SG11201407610WA - Cd33 antibodies and use of same to treat cancer - Google Patents
Cd33 antibodies and use of same to treat cancerInfo
- Publication number
- SG11201407610WA SG11201407610WA SG11201407610WA SG11201407610WA SG11201407610WA SG 11201407610W A SG11201407610W A SG 11201407610WA SG 11201407610W A SG11201407610W A SG 11201407610WA SG 11201407610W A SG11201407610W A SG 11201407610WA SG 11201407610W A SG11201407610W A SG 11201407610WA
- Authority
- SG
- Singapore
- Prior art keywords
- sgd
- lllll
- bothell
- international
- drive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261649110P | 2012-05-18 | 2012-05-18 | |
US13/804,227 US20130309223A1 (en) | 2012-05-18 | 2013-03-14 | CD33 Antibodies And Use Of Same To Treat Cancer |
PCT/US2013/041209 WO2013173496A2 (fr) | 2012-05-18 | 2013-05-15 | Anticorps cd33 et leur utilisation pour traiter le cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201407610WA true SG11201407610WA (en) | 2014-12-30 |
Family
ID=49581477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201407610WA SG11201407610WA (en) | 2012-05-18 | 2013-05-15 | Cd33 antibodies and use of same to treat cancer |
Country Status (19)
Country | Link |
---|---|
US (4) | US20130309223A1 (fr) |
EP (2) | EP3421048A1 (fr) |
JP (1) | JP6454269B2 (fr) |
KR (2) | KR102100467B1 (fr) |
CN (1) | CN104936617B (fr) |
AU (3) | AU2013262788B2 (fr) |
CA (1) | CA2873286C (fr) |
DK (1) | DK2850104T3 (fr) |
EA (1) | EA029987B1 (fr) |
ES (1) | ES2686618T3 (fr) |
HK (1) | HK1206750A1 (fr) |
IL (1) | IL235733B (fr) |
IN (1) | IN2014DN10653A (fr) |
MX (1) | MX350808B (fr) |
NZ (1) | NZ702748A (fr) |
SG (1) | SG11201407610WA (fr) |
TW (1) | TWI593707B (fr) |
WO (1) | WO2013173496A2 (fr) |
ZA (1) | ZA201409224B (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2523915T5 (es) | 2006-12-01 | 2022-05-26 | Seagen Inc | Agentes de unión a la diana variantes y usos de los mismos |
US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
CA2921707C (fr) | 2013-10-15 | 2023-03-28 | Seattle Genetics, Inc. | Lieurs de medicaments pegyles pour pharmacocinetique de conjugues ligand-medicament amelioree |
US10457976B2 (en) * | 2013-11-25 | 2019-10-29 | Seattle Genetics, Inc. | Preparing antibodies from CHO cell cultures for conjugation |
KR20160098328A (ko) * | 2013-12-13 | 2016-08-18 | 제넨테크, 인크. | 항-cd33 항체 및 면역접합체 |
EP4190809A1 (fr) | 2014-02-11 | 2023-06-07 | Seagen Inc. | Réduction sélective de protéines |
SG10202001468UA (en) | 2014-02-17 | 2020-04-29 | Seattle Genetics Inc | Hydrophilic antibody-drug conjugates |
DK3126390T3 (da) * | 2014-04-03 | 2020-01-20 | Cellectis | Cd33-specifikke kimære antigenreceptorer til cancerimmunterapi |
CN112481283A (zh) * | 2014-07-21 | 2021-03-12 | 诺华股份有限公司 | 使用cd33嵌合抗原受体治疗癌症 |
EP3250605A1 (fr) | 2015-01-26 | 2017-12-06 | Cellectis | Récepteurs d'antigènes chimériques (car) spécifiques anti-hsp70 pour une immunothérapie anticancéreuse |
TW201709932A (zh) | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Cd123抗體及其共軛物 |
WO2016201389A2 (fr) | 2015-06-12 | 2016-12-15 | Alector Llc | Anticorps anti-cd33 et leurs procédés d'utilisation |
US11136390B2 (en) | 2015-06-12 | 2021-10-05 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
CN107735105B (zh) | 2015-06-30 | 2022-09-16 | 西雅图基因公司 | 抗ntb-a抗体和相关组合物以及方法 |
