SG11201609830RA - 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are jak inhibitors - Google Patents
5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are jak inhibitorsInfo
- Publication number
- SG11201609830RA SG11201609830RA SG11201609830RA SG11201609830RA SG11201609830RA SG 11201609830R A SG11201609830R A SG 11201609830RA SG 11201609830R A SG11201609830R A SG 11201609830RA SG 11201609830R A SG11201609830R A SG 11201609830RA SG 11201609830R A SG11201609830R A SG 11201609830RA
- Authority
- SG
- Singapore
- Prior art keywords
- chloro
- jak inhibitors
- pyrazolopyrimidine compounds
- difluoromethoxyphenyl pyrazolopyrimidine
- difluoromethoxyphenyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462002547P | 2014-05-23 | 2014-05-23 | |
US201562101234P | 2015-01-08 | 2015-01-08 | |
US201562130098P | 2015-03-09 | 2015-03-09 | |
CNPCT/CN2015/077176 | 2015-04-22 | ||
PCT/EP2015/061350 WO2015177326A1 (fr) | 2014-05-23 | 2015-05-22 | Composés 5-chloro -2-difluorométhoxyphényl pyrazolopyrimidine utilisés en tant qu'inhibiteurs de jak |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201609830RA true SG11201609830RA (en) | 2016-12-29 |
Family
ID=53276096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201609830RA SG11201609830RA (en) | 2014-05-23 | 2015-05-22 | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are jak inhibitors |
Country Status (19)
Country | Link |
---|---|
US (5) | US9346815B2 (fr) |
EP (1) | EP3145929B1 (fr) |
JP (2) | JP2017516850A (fr) |
KR (1) | KR20170005870A (fr) |
CN (2) | CN106459039A (fr) |
AU (3) | AU2015261812B2 (fr) |
CA (1) | CA2948589A1 (fr) |
CL (1) | CL2016002877A1 (fr) |
EA (1) | EA032488B1 (fr) |
HR (1) | HRP20210935T1 (fr) |
HU (1) | HUE054784T2 (fr) |
IL (2) | IL248661B (fr) |
MX (1) | MX2016015062A (fr) |
PE (2) | PE20170663A1 (fr) |
PH (1) | PH12016502099A1 (fr) |
SG (1) | SG11201609830RA (fr) |
SI (1) | SI3145929T1 (fr) |
TW (1) | TWI699364B (fr) |
WO (1) | WO2015177326A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
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SG11201609830RA (en) * | 2014-05-23 | 2016-12-29 | Hoffmann La Roche | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are jak inhibitors |
US10544117B2 (en) | 2014-09-10 | 2020-01-28 | Temple University—Of the Commonwealth System of Higher Education | 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
WO2016183150A1 (fr) * | 2015-05-12 | 2016-11-17 | Temple University-Of The Commonwealth System Of Higher Education | Nouveaux liants des récepteurs sigma 2 et leur procédé d'utilisation |
TW201720828A (zh) * | 2015-11-23 | 2017-06-16 | 赫孚孟拉羅股份公司 | 治療性化合物及組合物以及其使用方法 |
CN108368112B (zh) * | 2015-12-18 | 2021-11-02 | 豪夫迈·罗氏有限公司 | 治疗性化合物、组合物和它们的使用方法 |
JP6936236B2 (ja) * | 2016-02-18 | 2021-09-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 治療化合物、組成物及びその方法の使用 |
KR20190100337A (ko) * | 2016-12-29 | 2019-08-28 | 에프. 호프만-라 로슈 아게 | 피라졸로피리미딘 화합물 및 이의 사용 방법 |
JP2020510061A (ja) * | 2017-03-14 | 2020-04-02 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ピラゾロクロロフェニル化合物、組成物及びその使用方法 |
KR20200010390A (ko) * | 2017-05-22 | 2020-01-30 | 에프. 호프만-라 로슈 아게 | 치료 화합물 및 조성물, 및 이의 사용 방법 |
US20180334465A1 (en) | 2017-05-22 | 2018-11-22 | Genentech, Inc. | Therapeutic compounds and compositions, and methods of use thereof |
EP3697759A4 (fr) | 2017-10-20 | 2021-05-12 | Vanderbilt University | Antagonistes du récepteur muscarinique de l'acétylcholine m4 |
