SG11201502741WA - Methods and systems for optimizing perfusion cell culture system - Google Patents

Methods and systems for optimizing perfusion cell culture system

Info

Publication number
SG11201502741WA
SG11201502741WA SG11201502741WA SG11201502741WA SG11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA SG 11201502741W A SG11201502741W A SG 11201502741WA
Authority
SG
Singapore
Prior art keywords
systems
methods
cell culture
culture system
perfusion cell
Prior art date
Application number
SG11201502741WA
Inventor
Yuval Shimoni
Volker Moehrle
Venkatesh Srinivasan
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of SG11201502741WA publication Critical patent/SG11201502741WA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02—Percolation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
SG11201502741WA 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system SG11201502741WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712190P 2012-10-10 2012-10-10
PCT/US2013/064159 WO2014059035A1 (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system

Publications (1)

Publication Number Publication Date
SG11201502741WA true SG11201502741WA (en) 2015-05-28

Family

ID=49448331

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201502741WA SG11201502741WA (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system
SG10201705806YA SG10201705806YA (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201705806YA SG10201705806YA (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system

Country Status (15)

Country Link
US (2) US20140099711A1 (en)
EP (1) EP2906677A1 (en)
JP (1) JP6393267B2 (en)
KR (1) KR20150063541A (en)
CN (1) CN104822821A (en)
AR (1) AR092967A1 (en)
AU (1) AU2013329318A1 (en)
CA (1) CA2887581A1 (en)
HK (1) HK1213285A1 (en)
IL (1) IL238179A0 (en)
MX (1) MX2015004516A (en)
RU (1) RU2015117547A (en)
SG (2) SG11201502741WA (en)
TW (1) TW201418455A (en)
WO (1) WO2014059035A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9944894B2 (en) 2015-01-16 2018-04-17 General Electric Company Pluripotent stem cell expansion and passage using a rocking platform bioreactor
CN105385731B (en) * 2015-12-25 2018-10-30 上海莱士血液制品股份有限公司 A kind of perfusion cultural method of eight factors of expression recombination
ITUB20160272A1 (en) * 2016-01-22 2017-07-22 Univ Degli Studi Di Palermo Disposable self-sufficient perfusion bioreactor for 3D cell growths
WO2017162467A1 (en) * 2016-03-21 2017-09-28 General Electric Company Pluripotent stem cell expansion and passage using a stirred tank bioreactor
CN111344558A (en) 2017-10-06 2020-06-26 龙沙有限公司 Automated control of cell culture using raman spectroscopy
EP4039786A1 (en) 2017-10-16 2022-08-10 Regeneron Pharmaceuticals, Inc. Perfusion bioreactor and related methods of use
GB201903813D0 (en) * 2019-03-20 2019-05-01 Cn Bio Innovations Ltd Dual circulation microphysiological system
WO2020232183A1 (en) * 2019-05-15 2020-11-19 Life Technologies Corporation Cell settler apparatus systems and methods for perfusion processes
WO2021110870A1 (en) 2019-12-05 2021-06-10 Acib Gmbh Method for producing a fermentation product

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6338964B1 (en) 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
US20040185534A1 (en) * 2000-10-02 2004-09-23 Knudsen Ida Molgaard Industrial-scale serum-free production of recombinant proteins in mammalian cells
JP2007510416A (en) * 2003-11-03 2007-04-26 セントカー・インコーポレーテツド Method for maintaining low shear in a bioprocessing system
WO2007071072A1 (en) * 2005-12-22 2007-06-28 Corporation De L'ecole Polytechnique De Montreal High-rate perfusion bioreactor
US20100167396A1 (en) * 2006-04-21 2010-07-01 Bayer Healthcare Llc Application of Anti-Apoptotic Gene Expression in Mammalian Cells for Perfusion Culture
US20090042253A1 (en) * 2007-08-09 2009-02-12 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
BRPI0915171A2 (en) * 2008-06-13 2015-08-04 Centocor Ortho Biotech Inc Methods to obtain high density of viable cells in mammalian cell culture
EP2686415B1 (en) * 2011-03-18 2017-11-15 GE Healthcare Bio-Sciences AB Flexible bag for cultivation of cells

Also Published As

Publication number Publication date
AU2013329318A1 (en) 2015-05-14
CN104822821A (en) 2015-08-05
EP2906677A1 (en) 2015-08-19
WO2014059035A1 (en) 2014-04-17
JP2015531241A (en) 2015-11-02
RU2015117547A (en) 2016-12-10
KR20150063541A (en) 2015-06-09
MX2015004516A (en) 2015-10-14
IL238179A0 (en) 2015-05-31
TW201418455A (en) 2014-05-16
SG10201705806YA (en) 2017-08-30
AR092967A1 (en) 2015-05-06
US20150299638A1 (en) 2015-10-22
CA2887581A1 (en) 2014-04-17
HK1213285A1 (en) 2016-06-30
JP6393267B2 (en) 2018-09-19
US20140099711A1 (en) 2014-04-10

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