US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
AU2016363013B2 (en) | 2015-12-04 | 2022-03-10 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
US11027021B2 (en) | 2016-03-15 | 2021-06-08 | Seagen Inc. | Combinations of PBD-based antibody drug conjugates with Bcl-2 inhibitors |
SG11201807827VA (en) | 2016-03-25 | 2018-10-30 | Seattle Genetics Inc | Process for the preparation of pegylated drug-linkers and intermediates thereof |
US20190117787A1 (en) * | 2016-04-15 | 2019-04-25 | Seattle Genetics, Inc. | Combinations of cd33 antibody drug conjugates with hypomethylating agents |
EP3463463A4 (fr) * | 2016-06-03 | 2020-01-15 | Seattle Genetics, Inc. | Combinaison de conjugués anticorps cd33 médicament avec des agents chimiothérapeutiques |
EP3469001A4 (fr) | 2016-06-09 | 2020-05-06 | Seattle Genetics, Inc. | Combinaisons de conjugués anticorps-médicament à base de pbd avec des d'inhibiteurs de flt3 |
TW201808343A (zh) | 2016-08-09 | 2018-03-16 | 美商西雅圖遺傳學公司 | 具有改善之生理化學性質之具自我穩定連接子之藥物結合物 |
BR112019006778A2 (pt) | 2016-10-18 | 2019-10-15 | Seattle Genetics Inc | Composição de conjugado de aglutinante-fármaco, formulação, uso da mesma, método para preparar uma composição ou composto de conjugado de aglutinantefármaco,e, composto de ligante de fármaco |
CA3045466A1 (fr) | 2016-12-01 | 2018-06-07 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-pd-l1 radiomarques pour imagerie immuno-pet |
JP7337698B2 (ja) | 2017-02-28 | 2023-09-04 | シージェン インコーポレイテッド | コンジュゲート化のためのシステイン突然変異抗体 |
MX2019010196A (es) | 2017-02-28 | 2019-12-19 | Vor Biopharma Inc | Composiciones y métodos para la inhibición de proteínas específicas del linaje. |
IL269398B2 (en) | 2017-03-24 | 2024-05-01 | Seagen Inc | A process for the preparation of glucuronide-drug binders and their intermediates |
KR20190141181A (ko) | 2017-04-27 | 2019-12-23 | 시애틀 지네틱스, 인크. | 사차화된 니코틴아미드 아데닌 다이뉴클레오타이드 구제 경로 억제제 콘쥬게이트 |
JP2020519640A (ja) * | 2017-05-17 | 2020-07-02 | イミュノジェン, インコーポレイテッド | 抗cd33イムノコンジュゲート投与計画 |
WO2018218207A1 (fr) * | 2017-05-26 | 2018-11-29 | Fred Hutchinson Cancer Research Center | Anticorps anti-cd33 et leurs utilisations |
BR112019023789A2 (pt) * | 2017-08-03 | 2020-07-28 | Alector Llc | anticorpos anti-cd33 e métodos de uso dos mesmos |
BR112019022752A2 (pt) | 2017-08-03 | 2020-05-19 | Alector Llc | anticorpos anti-trem2 e métodos de uso dos mesmos |
TWI820044B (zh) | 2017-09-29 | 2023-11-01 | 日商第一三共股份有限公司 | 抗體-吡咯并苯二氮呯衍生物複合體 |
SG11202007540SA (en) | 2018-02-20 | 2020-09-29 | Seattle Genetics Inc | Hydrophobic auristatin f compounds and conjugates thereof |
JP2021514206A (ja) * | 2018-02-20 | 2021-06-10 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Cd33を標的とする抗体可変ドメイン及びその使用 |
CN113423725A (zh) | 2018-08-28 | 2021-09-21 | Vor生物制药股份有限公司 | 遗传工程化造血干细胞及其用途 |
AU2019331018A1 (en) * | 2018-08-31 | 2021-03-11 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
EP4268831A3 (fr) | 2018-09-12 | 2024-05-22 | Fred Hutchinson Cancer Center | Réduction de l'expression de cd33 pour protéger sélectivement des cellules thérapeutiques |
US20210292413A1 (en) * | 2018-09-25 | 2021-09-23 | Academia Sinica | Anti-siglec antibody, pharmaceutical composition comprising the same, and uses thereof |
WO2020095107A1 (fr) | 2018-11-07 | 2020-05-14 | Crispr Therapeutics Ag | Immunothérapie cellulaire anti-cd33 contre le cancer |
