SG11201705223XA - NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME - Google Patents
NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAMEInfo
- Publication number
- SG11201705223XA SG11201705223XA SG11201705223XA SG11201705223XA SG11201705223XA SG 11201705223X A SG11201705223X A SG 11201705223XA SG 11201705223X A SG11201705223X A SG 11201705223XA SG 11201705223X A SG11201705223X A SG 11201705223XA SG 11201705223X A SG11201705223X A SG 11201705223XA
- Authority
- SG
- Singapore
- Prior art keywords
- same
- gene expression
- naturally occuring
- controlling gene
- mirna
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014266918 | 2014-12-27 | ||
JP2015130496 | 2015-06-29 | ||
PCT/JP2015/086378 WO2016104775A1 (ja) | 2014-12-27 | 2015-12-25 | 遺伝子発現制御のための天然型miRNAおよびその用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201705223XA true SG11201705223XA (en) | 2017-07-28 |
Family
ID=56150787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201705223XA SG11201705223XA (en) | 2014-12-27 | 2015-12-25 | NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME |
Country Status (15)
Country | Link |
---|---|
US (1) | US11027023B2 (ja) |
EP (1) | EP3239297B1 (ja) |
JP (1) | JP6471176B2 (ja) |
KR (1) | KR20170098914A (ja) |
CN (1) | CN107109415B (ja) |
AU (1) | AU2015368293B2 (ja) |
BR (1) | BR112017013664A2 (ja) |
CA (1) | CA2971827A1 (ja) |
ES (1) | ES2872527T3 (ja) |
HK (1) | HK1244032A1 (ja) |
IL (1) | IL252880B (ja) |
MX (1) | MX2017008587A (ja) |
RU (1) | RU2740032C2 (ja) |
SG (1) | SG11201705223XA (ja) |
WO (1) | WO2016104775A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3088524A4 (en) | 2013-12-26 | 2017-08-09 | Tokyo Medical University | Artificial mimic mirna for controlling gene expression, and use of same |
US10934542B2 (en) | 2013-12-27 | 2021-03-02 | Bonac Corporation | Artificial match-type miRNA for controlling gene expression and use therefor |
JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
EP3584319A4 (en) | 2017-02-06 | 2021-04-14 | Nissan Chemical Corporation | SINGLE-STRAND OLIGONUCLEOTIDE |
JPWO2018182008A1 (ja) * | 2017-03-31 | 2020-02-06 | 株式会社ボナック | 遺伝子発現制御機能を有する環状型核酸分子 |
JPWO2019074110A1 (ja) * | 2017-10-13 | 2020-12-24 | 株式会社ボナック | 一本鎖核酸分子およびその製造方法 |
TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
CN111868244A (zh) | 2018-03-20 | 2020-10-30 | 国立大学法人东京工业大学 | 降低了毒性的反义寡核苷酸 |
CN115490768A (zh) * | 2021-06-18 | 2022-12-20 | 佛山热休生物技术有限公司 | Col1a1的表位肽及所述表位肽与热休克蛋白的复合物 |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE873543C (de) | 1942-10-28 | 1953-04-16 | Basf Ag | Verfahren zur Herstellung von hydroxyl- bzw. sulfhydryl-gruppenhaltigen Dicarbaminsaeureestern |
US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
US4550163A (en) | 1979-02-05 | 1985-10-29 | Abbott Laboratories | Ligand analog-irreversible enzyme inhibitor conjugates |
US20030232355A1 (en) | 1992-05-22 | 2003-12-18 | Isis Pharmaceuticals, Inc. | Double-stranded peptide nucleic acids |
US5631148A (en) | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
GB9621367D0 (en) | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
US6197557B1 (en) | 1997-03-05 | 2001-03-06 | The Regents Of The University Of Michigan | Compositions and methods for analysis of nucleic acids |
EP1013770A1 (en) | 1998-12-23 | 2000-06-28 | Université Louis Pasteur de Strasbourg | Non-viral transfection vector |
FR2790757B1 (fr) | 1999-03-09 | 2003-08-01 | Bioalliance Pharma | Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant. |
