PT2164967E - Redução da toxicidade não dirigida do arn de interferência - Google Patents
Redução da toxicidade não dirigida do arn de interferência Download PDFInfo
- Publication number
- PT2164967E PT2164967E PT87564530T PT08756453T PT2164967E PT 2164967 E PT2164967 E PT 2164967E PT 87564530 T PT87564530 T PT 87564530T PT 08756453 T PT08756453 T PT 08756453T PT 2164967 E PT2164967 E PT 2164967E
- Authority
- PT
- Portugal
- Prior art keywords
- reduction
- target rna
- rna interference
- toxicity
- interference toxicity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93246807P | 2007-05-31 | 2007-05-31 | |
| US3868508P | 2008-03-21 | 2008-03-21 | |
| US7062208P | 2008-03-25 | 2008-03-25 | |
| US12/111,025 US20090036395A1 (en) | 2007-04-26 | 2008-04-28 | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2164967E true PT2164967E (pt) | 2015-10-27 |
Family
ID=40642385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87564530T PT2164967E (pt) | 2007-05-31 | 2008-05-29 | Redução da toxicidade não dirigida do arn de interferência |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8258286B2 (pt) |
| EP (2) | EP2530152B1 (pt) |
| AU (4) | AU2008260103B2 (pt) |
| CA (1) | CA2691617C (pt) |
| DK (1) | DK2164967T3 (pt) |
| ES (1) | ES2549122T3 (pt) |
| PT (1) | PT2164967E (pt) |
| WO (1) | WO2008150897A2 (pt) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080274989A1 (en) | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| US8592384B2 (en) | 2005-04-04 | 2013-11-26 | The Board Of Regents Of The University Of Texas System | Micro-RNA's that regulate muscle cells |
| CA2670967C (en) | 2006-11-29 | 2016-05-10 | University Of Iowa Research Foundation | Alternative export pathways for vector expressed rna interference |
| PT2164967E (pt) | 2007-05-31 | 2015-10-27 | Univ Iowa Res Found | Redução da toxicidade não dirigida do arn de interferência |
| KR100949791B1 (ko) * | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도 |
| JP5653899B2 (ja) | 2008-03-17 | 2015-01-14 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 神経筋シナプスの維持および再生に関与するマイクロｒｎａの同定 |
| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| DK2561073T3 (en) | 2010-04-23 | 2016-12-12 | Univ Massachusetts | Aav vectors targeted to central nervous system and methods of use thereof |
| CA2795815C (en) | 2010-04-23 | 2018-06-26 | Cold Spring Harbor Laboratory | Novel structurally designed shrnas |
| EP2561075B1 (en) * | 2010-04-23 | 2018-06-27 | University of Massachusetts | Aav-based treatment of cholesterol-related disorders |
| DK2631291T3 (da) | 2010-10-22 | 2019-06-11 | Olix Pharmaceuticals Inc | Nukleinsyremolekyler, der inducerer rna-interferens, og anvendelser deraf |
| WO2012109667A1 (en) * | 2011-02-12 | 2012-08-16 | University Of Iowa Research Foundation | Therapeutic compounds |
| ES2661680T3 (es) | 2011-04-21 | 2018-04-03 | University Of Massachusetts | Composiciones basadas en VAAr y métodos para tratar deficiencias de alfa-1 anti-tripsina |
| WO2013052432A1 (en) * | 2011-10-05 | 2013-04-11 | Dharmacon, Inc. | Optimization of vectors for effective delivery and expression of genetic content |
| US10125362B2 (en) | 2012-05-22 | 2018-11-13 | Olix Pharmaceuticals, Inc. | RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor |
| CN104379744A (zh) | 2012-05-26 | 2015-02-25 | 株式会社博纳克 | 具有递送功能的基因表达调控用单链核酸分子 |
| CA2879514C (en) * | 2012-07-17 | 2020-04-14 | Universite De Geneve | Nucleic acids for down-regulation of gene expression |
| WO2014117050A2 (en) * | 2013-01-26 | 2014-07-31 | Mirimus, Inc. | Modified mirna as a scaffold for shrna |
| EP3088524A4 (en) * | 2013-12-26 | 2017-08-09 | Tokyo Medical University | Artificial mimic mirna for controlling gene expression, and use of same |
| AU2014370829B2 (en) | 2013-12-27 | 2021-03-11 | Bonac Corporation | Artificial match-type miRNA for controlling gene expression and use therefor |