CN111565718A (zh) | 2017-10-31 | 2020-08-21 | 范德比尔特大学 | 毒蕈碱性乙酰胆碱受体m4的拮抗剂 |
CN111587250A (zh) * | 2018-01-15 | 2020-08-25 | 豪夫迈·罗氏有限公司 | 作为jak抑制剂的吡唑并嘧啶化合物 |
AU2019216492A1 (en) * | 2018-02-02 | 2020-08-20 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
CN111971287B (zh) * | 2018-03-28 | 2023-06-02 | 重庆复尚源创医药技术有限公司 | 作为trk激酶抑制剂的大环化合物 |
AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN113518771A (zh) | 2019-03-13 | 2021-10-19 | 大塚制药株式会社 | 向含有仲胺的化合物的胺部分导入氘代低级烷基的方法 |
TW202115069A (zh) * | 2019-06-18 | 2021-04-16 | 瑞士商赫孚孟拉羅股份公司 | Jak激酶之經四唑取代之吡唑并嘧啶抑制劑及其用途 |
JP2022537964A (ja) | 2019-06-18 | 2022-08-31 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Jakキナーゼのピラゾロピリミジンスルホン阻害剤およびその使用 |
WO2020257143A1 (fr) | 2019-06-18 | 2020-12-24 | Genentech, Inc. | Inhibiteurs éther-aryl-pyrazolopyrimidine de kinases jak et leurs utilisations |
KR20230069162A (ko) | 2020-09-18 | 2023-05-18 | 스미토모 파마 가부시키가이샤 | 아민 유도체 |
WO2022251533A1 (fr) * | 2021-05-27 | 2022-12-01 | Protego Biopharma, Inc. | Hétéroaryl-diamides activateurs d'ire1/xbp1s |
WO2022256358A1 (fr) | 2021-06-03 | 2022-12-08 | Genentech, Inc. | Procédé de préparation de médicaments |
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2015
- 2015-05-22 SG SG11201609830RA patent/SG11201609830RA/en unknown
- 2015-05-22 PE PE2016002240A patent/PE20170663A1/es unknown
- 2015-05-22 CN CN201580026680.7A patent/CN106459039A/zh active Pending
- 2015-05-22 WO PCT/EP2015/061350 patent/WO2015177326A1/fr active Application Filing
- 2015-05-22 JP JP2017513346A patent/JP2017516850A/ja not_active Withdrawn
- 2015-05-22 EP EP15726064.7A patent/EP3145929B1/fr active Active
- 2015-05-22 HU HUE15726064A patent/HUE054784T2/hu unknown
- 2015-05-22 TW TW104116569A patent/TWI699364B/zh active
- 2015-05-22 MX MX2016015062A patent/MX2016015062A/es unknown
- 2015-05-22 CN CN201910249668.2A patent/CN109970743B/zh active Active
- 2015-05-22 SI SI201531621T patent/SI3145929T1/sl unknown
- 2015-05-22 AU AU2015261812A patent/AU2015261812B2/en active Active
- 2015-05-22 CA CA2948589A patent/CA2948589A1/fr active Granted
- 2015-05-22 PE PE2021000895A patent/PE20211782A1/es unknown
- 2015-05-22 EA EA201692338A patent/EA032488B1/ru not_active IP Right Cessation
- 2015-05-22 US US14/720,323 patent/US9346815B2/en active Active
- 2015-05-22 KR KR1020167036075A patent/KR20170005870A/ko not_active Application Discontinuation
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2016
- 2016-04-26 US US15/139,164 patent/US9604984B2/en active Active
- 2016-10-20 PH PH12016502099A patent/PH12016502099A1/en unknown
- 2016-10-31 IL IL24866116A patent/IL248661B/en active IP Right Grant
- 2016-11-11 CL CL2016002877A patent/CL2016002877A1/es unknown
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2017
- 2017-02-03 US US15/424,536 patent/US20170145020A1/en not_active Abandoned
- 2017-11-22 US US15/820,515 patent/US20180305355A1/en not_active Abandoned
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2019
- 2019-06-11 US US16/438,135 patent/US20190322661A1/en not_active Abandoned
- 2019-08-01 IL IL268446A patent/IL268446A/en unknown
- 2019-10-30 AU AU2019257450A patent/AU2019257450A1/en not_active Abandoned
-
2020
- 2020-06-24 JP JP2020108861A patent/JP7041198B2/ja active Active
-
2021
- 2021-06-07 AU AU2021203734A patent/AU2021203734A1/en not_active Abandoned
- 2021-06-10 HR HRP20210935TT patent/HRP20210935T1/hr unknown
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