US6852334B1 (en) | 1999-04-20 | 2005-02-08 | The University Of British Columbia | Cationic peg-lipids and methods of use |
US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
US6962906B2 (en) | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
WO2002072865A2 (en) | 2001-03-09 | 2002-09-19 | Boston Probes, Inc. | Methods, kits and compositions of combination oligomers |
EP1627061B1 (en) | 2001-05-18 | 2009-08-12 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) |
US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
MXPA04004056A (es) | 2001-10-29 | 2004-09-10 | Univ Mcgill | Oligonucleotidos que contienen enlazador aciclico y usos de los mismos. |
US20060111312A1 (en) | 2002-02-22 | 2006-05-25 | The John Hopkins University | Antigene locks and therapeutic uses thereof |
CA2479530A1 (en) | 2002-03-20 | 2003-10-02 | Massachusetts Institute Of Technology | Hiv therapeutic |
AU2003260370B2 (en) | 2002-08-05 | 2008-05-22 | Silence Therapeutics Gmbh | Further novel forms of interfering RNA molecules |
AU2003256857A1 (en) | 2002-08-08 | 2004-02-25 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
US6936651B2 (en) | 2002-12-17 | 2005-08-30 | E. I. Du Pont De Nemours And Company | Compatibility improvement in crystalline thermoplastics with mineral fillers |
AU2004227414A1 (en) | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | iRNA conjugates |
AU2004247729A1 (en) | 2003-06-12 | 2004-12-23 | Applera Corporation | Combinatorial nucleobase oligomers comprising universal base analogues and methods for making and using same |
WO2005047505A2 (en) | 2003-08-07 | 2005-05-26 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro rnas |
CA2538215A1 (en) | 2003-09-30 | 2005-04-07 | Anges Mg, Inc. | Staple oligonucleotides and medicaments comprising the same |
EP1680439A2 (en) | 2003-10-14 | 2006-07-19 | Kernel Biopharma Inc. | Dual phase-pna conjugates for the delivery of pna through the blood brain barrier |
WO2005037317A2 (en) | 2003-10-17 | 2005-04-28 | Cornell Research Foundation, Inc. | Mast cell-derived renin |
WO2006088490A2 (en) | 2004-06-30 | 2006-08-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
DK1781787T3 (en) | 2004-08-23 | 2017-07-31 | Sylentis Sau | TREATMENT OF EYE DISORDERS FEATURED BY AN INCREASED INTRAOCULAR PRESSURE WITH SIRNAS |
WO2006022325A1 (ja) | 2004-08-26 | 2006-03-02 | Nippon Shinyaku Co., Ltd. | ガラクトース誘導体、薬物担体及び医薬組成物 |
AU2005278918B2 (en) | 2004-08-31 | 2010-07-29 | Sylentis S.A.U. | Methods and compositions to inhibit P2X7 receptor expression |
CA2583690C (en) | 2004-10-12 | 2016-04-05 | The Rockefeller University | Microrna constructs for the suppression of the expression of targeted genes or the down regulation of targeted genes and methods therefore |
US8173611B2 (en) * | 2004-11-12 | 2012-05-08 | Asuragen Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
MX2007008065A (es) | 2004-12-30 | 2008-03-04 | Todd M Hauser | Composiciones y metodos para modular la expresion genica usando oligonucleotidos autoprotegidos. |
EP2003140B1 (en) | 2006-03-01 | 2010-01-20 | Nippon Shinyaku Co., Ltd. | Galactose derivative, drug carrier and medicinal composition |
CN103554205A (zh) | 2006-05-05 | 2014-02-05 | Isis制药公司 | 调节gccr的表达的化合物和方法 |
EP2029597A4 (en) | 2006-05-31 | 2011-11-23 | Univ California | purine analogs |
EP1890152A1 (en) | 2006-08-14 | 2008-02-20 | Charite Universitätsmedizin-Berlin | Determination of renin/prorenin receptor activity |