| WO2015127128A2 (en) | 2014-02-19 | 2015-08-27 | University Of Massachusetts | Recombinant aavs having useful transcytosis properties |
| WO2015143078A1 (en) | 2014-03-18 | 2015-09-24 | University Of Massachusetts | Raav-based compositions and methods for treating amyotrophic lateral sclerosis |
| WO2015164786A1 (en) | 2014-04-25 | 2015-10-29 | University Of Massachusetts | Recombinant aav vectors useful for reducing immunity against transgene products |
| AU2015264263B2 (en) * | 2014-05-20 | 2021-08-05 | University Of Iowa Research Foundation | Huntington's disease therapeutic compounds |
| US20160237425A1 (en) * | 2014-05-22 | 2016-08-18 | Alan M.H. Beem | Pri-mirna libraries and methods for making and using pri-mirna libraries |
| WO2015187825A2 (en) | 2014-06-03 | 2015-12-10 | University Of Massachusetts | Compositions and methods for modulating dysferlin expression |
| WO2016040347A2 (en) | 2014-09-08 | 2016-03-17 | University Of Iowa Research Foundation | Microrna inhibitor system and methods of use thereof |
| US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
| JP6842410B2 (ja) | 2014-10-03 | 2021-03-17 | ユニバーシティ オブ マサチューセッツ | 新規の高効率ライブラリーにより同定されるａａｖベクター |
| JP7023108B2 (ja) | 2014-10-21 | 2022-02-21 | ユニバーシティ オブ マサチューセッツ | 組み換えａａｖバリアントおよびその使用 |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| CN112375760A (zh) | 2014-11-14 | 2021-02-19 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| CA2971920A1 (en) * | 2014-12-24 | 2016-06-30 | Uniqure Ip B.V. | Rnai induced huntingtin gene suppression |
| AU2015368293B2 (en) | 2014-12-27 | 2021-07-22 | Bonac Corporation | Naturally occuring miRNA for controlling gene expression, and use of same |
| MY194175A (en) * | 2015-02-10 | 2022-11-17 | Genzyme Corp | Variant rnai |
| WO2016131009A1 (en) | 2015-02-13 | 2016-08-18 | University Of Massachusetts | Compositions and methods for transient delivery of nucleases |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| WO2016172008A1 (en) | 2015-04-24 | 2016-10-27 | University Of Massachusetts | Modified aav constructions and uses thereof |
| WO2016196507A1 (en) | 2015-05-29 | 2016-12-08 | University Of Iowa Research Foundation | Methods of delivery of transgenes for treating brain diseases |
| CA3002980A1 (en) | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Prostate-targeting adeno-associated virus serotype vectors |
| CA3002982A1 (en) | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Methods and compositions for treating metabolic imbalance in neurodegenerative disease |
| KR20180071362A (ko) | 2015-11-16 | 2018-06-27 | 올릭스 주식회사 | MyD88 또는 TLR3을 타겟팅하는 RNA 복합체를 이용한 연령-관련 황반 변성의 치료 |
| EP3411059A4 (en) | 2016-02-02 | 2019-10-16 | University Of Massachusetts | METHOD FOR INCREASING THE EFFECTIVENESS OF THE SYSTEMIC DELIVERY OF AVV GENES TO THE CENTRAL NERVOUS SYSTEM |
| KR20180104692A (ko) | 2016-02-02 | 2018-09-21 | 올릭스 주식회사 | Angpt2 및 pdgfb를 표적화하는 rna 복합체를 사용하는 혈관신생 관련 질환의 치료 |
| JP6944942B2 (ja) | 2016-02-02 | 2021-10-06 | オリックス ファーマシューティカルズ，インコーポレーテッド | ＩＬ４Ｒα、ＴＲＰＡ１、またはＦ２ＲＬ１を標的とするＲＮＡ複合体を用いたアトピー性皮膚炎および喘息の治療 |
| EP4094780A3 (en) | 2016-02-12 | 2023-02-08 | University of Massachusetts | Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization |
| EP4335502A2 (en) * | 2016-04-02 | 2024-03-13 | Research Institute at Nationwide Children's Hospital | Modified u6 promoter system for tissue specific expression |
| KR102339886B1 (ko) | 2016-04-11 | 2021-12-17 | 올릭스 주식회사 | 연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법 |
| US11413356B2 (en) | 2016-04-15 | 2022-08-16 | University Of Massachusetts | Methods and compositions for treating metabolic imbalance |
| BR112018073472A2 (pt) | 2016-05-18 | 2019-08-27 | Voyager Therapeutics Inc | composições e métodos de tratamento da doença de huntington |
| EP3458588A4 (en) | 2016-05-18 | 2020-01-15 | Voyager Therapeutics, Inc. | MODULATING POLYNUCLEOTIDES |
| WO2017218852A1 (en) | 2016-06-15 | 2017-12-21 | University Of Massachusetts | Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