SG11202104993SA (en) | 2018-11-14 | 2021-06-29 | Daiichi Sankyo Co Ltd | Anti-cdh6 antibody-pyrrolobenzodiazepine derivative conjugate |
EP3949987A4 (fr) | 2019-03-25 | 2023-02-22 | Daiichi Sankyo Company, Limited | Conjugué anticorps anti-her2/dérivé de pyrrolobenzodiazépine |
JPWO2020196474A1 (fr) | 2019-03-25 | 2020-10-01 | ||
EP3949988A4 (fr) | 2019-03-27 | 2022-11-16 | Daiichi Sankyo Company, Limited | Combinaison d'un conjugué anticorps-dérivé de pyrrolobenzodiazépine et d'un inhibiteur de parp |
CN114007642A (zh) | 2019-04-30 | 2022-02-01 | 森迪生物科学公司 | 嵌合受体及其使用方法 |
EP4084821A4 (fr) | 2020-01-03 | 2024-04-24 | Marengo Therapeutics, Inc. | Molécules multifonctionnelles se liant à cd33 et utilisations associées |
US20230173093A1 (en) | 2020-04-10 | 2023-06-08 | Seagen Inc. | Charge variant linkers |
US20210402001A1 (en) * | 2020-06-30 | 2021-12-30 | David I. Cohen | Zinc Porters, and their Monoclonal Antibody Conjugates, for the Prevention and Treatment of COVID-19 (SARS-CoV-2), Other Infections, and Cancers |
EP4209506A1 (fr) | 2020-09-02 | 2023-07-12 | Daiichi Sankyo Company, Limited | Nouvelle endo-?-n-acétylglucosaminidase |
EP4244259A1 (fr) * | 2020-11-11 | 2023-09-20 | Versapeutics Inc. | Variants d'anticorps dirigés contre le récepteur de wnt ryk |
JP2024503657A (ja) | 2021-01-13 | 2024-01-26 | メモリアル スローン-ケタリング キャンサー センター | 抗体-ピロロベンゾジアゼピン誘導体コンジュゲート |
EP4284394A1 (fr) | 2021-01-26 | 2023-12-06 | Cytocares (Shanghai) Inc. | Constructions de récepteur antigénique chimérique (car) et cellules nk exprimant des constructions de car |
JP2024514673A (ja) | 2021-04-20 | 2024-04-02 | シージェン インコーポレイテッド | 抗体依存性細胞傷害の調節 |
AU2022283467A1 (en) | 2021-05-28 | 2023-12-07 | Seagen Inc. | Anthracycline antibody conjugates |
TW202334238A (zh) | 2021-11-30 | 2023-09-01 | 日商第一三共股份有限公司 | 蛋白酶分解性遮蔽抗體 |
TW202400137A (zh) | 2022-03-17 | 2024-01-01 | 美商思進公司 | 喜樹鹼偶聯物 |
WO2024129756A1 (fr) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Conjugués anticorps-médicament modifiés par la cystéine spécifiques d'un site |
CN116375874B (zh) * | 2023-04-14 | 2023-12-26 | 上海精翰生物科技有限公司 | 一种cd33抗体及其应用 |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4634666A (en) | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
EP0307434B2 (fr) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Anticorps alteres |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
AU633698B2 (en) | 1990-01-12 | 1993-02-04 | Amgen Fremont Inc. | Generation of xenogeneic antibodies |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
WO1992003918A1 (fr) | 1990-08-29 | 1992-03-19 | Genpharm International, Inc. | Animaux non humains transgeniques capables de produire des anticorps heterologues |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
EP1400536A1 (fr) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Procédé pour fabriquer des anticorps humanisés |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
EP0746609A4 (fr) | 1991-12-17 | 1997-12-17 | Genpharm Int | Animaux transgeniques non humains capables de produire des anticorps heterologues |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US5837242A (en) | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US5877218A (en) | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