JP2008220366A (ja) | 2007-02-16 | 2008-09-25 | National Institute Of Advanced Industrial & Technology | 修飾型pna/rna複合体 |
JP5145557B2 (ja) | 2007-03-01 | 2013-02-20 | 財団法人ヒューマンサイエンス振興財団 | マイクロrnaを有効成分として含有する腫瘍増殖抑制剤、および癌治療用医薬組成物 |
BRPI0809130A8 (pt) | 2007-03-21 | 2021-11-03 | Brookhaven Science Ass Llc | Composições combinadas hairpin-antissenso e métodos para modulação da expressão |
CN101121934B (zh) | 2007-04-11 | 2011-12-07 | 哈尔滨医科大学 | 多靶点miRNA反义核苷酸的制备方法 |
WO2008137867A2 (en) | 2007-05-03 | 2008-11-13 | Rosetta Inpharmatics Llc | Compositions comprising mir34 therapeutic agents for treating cancer |
JP5296328B2 (ja) | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | 1本鎖環状rnaおよびその製造方法 |
WO2009023333A2 (en) | 2007-05-17 | 2009-02-19 | Baylor College Of Medicine | Inhibition of the sh2-domain containing protein tyr-phosphatase, shp-1, to enhance vaccines |
WO2008147837A1 (en) | 2007-05-23 | 2008-12-04 | Dharmacon, Inc. | Micro-rna scaffolds, non-naturally occurring micro-rnas, and methods for optimizing non-naturally occurring micro-rnas |
PT2164967E (pt) | 2007-05-31 | 2015-10-27 | Univ Iowa Res Found | Redução da toxicidade não dirigida do arn de interferência |
WO2009000520A1 (en) | 2007-06-25 | 2008-12-31 | Universität Duisburg-Essen | Screening-method for polymorphic markers in htra1 gene in neurodegenerative disorders |
CN105018492B (zh) * | 2007-08-27 | 2018-08-24 | 北京强新生物科技有限公司 | 不对称干扰rna的组合物及其用途 |
WO2009048932A2 (en) * | 2007-10-09 | 2009-04-16 | Children's Medical Center Corporation | Methods to regulate mirna processing by targeting lin-28 |
EP2209894B1 (en) | 2007-10-12 | 2015-06-03 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin | Method for opening tight junctions |
TW200927177A (en) | 2007-10-24 | 2009-07-01 | Nat Inst Of Advanced Ind Scien | Lipid-modified double-stranded RNA having potent RNA interference effect |
TW200930405A (en) | 2007-11-15 | 2009-07-16 | Alcon Res Ltd | Low density lipoprotein receptor-mediated siRNA delivery |
WO2009074076A1 (fr) | 2007-11-29 | 2009-06-18 | Suzhou Ribo Life Science Co., Ltd | Molécule complexe interférant avec l'expression de gènes cibles, et ses méthodes de préparation |
CA2910760C (en) | 2007-12-04 | 2019-07-09 | Muthiah Manoharan | Targeting lipids |
US20110159586A1 (en) | 2007-12-07 | 2011-06-30 | Halo-Bio Rnai Therapeutics, Inc. | Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides |
JP5540312B2 (ja) | 2008-02-15 | 2014-07-02 | 独立行政法人理化学研究所 | 環状1本鎖核酸複合体およびその製造方法 |
ES2605618T3 (es) | 2008-03-31 | 2017-03-15 | National Institute Of Advanced Industrial Science And Technology | ARN de doble cadena, modificado con lípidos con elevado efecto de interferencia por ARN |
WO2009126563A1 (en) | 2008-04-11 | 2009-10-15 | The University Of North Carolina At Chapel Hill | Methods and compositions for the regulation of microrna processing |
WO2009143619A1 (en) | 2008-05-27 | 2009-12-03 | Chum | Methods of treating or preventing obesity and obesity-related hypertension |
WO2010056737A2 (en) | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
JP5794559B2 (ja) | 2008-11-19 | 2015-10-14 | 国立大学法人岐阜大学 | 間葉系細胞の分化を調節するための薬剤及びその利用 |
EP2411518A2 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Rna interference mediated inhibition of the high affinity ige receptor alpha chain (fcerla) gene expression using short interfering nucleic acid (sina) |
