * 2013-04-15 2016-07-05 Wisconsin Alumni Research Foundation Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells
WO2014200030A1 (ja) * 2013-06-12 2014-12-18 国立大学法人京都大学 人工多能性幹細胞の選別方法および血球への分化誘導方法
CN103361310B (zh) * 2013-06-25 2015-09-23 中国人民解放军军事医学科学院野战输血研究所 培养基、试剂盒及其用途
EP3057432B1 (en) 2013-10-17 2018-11-21 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
KR20240091064A (ko) 2014-03-04 2024-06-21 페이트 세러퓨틱스, 인코포레이티드 개선된 재프로그래밍 방법 및 세포 배양 플랫폼
CN106715467B (zh) 2014-03-28 2021-07-27 明尼苏达大学评议会 涉及经工程改造的cd16的多肽、细胞和方法
CN103937743B (zh) * 2014-04-27 2017-12-01 浙江大学 一种利用三维诱导系统获得造血干细胞的方法
CN112481211B (zh) 2015-01-26 2024-07-05 儿童医院公司 免疫调节性提高的细胞及其使用和生产方法
US10626372B1 (en) 2015-01-26 2020-04-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
CN104745529B (zh) * 2015-03-13 2019-03-05 华南生物医药研究院 瘦素在诱导胚胎干细胞分化为造血干/祖细胞中的用途及其应用
US20170020922A1 (en) * 2015-07-16 2017-01-26 Batu Biologics Inc. Gene editing for immunological destruction of neoplasia
WO2017062451A1 (en) 2015-10-05 2017-04-13 Precision Biosciences, Inc. Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene
EP4249074A3 (en) 2015-11-04 2024-01-10 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
WO2017078807A1 (en) 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
EP3434761B1 (en) * 2016-03-23 2023-01-18 Kyoto University Mesoderm induction method having high blood cell differentiation capacity
CN109790517B (zh) 2016-04-15 2023-05-02 纪念斯隆-凯特林癌症中心 转基因t细胞和嵌合抗原受体t细胞组合物和相关方法

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