SG11201502741WA - Methods and systems for optimizing perfusion cell culture system - Google Patents

Methods and systems for optimizing perfusion cell culture system

Info

Publication number
SG11201502741WA
SG11201502741WA SG11201502741WA SG11201502741WA SG11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA
Authority
SG
Singapore
Prior art keywords
systems
methods
cell culture
culture system
perfusion cell
Prior art date
Application number
SG11201502741WA
Other languages
English (en)
Inventor
Yuval Shimoni
Volker Moehrle
Venkatesh Srinivasan
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of SG11201502741WA publication Critical patent/SG11201502741WA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18External loop; Means for reintroduction of fermented biomass or liquid percolate
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02Percolation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02Separating microorganisms from the culture medium; Concentration of biomass
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10Separation or concentration of fermentation products

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201502741WA 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system SG11201502741WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712190P 2012-10-10 2012-10-10
PCT/US2013/064159 WO2014059035A1 (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system

Publications (1)

Publication Number Publication Date
SG11201502741WA true SG11201502741WA (en) 2015-05-28

Family

ID=49448331

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201502741WA SG11201502741WA (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system
SG10201705806YA SG10201705806YA (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201705806YA SG10201705806YA (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system

Country Status (15)

Country Link
US (2) US20140099711A1 (enExample)
EP (1) EP2906677A1 (enExample)
JP (1) JP6393267B2 (enExample)
KR (1) KR20150063541A (enExample)
CN (1) CN104822821A (enExample)
AR (1) AR092967A1 (enExample)
AU (1) AU2013329318A1 (enExample)
CA (1) CA2887581A1 (enExample)
HK (1) HK1213285A1 (enExample)
IL (1) IL238179A0 (enExample)
MX (1) MX2015004516A (enExample)
RU (1) RU2015117547A (enExample)
SG (2) SG11201502741WA (enExample)
TW (1) TW201418455A (enExample)
WO (1) WO2014059035A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9944894B2 (en) 2015-01-16 2018-04-17 General Electric Company Pluripotent stem cell expansion and passage using a rocking platform bioreactor
CN105385731B (zh) * 2015-12-25 2018-10-30 上海莱士血液制品股份有限公司 一种表达重组八因子的灌注培养方法
ITUB20160272A1 (it) * 2016-01-22 2017-07-22 Univ Degli Studi Di Palermo Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D
EP3433352A1 (en) * 2016-03-21 2019-01-30 General Electric Company Pluripotent stem cell expansion and passage using a stirred tank bioreactor
IL273549B2 (en) 2017-10-06 2023-10-01 Lonza Ag Automated control of cell culture using Raman spectroscopy
TW202538049A (zh) 2017-10-16 2025-10-01 美商再生元醫藥公司 灌注生物反應器及相關使用方法
EP3797149A1 (en) * 2018-05-22 2021-03-31 Nantkwest, Inc. Methods and systems for cell bed formation during bioprocessing
WO2019229764A1 (en) * 2018-06-01 2019-12-05 Gennova Biopharmaceuticals Limited Process for production of recombinant tnk-tpa by packed-bed perfusion system
JP7453151B2 (ja) * 2018-11-02 2024-03-19 協和キリン株式会社 液体培地の調製方法
GB201903813D0 (en) * 2019-03-20 2019-05-01 Cn Bio Innovations Ltd Dual circulation microphysiological system
US12325848B2 (en) 2019-05-15 2025-06-10 Life Technologies Corporation Cell settler apparatus systems and methods for perfusion processes
EP4055136A1 (en) * 2019-11-07 2022-09-14 Merck Patent GmbH Methods and systems for performing perfusion cell culture
JP2023503849A (ja) 2019-11-15 2023-02-01 ロンザ リミテッド 接種物を生産するためのプロセスおよびシステム
WO2021110870A1 (en) 2019-12-05 2021-06-10 Acib Gmbh Method for producing a fermentation product
KR20220120606A (ko) * 2019-12-19 2022-08-30 우니베르지태트 퓌르 보덴쿨투르 빈 고체로부터 공정 재료의 연속 재구성

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6338964B1 (en) 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
US20040185534A1 (en) * 2000-10-02 2004-09-23 Knudsen Ida Molgaard Industrial-scale serum-free production of recombinant proteins in mammalian cells
JP2007510416A (ja) * 2003-11-03 2007-04-26 セントカー・インコーポレーテツド バイオプロセッシングシステムにおいて低剪断を維持する方法
US20090280565A1 (en) * 2005-12-22 2009-11-12 Corporation De L'ecole Polytechique Montr'eal High-rate perfusion bioreactor
JP2009535019A (ja) * 2006-04-21 2009-10-01 バイエル・ヘルスケア・エルエルシー 灌流培養への哺乳動物細胞中の抗アポトーシス遺伝子の応用
ES2657055T3 (es) * 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores
KR101648765B1 (ko) * 2008-06-13 2016-08-17 센토코 오르토 바이오테크 인코포레이티드 포유류 세포 배양에서 고 생존 세포 밀도를 얻는 방법
EP2686415B1 (en) * 2011-03-18 2017-11-15 GE Healthcare Bio-Sciences AB Flexible bag for cultivation of cells

Also Published As

Publication number Publication date
KR20150063541A (ko) 2015-06-09
JP2015531241A (ja) 2015-11-02
SG10201705806YA (en) 2017-08-30
WO2014059035A1 (en) 2014-04-17
CA2887581A1 (en) 2014-04-17
IL238179A0 (en) 2015-05-31
AR092967A1 (es) 2015-05-06
US20140099711A1 (en) 2014-04-10
MX2015004516A (es) 2015-10-14
AU2013329318A1 (en) 2015-05-14
RU2015117547A (ru) 2016-12-10
CN104822821A (zh) 2015-08-05
EP2906677A1 (en) 2015-08-19
HK1213285A1 (zh) 2016-06-30
JP6393267B2 (ja) 2018-09-19
TW201418455A (zh) 2014-05-16
US20150299638A1 (en) 2015-10-22

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