EP2438168B1 (en) | 2009-06-01 | 2020-02-12 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
EP2454371B1 (en) | 2009-07-13 | 2021-01-20 | Somagenics, Inc. | Chemical modification of small hairpin rnas for inhibition of gene expression |
US20120258104A1 (en) | 2009-07-22 | 2012-10-11 | Cenix Bioscience Gmbh | Delivery System and Conjugates For Compound Delivery Via Naturally Occurring Intracellular Transport Routes |
WO2011028550A1 (en) | 2009-08-24 | 2011-03-10 | Merck Sharp & Dohme Corp. | Segmented micro rna mimetics |
US20110052666A1 (en) | 2009-09-03 | 2011-03-03 | Medtronic, Inc. | Compositions, Methods, and Systems for SIRNA Delivery |
US8871509B2 (en) | 2009-11-06 | 2014-10-28 | Chung-Ang University-Academy Corporation Foundation | Nanoparticle-based gene delivery systems |
CA2784568A1 (en) | 2009-12-18 | 2011-06-23 | Martin A. Maier | Lipid particles for delivery of nucleic acids |
AU2010334799A1 (en) | 2009-12-23 | 2012-07-12 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Influenza targets |
US20110200582A1 (en) | 2009-12-23 | 2011-08-18 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
WO2011119887A1 (en) | 2010-03-24 | 2011-09-29 | Rxi Pharmaceuticals Corporation | Rna interference in dermal and fibrotic indications |
CN101845071B (zh) | 2010-03-25 | 2012-02-01 | 北京欧凯纳斯科技有限公司 | 一种2’或3’偶联氨基酸的核苷衍生物、其制备方法及应用 |
JP5555940B2 (ja) | 2010-04-14 | 2014-07-23 | 国立大学法人佐賀大学 | 増殖糖尿病網膜症の検出方法および予防・治療剤のスクリーニング方法 |
WO2011132672A1 (ja) | 2010-04-19 | 2011-10-27 | 独立行政法人理化学研究所 | 機能性核酸の安定化法 |
LT2561078T (lt) | 2010-04-23 | 2019-01-10 | Cold Spring Harbor Laboratory | Naujos struktūriškai sukonstruotos shrnr |
US8785121B2 (en) | 2010-07-08 | 2014-07-22 | Bonac Corporation | Single-stranded nucleic acid molecule for controlling gene expression |
TWI527901B (zh) | 2010-07-08 | 2016-04-01 | Bonac Corp | A single stranded nucleic acid molecule used to control gene expression |
US8618073B2 (en) | 2010-07-22 | 2013-12-31 | The University Of North Carolina At Chapel Hill | Use of miR-29 for cell protection |
US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
EP2628801B1 (en) * | 2010-08-03 | 2015-01-07 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
US20130253168A1 (en) | 2010-08-31 | 2013-09-26 | Steven L. Colletti | Novel single chemical entities and methods for delivery of oligonucleotides |
WO2012074038A1 (ja) | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | 修飾1本鎖ポリヌクレオチド |
CN102559666B (zh) | 2010-12-18 | 2013-12-25 | 中国科学院上海生命科学研究院 | 抑制植物病毒的人工miRNA及其构建和用途 |
AU2012212023B9 (en) * | 2011-02-03 | 2017-01-12 | Mirna Therapeutics, Inc. | Synthetic mimics of miR-34 |
CN102784398B (zh) | 2011-05-16 | 2014-06-18 | 南京大学 | 内皮抑素作为递送系统和化学合成的rna干扰分子组成的组合物及应用 |
WO2012161124A1 (ja) | 2011-05-20 | 2012-11-29 | 国立大学法人愛媛大学 | マイクロrna又はその発現系を含む組成物 |
EP2527440A1 (en) | 2011-05-27 | 2012-11-28 | Institut Curie | Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia |
JP2013055913A (ja) | 2011-09-09 | 2013-03-28 | Bonac Corp | 遺伝子発現制御のための一本鎖rna分子 |
WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
WO2013103146A1 (ja) | 2012-01-07 | 2013-07-11 | 株式会社ボナック | アミノ酸骨格を有する一本鎖核酸分子 |
JP2013153736A (ja) * | 2012-01-07 | 2013-08-15 | Bonac Corp | ペプチド骨格を有する一本鎖核酸分子 |
CN104271742B (zh) * | 2012-03-04 | 2018-06-05 | 株式会社博纳克 | 微小rna抑制剂 |
AR090905A1 (es) | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica |
EP2857513A4 (en) | 2012-05-26 | 2016-05-25 | Bonac Corp | SINGLE STRANDED NUCLEIC ACID MOLECULE FOR CONTROLLING THE EXPRESSION OF A GENE HAVING AN ADMINISTRATION FUNCTION |