DE60045319D1 (de) | 1999-02-05 | 2011-01-13 | Samsung Electronics Co Ltd | Verfahren und Vorrichtung zum Wiederauffinden von Texturbildern |
CN1468259A (zh) * | 2000-08-08 | 2004-01-14 | ͨ��ҽ�ƹ�˾ | 慢性髓细胞白血病的免疫疗法 |
EP1539233B1 (fr) | 2001-07-12 | 2011-04-27 | FOOTE, Jefferson | Anticorps super humanises |
WO2004010957A2 (fr) | 2002-07-31 | 2004-02-05 | Seattle Genetics, Inc. | Conjugues de medicaments et leur utilisation dans le traitement du cancer, d'une maladie auto-immune ou d'une maladie infectieuse |
EA010570B1 (ru) * | 2002-11-07 | 2008-10-30 | Иммьюноджен, Инк. | Антитело к cd33 и способы его применения |
WO2004078215A2 (fr) | 2003-02-28 | 2004-09-16 | The Board Of Trustees Of The University Of Illinois | Utilisation d'enzymes specifiquement mises au point pour renforcer l'efficacite de promedicaments |
BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
AR048098A1 (es) * | 2004-03-15 | 2006-03-29 | Wyeth Corp | Conjugados de caliqueamicina |
EP2298807A3 (fr) | 2004-07-30 | 2011-05-18 | Rinat Neuroscience Corp. | Anticorps anti peptide amyloide beta, et leurs procedes d' utilisation |
CA2580141C (fr) | 2004-09-23 | 2013-12-10 | Genentech, Inc. | Anticorps et conjugues produits avec de la cysteine |
US8343928B2 (en) | 2005-07-07 | 2013-01-01 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus |
WO2007008848A2 (fr) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Composes de monomethylvaline presentant des modifications carboxy phenylalanine a la terminaison c |
US7910702B2 (en) | 2006-07-28 | 2011-03-22 | The Governors Of The University Of Alberta | Recombinant antibodies to sclerotinia antigens |
ES2523915T5 (es) | 2006-12-01 | 2022-05-26 | Seagen Inc | Agentes de unión a la diana variantes y usos de los mismos |
US7968687B2 (en) | 2007-10-19 | 2011-06-28 | Seattle Genetics, Inc. | CD19 binding agents and uses thereof |
CN106039307A (zh) * | 2008-08-05 | 2016-10-26 | 东丽株式会社 | 用于治疗和预防癌症的药物组合物 |
GB0819095D0 (en) * | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
EP2406285B1 (fr) * | 2009-03-10 | 2016-03-09 | Gene Techno Science Co., Ltd. | Génération, expression et caractérisation de l'anticorps monoclonal humanisé k33n |
DE102009045006A1 (de) | 2009-09-25 | 2011-04-14 | Technische Universität Dresden | Anti-CD33 Antikörper und ihre Anwendung zum Immunotargeting bei der Behandlung von CD33-assoziierten Erkrankungen |
EA024118B1 (ru) | 2010-04-15 | 2016-08-31 | Сиэтл Дженетикс, Инк. | Конъюгаты пирролбензодиазепина направленного действия |
UA112062C2 (uk) * | 2010-10-04 | 2016-07-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Cd33-зв'язувальний агент |
US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
CA2884313C (fr) * | 2012-12-13 | 2023-01-03 | Immunomedics, Inc. | Dosages d'immuno-conjugues d'anticorps et de sn-38 pour ameliorer l'efficacite et reduire la toxicite |
SG10202009046SA (en) * | 2013-03-13 | 2020-10-29 | Seattle Genetics Inc | Cyclodextrin and antibody-drug conjugate formulations |
-
2013
- 2013-03-14 US US13/804,227 patent/US20130309223A1/en not_active Abandoned
- 2013-05-15 MX MX2014013866A patent/MX350808B/es active IP Right Grant
- 2013-05-15 AU AU2013262788A patent/AU2013262788B2/en active Active
- 2013-05-15 DK DK13790467.8T patent/DK2850104T3/en active
- 2013-05-15 KR KR1020147035516A patent/KR102100467B1/ko active IP Right Grant