| AU2017341849B2 (en) | 2016-10-13 | 2024-03-21 | University Of Massachusetts | AAV capsid designs |
| US11142765B2 (en) * | 2016-12-14 | 2021-10-12 | Benitec Ip Holdings, Inc. | Reagents for treatment of oculopharyngeal muscular dystrophy (OPMD) and use thereof |
| US11591600B2 (en) | 2017-02-10 | 2023-02-28 | OliX Pharmaceuticals. Inc. | Long double-stranded RNA for RNA interference |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| AU2018261790A1 (en) | 2017-05-05 | 2019-11-28 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| JP7327803B2 (ja) | 2017-05-09 | 2023-08-16 | ユニバーシティ オブ マサチューセッツ | 筋萎縮性側索硬化症（ａｌｓ）を処置する方法 |
| EP3684937A4 (en) | 2017-09-22 | 2021-06-02 | University of Massachusetts | DUAL EXPRESSION VECTORS OF SOD1 AND THEIR USES |
| AU2018335410A1 (en) | 2017-09-22 | 2020-05-07 | Genzyme Corporation | Variant RNAi |
| US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
| CN112805382A (zh) | 2018-08-03 | 2021-05-14 | 建新公司 | 针对α-突触核蛋白的变体RNAi |
| US20210324417A1 (en) * | 2018-08-29 | 2021-10-21 | Research Institute At Nationwide Children's Hospital | Products and methods for inhibition of expression of mutant gars protein |
| US20220288101A1 (en) * | 2019-08-15 | 2022-09-15 | The Children's Hospital Of Philadelphia | Combined transgene and intron-derived mirna therapy for treatment of sca1 |
| CN112980837B (zh) * | 2019-12-13 | 2023-07-04 | 深圳艾码生物科技有限公司 | 一种抑制HTT基因表达的siRNA及其前体和应用 |
| JP2024505575A (ja) * | 2021-02-03 | 2024-02-06 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | Ｄｕｘ４過剰発現に関連する疾患を治療するための組成物及び方法 |
| KR20230162024A (ko) * | 2021-03-29 | 2023-11-28 | 알닐람 파마슈티칼스 인코포레이티드 | 헌팅틴(HTT) iRNA 제제 조성물 및 이의 사용 방법 |
| WO2023069979A1 (en) | 2021-10-20 | 2023-04-27 | University Of Rochester | Isolated glial progenitor cells for use in the competition treatment of age-related white matter loss |
| WO2023196862A1 (en) | 2022-04-06 | 2023-10-12 | Genzyme Corporation | Targeted gene therapy for dm-1 myotonic dystrophy |
| WO2023205354A1 (en) * | 2022-04-20 | 2023-10-26 | Texas Tech University System | Synaptosomal micro rnas and synapse functions in alzheimer's disease |
| WO2023225160A1 (en) | 2022-05-18 | 2023-11-23 | The Children's Hospital Of Philadelphia | Compositions and methods for inducible alternative splicing regulation of gene expression |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US4962091A (en) | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| CA2145093C (en) | 1992-09-25 | 2007-04-10 | Lawrence Leroy Kunz | Therapeutic inhibitor of vascular smooth muscle cells |
| AU7676894A (en) | 1993-08-27 | 1995-03-21 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Convection-enhanced drug delivery |
| ES2326893T3 (es) | 1998-05-27 | 2009-10-21 | Genzyme Corporation | Vectores aav para la fabricacion de medicamentos para administracion potenciada por conveccion. |
| CA2327208A1 (en) | 2000-11-30 | 2002-05-30 | The Government Of The United States Of America | Methods of increasing distribution of therapeutic agents |
| US7182944B2 (en) | 2001-04-25 | 2007-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of increasing distribution of nucleic acids |
| EP2390330B1 (en) | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| US20080176812A1 (en) | 2002-08-05 | 2008-07-24 | Davidson Beverly L | Allele-specific silencing of disease genes |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| US20050255086A1 (en) | 2002-08-05 | 2005-11-17 | Davidson Beverly L | Nucleic acid silencing of Huntington's Disease gene |
| US20090105169A1 (en) | 2002-08-05 | 2009-04-23 | University Of Iowa Research Foundation | Allele-specific silencing of disease genes |
| US20040023390A1 (en) | 2002-08-05 | 2004-02-05 | Davidson Beverly L. | SiRNA-mediated gene silencing with viral vectors |
| US20080274989A1 (en) | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