CA2942833A1 (en) * | 2013-03-15 | 2014-09-18 | Ohio State Innovation Foundation | Inhibitors of prmt5 and methods of their use |
IL293657A (en) | 2013-05-22 | 2022-08-01 | Alnylam Pharmaceuticals Inc | Preparations of tmprss6 irna and methods of using them |
WO2015093495A1 (ja) | 2013-12-16 | 2015-06-25 | 株式会社ボナック | TGF-β1遺伝子発現制御のための一本鎖核酸分子 |
EP3088524A4 (en) | 2013-12-26 | 2017-08-09 | Tokyo Medical University | Artificial mimic mirna for controlling gene expression, and use of same |
JP6492014B2 (ja) | 2013-12-27 | 2019-03-27 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型miRNAおよびその用途 |
US10934542B2 (en) | 2013-12-27 | 2021-03-02 | Bonac Corporation | Artificial match-type miRNA for controlling gene expression and use therefor |
WO2015161255A1 (en) * | 2014-04-18 | 2015-10-22 | Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno | Methods for enhancing or decreasing the levels of mir124 and mir29 in subjects with muscular dystrophy |
JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
CA3009769C (en) | 2015-12-29 | 2021-01-12 | National University Corporation Hokkaido University | Single-stranded nucleic acid molecule inhibiting expression of prorenin gene or prorenin receptor gene, and use thereof |
-
2015
- 2015-12-25 AU AU2015368293A patent/AU2015368293B2/en not_active Ceased
- 2015-12-25 CA CA2971827A patent/CA2971827A1/en not_active Abandoned
- 2015-12-25 KR KR1020177020653A patent/KR20170098914A/ko not_active Application Discontinuation
- 2015-12-25 SG SG11201705223XA patent/SG11201705223XA/en unknown
- 2015-12-25 EP EP15873343.6A patent/EP3239297B1/en active Active
- 2015-12-25 JP JP2016566558A patent/JP6471176B2/ja not_active Expired - Fee Related
- 2015-12-25 CN CN201580071374.5A patent/CN107109415B/zh not_active Expired - Fee Related
- 2015-12-25 US US15/539,226 patent/US11027023B2/en active Active
- 2015-12-25 ES ES15873343T patent/ES2872527T3/es active Active
- 2015-12-25 RU RU2017126566A patent/RU2740032C2/ru active
- 2015-12-25 MX MX2017008587A patent/MX2017008587A/es unknown
- 2015-12-25 WO PCT/JP2015/086378 patent/WO2016104775A1/ja active Application Filing
- 2015-12-25 BR BR112017013664-3A patent/BR112017013664A2/ja not_active IP Right Cessation
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2017
- 2017-06-13 IL IL252880A patent/IL252880B/en active IP Right Grant
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2018
- 2018-03-14 HK HK18103547.2A patent/HK1244032A1/zh unknown
Also Published As
Publication number | Publication date |
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CN107109415A (zh) | 2017-08-29 |
AU2015368293B2 (en) | 2021-07-22 |
RU2740032C2 (ru) | 2020-12-30 |
JP6471176B2 (ja) | 2019-02-13 |
HK1244032A1 (zh) | 2018-07-27 |
KR20170098914A (ko) | 2017-08-30 |
IL252880B (en) | 2020-10-29 |
CN107109415B (zh) | 2021-07-09 |
CA2971827A1 (en) | 2016-06-30 |
ES2872527T3 (es) | 2021-11-02 |
RU2017126566A3 (ja) | 2019-06-06 |
EP3239297A4 (en) | 2018-07-25 |
RU2017126566A (ru) | 2019-01-28 |
WO2016104775A1 (ja) | 2016-06-30 |
EP3239297A1 (en) | 2017-11-01 |
US20180326091A1 (en) | 2018-11-15 |
MX2017008587A (es) | 2017-10-20 |
JPWO2016104775A1 (ja) | 2017-08-24 |
IL252880A0 (en) | 2017-08-31 |
EP3239297B1 (en) | 2021-03-10 |
AU2015368293A1 (en) | 2017-07-13 |
US11027023B2 (en) | 2021-06-08 |
BR112017013664A2 (ja) | 2018-03-13 |
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