- 2013-05-15 WO PCT/US2013/041209 patent/WO2013173496A2/fr active Application Filing
- 2013-05-15 CN CN201380026079.9A patent/CN104936617B/zh active Active
- 2013-05-15 JP JP2015512801A patent/JP6454269B2/ja active Active
- 2013-05-15 IN IN10653DEN2014 patent/IN2014DN10653A/en unknown
- 2013-05-15 US US14/401,837 patent/US9587019B2/en active Active
- 2013-05-15 KR KR1020207010113A patent/KR102241478B1/ko active IP Right Grant
- 2013-05-15 EA EA201492137A patent/EA029987B1/ru unknown
- 2013-05-15 EP EP18171884.2A patent/EP3421048A1/fr active Pending
- 2013-05-15 CA CA2873286A patent/CA2873286C/fr active Active
- 2013-05-15 EP EP13790467.8A patent/EP2850104B1/fr active Active
- 2013-05-15 ES ES13790467.8T patent/ES2686618T3/es active Active
- 2013-05-15 NZ NZ702748A patent/NZ702748A/en unknown
- 2013-05-15 SG SG11201407610WA patent/SG11201407610WA/en unknown
- 2013-05-17 TW TW102117539A patent/TWI593707B/zh active
-
2014
- 2014-11-17 IL IL235733A patent/IL235733B/en unknown
- 2014-12-15 ZA ZA2014/09224A patent/ZA201409224B/en unknown
-
2015
- 2015-07-23 HK HK15107059.6A patent/HK1206750A1/xx unknown
-
2017
- 2017-01-20 US US15/411,947 patent/US10787514B2/en active Active
-
2018
- 2018-05-17 AU AU2018203508A patent/AU2018203508C1/en active Active
-
2020
- 2020-05-22 AU AU2020203365A patent/AU2020203365B2/en active Active
- 2020-07-29 US US16/942,647 patent/US20210047404A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201407610WA (en) | Cd33 antibodies and use of same to treat cancer | |
SG11201806261XA (en) | Bcma antibodies and use of same to treat cancer and immunological disorders | |
SG11201811003PA (en) | Anti-pd-l1 antibodies and uses thereof | |
SG11201807437XA (en) | Antibodies specific to human poliovirus receptor (pvr) | |
SG11201803703UA (en) | Anti-complement factor c1q fab fragments and uses thereof | |
SG11201805709RA (en) | Anti-pro/latent myostatin antibodies and methods of use thereof | |
SG11201804161VA (en) | Compositions comprising bacterial strains | |
SG11201408002TA (en) | Multi-parameter diabetes risk evaluations | |
SG11201407888RA (en) | Method of sequence determination using sequence tags | |
SG11201407233RA (en) | Ethylene oligomerization process | |
SG11201408780XA (en) | Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof | |
SG11201407534PA (en) | New diazaspirocycloalkane and azaspirocycloalkane | |
SG11201407669QA (en) | Methods for improving safety of blood-brain barrier transport | |
SG11201408385TA (en) | Methods of detecting diseases or conditions | |
SG11201408022XA (en) | Enterprise triggered 2chk association | |
SG11201407898WA (en) | Electrode testing apparatus | |
SG11201806496SA (en) | Antigen binding proteins that bind pd-l1 | |
SG11201407859YA (en) | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists | |
SG11201407200TA (en) | Liquid formulation | |
SG11201407370QA (en) | Humanized il-7 rodents | |
SG11201903785TA (en) | Bivalent antibodies masked by coiled coils | |
SG11201403106SA (en) | Anti-phf-tau antibodies and their uses | |
SG11201407473XA (en) | Nontransactional store instruction | |
SG11201407891QA (en) | Interest profile of a user of a mobile application | |
SG11201809830WA (en) | Selective reduction of cysteine-engineered antibodies |