| US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| US7605249B2 (en) | 2002-11-26 | 2009-10-20 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
| US10793873B2 (en) * | 2003-11-21 | 2020-10-06 | Revivicor, Inc. | Use of interfering RNA in the production of transgenic animals |
| EP1735443A2 (en) | 2004-04-14 | 2006-12-27 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF POLYGLUTAMINE (POLYQ) REPEAT EXPANSION DISEASES USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP1809748B1 (en) * | 2004-10-12 | 2012-12-26 | The Rockefeller University | Micrornas |
| AU2006210973A1 (en) | 2005-01-31 | 2006-08-10 | University Of Iowa Research Foundation | Nucleic acid silencing of Huntington's Disease gene |
| WO2006121960A2 (en) | 2005-05-06 | 2006-11-16 | Medtronic, Inc. | Methods and sequences to suppress primate huntington gene expression |
| US7902352B2 (en) | 2005-05-06 | 2011-03-08 | Medtronic, Inc. | Isolated nucleic acid duplex for reducing huntington gene expression |
| WO2007022506A2 (en) | 2005-08-18 | 2007-02-22 | University Of Massachusetts | Methods and compositions for treating neurological disease |
| AU2006305886C1 (en) | 2005-10-28 | 2011-03-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of huntingtin gene |
| JP5425474B2 (ja) | 2006-01-26 | 2014-02-26 | アイシス ファーマシューティカルズ， インコーポレーテッド | ハンチンチン対する、組成物及びその使用 |
| CA2670967C (en) | 2006-11-29 | 2016-05-10 | University Of Iowa Research Foundation | Alternative export pathways for vector expressed rna interference |
| CA2688514A1 (en) | 2007-04-26 | 2008-11-06 | University Of Iowa Research Foundation | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
| PT2164967E (pt) | 2007-05-31 | 2015-10-27 | Univ Iowa Res Found | Redução da toxicidade não dirigida do arn de interferência |
| EP3396952B1 (en) | 2017-04-25 | 2019-04-17 | Axis AB | Method and image processing unit for forming a video stream |
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2008
- 2008-05-29 PT PT87564530T patent/PT2164967E/pt unknown
- 2008-05-29 WO PCT/US2008/065130 patent/WO2008150897A2/en active Application Filing
- 2008-05-29 EP EP12176494.8A patent/EP2530152B1/en active Active
- 2008-05-29 ES ES08756453.0T patent/ES2549122T3/es active Active
- 2008-05-29 CA CA2691617A patent/CA2691617C/en active Active
- 2008-05-29 EP EP08756453.0A patent/EP2164967B1/en active Active
- 2008-05-29 AU AU2008260103A patent/AU2008260103B2/en active Active
- 2008-05-29 US US12/129,523 patent/US8258286B2/en active Active
- 2008-05-29 DK DK08756453.0T patent/DK2164967T3/en active
-
2012
- 2012-07-18 US US13/552,454 patent/US8524881B2/en active Active
-
2013
- 2013-08-27 US US14/011,539 patent/US9650631B2/en active Active
-
2014
- 2014-07-02 AU AU2014203611A patent/AU2014203611A1/en not_active Abandoned
-
2016
- 2016-09-07 AU AU2016225830A patent/AU2016225830A1/en not_active Abandoned
-
2017
- 2017-04-07 US US15/482,284 patent/US10093927B2/en active Active
-
2018
- 2018-06-19 AU AU2018204404A patent/AU2018204404A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2530152A1 (en) | 2012-12-05 |
| WO2008150897A2 (en) | 2008-12-11 |
| AU2014203611A1 (en) | 2014-07-17 |
| ES2549122T3 (es) | 2015-10-23 |
| EP2164967B1 (en) | 2015-07-08 |
| AU2008260103A1 (en) | 2008-12-11 |
| AU2018204404A1 (en) | 2018-07-05 |
| AU2008260103B2 (en) | 2014-04-03 |
| CA2691617C (en) | 2020-07-21 |
| EP2530152B1 (en) | 2017-12-27 |
| DK2164967T3 (en) | 2015-10-19 |
| WO2008150897A3 (en) | 2009-06-11 |
| US20170022495A9 (en) | 2017-01-26 |
| US8258286B2 (en) | 2012-09-04 |
| US20090130751A1 (en) | 2009-05-21 |
| US10093927B2 (en) | 2018-10-09 |
| US20140303362A1 (en) | 2014-10-09 |
| US20170369877A1 (en) | 2017-12-28 |
| AU2016225830A1 (en) | 2016-09-29 |
| EP2164967A2 (en) | 2010-03-24 |
| US9650631B2 (en) | 2017-05-16 |
| CA2691617A1 (en) | 2008-12-11 |
| US8524881B2 (en) | 2013-09-03 |
| US20120283424A1 (en) | 2012-11-08 |
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